Mouse IL-6 Quantikine ELISA Kit

(254 citations)
(3 Reviews)
  
  • Assay Length
    4.5 hours
  • Sample Type & Volume Required Per Well
    Cell Culture Supernates (50 uL), Serum (50 uL), Heparin Plasma (50 uL)
  • Sensitivity
    1.8 pg/mL
  • Assay Range
    7.8 - 500 pg/mL (Cell Culture Supernates, Serum, Heparin Plasma)
  • Specificity
    Natural and recombinant mouse IL-6
  • Cross-reactivity
    < 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
  • Interference
    No significant interference observed with available related molecules.
Product Summary
The Quantikine Mouse IL-6 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse IL-6 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse IL-6 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant mouse IL-6. Results obtained using natural mouse IL-6 showed dose response curves that were parallel to the standard curves obtained using the Quantikine mouse kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-6.

Precision
Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision.
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision.
Cell Culture Supernates, Serum, Heparin Plasma
Intra-Assay Precision Inter-Assay Precision
Sample123123
n202020282227
Mean30872322985238
Standard Deviation23.48.11.87.518.1
CV%6.73.93.56.18.97.6

Recovery

The recovery of mouse IL-6 spiked to three levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Supernates (n=5) 110 86-120
Heparin Plasma (n=6) 101 81-115
Serum (n=5) 99 84-113
Linearity
To assess the linearity of the assay, samples containing and/or spiked with high concentrations of mouse IL-6 were serially diluted with Calibrator Diluent to produce samples with values within the dynamic range of the assay.
Mouse IL-6 Quantikine ELISA Kit
Preparation and Storage
  • Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: IL-6
IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. It contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 signals through a receptor complex of IL-6 R alpha and gp130. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha.
    • Long Name
      Interleukin 6
    • Entrez Gene IDs
      3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 280826 (Bovine); 403985 (Canine); 100034196 (Equine); 493687 (Feline); 100008733 (Rabbit);
    • Alternate Names
      B cell stimulatory factor-2; B-cell differentiation factor; BSF-2; BSF2CTL differentiation factor; CDF; HGFHSFIFNB2Hybridoma growth factor; IFN-beta-2; IL6; IL-6; IL-6B-cell stimulatory factor 2; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; interleukin-6; MGI-2A;
    Related Research Areas
    Citations:

    R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

    254 Citations: Showing 1 - 10
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    Species
    Sample Type
    1. The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes-associated osteoarthritis
      Authors: C Vaamonde-G, A Courties, A Pigenet, MC Laiguillon, A Sautet, X Houard, S Kerdine-Rö, R Meijide, F Berenbaum, J Sellam
      J. Biol. Chem., 2017;0(0):.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    2. Impact of Acetazolamide, a Carbonic Anhydrase Inhibitor, on the Development of Intestinal Polyps in Min Mice
      Authors: N Noma, G Fujii, S Miyamoto, M Komiya, R Nakanishi, M Shimura, SI Tanuma, M Mutoh
      Int J Mol Sci, 2017;18(4):.
      Species: Mouse
      Sample Type: Serum
    3. A Phosphoproteomic Screen Identifies a Guanine Nucleotide Exchange Factor for Rab3A Protein as a Mitogen-activated Protein (MAP) Kinase Phosphatase-5-regulated MAP Kinase Target in Interleukin 6 (IL-6) Secretion and Myogenesis
      Authors: H Lee, K Min, JS Yi, H Shi, W Chang, L Jackson, AM Bennett
      J. Biol. Chem, 2017;292(9):3581-3590.
      Species: Mouse
      Sample Type: Serum
    4. Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice
      Authors: T Feng, J Dzieran, X Yuan, A Dropmann, T Maass, A Teufel, S Marhenke, T Gaiser, F Rückert, I Kleiter, S Kanzler, MP Ebert, A Vogel, P Ten Dijke, S Dooley, NM Meindl-Bei
      Oncogenesis, 2017;6(1):e294.
      Species: Mouse
      Sample Type: Serum
    5. Modifying Antigen-Encapsulating Liposomes with KALA Facilitates MHC Class I Antigen Presentation and Enhances Anti-tumor Effects
      Authors: N Miura, H Akita, N Tateshita, T Nakamura, H Harashima
      Mol. Ther, 2017;0(0):.
      Species: Mouse
      Sample Type: Serum
    6. Cigarette Smoke Impairs A2A Adenosine Receptor Mediated Wound Repair through Up-regulation of Duox-1 Expression
      Authors: Z Tian, H Zhang, J Dixon, N Traphagen, TA Wyatt, K Kharbanda, S Simet Chad, N Kolliputi, DS Allen-Gips
      Sci Rep, 2017;7(0):44405.
    7. The Effect of Low-Dose Proteasome Inhibition on Pre-Existing Atherosclerosis in LDL Receptor-Deficient Mice
      Authors: N Wilck, M Fechner, C Dan, V Stangl, K Stangl, A Ludwig
      Int J Mol Sci, 2017;18(4):.
      Species: Mouse
      Sample Type: Serum
    8. TDAG8, TRPV1, and ASIC3 involved in establishing hyperalgesic priming in experimental rheumatoid arthritis
      Authors: WS Hsieh, CC Kung, SL Huang, SC Lin, WH Sun
      Sci Rep, 2017;7(1):8870.
      Species: Mouse
      Sample Type: Serum
    9. Autoantibody-induced internalization of CNS AQP4 water channel and EAAT2 glutamate transporter requires astrocytic Fc receptor
      Authors: SR Hinson, IC Clift, N Luo, TJ Kryzer, VA Lennon
      Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    10. The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity
      Authors: S Kitajima, A Yoshida, S Kohno, F Li, S Suzuki, N Nagatani, Y Nishimoto, N Sasaki, H Muranaka, Y Wan, TC Thai, N Okahashi, F Matsuda, H Shimizu, T Nishiuchi, Y Suzuki, K Tominaga, N Gotoh, M Suzuki, ME Ewen, DA Barbie, O Hirose, T Tanaka, C Takahashi
      Oncogene, 2017;0(0):.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    11. Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice
      Authors: HL Kammoun, TL Allen, DC Henstridge, MJ Kraakman, L Peijs, S Rose-John, MA Febbraio
      PLoS ONE, 2017;12(6):e0179099.
      Species: Mouse
      Sample Type: Plasma
    12. Protective Efficacy of the Trivalent Pseudomonas aeruginosa Vaccine Candidate PcrV-OprI-Hcp1 in Murine Pneumonia and Burn Models
      Authors: F Yang, J Gu, L Yang, C Gao, H Jing, Y Wang, H Zeng, Q Zou, F Lv, J Zhang
      Sci Rep, 2017;7(1):3957.
      Species: Mouse
      Sample Type: BALF
    13. Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
      Authors: EE To, R Vlahos, R Luong, ML Halls, PC Reading, PT King, C Chan, GR Drummond, CG Sobey, BRS Broughton, MR Starkey, R van der Sl, SR Lewin, S Bozinovski, LAJ O'Neill, T Quach, CJH Porter, DA Brooks, JJ O'Leary, S Selemidis
      Nat Commun, 2017;8(1):69.
      Species: Mouse
      Sample Type: BALF
    14. Regulatory T cells exhibit neuroprotective effect in a mouse model of traumatic brain injury
      Mol Med Rep, 2016;14(6):5556-5566.
      Species: Mouse
      Sample Type: Tissue Homogenates
    15. Ultrapure laser-synthesized Si-based nanomaterials for biomedical applications: in vivo assessment of safety and biodistribution
      Sci Rep, 2016;6(0):25400.
      Species: Mouse
      Sample Type: Serum
    16. Anti-inflammatory effect of cannabinoid agonist WIN55, 212 on mouse experimental colitis is related to inhibition of p38MAPK
      World J. Gastroenterol., 2016;22(43):9515-9524.
      Species: Mouse
      Sample Type: Plasma
    17. The Phosphocarrier Protein HPr Contributes to Meningococcal Survival during Infection
      PLoS ONE, 2016;11(9):e0162434.
      Species: Mouse
      Sample Type: Peritoneal Fluid
    18. Protective effect of Cl-amidine against CLP-induced lethal septic shock in mice
      Sci Rep, 2016;6(0):36696.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    19. KLHDC10 Deficiency Protects Mice against TNF?-Induced Systemic Inflammation
      PLoS ONE, 2016;11(9):e0163118.
      Species: Mouse
      Sample Type: Serum
    20. Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis
      PLoS ONE, 2016;11(7):e0158967.
    21. Leptin Production by Encapsulated Adipocytes Increases Brown Fat, Decreases Resistin, and Improves Glucose Intolerance in Obese Mice
      Authors: DJ DiSilvestr, E Melgar-Ber, R Yasmeen, P Fadda, LJ Lee, A Kalyanasun, CL Gilor, O Ziouzenkov
      PLoS ONE, 2016;11(4):e0153198.
      Species: Mouse
      Sample Type: Plasma
    22. Kruppel-like factor 6 promotes macrophage-mediated inflammation by suppressing B cell leukemia/lymphoma 6 expression
      J Biol Chem, 2016;0(0):.
      Species: Mouse
      Sample Type: Tissue Homogenates
    23. Toll-like Receptor 4 Agonistic Antibody Promotes Host Defense against Chronic Pseudomonas aeruginosa Lung Infection in Mice
      Authors: S Nakamura, N Iwanaga, M Seki, K Fukudome, K Oshima, T Miyazaki, K Izumikawa, K Yanagihara, Y Miyazaki, H Mukae, S Kohno
      Infect Immun, 2016;0(0):.
      Species: Mouse
      Sample Type: Tissue Homogenates
    24. Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice
      Authors: K Dinger, P Kasper, E Hucklenbru, C Vohlen, E Jobst, R Janoschek, I Bae-Gartz, S van Koning, C Plank, J Dötsch, MA Alejandre
      Sci Rep, 2016;6(0):24168.
      Species: Mouse
      Sample Type: Serum
    25. Subtilisin-like protease-1 secreted through type IV secretion system contributes to high virulence of Streptococcus suis 2
      Authors: Supeng Yin
      Sci Rep, 2016;6(0):27369.
      Species: Mouse
      Sample Type: Serum
    26. CF Lung Infection and Inflammation: IL-17 Pathophysiology and Therapeutic Intervention
      Authors: Daniel Hsu
      Infect Immun, 2016;0(0):.
      Species: Mouse
      Sample Type: BALF
    27. DNMT1-PPAR? pathway in macrophages regulates chronic inflammation and atherosclerosis development in mice
      Sci Rep, 2016;6(0):30053.
      Species: Mouse
      Sample Type: Plasma
    28. The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages
      Sci Rep, 2016;6(0):28845.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    29. Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease
      Sci Rep, 2016;6(0):31652.
      Species: Mouse
      Sample Type: Serum
    30. Toll-Like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss
      PLoS ONE, 2016;11(8):e0158735.
      Species: Mouse
      Sample Type: BALF
    31. Soluble Vascular Cell Adhesion Molecule-1 (VCAM-1) as a Biomarker in the Mouse Model of Experimental Autoimmune Myocarditis (EAM)
      PLoS ONE, 2016;11(8):e0158299.
      Species: Mouse
      Sample Type: Tissue Homogenates
    32. Intravenous hMSCs Ameliorate Acute Pancreatitis in Mice via Secretion of Tumor Necrosis Factor-? Stimulated Gene/Protein 6
      Sci Rep, 2016;6(0):38438.
      Species: Mouse
      Sample Type: Serum
    33. Inhibition of Interleukin-6 Receptor in a Murine Model of Myocardial Ischemia-Reperfusion
      PLoS ONE, 2016;11(12):e0167195.
      Species: Mouse
      Sample Type: Plasma
    34. Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice
      Authors: R Das, T Strowig, R Verma, S Koduru, A Hafemann, S Hopf, MH Kocoglu, C Borsotti, L Zhang, A Branagan, E Eynon, MG Manz, RA Flavell, MV Dhodapkar
      Nat. Med., 2016;22(11):1351-1357.
      Species: Mouse
      Sample Type: Serum
    35. Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells
      Authors: NS Nagathihal, JA Castellano, MN VanSaun, X Dai, M Ambrose, Q Guo, Y Xiong, NB Merchant
      Oncotarget, 2016;7(40):65982-65992.
      Species: Mouse
      Sample Type: Serum
    36. Conditioned media from adipose stromal cells limit lipopolysaccharide-induced lung injury, endothelial hyperpermeability and apoptosis.
      Authors: Lu H, Poirier C, Cook T, Traktuev D, Merfeld-Clauss S, Lease B, Petrache I, March K, Bogatcheva N
      J Transl Med, 2015;13(0):67.
      Species: Mouse
      Sample Type: BALF
    37. Pharmacologic Inhibition of JAK1/JAK2 Signaling Reduces Experimental Murine Acute GVHD While Preserving GVT Effects.
      Authors: Carniti C, Gimondi S, Vendramin A, Recordati C, Confalonieri D, Bermema A, Corradini P, Mariotti J
      Clin Cancer Res, 2015;21(16):3740-9.
      Species: Mouse
      Sample Type: Serum
    38. Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells.
      Authors: Jeschke A, Catala-Lehnen P, Sieber S, Bickert T, Schweizer M, Koehne T, Wintges K, Marshall R, Mautner A, Duchstein L, Otto B, Horst A, Amling M, Kreienkamp H, Schinke T
      J Immunol, 2015;195(8):3675-84.
      Species: Mouse
      Sample Type: Serum
    39. Systemic siRNA Nanoparticle-Based Drugs Combined with Radiofrequency Ablation for Cancer Therapy.
      Authors: Ahmed M, Kumar G, Navarro G, Wang Y, Gourevitch S, Moussa M, Rozenblum N, Levchenko T, Galun E, Torchilin V, Goldberg S
      PLoS ONE, 2015;10(7):e0128910.
      Species: Mouse
      Sample Type: Tissue Homogenates
    40. Activation of p38 Mitogen-Activated Protein Kinase in Gaucher's Disease.
      Authors: Kitatani K, Wada M, Perry D, Usui T, Sun Y, Obeid L, Yaegashi N, Grabowski G, Hannun Y
      PLoS ONE, 2015;10(8):e0136633.
      Species: Mouse
      Sample Type: Serum
    41. Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice.
      Authors: Charolidi N, Schilling T, Eder C
      PLoS ONE, 2015;10(5):e0128463.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    42. Pharmacokinetic and Pharmacodynamic Characterisation of an Anti-Mouse TNF Receptor 1 Domain Antibody Formatted for In Vivo Half-Life Extension.
      Authors: Goodall L, Ovecka M, Rycroft D, Friel S, Sanderson A, Mistry P, Davies M, Stoop A
      PLoS ONE, 2015;10(9):e0137065.
    43. Sevoflurane inhibits nuclear factor-kappaB activation in lipopolysaccharide-induced acute inflammatory lung injury via toll-like receptor 4 signaling.
      Authors: Sun X, Li X, Wang X, Tan W, Wang J
      PLoS ONE, 2015;10(4):e0122752.
      Species: Mouse
      Sample Type: BALF
    44. Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency.
      Authors: Abdel Fattah E, Bhattacharya A, Herron A, Safdar Z, Eissa N
      J Immunol, 2015;194(11):5407-16.
      Species: Mouse
      Sample Type: BALF
    45. Loss of the polarity protein PAR3 activates STAT3 signaling via an atypical protein kinase C (aPKC)/NF-kappaB/interleukin-6 (IL-6) axis in mouse mammary cells.
      Authors: Guyer R, Macara I
      J Biol Chem, 2015;290(13):8457-68.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    46. Innate sensing of microbial products promotes wound-induced skin cancer.
      Authors: Hoste E, Arwert E, Lal R, South A, Salas-Alanis J, Murrell D, Donati G, Watt F
      Nat Commun, 2015;6(0):5932.
      Species: Mouse
      Sample Type: Serum
    47. MicroRNA-22 impairs anti-tumor ability of dendritic cells by targeting p38.
      Authors: Liang X, Liu Y, Mei S, Zhang M, Xin J, Zhang Y, Yang R
      PLoS ONE, 2015;10(3):e0121510.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    48. Chronic morphine-induced microRNA-124 promotes microglial immunosuppression by modulating P65 and TRAF6.
      Authors: Qiu S, Feng Y, LeSage G, Zhang Y, Stuart C, He L, Li Y, Caudle Y, Peng Y, Yin D
      J Immunol, 2015;194(3):1021-30.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    49. Thrombomodulin alleviates murine GVHD in association with an increase in the proportion of regulatory T cells in the spleen.
      Authors: Ikezoe T, Yang J, Nishioka C, Yokoyama A
      Bone Marrow Transplant, 2015;50(1):113-20.
      Species: Mouse
      Sample Type: Plasma
    50. Pycnogenol Attenuates the Release of Proinflammatory Cytokines and Expression of Perilipin 2 in Lipopolysaccharide-Stimulated Microglia in Part via Inhibition of NF-kappaB and AP-1 Activation.
      Authors: Fan B, Dun S, Gu J, Guo Y, Ikuyama S
      PLoS ONE, 2015;10(9):e0137837.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    51. Microglia trigger astrocyte-mediated neuroprotection via purinergic gliotransmission.
      Authors: Shinozaki Y, Nomura M, Iwatsuki K, Moriyama Y, Gachet C, Koizumi S
      Sci Rep, 2014;4(0):4329.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    52. Elevated levels of mast cells are involved in pruritus associated with polycythemia vera in JAK2V617F transgenic mice.
      Authors: Jin X, Zhao W, Kirabo A, Park S, Ho W, Sayeski P, Zhao Z
      J Immunol, 2014;193(2):477-84.
      Species: Mouse
      Sample Type: Tissue Homogenates
    53. Role of ferulic acid in the amelioration of ionizing radiation induced inflammation: a murine model.
      Authors: Das U, Manna K, Sinha M, Datta S, Das D, Chakraborty A, Ghosh M, Saha K, Dey S
      PLoS ONE, 2014;9(5):e97599.
      Species: Mouse
      Sample Type: Serum
    54. CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice.
      Authors: Bignon A, Gaudin F, Hemon P, Tharinger H, Mayol K, Walzer T, Loetscher P, Peuchmaur M, Berrebi D, Balabanian K
      J Immunol, 2014;192(3):886-96.
      Species: Mouse
      Sample Type: Serum
    55. The effects of protein malnutrition on the TNF-RI and NF-kappaB expression via the TNF-alpha signaling pathway.
      Authors: de Oliveira D, Hastreiter A, Mello A, de Oliveira Beltran J, Oliveira Santos E, Borelli P, Fock R
      Cytokine, 2014;69(2):218-25.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    56. Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2.
      Authors: Tancevski I, Nairz M, Duwensee K, Auer K, Schroll A, Heim C, Feistritzer C, Hoefer J, Gerner R, Moschen A, Heller I, Pallweber P, Li X, Theurl M, Demetz E, Wolf A, Wolf D, Eller P, Ritsch A, Weiss G
      EMBO Mol Med, 2014;6(6):810-20.
      Species: Mouse
      Sample Type: Serum
    57. Rho-kinase activation in leukocytes plays a pivotal role in myocardial ischemia/reperfusion injury.
      Authors: Kitano K, Usui S, Ootsuji H, Takashima S, Kobayashi D, Murai H, Furusho H, Nomura A, Kaneko S, Takamura M
      PLoS ONE, 2014;9(3):e92242.
    58. Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts.
      Authors: Le Goff B, Singbrant S, Tonkin B, Martin T, Romas E, Sims N, Walsh N
      Cytokine, 2014;68(2):101-9.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    59. Ad5/48 hexon oncolytic virus expressing sTGFbetaRIIFc produces reduced hepatic and systemic toxicities and inhibits prostate cancer bone metastases.
      Authors: Xu W, Zhang Z, Yang Y, Hu Z, Wang C, Morgan M, Wu Y, Hutten R, Xiao X, Stock S, Guise T, Prabhakar B, Brendler C, Seth P
      Mol Ther, 2014;22(8):1504-17.
      Species: Mouse
      Sample Type: Serum
    60. Effect of ADAMTS-13 on cerebrovascular microthrombosis and neuronal injury after experimental subarachnoid hemorrhage.
      Authors: Muroi C, Fujioka M, Mishima K, Irie K, Fujimura Y, Nakano T, Fandino J, Keller E, Iwasaki K, Fujiwara M
      J Thromb Haemost, 2014;12(4):505-14.
      Species: Mouse
      Sample Type: Whole Blood
    61. Kruppel-like factor 9 deficiency in uterine endometrial cells promotes ectopic lesion establishment associated with activated notch and hedgehog signaling in a mouse model of endometriosis.
      Authors: Heard M, Simmons C, Simmen F, Simmen R
      Endocrinology, 2014;155(4):1532-46.
      Species: Mouse
      Sample Type: Serum
    62. NF-kappaB signaling modulates radiationinduced microglial activation.
      Authors: Xue J, Dong J, Huang G, Qu X, Wu G, Dong X
      Oncol Rep, 2014;31(6):2555-60.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    63. Diisopropylamine dichloroacetate, a novel pyruvate dehydrogenase kinase 4 inhibitor, as a potential therapeutic agent for metabolic disorders and multiorgan failure in severe influenza.
      Authors: Yamane, Kazuhiko, Indalao, Irene L, Chida, Junji, Yamamoto, Yoshikaz, Hanawa, Masaaki, Kido, Hiroshi
      PLoS ONE, 2014;9(5):e98032.
      Species: Mouse
      Sample Type: Tissue Homogenates
    64. Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages.
      Authors: Iwasaki Y, Suganami T, Hachiya R, Shirakawa I, Kim-Saijo M, Tanaka M, Hamaguchi M, Takai-Igarashi T, Nakai M, Miyamoto Y, Ogawa Y
      Diabetes, 2014;63(1):152-61.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    65. Celecoxib sensitizes Staphylococcus aureus to antibiotics in macrophages by modulating SIRT1.
      Authors: Annamanedi M, Kalle A
      PLoS ONE, 2014;9(6):e99285.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    66. Knockdown of TrkA in cumulus oocyte complexes (COCs) inhibits EGF-induced cumulus expansion by down-regulation of IL-6.
      Authors: Wang Y, Liang N, Yao G, Tian H, Zhai Y, Yin Y, Sun F
      Mol Cell Endocrinol, 2014;382(2):804-13.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    67. Running exercise alleviates trabecular bone loss and osteopenia in hemizygous beta-globin knockout thalassemic mice.
      Authors: Thongchote K, Svasti S, Teerapornpuntakit J, Krishnamra N, Charoenphandhu N
      Am J Physiol Endocrinol Metab, 2014;306(12):E1406-17.
      Species: Mouse
      Sample Type: Serum
    68. Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-kappaB activation through TBK1.
      Authors: Abe T, Barber G
      J Virol, 2014;88(10):5328-41.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    69. Role of TLR5 and flagella in bacillus intraocular infection.
      Authors: Parkunan, Salai Ma, Astley, Roger, Callegan, Michelle
      PLoS ONE, 2014;9(6):e100543.
      Species: Mouse
      Sample Type: Tissue Homogenates
    70. Peripheral surgical wounding and age-dependent neuroinflammation in mice.
      Authors: Xu Z, Dong Y, Wang H, Culley D, Marcantonio E, Crosby G, Tanzi R, Zhang Y, Xie Z
      PLoS ONE, 2014;9(5):e96752.
      Species: Mouse
      Sample Type: Tissue Homogenates
    71. Akt2 deficiency protects from acute lung injury via alternative macrophage activation and miR-146a induction in mice.
      Authors: Vergadi, Eleni, Vaporidi, Katerina, Theodorakis, Emmanuel, Doxaki, Christin, Lagoudaki, Eleni, Ieronymaki, Elefther, Alexaki, Vassilia, Helms, Mike, Kondili, Eumorfia, Soennichsen, Birte, Stathopoulos, Efstathi, Margioris, Andrew N, Georgopoulos, Dimitrio, Tsatsanis, Christos
      J Immunol, 2014;192(1):394-406.
      Species: Mouse
      Sample Type: BALF
    72. TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation.
      Authors: Sun Q, Sammut B, Wang F, Kurihara N, Windle J, Roodman G, Galson D
      J Bone Miner Res, 2014;29(1):90-102.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    73. Fatty acids increase hepatitis B virus X protein stabilization and HBx-induced inflammatory gene expression.
      Authors: Cho H, Kim S, Yoo S, Choi Y, Cheong J
      FEBS J, 2014;281(9):2228-39.
      Species: Mouse
      Sample Type: Tissue Homogenates
    74. Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-alpha antibodies.
      Authors: Bhargava R, Altmann C, Andres-Hernando A, Webb R, Okamura K, Yang Y, Falk S, Schmidt E, Faubel S
      PLoS ONE, 2013;8(11):e79037.
      Species: Mouse
      Sample Type: Urine
    75. Antisense oligonucleotide treatment enhances the recovery of acute lung injury through IL-10-secreting M2-like macrophage-induced expansion of CD4+ regulatory T cells.
      Authors: Guo Z, Wen Z, Qin A, Zhou Y, Liao Z, Liu Z, Liang Y, Ren T, Xu L
      J Immunol, 2013;190(8):4337-48.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    76. Sirt2 suppresses inflammatory responses in collagen-induced arthritis.
      Authors: Lin J, Sun B, Jiang C, Hong H, Zheng Y
      Biochem Biophys Res Commun, 2013;441(4):897-903.
      Species: Mouse
      Sample Type: Serum
    77. mTORC1 and mTORC2 play different roles in the functional survival of transplanted adipose-derived stromal cells in hind limb ischemic mice via regulating inflammation in vivo.
      Authors: Fan W, Cheng K, Qin X, Narsinh K, Wang S, Hu S, Wang Y, Chen Y, Wu J, Xiong L, Cao F
      Stem Cells, 2013;31(1):203-14.
      Species: Mouse
      Sample Type: Tissue Homogenates
    78. Inflammation induced by MMP-9 enhances tumor regression of experimental breast cancer.
      Authors: Leifler K, Svensson S, Abrahamsson A, Bendrik C, Robertson J, Gauldie J, Olsson A, Dabrosin C
      J Immunol, 2013;190(8):4420-30.
      Species: Mouse
      Sample Type: Tissue Homogenates
    79. MEKK2 kinase association with 14-3-3 protein regulates activation of c-Jun N-terminal kinase.
      Authors: Matitau A, Gabor T, Gill R, Scheid M
      J Biol Chem, 2013;288(39):28293-302.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    80. Inhibition of geranylgeranyltransferase attenuates neutrophil accumulation and tissue injury in severe acute pancreatitis.
      Authors: Merza M, Wetterholm E, Zhang S, Regner S, Thorlacius H
      J Leukoc Biol, 2013;94(3):493-502.
      Species: Mouse
      Sample Type: Plasma
    81. Expression of HIV transgene aggravates kidney injury in diabetic mice.
      Authors: Mallipattu S, Liu R, Zhong Y, Chen E, D'Agati V, Kaufman L, Ma'ayan A, Klotman P, Chuang P, He J
      Kidney Int, 2013;83(4):626-34.
      Species: Mouse
      Sample Type: Serum
    82. Enhanced immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to dendritic cells via Dectin-1 by incorporating beta-glucan.
      Authors: Lipinski T, Fitieh A, St Pierre J, Ostergaard H, Bundle D, Touret N
      J Immunol, 2013;190(8):4116-28.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    83. Hypoxia antagonizes glucose deprivation on interleukin 6 expression in an Akt dependent, but HIF-1/2alpha independent manner.
      Authors: Choi S, Shin I, Je K, Min E, Kim E, Kim H, Choe S, Kim D, Lee D
      PLoS ONE, 2013;8(3):e58662.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    84. Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.
      Authors: Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T
      Am. J. Pathol., 2012;179(1):302-14.
      Species: Mouse
      Sample Type: Tissue Homogenates
    85. Treatment of diabetic mice with undenatured whey protein accelerates the wound healing process by enhancing the expression of MIP-1alpha, MIP-2, KC, CX3CL1 and TGF-beta in wounded tissue.
      BMC Immunol., 2012;13(0):32.
      Species: Mouse
      Sample Type: Tissue Homogenates
    86. Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice.
      Mol. Cell. Endocrinol., 2012;358(1):127-34.
      Species: Mouse
      Sample Type: Serum
    87. Inhalative vs. systemic IL-10 administration: differences in the systemic inflammatory response and end-organ inflammation following hemorrhagic shock.
      Authors: Pfeifer R, Lichte P, Schreiber H, Sellei R, Schmidt J, Dombroski D, Pape H, Kobbe P
      Cytokine, 2012;60(1):266-70.
      Species: Mouse
      Sample Type: Serum
    88. Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype.
      Authors: Ylostalo J, Bartosh T, Coble K, Prockop D
      Stem Cells, 2012;30(10):2283-96.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    89. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance.
      Nat Med, 2012;18(0):1279.
      Species: Mouse
      Sample Type: Serum
    90. The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi.
      Authors: Calderon J, Maganto-Garcia E, Punzon C, Carrion J, Terhorst C, Fresno M
      PLoS Pathog., 2012;8(7):e1002799.
      Species: Mouse
      Sample Type: Serum
    91. Cutting edge: Divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis.
      Authors: Gais P, Reim D, Jusek G, Rossmann-Bloeck T, Weighardt H, Pfeffer K, Altmayr F, Janssen KP, Holzmann B
      J. Immunol., 2012;188(12):5833-7.
      Species: Mouse
      Sample Type: Plasma
    92. Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression.
      Authors: Ito Y, Shigemori S, Sato T, Shimazu T, Hatano K, Otani H, Kitazawa H, Shimosato T
      FEBS Open Bio, 2012;3(0):41-5.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    93. The axonal guidance receptor neogenin promotes acute inflammation.
      Authors: Konig K, Gatidou D, Granja T, Meier J, Rosenberger P, Mirakaj V
      PLoS ONE, 2012;7(3):e32145.
      Species: Mouse
      Sample Type: Peritoneal Lavage
    94. Endothelial cell peroxisome proliferator-activated receptor gamma reduces endotoxemic pulmonary inflammation and injury.
      Authors: Reddy A, Lakshmi S, Kleinhenz J, Sutliff R, Hart C, Reddy R
      J Immunol, 2012;189(11):5411-20.
      Species: Mouse
      Sample Type: BALF
    95. Impairment of bilirubin clearance and intestinal interleukin-6 expression in bile duct-ligated vitamin D receptor null mice.
      Authors: Ishizawa M, Ogura M, Kato S, Makishima M
      PLoS ONE, 2012;7(12):e51664.
      Species: Mouse
      Sample Type: Plasma
    96. Absence of T and B lymphocytes modulates dystrophic features in dysferlin deficient animal model.
      Authors: Farini A, Sitzia C, Navarro C, D'Antona G, Belicchi M, Parolini D, Del Fraro G, Razini P, Bottinelli R, Meregalli M, Torrente Y
      Exp. Cell Res., 2012;318(10):1160-74.
      Species: Mouse
      Sample Type: Tissue Homogenates
    97. Toll-like receptor-mediated inhibition of Gas6 and ProS expression facilitates inflammatory cytokine production in mouse macrophages.
      Authors: Deng T, Zhang Y, Chen Q, Yan K, Han D
      Immunology, 2012;135(1):40-50.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    98. TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity.
      Authors: Chen K, Chang C, Huang C, Lin C, Lin W, Lo Y, Yang C, Hsing E, Chen L, Shih S, Shiau A, Lei H, Tan T, Ling P
      J Biol Chem, 2012;287(38):32216-21.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    99. Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance.
      Authors: Ernst MC, Haidl ID, Zúñiga LA, Dranse HJ, Rourke JL, Zabel BA, Butcher EC, Sinal CJ
      Endocrinology, 2012;153(2):672-82.
      Species: Mouse
      Sample Type: Serum
    100. Netrin-1 protects against L-Arginine-induced acute pancreatitis in mice.
      Authors: Chen J, Cai Q, Shen P, Yan R, Wang C, Yang D, Fu H, Chen X
      PLoS ONE, 2012;7(9):e46201.
      Species: Mouse
      Sample Type: Plasma
    101. Stress augments insulin resistance and prothrombotic state: role of visceral adipose-derived monocyte chemoattractant protein-1.
      Authors: Uchida Y, Takeshita K, Yamamoto K, Kikuchi R, Nakayama T, Nomura M, Cheng XW, Egashira K, Matsushita T, Nakamura H, Murohara T
      Diabetes, 2012;61(6):1552-61.
      Species: Mouse
      Sample Type: Serum
    102. Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice.
      Authors: Xue M, Dervish S, Harrison LC, Fulcher G, Jackson CJ
      J. Biol. Chem., 2012;287(20):16356-64.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    103. The adaptor molecule CARD9 is essential for tuberculosis control.
      Authors: Dorhoi A, Desel C, Yeremeev V, Pradl L, Brinkmann V, Mollenkopf HJ, Hanke K, Gross O, Ruland J, Kaufmann SH
      J. Exp. Med., 2011;207(4):777-92.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    104. Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10.
      Authors: Wang H, Cheng F
      J. Immunol., 2011;186(0):3986.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    105. Sterol regulatory element-binding protein 2 (SREBP2) activation after excess triglyceride storage induces chemerin in hypertrophic adipocytes.
      Authors: Bauer S, Wanninger J, Schmidhofer S, Weigert J, Neumeier M, Dorn C, Hellerbrand C, Zimara N, Schaffler A, Aslanidis C, Buechler C
      Endocrinology, 2011;152(1):26-35.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    106. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation.
      Authors: Steinbicker AU, Sachidanandan C, Vonner AJ
      Blood, 2011;117(18):4915-23.
      Species: Mouse
      Sample Type: Serum
    107. Deletion of tristetraprolin caused spontaneous reactive granulopoiesis by a non-cell-autonomous mechanism without disturbing long-term hematopoietic stem cell quiescence.
      Authors: Kaplan IM, Morisot S, Heiser D, Cheng WC, Kim MJ, Civin CI
      J. Immunol., 2011;186(5):2826-34.
      Species: Mouse
      Sample Type: Plasma
    108. IL-33-activated dendritic cells are critical for allergic airway inflammation.
      Authors: Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B
      Eur. J. Immunol., 2011;41(6):1675-86.
      Species: Mouse
      Sample Type: BALF
    109. Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-alpha stimulated gene/protein 6.
      Authors: Roddy GW, Oh JY, Lee RH, Bartosh TJ, Ylostalo J, Coble K, Rosa RH, Prockop DJ
      Stem Cells, 2011;29(10):1572-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    110. TLR4 through IFN-beta promotes low molecular mass hyaluronan-induced neutrophil apoptosis.
      Authors: Leu SW, Shi L, Xu C, Zhao Y, Liu B, Li Y, Shiedlin A, Xiang C, Shen H, Quinn DA, Hales CA, Zhao H
      J. Immunol., 2011;186(1):556-62.
      Species: Mouse
      Sample Type: BALF
    111. Tumors Suppress In Situ Proliferation of Cytotoxic T Cells by Promoting Differentiation of Gr-1+ Conventional Dendritic Cells through IL-6.
      Authors: Diao J, Zhao J, Winter E
      J. Immunol., 2011;186(9):5058-67.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    112. The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria.
      Authors: Ghose P, Ali AQ, Fang R, Forbes D, Ballard B, Ismail N
      J. Immunol., 2011;187(3):1333-46.
      Species: Mouse
      Sample Type: Serum
    113. Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis.
      Authors: Nakahama T, Kimura A, Nguyen NT, Chinen I, Hanieh H, Nohara K, Fujii-Kuriyama Y, Kishimoto T
      Proc. Natl. Acad. Sci. U.S.A., 2011;108(34):14222-7.
      Species: Mouse
      Sample Type: Serum
    114. Differential host determinants contribute to the pathogenesis of 2009 pandemic H1N1 and human H5N1 influenza A viruses in experimental mouse models.
      Authors: Otte A, Sauter M, Alleva L, Baumgarte S, Klingel K, Gabriel G
      Am. J. Pathol., 2011;179(1):230-9.
      Species: Mouse
      Sample Type: Serum
    115. Serotonin activates dendritic cell function in the context of gut inflammation.
      Authors: Li N, Ghia JE, Wang H, McClemens J, Cote F, Suehiro Y, Mallet J, Khan WI
      Am. J. Pathol., 2011;178(2):662-71.
      Species: Mouse
      Sample Type: Tissue Homogenates
    116. Improved host defense against septic peritonitis in mice lacking MyD88 and TRIF is linked to a normal interferon response.
      Authors: Reim D, Rossmann-Bloeck T, Jusek G, Prazeres da Costa O, Holzmann B
      J. Leukoc. Biol., 2011;90(3):613-20.
      Species: Mouse
      Sample Type: Plasma
    117. Repulsive guidance molecule-A (RGM-A) inhibits leukocyte migration and mitigates inflammation.
      Authors: Mirakaj V, Brown S, Laucher S, Steinl C, Klein G, Kohler D, Skutella T, Meisel C, Brommer B, Rosenberger P, Schwab JM
      Proc. Natl. Acad. Sci. U.S.A., 2011;108(16):6555-60.
      Species: Mouse
      Sample Type: Peritoneal Lavage
    118. Crawling Phagocytes Recruited in the Brain Vasculature after Pertussis Toxin Exposure through IL6, ICAM1 and ITGalphaM.
      Authors: Richard JF, Roy M, Audoy-Remus J, Tremblay P, Vallieres L
      Brain Pathol., 2011;21(0):661.
      Species: Mouse
      Sample Type: Serum
    119. Mechanisms inducing low bone density in duchenne muscular dystrophy in mice and humans.
      Authors: Rufo A, Del Fattore A, Capulli M, Carvello F, De Pasquale L, Ferrari S, Pierroz D, Morandi L, De Simone M, Rucci N, Bertini E, Bianchi ML, De Benedetti F, Teti A
      J. Bone Miner. Res., 2011;26(8):1891-903.
      Species: Mouse
      Sample Type: Serum
    120. XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1beta-mediated diseases.
      Authors: Owyang AM, Issafras H, Corbin J, Ahluwalia K, Larsen P, Pongo E, Handa M, Horwitz AH, Roell MK, Haak-Frendscho M, Masat L
      MAbs, 2011;3(1):49-60.
      Species: Mouse
      Sample Type: Serum
    121. TLR4 is a negative regulator in noninfectious lung inflammation.
      Authors: Zhao H, Leu SW, Shi L, Dedaj R, Zhao G, Garg HG, Shen L, Lien E, Fitzgerald KA, Shiedlin A, Shen H, Quinn DA, Hales CA
      J. Immunol., 2010;184(9):5308-14.
      Species: Mouse
      Sample Type: BALF
    122. Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia.
      Authors: Schabbauer G, Matt U, Gunzl P, Warszawska J, Furtner T, Hainzl E, Elbau I, Mesteri I, Doninger B, Binder BR, Knapp S
      J. Immunol., 2010;185(1):468-76.
      Species: Mouse
      Sample Type: BALF
    123. Loss of ability to self-heal malaria upon taurine transporter deletion.
      Authors: Delic D, Warskulat U, Borsch E, Al-Qahtani S, Al-Quraishi S, Haussinger D, Wunderlich F
      Infect. Immun., 2010;78(4):1642-9.
      Species: Mouse
      Sample Type: Serum
    124. Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene.
      Authors: Sio SW, Moochhala S, Lu J
      Am. J. Respir. Crit. Care Med., 2010;181(1):36-46.
      Species: Mouse
      Sample Type: Tissue Homogenates
    125. Systemic inflammation sensitizes the neonatal brain to excitotoxicity through a pro-/anti-inflammatory imbalance: key role of TNFalpha pathway and protection by etanercept.
      Authors: Aden U, Favrais G, Plaisant F, Winerdal M, Felderhoff-Mueser U, Lampa J, Lelievre V, Gressens P
      Brain Behav. Immun., 2010;24(5):747-58.
      Species: Mouse
      Sample Type: Tissue Homogenates
    126. Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model.
      Authors: Ito H, Hoshi M, Ohtaki H, Taguchi A, Ando K, Ishikawa T, Osawa Y, Hara A, Moriwaki H, Saito K, Seishima M
      J. Immunol., 2010;185(8):4554-60.
      Species: Mouse
      Sample Type: Serum
    127. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
      Authors: Yoshizaki A, Yanaba K, Iwata Y
      J. Immunol., 2010;185(4):2502-15.
      Species: Mouse
      Sample Type: Serum
    128. Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice.
      Authors: Pini M, Fantuzzi G
      J. Leukoc. Biol., 2010;87(1):51-8.
      Species: Mouse
      Sample Type: Peritoneal Lavage
    129. Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance.
      Authors: Kiefer FW, Zeyda M, Gollinger K, Pfau B, Neuhofer A, Weichhart T, Saemann MD, Geyeregger R, Schlederer M, Kenner L, Stulnig TM
      Diabetes, 2010;59(4):935-46.
      Species: Mouse
      Sample Type: Plasma
    130. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes.
      Authors: Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nunez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA
      Nat. Immunol., 2010;11(10):897-904.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    131. TLR4 activation is required for IL-17-induced multiple tissue inflammation and wasting in mice.
      Authors: Tang H, Pang S, Wang M
      J. Immunol., 2010;185(4):2563-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    132. Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model.
      Authors: Matsumoto S, Hara T, Mitsuyama K, Yamamoto M, Tsuruta O, Sata M, Scheller J, Rose-John S, Kado S, Takada T
      J. Immunol., 2010;184(3):1543-51.
      Species: Mouse
      Sample Type: Tissue Homogenates
    133. Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice.
      Authors: Alm AS, Li K, Yang D, Andersson R, Lu Y, Wang X
      Cytokine, 2010;49(3):256-63.
      Species: Mouse
      Sample Type: BALF
    134. Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation.
      Authors: Ding BS, Hong N, Christofidou-Solomidou M, Gottstein C, Albelda SM, Cines DB, Fisher AB, Muzykantov VR
      Am. J. Respir. Crit. Care Med., 2009;180(3):247-56.
      Species: Mouse
      Sample Type: BALF
    135. Uropathogenic Escherichia coli-induced inflammation alters mouse urinary bladder contraction via an interleukin-6-activated inducible nitric oxide synthase-related pathway.
      Authors: Weng TI, Wu HY, Lin PY, Liu SH
      Infect. Immun., 2009;77(8):3312-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    136. Ethyl pyruvate administration inhibits hepatic tumor growth.
      Authors: Liang X, Chavez AR, Schapiro NE, Loughran P, Thorne SH, Amoscato AA, Zeh HJ, Beer-Stolz D, Lotze MT, de Vera ME
      J. Leukoc. Biol., 2009;86(3):599-607.
      Species: Mouse
      Sample Type: Plasma
    137. TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation.
      Authors: Borges VM, Vandivier RW, McPhillips KA, Kench JA, Morimoto K, Groshong SD, Richens TR, Graham BB, Muldrow AM, Van Heule L, Henson PM, Janssen WJ
      Am. J. Physiol. Lung Cell Mol. Physiol., 2009;297(4):L586-95.
      Species: Mouse
      Sample Type: BALF
    138. Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis.
      Authors: Siegemund S, Schutze N, Schulz S, Wolk K, Nasilowska K, Straubinger RK, Sabat R, Alber G
      Int. Immunol., 2009;21(5):555-65.
      Species: Mouse
      Sample Type: Peritoneal Lavage
    139. Effects of a leukotriene B4 receptor antagonist on bleomycin-induced pulmonary fibrosis.
      Authors: Izumo T, Kondo M, Nagai A
      Eur. Respir. J., 2009;34(6):1444-51.
      Species: Mouse
      Sample Type: BALF
    140. Silencing of TLR4 decreases liver tumor burden in a murine model of colorectal metastasis and hepatic steatosis.
      Authors: Earl TM, Nicoud IB, Pierce JM, Wright JP, Majoras NE, Rubin JE, Pierre KP, Gorden DL, Chari RS
      Ann. Surg. Oncol., 2009;16(4):1043-50.
      Species: Mouse
      Sample Type: Serum
    141. Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation.
      Authors: Leeper NJ, Tedesco MM, Kojima Y, Schultz GM, Kundu RK, Ashley EA, Tsao PS, Dalman RL, Quertermous T
      Am. J. Physiol. Heart Circ. Physiol., 2009;296(5):H1329-35.
      Species: Mouse
      Sample Type: Serum
    142. Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice.
      Authors: Pierroz DD, Rufo A, Bianchi EN, Glatt V, Capulli M, Rucci N, Cavat F, Rizzoli R, Teti A, Bouxsein ML, Ferrari SL
      J. Bone Miner. Res., 2009;24(5):775-84.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    143. Plasminogen activator inhibitor-1 regulates neutrophil influx during acute pyelonephritis.
      Authors: Roelofs JJ, Teske GJ, Bonta PI, de Vries CJ, Meijers JC, Weening JJ, van der Poll T, Florquin S
      Kidney Int., 2009;75(1):52-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    144. Combined inhibition of janus kinase 1/2 for the treatment of JAK2V617F-driven neoplasms: selective effects on mutant cells and improvements in measures of disease severity.
      Authors: Liu PC, Caulder E, Li J, Waeltz P, Margulis A, Wynn R, Becker-Pasha M, Li Y, Crowgey E, Hollis G, Haley P, Sparks RB, Combs AP, Rodgers JD, Burn TC, Vaddi K, Fridman JS
      Clin. Cancer Res., 2009;15(22):6891-900.
      Species: Mouse
      Sample Type: Plasma
    145. The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice.
      Authors: Minami T, Yano K, Miura M, Kobayashi M, Suehiro J, Reid PC, Hamakubo T, Ryeom S, Aird WC, Kodama T
      J. Clin. Invest., 2009;119(8):2257-70.
      Species: Mouse
      Sample Type: Plasma
    146. C/EBPalpha is required for pulmonary cytoprotection during hyperoxia.
      Authors: Xu Y, Saegusa C, Schehr A, Grant S, Whitsett JA, Ikegami M
      Am. J. Physiol. Lung Cell Mol. Physiol., 2009;297(2):L286-98.
      Species: Mouse
      Sample Type: Tissue Homogenates
    147. Loss-of-function mutation in myostatin reduces tumor necrosis factor alpha production and protects liver against obesity-induced insulin resistance.
      Authors: Wilkes JJ, Lloyd DJ, Gekakis N
      Diabetes, 2009;58(5):1133-43.
      Species: Mouse
      Sample Type: Plasma
    148. Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.
      Authors: Fukui R, Saitoh S, Matsumoto F, Kozuka-Hata H, Oyama M, Tabeta K, Beutler B, Miyake K
      J. Exp. Med., 2009;206(6):1339-50.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    149. An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells.
      Authors: Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Kaitani A, Sugiuchi M, Takahashi M, Maehara A, Enomoto Y, Oki T, Takai T, Kitamura T
      J. Immunol., 2009;183(2):925-36.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    150. Urokinase plasminogen activator receptor-deficient mice demonstrate reduced hyperoxia-induced lung injury.
      Authors: van Zoelen MA, Florquin S, de Beer R, Pater JM, Verstege MI, Meijers JC, van der Poll T
      Am. J. Pathol., 2009;174(6):2182-9.
      Species: Mouse
      Sample Type: BALF
    151. Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines.
      Authors: Hayashida K, Parks WC, Park PW
      Blood, 2009;114(14):3033-43.
      Species: Mouse
      Sample Type: Serum
    152. Anti-inflammatory effects of ethyl acetate fraction from Melilotus suaveolens Ledeb on LPS-stimulated RAW 264.7 cells.
      Authors: Tao JY, Zheng GH, Zhao L, Wu JG, Zhang XY, Zhang SL, Huang ZJ, Xiong FL, Li CM
      J Ethnopharmacol, 2009;123(1):97-105.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    153. Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis.
      Authors: Palmer G, Talabot-Ayer D, Lamacchia C, Toy D, Seemayer CA, Viatte S, Finckh A, Smith DE, Gabay C
      Arthritis Rheum., 2009;60(3):738-49.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    154. Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
      Authors: Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini MC, Pallone F, MacDonald TT, Monteleone G
      Blood, 2009;113(15):3512-9.
      Species: Mouse
      Sample Type: Serum
    155. Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia.
      Authors: Rosenberger P, Schwab JM, Mirakaj V, Masekowsky E, Mager A, Morote-Garcia JC, Unertl K, Eltzschig HK
      Nat. Immunol., 2009;10(2):195-202.
      Species: Mouse
      Sample Type: Serum
    156. Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7.
      Authors: Vultaggio A, Nencini F, Fitch PM, Fili L, Maggi L, Fanti P, deVries A, Beccastrini E, Palandri F, Manuelli C, Bani D, Giudizi MG, Guarna A, Annunziato F, Romagnani S, Maggi E, Howie SE, Parronchi P
      J. Immunol., 2009;182(2):880-9.
      Species: Mouse
      Sample Type: Serum
    157. Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse.
      Authors: Wang S, Wu D, Matthan NR, Lamon-Fava S, Lecker JL, Lichtenstein AH
      Atherosclerosis, 2009;204(1):147-55.
      Species: Mouse
      Sample Type: Plasma
    158. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
      Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
      J. Immunol., 2009;183(2):1291-300.
      Species: Mouse
      Sample Type: BALF
    159. A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis.
      Authors: Crane DD, Warner SL, Bosio CM
      J. Immunol., 2009;183(7):4593-600.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    160. Inhibitory effect of atractylenolide I on angiogenesis in chronic inflammation in vivo and in vitro.
      Authors: Wang C, Duan H, He L
      Eur. J. Pharmacol., 2009;612(1):143-52.
      Species: Mouse
      Sample Type: Air Pouch Exudate
    161. Bbeta(15-42) protects against acid-induced acute lung injury and secondary pseudomonas pneumonia in vivo.
      Authors: Matt U, Warszawska JM, Bauer M, Dietl W, Mesteri I, Doninger B, Haslinger I, Schabbauer G, Perkmann T, Binder CJ, Reingruber S, Petzelbauer P, Knapp S
      Am. J. Respir. Crit. Care Med., 2009;180(12):1208-17.
      Species: Mouse
      Sample Type: BALF
    162. Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice.
      Authors: Lafdil F, Chobert MN, Deveaux V, Zafrani ES, Mavier P, Nakano T, Laperche Y, Brouillet A
      J. Hepatol., 2009;51(1):55-66.
      Species: Mouse
      Sample Type: Tissue Homogenates
    163. VAMP8 is essential in anaphylatoxin-induced degranulation, TNF-alpha secretion, peritonitis, and systemic inflammation.
      Authors: Pushparaj PN, Tay HK, Wang CC, Hong W, Melendez AJ
      J. Immunol., 2009;183(2):1413-8.
      Species: Mouse
      Sample Type: Serum
    164. Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy.
      Authors: Yang SJ, IglayReger HB, Kadouh HC, Bodary PF
      Diabetologia, 2009;52(0):972-81.
      Species: Mouse
      Sample Type: Plasma
    165. Low-dose acetylsalicylic acid inhibits the secretion of interleukin-6 from white adipose tissue.
      Authors: Ogston NC, Karastergiou K, Hosseinzadeh-Attar MJ, Bhome R, Madani R, Stables M, Gilroy D, Flachs P, Hensler M, Kopecky J, Mohamed-Ali V
      Int J Obes (Lond), 2008;32(12):1807-15.
    166. Functional roles for C5a receptors in sepsis.
      Authors: Rittirsch D, Flierl MA, Nadeau BA, Day DE, Huber-Lang M, Mackay CR, Zetoune FS, Gerard NP, Cianflone K, Kohl J, Gerard C, Sarma JV, Ward PA
      Nat. Med., 2008;14(5):551-7.
      Species: Mouse
      Sample Type: Plasma
    167. Suppression of activation and induction of apoptosis in RAW264.7 cells by amniotic membrane extract.
      Authors: He H, Li W, Chen SY, Zhang S, Chen YT, Hayashida Y, Zhu YT, Tseng SC
      Invest. Ophthalmol. Vis. Sci., 2008;49(10):4468-75.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    168. The selective MMP-12 inhibitor, AS111793 reduces airway inflammation in mice exposed to cigarette smoke.
      Authors: Le Quement C, Guenon I, Gillon JY, Valenca S, Cayron-Elizondo V, Lagente V, Boichot E
      Br. J. Pharmacol., 2008;154(6):1206-15.
      Species: Mouse
      Sample Type: BALF
    169. Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis.
      Authors: Beraza N, Malato Y, Vander Borght S, Liedtke C, Wasmuth HE, Dreano M, De Vos R, Roskams T, Trautwein C
      Gut, 2008;57(5):655-63.
      Species: Mouse
      Sample Type: Tissue Homogenates
    170. Stem cell factor and its receptor, c-kit, are important for hepatocyte proliferation in wild-type and tumor necrosis factor receptor-1 knockout mice after 70% hepatectomy.
      Authors: Ren X, Hu B, Colletti L
      Surgery, 2008;143(6):790-802.
      Species: Mouse
      Sample Type: Tissue Homogenates
    171. Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice.
      Authors: Mingam R, Moranis A, Bluthe RM, De Smedt-Peyrusse V, Kelley KW, Guesnet P, Lavialle M, Dantzer R, Laye S
      Eur. J. Neurosci., 2008;28(9):1877-86.
      Species: Mouse
      Sample Type: Plasma
    172. Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses.
      Authors: Son A, Nakamura H, Okuyama H, Oka S, Yoshihara E, Liu W, Matsuo Y, Kondo N, Masutani H, Ishii Y, Iyoda T, Inaba K, Yodoi J
      Eur. J. Immunol., 2008;38(5):1358-67.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    173. Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation.
      Authors: Bartlett NW, Walton RP, Edwards MR, Aniscenko J, Caramori G, Zhu J, Glanville N, Choy KJ, Jourdan P, Burnet J, Tuthill TJ, Pedrick MS, Hurle MJ, Plumpton C, Sharp NA, Bussell JN, Swallow DM, Schwarze J, Guy B, Almond JW, Jeffery PK, Lloyd CM, Papi A, Killington RA, Rowlands DJ, Blair ED, Clarke NJ, Johnston SL
      Nat. Med., 2008;14(2):199-204.
      Species: Mouse
      Sample Type: BALF
    174. The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-gamma response.
      Authors: Palma C, Iona E, Giannoni F, Pardini M, Brunori L, Fattorini L, Del Giudice G, Cassone A
      Vaccine, 2008;26(33):4237-43.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    175. Adiponectin blocks multiple signaling cascades associated with leptin-induced cell proliferation in Apc Min/+ colon epithelial cells.
      Authors: Fenton JI, Birmingham JM, Hursting SD, Hord NG
      Int. J. Cancer, 2008;122(11):2437-45.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    176. Adverse functions of IL-17A in experimental sepsis.
      Authors: Flierl MA, Rittirsch D, Gao H, Hoesel LM, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ferrara JL, Ward PA
      FASEB J., 2008;22(7):2198-205.
      Species: Mouse
      Sample Type: Plasma
    177. Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin.
      Authors: Izumi-Nagai K, Nagai N, Ohgami K, Satofuka S, Ozawa Y, Tsubota K, Ohno S, Oike Y, Ishida S
      Invest. Ophthalmol. Vis. Sci., 2008;49(4):1679-85.
      Species: Mouse
      Sample Type: Tissue Homogenates
    178. Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
      Authors: Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A
      Eur. J. Pharmacol., 2008;590(1):400-8.
      Species: Mouse
      Sample Type: Tissue Homogenates
    179. Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokines.
      Authors: Olleros ML, Martin ML, Vesin D, Fotio AL, Santiago-Raber ML, Rubbia-Brandt L, Spahr L, Hadengue A, Garcia I
      Cytokine, 2008;44(1):118-25.
      Species: Mouse
      Sample Type: Serum
    180. Identification of galectin-3-binding protein as a factor secreted by tumor cells that stimulates interleukin-6 expression in the bone marrow stroma.
      Authors: Fukaya Y, Shimada H, Wang LC, Zandi E, DeClerck YA
      J. Biol. Chem., 2008;283(27):18573-81.
      Species: Human
      Sample Type: Cell Culture Supernates
    181. Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis.
      Authors: Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ
      J. Immunol., 2008;181(2):1491-8.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    182. Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis.
      Authors: Zhang H, Moochhala SM, Bhatia M
      J. Immunol., 2008;181(6):4320-31.
      Species: Mouse
      Sample Type: Tissue Homogenates
    183. The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors.
      Authors: Pobezinskaya YL, Kim YS, Choksi S, Morgan MJ, Li T, Liu C, Liu Z
      Nat. Immunol., 2008;9(9):1047-54.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    184. Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance.
      Authors: Ashare A, Nymon AB, Doerschug KC, Morrison JM, Monick MM, Hunninghake GW
      Am. J. Respir. Crit. Care Med., 2008;178(2):149-57.
      Species: Mouse
      Sample Type: Tissue Homogenates
    185. The neuropeptide substance P is a critical mediator of burn-induced acute lung injury.
      Authors: Sio SW, Puthia MK, Lu J, Moochhala S, Bhatia M
      J. Immunol., 2008;180(12):8333-41.
      Species: Mouse
      Sample Type: Tissue Homogenates
    186. Graft produced interleukin-6 functions as a danger signal and promotes rejection after transplantation.
      Authors: Liang Y, Christopher K, Finn PW, Colson YL, Perkins DL
      Transplantation, 2007;84(6):771-7.
      Species: Mouse
      Sample Type: Serum
    187. Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat.
      Authors: Nenan S, Lagente V, Planquois JM, Hitier S, Berna P, Bertrand CP, Boichot E
      Eur. J. Pharmacol., 2007;559(1):75-81.
      Species: Mouse
      Sample Type: Tissue Homogenates
    188. CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease.
      Authors: Hollingsworth JW, Li Z, Brass DM, Garantziotis S, Timberlake SH, Kim A, Hossain I, Savani RC, Schwartz DA
      Am. J. Respir. Cell Mol. Biol., 2007;37(2):248-53.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    189. Cell-based angiopoietin-1 gene therapy for acute lung injury.
      Authors: McCarter SD, Mei SH, Lai PF, Zhang QW, Parker CH, Suen RS, Hood RD, Zhao YD, Deng Y, Han RN, Dumont DJ, Stewart DJ
      Am. J. Respir. Crit. Care Med., 2007;175(10):1014-26.
      Species: Mouse
      Sample Type: BALF
    190. IL-17 receptor signaling influences virus-induced corneal inflammation.
      Authors: Molesworth-Kenyon SJ, Yin R, Oakes JE, Lausch RN
      J. Leukoc. Biol., 2007;83(2):401-8.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    191. CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis.
      Authors: Nolan A, Weiden M, Kelly A, Hoshino Y, Hoshino S, Mehta N, Gold JA
      Am. J. Respir. Crit. Care Med., 2007;177(3):301-8.
      Species: Mouse
      Sample Type: Plasma
    192. Entry route of Salmonella typhimurium directs the type of induced immune response.
      Authors: Martinoli C, Chiavelli A, Rescigno M
      Immunity, 2007;27(6):975-84.
      Species: Mouse
      Sample Type: Tissue Homogenates
    193. Neuronal NF-kappaB influences thermoregulation and survival in a sepsis model.
      Authors: Juttler E, Inta I, Eigler V, Herrmann O, Maegele I, Maser-Gluth C, Schwaninger M
      J. Neuroimmunol., 2007;189(1):41-9.
      Species: Mouse
      Sample Type: Serum
    194. Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages.
      Authors: Kang JH, Kim CS, Han IS, Kawada T, Yu R
      FEBS Lett., 2007;581(23):4389-96.
      Species: Mouse
      Sample Type: Tissue Homogenates
    195. TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways.
      Authors: Shigeoka AA, Holscher TD, King AJ, Hall FW, Kiosses WB, Tobias PS, Mackman N, McKay DB
      J. Immunol., 2007;178(10):6252-8.
      Species: Mouse
      Sample Type: Tissue Homogenates
    196. The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells.
      Authors: Fujita H, Asahina A, Komine M, Tamaki K
      Cell. Immunol., 2007;245(2):70-9.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    197. Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection.
      Authors: Gregory AD, Hogue LA, Ferkol TW, Link DC
      Blood, 2007;109(8):3235-43.
      Species: Mouse
      Sample Type: Epithelial Fluid
    198. Identification of an immune-responsive mesolimbocortical serotonergic system: potential role in regulation of emotional behavior.
      Authors: Lowry CA, Hollis JH, de Vries A, Pan B, Brunet LR, Hunt JR, Paton JF, van Kampen E, Knight DM, Evans AK, Rook GA, Lightman SL
      Neuroscience, 2007;146(2):756-72.
      Species: Mouse
      Sample Type: Plasma
    199. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock.
      Authors: Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen MA, Nacken W, Foell D, van der Poll T, Sorg C, Roth J
      Nat. Med., 2007;13(9):1042-9.
      Species: Mouse
      Sample Type: Serum
    200. Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk.
      Authors: Ryu M, Kim EH, Chun M, Kang S, Shim B, Yu YB, Jeong G, Lee JS
      J Ethnopharmacol, 2007;115(2):184-93.
      Species: Mouse
      Sample Type: Air Pouch Exudate
    201. Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion.
      Authors: Kaczorowski DJ, Nakao A, Mollen KP, Vallabhaneni R, Sugimoto R, Kohmoto J, Tobita K, Zuckerbraun BS, McCurry KR, Murase N, Billiar TR
      Transplantation, 2007;84(10):1279-87.
      Species: Mouse
      Sample Type: Serum
    202. Effect of chronic IL-6 infusion on acute pressor responses to vasoconstrictors in mice.
      Authors: Boesen EI, Pollock DM
      Am. J. Physiol. Heart Circ. Physiol., 2007;293(3):H1745-9.
      Species: Mouse
      Sample Type: Plasma
    203. Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling.
      Authors: Denis O, van den Brule S, Heymans J, Havaux X, Rochard C, Huaux F, Huygen K
      Immunology, 2007;122(2):268-78.
      Species: Mouse
      Sample Type: BALF
    204. Acute brain injury triggers MyD88-dependent, TLR2/4-independent inflammatory responses.
      Authors: Koedel U, Merbt UM, Schmidt C, Angele B, Popp B, Wagner H, Pfister HW, Kirschning CJ
      Am. J. Pathol., 2007;171(1):200-13.
      Species: Mouse
      Sample Type: Tissue Homogenates
    205. Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study.
      Authors: Vazquez JF, Clement HW, Sommer O, Schulz E, van Calker D
      J. Neurochem., 2007;105(3):904-9.
      Species: Mouse
      Sample Type: Recombinant Protein
    206. Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells.
      Authors: Kurooka M, Kaneda Y
      Cancer Res., 2007;67(1):227-36.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    207. ST2 is essential for Th2 responsiveness and resistance to pseudomonas aeruginosa keratitis.
      Authors: Huang X, Du W, Barrett RP, Hazlett LD
      Invest. Ophthalmol. Vis. Sci., 2007;48(10):4626-33.
      Species: Mouse
      Sample Type: Tissue Homogenates
    208. The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro.
      Authors: Yeh CC, Kao SJ, Lin CC, Wang SD, Liu CJ, Kao ST
      Life Sci., 2007;80(20):1821-31.
      Species: Mouse
      Sample Type: BALF
    209. Interleukin-1beta is the primary initiator of pulmonary inflammation following liver injury in mice.
      Authors: Glasgow SC, Ramachandran S, Blackwell TS, Mohanakumar T, Chapman WC
      Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(2):L491-6.
      Species: Mouse
      Sample Type: Serum
    210. Cathelicidin-deficient (Cnlp -/- ) mice show increased susceptibility to Pseudomonas aeruginosa keratitis.
      Authors: Huang LC, Reins RY, Gallo RL, McDermott AM
      Invest. Ophthalmol. Vis. Sci., 2007;48(10):4498-508.
      Species: Mouse
      Sample Type: Tissue Homogenates
    211. Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy.
      Authors: Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS
      Proc. Natl. Acad. Sci. U.S.A., 2007;104(43):17069-74.
      Species: Mouse
      Sample Type: Plasma
    212. Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeability.
      Authors: Geny B, Khun H, Fitting C, Zarantonelli L, Mazuet C, Cayet N, Szatanik M, Prevost MC, Cavaillon JM, Huerre M, Popoff MR
      Am. J. Pathol., 2007;170(3):1003-17.
      Species: Mouse
      Sample Type: Tissue Homogenates
    213. Maternal immune activation alters fetal brain development through interleukin-6.
      Authors: Smith SE, Li J, Garbett K, Mirnics K, Patterson PH
      J. Neurosci., 2007;27(40):10695-702.
      Species: Mouse
      Sample Type: Serum
    214. Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis.
      Authors: Furuta T, Yoshikawa Y
      Int. Immunol., 2006;18(12):1655-62.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    215. A coagulation factor VII deficiency protects against acute inflammatory responses in mice.
      Authors: Xu H, Ploplis VA, Castellino FJ
      J. Pathol., 2006;210(4):488-96.
      Species: Mouse
      Sample Type: Plasma
    216. The urokinase plasminogen activator receptor is crucially involved in host defense during acute pyelonephritis.
      Authors: Roelofs JJ, Rouschop KM, Teske GJ, Claessen N, Weening JJ, van der Poll T, Florquin S
      Kidney Int., 2006;70(11):1942-7.
      Species: Mouse
      Sample Type: Tissue Homogenates
    217. Bim deficiency leads to exacerbation and prolongation of joint inflammation in experimental arthritis.
      Authors: Scatizzi JC, Bickel E, Hutcheson J, Haines GK, Perlman H
      Arthritis Rheum., 2006;54(10):3182-93.
      Species: Mouse
      Sample Type: Tissue Homogenates
    218. Impact of the loss of Hoxa5 function on lung alveogenesis.
      Authors: Mandeville I, Aubin J, Leblanc M, Lalancette-Hebert M, Janelle MF, Tremblay GM, Jeannotte L
      Am. J. Pathol., 2006;169(4):1312-27.
      Species: Mouse
      Sample Type: BALF
    219. Vaccinia virus infection attenuates innate immune responses and antigen presentation by epidermal dendritic cells.
      Authors: Deng L, Dai P, Ding W, Granstein RD, Shuman S
      J. Virol., 2006;80(20):9977-87.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    220. Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis.
      Authors: Nemeth ZH, Csoka B, Wilmanski J, Xu D, Lu Q, Ledent C, Deitch EA, Pacher P, Spolarics Z, Hasko G
      J. Immunol., 2006;176(9):5616-26.
      Species: Mouse
      Sample Type: Plasma
    221. Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters.
      Authors: Li RW, Theriault AG, Au K, Douglas TD, Casaschi A, Kurowska EM, Mukherjee R
      Life Sci., 2006;79(4):365-73.
      Species: Mouse
      Sample Type: Serum
    222. Protease-activated receptor-2 activation: a major role in the pathogenesis of Porphyromonas gingivalis infection.
      Authors: Holzhausen M, Spolidorio LC, Ellen RP, Jobin MC, Steinhoff M, Andrade-Gordon P, Vergnolle N
      Am. J. Pathol., 2006;168(4):1189-99.
      Species: Mouse
      Sample Type: Blister Fluid
    223. Rubus coreanus Miq. extract promotes osteoblast differentiation and inhibits bone-resorbing mediators in MC3T3-E1 cells.
      Authors: Lee KH, Choi EM
      Am. J. Chin. Med., 2006;34(4):643-54.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    224. Persistent effects induced by IL-13 in the lung.
      Authors: Fulkerson PC, Fischetti CA, Hassman LM, Nikolaidis NM, Rothenberg ME
      Am. J. Respir. Cell Mol. Biol., 2006;35(3):337-46.
      Species: Mouse
      Sample Type: BALF
    225. Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation.
      Authors: Card JW, Carey MA, Bradbury JA, DeGraff LM, Morgan DL, Moorman MP, Flake GP, Zeldin DC
      J. Immunol., 2006;177(1):621-30.
      Species: Mouse
      Sample Type: BALF
    226. Altered postnatal lung development in C3H/HeJ mice.
      Authors: Sampath V, Davis K, Senft AP, Richardson TR, Kitzmiller JA, Berclaz PY, Korfhagen TR
      Pediatr. Res., 2006;60(6):663-8.
      Species: Mouse
      Sample Type: Tissue Homogenates
    227. Delayed inflammatory responses to endotoxin in fibrinogen-deficient mice.
      Authors: Cruz-Topete D, Iwaki T, Ploplis VA, Castellino FJ
      J. Pathol., 2006;210(3):325-33.
      Species: Mouse
      Sample Type: Plasma
    228. Organ-specific role of MyD88 for gene regulation during polymicrobial peritonitis.
      Authors: Weighardt H, Mages J, Jusek G, Kaiser-Moore S, Lang R, Holzmann B
      Infect. Immun., 2006;74(6):3618-32.
      Species: Mouse
      Sample Type: Tissue Homogenates
    229. Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways.
      Authors: Wang ZY, Yang D, Chen Q, Leifer CA, Segal DM, Su SB, Caspi RR, Howard ZO, Oppenheim JJ
      Exp. Hematol., 2006;34(8):1115-24.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    230. Prostaglandin D2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells.
      Authors: Bate C, Kempster S, Williams A
      Neuropharmacology, 2006;50(2):229-37.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    231. MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis.
      Authors: Hegen M, Gaestel M, Nickerson-Nutter CL, Lin LL, Telliez JB
      J. Immunol., 2006;177(3):1913-7.
      Species: Mouse
      Sample Type: Serum
    232. Allergic airway inflammation inhibits pulmonary antibacterial host defense.
      Authors: Beisswenger C, Kandler K, Hess C, Garn H, Felgentreff K, Wegmann M, Renz H, Vogelmeier C, Bals R
      J. Immunol., 2006;177(3):1833-7.
      Species: Mouse
      Sample Type: BALF
    233. GM-CSF and the impaired pulmonary innate immune response following hyperoxic stress.
      Authors: Baleeiro CE, Christensen PJ, Morris SB, Mendez MP, Wilcoxen SE, Paine R
      Am. J. Physiol. Lung Cell Mol. Physiol., 2006;291(6):L1246-55.
      Species: Mouse
      Sample Type: Tissue Homogenates
    234. The pulmonary and hepatic immune microenvironment and its contribution to the early systemic inflammation following blunt chest trauma.
      Authors: Perl M, Gebhard F, Braumuller S, Tauchmann B, Bruckner UB, Kinzl L, Knoferl MW
      Crit. Care Med., 2006;34(4):1152-9.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    235. CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome.
      Authors: Wieland CW, Kerver ME, Florquin S, Nolte MA, Borst J, van Lier R, van Oers MH, van der Poll T
      Int. Immunol., 2006;18(11):1531-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    236. Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation.
      Authors: Sergejeva S, Ivanov S, Lotvall J, Linden A
      Am. J. Respir. Cell Mol. Biol., 2005;33(3):248-53.
      Species: Mouse
      Sample Type: BALF
    237. Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580.
      Authors: Conway JG, Conway&lt;/LastName&gt;&lt;ForeNam JG&lt;/Initia, McDonald B, Parham J, Keith B, Rusnak DW, Shaw E, Jansen M, Lin P, Payne A, Crosby RM, Johnson JH, Frick L, Lin MH, Depee S, Tadepalli S, Votta B, James I, Fuller K, Chambers TJ, Kull FC, Chamberlain SD, Hutchins JT
      Proc. Natl. Acad. Sci. U.S.A., 2005;102(44):16078-83.
      Species: Mouse
      Sample Type: Plasma
    238. A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppression.
      Authors: Liao HF, Chen YJ, Yang YC
      Life Sci., 2005;77(4):400-13.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    239. A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).
      Authors: Biswas SK, Gangi L, Paul S, Schioppa T, Saccani A, Sironi M, Bottazzi B, Doni A, Vincenzo B, Pasqualini F, Vago L, Nebuloni M, Mantovani A, Sica A
      Blood, 2005;107(5):2112-22.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    240. Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice.
      Authors: Thakur A, Barrett RP, McClellan S, Hazlett LD
      Curr. Eye Res., 2004;29(4):225-33.
      Species: Mouse
      Sample Type: Tissue Homogenates
    241. Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow.
      Authors: Bleier JI, Pillarisetty VG, Shah AB, DeMatteo RP
      J. Immunol., 2004;172(12):7408-16.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    242. IL-22 increases the innate immunity of tissues.
      Authors: Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R
      Immunity, 2004;21(2):241-54.
      Species: Mouse
      Sample Type: Plasma
    243. Increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P. acnes.
      Authors: Megid J, Kaneno R, Nozaki CN, Brito CJ, Almeida MF
      Comp. Immunol. Microbiol. Infect. Dis., 2004;27(6):393-411.
      Species: Mouse
      Sample Type: Serum
    244. Systemic up-regulation of sTNFR2 and IL-6 in Porphyromonas gingivalis pneumonia in mice.
      Authors: Petelin M, Naruishi K, Shiomi N, Mineshiba J, Arai H, Nishimura F, Takashiba S, Murayama Y
      Exp. Mol. Pathol., 2004;76(1):76-81.
      Species: Mouse
      Sample Type: Serum
    245. T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis.
      Authors: Hao Z, Hampel B, Yagita H, Rajewsky K
      J. Exp. Med., 2004;199(10):1355-65.
      Species: Mouse
      Sample Type: Serum
    246. Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways.
      Authors: Miyamoto M, Prause O, Sjostrand M, Laan M, Lotvall J, Linden A
      J. Immunol., 2003;170(9):4665-72.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    247. Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia.
      Authors: Pawlinski R, Pedersen B, Schabbauer G, Tencati M, Holscher T, Boisvert W, Andrade-Gordon P, Frank RD, Mackman N
      Blood, 2003;103(4):1342-7.
      Species: Mouse
      Sample Type: Plasma
    248. Intra-amniotic lipopolysaccharide leads to fetal cardiac dysfunction. A mouse model for fetal inflammatory response.
      Authors: Rounioja S, Rasanen J, Glumoff V, Ojaniemi M, Makikallio K, Hallman M
      Cardiovasc. Res., 2003;60(1):156-64.
      Species: Mouse
      Sample Type: Amniotic Fluid
    249. Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.
      Authors: McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N
      J. Clin. Invest., 2003;112(4):598-607.
      Species: Mouse
      Sample Type: Peritoneal Fluid
    250. Endogenous granulocyte-macrophage colony-stimulating factor overexpression in vivo results in the long-term recruitment of a distinct dendritic cell population with enhanced immunostimulatory function.
      Authors: Miller G, Pillarisetty VG, Shah AB, Lahrs S, Xing Z, DeMatteo RP
      J. Immunol., 2002;169(6):2875-85.
      Species: Mouse
      Sample Type: Serum
    251. The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls.
      Authors: Hanisch UK, Prinz M, Angstwurm K, Hausler KG, Kann O, Kettenmann H, Weber JR
      Eur. J. Immunol., 2001;31(7):2104-15.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    252. A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells.
      Authors: Shih CC, Hu MC, Hu J
      Blood, 2000;95(6):1957-66.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    253. Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation.
      Authors: Liu F, Poursine-Laurent J, Wu HY, Link DC
      Blood, 1997;90(7):2583-90.
      Species: Mouse
      Sample Type: Serum
    254. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.
      Authors: Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Schaefer R, Grone HJ, Schaefer L
      J Biol Chem, 0;284(36):24035-48.
      Species: Mouse
      Sample Type: Plasma
    Expand to show all 254 Citations
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      Excellent
      Anonymous 09/01/2017
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    Sample TestedBrain tissue
      Excellent
      Anonymous 07/19/2017
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    Sample TestedSerum,Brain (cortex) tissue

    Other Experimental Details

    Other Experimental DetailsJust wanted to let anyone know that the second kit used worked flawless compared to the review I posted above.
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      Anonymous 07/15/2016
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     Mouse IL-6 Quantikine ELISA Kit M6000B
    : Mouse IL-6 Quantikine ELISA Kit [M6000B]

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    Sample TestedSerum,Liver tissue,Brain (cerebral cortex),choroid plexus,Adipose tissue

    Other Experimental Details

    Other Experimental DetailsOne plate performed really good but one plate turned out blank. The costumer support were really helpful with diagnosing the error. Attached you find a photo of the plate that didn't work out:

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