Mouse Integrin  alpha M/CD11b Fluorescein-conjugated Antibody

Catalog # Availability Size / Price Qty
FAB1124F-100
FAB1124F-025
Mouse Integrin  alpha M/CD11b Fluorescein-conjugated Antibody in Data
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Citations (5)
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Mouse Integrin  alpha M/CD11b Fluorescein-conjugated Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse Integrin alpha M/CD11b. Cross-reaction with human Integrin alpha M has been reported (1, 2).
Source
Monoclonal Rat IgG2B Clone # M1/70
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Con A-activated C57BL/10 splenocytes
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Fluorescein (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Flow Cytometry Detection of Integrin aM/CD11b antibody in Mouse Peripheral Blood Cells antibody by Flow Cytometry. View Larger

Detection of Integrin alpha M/CD11b in Mouse Peripheral Blood Cells by Flow Cytometry. Mouse peripheral blood cells were stained with Rat Anti-Mouse Integrin aM/CD11b Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB1124F, filled histogram) or isotype control antibody (Catalog # IC013F, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: CD11b/Integrin alpha M

The Integrin family proteins are heterodimeric transmembrane receptors composed of an alpha  and a beta  subunit. The Integrin  alpha M subunit, also known as MAC-1 alpha subunit or CD11b, combines with the Integrin  beta 2 subunit (CD18) to form the non-covalent heterodimer Integrin  alpha M/ beta 2, also known as MAC-1 and Complement Receptor type 3 (CR3). Integrin  alpha M/ beta 2 is expressed on granulocytes, macrophages, dendritic cells and natural killer cells. Upon activation, alpha M/ beta 2 can bind several ligands (including ICAM-1, Fibrinogen, and the C3 Complement Fragment, C3bi) to mediate phagocyte adhesion, migration and ingestion of complement-opsonized particles.

Entrez Gene IDs
3684 (Human); 16409 (Mouse)
Alternate Names
antigen CD11b (p170); CD11 antigen-like family member B; CD11b antigen; CD11b; Cell surface glycoprotein MAC-1 subunit alpha; Complement component 3 receptor 3 subunit; CR-3 alpha chain; CR3A; CR3AMGC117044; Integrin alpha M; integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); ITGAM; Leukocyte adhesion receptor MO1; MAC-1; MAC1A; macrophage antigen alpha polypeptide; MO1A; neutrophil adherence receptor alpha-M subunit; Neutrophil adherence receptor; SLEB6

Product Datasheets

Citations for Mouse Integrin  alpha M/CD11b Fluorescein-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Swainsonine, an alpha-mannosidase inhibitor, may worsen cervical cancer progression through the increase in myeloid derived suppressor cells population
    Authors: CRF Silveira, M Cipelli, C Manzine, SH Rabelo-San, LC Zeferino, G Rodríguez, JB de Assis, S Hebster, I Bernadinel, F Laginha, E Boccardo, LL Villa, L Termini, AP Lepique
    PLoS ONE, 2019;14(3):e0213184.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Flow Cytometry
  2. Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis via suppressing neutrophils and macrophages
    Authors: YX Yan, MJ Shao, Q Qi, YS Xu, XQ Yang, FH Zhu, SJ He, PL He, CL Feng, YW Wu, H Li, W Tang, JP Zuo
    Acta Pharmacol. Sin., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  3. Cigarette smoke exposure promotes differentiation of CD4+ T cells toward Th17 cells by CD40-CD40L costimulatory pathway in mice
    Authors: Y Liang, Y Shen, L Kuang, G Zhou, L Zhang, X Zhong, J Zhang, J Liu
    Int J Chron Obstruct Pulmon Dis, 2018;13(0):959-968.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  4. Granulocyte-macrophage colony-stimulating factor increases tumor growth and angiogenesis directly by promoting endothelial cell function and indirectly by enhancing the mobilization and recruitment of proangiogenic granulocytes
    Authors: Q Zheng, X Li, X Cheng, T Cui, Y Zhuo, W Ma, X Zhao, P Zhao, X Liu, W Feng
    Tumour Biol, 2017;39(2):1010428317692.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. Regulation of Leishmania (L.) amazonensis protein expression by host T cell dependent responses: differential expression of oligopeptidase B, tryparedoxin peroxidase and HSP70 isoforms in amastigotes isolated from BALB/c and BALB/c nude mice.
    Authors: Teixeira P, Velasquez L, Lepique A, de Rezende E, Bonatto J, Barcinski M, Cunha-Neto E, Stolf B
    PLoS Negl Trop Dis, 2015;9(2):e0003411.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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