Human Serpin C1/Antithrombin-III Antibody
Human Serpin C1/Antithrombin-III Antibody Summary
His33-Lys464
Accession # P01008
Applications
Antithrombin-III (Catalog # 1267-PI), see our available Western blot detection antibodies
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Serpin C1/Antithrombin-III
Serpin C1 is a member of the Serpin superfamily of the serine protease inhibitors (1). It is the principal plasma Serpin of blood clotting proteases and inhibits thrombin as well as several factors such as Xa (2). Similar to Serpins A5 and D1, its thrombin inhibitory activity is enhanced by heparin. Hereditary and acquired Serpin C1 deficiency is the cause of an increased thrombotic tendency in many cases (3). For example, acquired Serpin C1 deficiency is a common condition in sepsis, after major trauma or surgery (4).
- Silverman, G.A. et al. (2001) J. Biol. Chem. 276:33293.
- Chuang, Y.-J. et al. (2001) Biochemistry 40:6670.
- Vinazzer, H. (1999) Semin. Thromb. Hemost. 25:257.
- Risberg, B. (1998) Blood Coagul. Fibrinolysis Suppl. 3:S3.
Product Datasheets
Citation for Human Serpin C1/Antithrombin-III Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1.
Authors: Tseng IC, Chou FP, Su SF, Oberst M, Madayiputhiya N, Lee MS, Wang JK, Sloane DE, Johnson M, Lin CY
Am. J. Physiol., Cell Physiol., 2008;295(2):C423-31.
Species: Human
Sample Types: Milk
Applications: Western Blot
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Purified antithrombin bound to cell surface heparan sulfate was detected using 0.2 ug/ml serpin C1/antithrombin antibody and anti-goat-IgG-AlexaFluor488.
