Mouse FAM3B Antibody

Catalog # Availability Size / Price Qty
AF2867
AF2867-SP
Product Details
Citations (2)
FAQs
Supplemental Products
Reviews

Mouse FAM3B Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse FAM3B in direct ELISAs and Western blots. In direct ELISAs, approximately 35% cross‑reactivity with recombinant human FAM3B is observed, approximately 5% cross-reactivity with recombinant mouse (rm) FAM3C is observed, and less than 1% cross-reactivity with rmFAM3D is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse FAM3B
Glu30-Arg235
Accession # Q9D309
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Mouse FAM3B

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: FAM3B

FAM3B, also known as Pancreatic-Derived factor (PANDER), is a secreted, monomeric, 23 kDa glycoprotein that belongs to a new family of four-helix bundle cytokines. It is highly expressed in pancreatic islet cells and reproductive epithelium. FAM3B has been shown to induce b-cell apoptosis and decrease insulin secretion. Two alternative N-termini, at Glu 30 and Ser 46, have been observed for mature FAM3B. The long version of mature mouse FAM3B shares 80%, 92%, and 75% amino acid sequence homology with the human, rat and canine mature FAM3B, respectively.

Long Name
Family With Sequence Similarity 3, Member B
Entrez Gene IDs
54097 (Human)
Alternate Names
2-21; C21orf11; C21orf76PANDER; chromosome 21 open reading frame 11; Cytokine-like protein 2-21; D21M16SJHU19e; FAM3B; family with sequence similarity 3, member B; ORF9; pancreatic derived factor; Pancreatic-derived factor; PANDER; PRED44

Product Datasheets

Citations for Mouse FAM3B Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties
    Authors: C Azevedo, G Teku, Y Pomeshchik, JF Reyes, M Chumarina, K Russ, E Savchenko, A Hammarberg, NJ Lamas, A Collin, GK Gouras, O Klementiev, M Hallbeck, R Taipa, M Vihinen, L Roybon
    Proceedings of the National Academy of Sciences of the United States of America, 2022;119(12):e2111405119.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  2. Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic beta-cells by MCP-1 (CCL2).
    Authors: Hou X, Wang O, Li Z, Mou H, Chen J, Deng B, Qian L, Liu X, Le Y
    Mol. Cell. Endocrinol., 2011;343(1):18-24.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot

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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

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