Human URB Antibody

Catalog # Availability Size / Price Qty
Product Details
Citations (1)
Supplemental Products

Human URB Antibody Summary

Species Reactivity
Detects human URB in direct ELISAs and Western blots.
Polyclonal Goat IgG
Antigen Affinity-purified
Mouse myeloma cell line NS0-derived recombinant human URB
Accession # Q76M96
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Human URB (Catalog # 3410-UR)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: URB

URB (upregulated in BRS-3 deficient mice) is a 150 kDa, secreted glycoprotein that belongs to the sushi-repeat-containing protein superfamily (1, 2). Sushi repeats, otherwise known as short consensus repeats (SCRs), are 60 amino acid (aa) sequences usually involved in protein-protein interaction. They are characterized by the presence of four Cys, two Pro, one Gly and one Trp (3). Human URB is synthesized as a 950 aa precursor that contains a 21 aa signal sequence and a 929 aa mature region. The mature molecule contains three extended sushi/SCR domains of approximately 140 aa each. They bear resemblance to the fifth sushi-repeat in human SPRX (4). The three lie between aa 141‑281, 615‑760, and 771‑913, respectively. Between the first and second SCR lie two amino acid-rich regions, a Thr-rich domain (aa 347‑404), and a Lys-rich domain (aa 487‑588). Three potential N-linked glycosylation sites exist in the last two SCR’s, while six potential bipartite nuclear localization signals (NLS) occur between aa 420‑780. There are two potential alternate splice forms for human URB. One is 594 aa in length, and shows a simple truncation at Ser594. This effectively removes the second and third SCRs and two bipartite NLS (5). The second is 553 aa in length and shows a simple truncation after Lys553. This eliminates four bipartite NLSs, the second and third SCRs, and part of the Lys-rich domain (6). Full-length human URB is 83%, 84% and 87% aa identical to rat, mouse and bovine URB, respectively. URB is found in chondrocytes and appears to be downregulated upon CFU-Fibroblast differentiation (1). Thus, it may play a role in skeletogenesis.

  1. Liu, Y. et al. (2004) Biochem. Biophys. Res. Commun. 322:497.
  2. Aoki, K. et al. (2002) Biochem. Biophys. Res. Commun. 290:1282.
  3. Anatova, J. et al. (1989) Biochemistry 28:4754.
  4. Meindl, A. et al. (1995) Hum. Mol. Genet. 4:2339.
  5. Isogai, T. et al. (2002) GenBank Accession # BAC11475.
  6. Strausberg, R.L. et al. (2002) GenBank Accession # AAH86876.
Long Name
Up-regulated in BRS-3 Deficient Mouse/Okuribin/Coiled-coil Domain Containing Protein 80
Entrez Gene IDs
151887 (Human); 67896 (Mouse); 64387 (Rat)
Alternate Names
CCDC80; coiled-coil domain containing 80; down-regulated by oncogenes protein 1; DRO1; SSG1; Steroid-sensitive protein 1; URB

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Citation for Human URB Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. URB is abundantly expressed in adipose tissue and dysregulated in obesity.
    Authors: Okada T, Nishizawa H, Kurata A, Tamba S, Sonoda M, Yasui A, Kuroda Y, Hibuse T, Maeda N, Kihara S, Hadama T, Tobita K, Akamatsu S, Maeda K, Shimomura I, Funahashi T
    Biochem. Biophys. Res. Commun., 2008;367(2):370-6.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot


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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

Goat IgG (H+L) Antibody


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