Western blot shows lysates of human peripheral blood leukocyte. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human Syntaxin-BP2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5900) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for Syntaxin-BP2 at approximately 68 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.
Preparation and Storage
Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Syntaxin‑BP2 (STXBP2; Syntaxin-binding protein 2; also Unc18-2 and Unc18B) is a 64‑66 kDa member of the SNARE-interacting Sec1/Unc18/STXBP family of proteins. It is widely expressed, particularly in hematopoietic cells, and is found both in cytoplasm, and associated with membranes, where it binds to STX1A, 2, and 3. Thus, it presumably participates in primary granule exocytosis by promoting granule fusion. Human STXBP2 is 593 amino acids (aa) in length. It contains one SEC1 domain (aa 28‑576) with Trp28, Ser42, and Glu59 all playing a key role in syntaxin binding. There is one splice variant that shows a deletion of aa 83‑85. Over aa 80‑223, human and mouse STXBP2 share 95% aa sequence identity.
Syntaxin-binding Protein 2
Entrez Gene IDs:
6813 (Human); 20911 (Mouse); 81804 (Rat)
FHL5; Hunc18b; MUNC18-2; Protein unc-18 homolog 2; Protein unc-18 homolog B; STXBP2; syntaxin binding protein 2; syntaxin-binding protein 2; SyntaxinBP2; Syntaxin-BP2; Unc18-2; UNC18B; unc-18B; UNC18Bpp10122
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