Home / PDGF R alpha / Mouse PDGF R alpha Antibody

Mouse PDGF R alpha Antibody

AF1062 66 Citations 9 Reviews Datasheet / COA / SDS
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AF1062
AF1062-SP
Mouse PDGF R alpha Antibody in Data
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Product Details
Citations (66)
FAQs
Supplemental Products
Reviews (9)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse PDGF R alpha Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse PDGF R alpha in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) PDGF R alpha, rhPDGF R beta, and recombinant mouse PDGF R beta is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse PDGF R alpha
Leu25-Glu524 (Asp65Glu, Gly439Ala, Thr440Ala)
Accession # P26618
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below
Immunohistochemistry
5-15 µg/mL
See below
Neutralization
Measured by its ability to neutralize PDGF‑AA-induced proliferation in the NR6R‑3T3 mouse fibroblast cell line. The Neutralization Dose (ND50) is typically 0.2 - 1.6 µg/mL in the presence of 250 ng/mL Recombinant Human PDGF‑AA.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Examples

Western Blot Detection of Mouse PDGF Ra antibody by Western Blot. View Larger

Detection of Mouse PDGF R alpha by Western Blot. Western blot shows lysates of mouse uterus tissue and mouse lung tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Mouse PDGF Ra Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1062) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). Specific bands were detected for PDGF Ra at approximately 160-200 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunohistochemistry PDGF Ra antibody in Mouse Embryo by Immunohistochemistry (IHC-Fr). View Larger

PDGF R alpha in Mouse Embryo. PDGF Ra was detected in immersion fixed frozen sections of mouse embryo using Goat Anti-Mouse PDGF Ra Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1062) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Immunohistochemistry PDGF Ra antibody in Mouse Embryo by Immunohistochemistry (IHC-Fr). View Larger

PDGF R alpha in Mouse Embryo. PDGF Ra was detected in immersion fixed frozen sections of mouse embryo using 15 µg/mL Goat Anti-Mouse PDGF Ra Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1062) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific labeling was localized to the plasma membrane of mesenchymal cells. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Neutralization Cell Proliferation Induced by PDGF‑AA and Neutralization by Mouse PDGF R alpha Antibody. View Larger

Cell Proliferation Induced by PDGF‑AA and Neutralization by Mouse PDGF R alpha Antibody. Recombinant Human PDGF-AA (Catalog # 221-AA) stimulates proliferation in the NR6R-3T3 mouse fibroblast cell line in a dose-dependent manner (orange line), as measured by Resazurin (Catalog # AR002. Proliferation elicited by Recombinant Human PDGF-AA (250 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse PDGF Ra Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1062). The ND50 is typically 0.2-1.6 µg/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: PDGF R alpha

The platelet-derived growth factor (PDGF) family consists of proteins derived from four genes (PDGF-A, -B, -C, and -D) that form disulfide-linked homodimers (PDGF-AA, -BB, -CC, and -DD) and a heterodimer (PDGF-AB) (1, 2). These proteins regulate diverse cellular functions by binding to and inducing the homo- or hetero-dimerization of two receptors (PDGF R alpha  and R beta ). Whereas alpha / alpha homo-dimerization is induced by PDGF-AA, -BB, -CC, and -AB, alpha / beta  hetero-dimerization is induced by PDGF-AB, -BB, -CC, and -DD, and beta / beta  homo-dimerization is induced only by PDGF-BB and -DD (1-4). Both PDGF R alpha  and R beta are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, SCF, and Flt-3 ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. Ligand-induced receptor dimerization results in autophosphorylation in trans resulting in the activation of several intracellular signaling pathways that can lead to cell proliferation, cell survival, cytoskeletal rearrangement, and cell migration. Many cell types, including fibroblasts and smooth muscle cells, express both the alpha  and beta  receptors. Others have only the alpha  receptors (oligodendrocyte progenitor cells, mesothelial cells, liver sinusoidal endothelial cells, astrocytes, platelets, and megakaryocytes) or only the  beta receptors (myoblasts, capillary endothelial cells, pericytes, T cells, myeloid hematopoietic cells, and macrophages) (1, 2). Recombinant mouse and human soluble PDGF R beta  bind PDGF with high affinity and are potent PDGF antagonists.

References
  1. Betsholtz, C. et al. (2001) BioEssays 23:494.
  2. Ostman, A. and A.H. Heldin (2001) Advances in Cancer Research 80:1.
  3. Gilbertson, D. et al. (2001) J. Biol. Chem. 276:27406.
  4. LaRochells, W.J. et al. (2001) Nature Cell Biol. 3:517.
Long Name
Platelet-derived Growth Factor Receptor alpha
Entrez Gene IDs
5156 (Human); 18595 (Mouse)
Alternate Names
alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; CD140a; EC 2.7.10; EC 2.7.10.1; MGC74795; PDGF R alpha; PDGFR alpha; PDGFR2; PDGFRA; PDGFRA/BCR fusion; PDGF-R-alpha; platelet-derived growth factor receptor, alpha polypeptide; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alphafusion protein; RHEPDGFRA

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Citations for Mouse PDGF R alpha Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

66 Citations: Showing 1 - 10
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  1. Neuronal activity-dependent myelin repair promotes motor function recovery after contusion spinal cord injury
    Authors: M Luo, Y Yin, D Li, W Tang, Y Liu, L Pan, L Yu, B Tan
    Brain Res Bull, 2020;166(0):73-81.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  2. Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth
    Authors: S Davidson, M Efremova, A Riedel, B Mahata, J Pramanik, J Huuhtanen, G Kar, R Vento-Torm, T Hagai, X Chen, MA Haniffa, JD Shields, SA Teichmann
    Cell Rep, 2020;31(7):107628.
    Species: Mouse
    Sample Types: Whole Cell
    Applications: Flow Cytometry
  3. PDGFRA in vascular adventitial MSCs promotes neointima formation in arteriovenous fistula in chronic kidney disease
    Authors: K Song, Y Qing, Q Guo, EK Peden, C Chen, WE Mitch, L Truong, J Cheng
    JCI Insight, 2020;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient
    Authors: N McCarthy, E Manieri, EE Storm, A Saadatpour, AM Luoma, VN Kapoor, S Madha, LT Gaynor, C Cox, S Keerthivas, K Wucherpfen, GC Yuan, FJ de Sauvage, SJ Turley, RA Shivdasani
    Cell Stem Cell, 2020;0(0):.
    Species: Mouse
    Sample Types: Tissue
    Applications: IHC
  5. BCAS1-positive immature oligodendrocytes are affected by the &alpha-synuclein-induced pathology of multiple system atrophy
    Authors: S Kaji, T Maki, J Ueda, T Ishimoto, Y Inoue, K Yasuda, M Sawamura, R Hikawa, T Ayaki, H Yamakado, R Takahashi
    Acta Neuropathol Commun, 2020;8(1):120.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  6. The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination
    Authors: A Pu, MK Mishra, Y Dong, S Ghorbaniga, EL Stephenson, KS Rawji, C Silva, H Kitagawa, S Sawcer, VW Yong
    J Neuroinflammation, 2020;17(1):220.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  7. Lgr5+�telocytes are a signaling source at the intestinal villus tip
    Authors: K Bahar Halp, H Massalha, RK Zwick, AE Moor, D Castillo-A, M Rozenberg, L Farack, A Egozi, DR Miller, I Averbukh, Y Harnik, N Weinberg-C, FJ de Sauvage, I Amit, OD Klein, M Shoshkes-C, S Itzkovitz
    Nat Commun, 2020;11(1):1936.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  8. Embryonic microglia influence developing hypothalamic glial populations
    Authors: CM Marsters, D Nesan, R Far, N Klenin, QJ Pittman, DM Kurrasch
    J Neuroinflammation, 2020;17(1):146.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  9. Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles
    Authors: J Camps, N Breuls, A Sifrim, N Giarratana, M Corvelyn, L Danti, H Grosemans, S Vanuytven, I Thiry, M Belicchi, M Meregalli, K Platko, ME MacDonald, RC Austin, R Gijsbers, G Cossu, Y Torrente, T Voet, M Sampaolesi
    Cell Rep, 2020;31(5):107597.
    Species: Human
    Sample Types: Whole Cells
  10. Variation of Human Neural Stem Cells Generating Organizer States In�Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates
    Authors: N Micali, SK Kim, M Diaz-Busta, G Stein-O'Br, S Seo, JH Shin, BG Rash, S Ma, Y Wang, NA Olivares, JI Arellano, KR Maynard, EJ Fertig, AJ Cross, RW Bürli, NJ Brandon, DR Weinberger, JG Chenoweth, DJ Hoeppner, N Sestan, P Rakic, C Colantuoni, RD McKay
    Cell Rep, 2020;31(5):107599.
    Species: Human
    Sample Types:
    Applications: IF
  11. In Situ Modification of Tissue Stem and Progenitor Cell Genomes
    Authors: JM Goldstein, M Tabebordba, K Zhu, LD Wang, KA Messemer, B Peacker, S Ashrafi Ka, M Gonzalez-C, Y Shwartz, JKW Cheng, R Xiao, T Barungi, C Albright, YC Hsu, LH Vandenberg, AJ Wagers
    Cell Rep, 2019;27(4):1254-1264.e7.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  12. Myelin repair stimulated by CNS-selective thyroid hormone action
    Authors: MD Hartley, T Banerji, IJ Tagge, LL Kirkemo, P Chaudhary, E Calkins, D Galipeau, MD Shokat, MJ DeBell, S Van Leuven, H Miller, G Marracci, E Pocius, T Banerji, SJ Ferrara, JM Meinig, B Emery, D Bourdette, TS Scanlan
    JCI Insight, 2019;4(8):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  13. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
    Authors: D Aran, AP Looney, L Liu, E Wu, V Fong, A Hsu, S Chak, RP Naikawadi, PJ Wolters, AR Abate, AJ Butte, M Bhattachar
    Nat. Immunol., 2019;20(2):163-172.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  14. Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors
    Authors: L Lukjanenko, S Karaz, P Stuelsatz, U Gurriaran-, J Michaud, G Dammone, F Sizzano, O Mashinchia, S Ancel, E Migliavacc, S Liot, G Jacot, S Metairon, F Raymond, P Descombes, A Palini, B Chazaud, MA Rudnicki, CF Bentzinger, JN Feige
    Cell Stem Cell, 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  15. Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice
    Authors: X Zhang, X Wang, H Yin, L Zhang, A Feng, QX Zhang, Y Lin, B Bao, LL Hernandez, GP Shi, J Liu
    Cell Rep, 2019;28(3):792-803.e4.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  16. Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration
    Authors: X Han, Y Wang, W Pu, X Huang, L Qiu, Y Li, W Yu, H Zhao, X Liu, L He, L Zhang, Y Ji, J Lu, KO Lui, B Zhou
    Stem Cell Reports, 2019;12(3):624-638.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  17. Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds
    Authors: CF Guerrero-J, PH Dedhia, S Jin, R Ruiz-Vega, D Ma, Y Liu, K Yamaga, O Shestova, DL Gay, Z Yang, K Kessenbroc, Q Nie, WS Pear, G Cotsarelis, MV Plikus
    Nat Commun, 2019;10(1):650.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  18. PDGFR?+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland
    Authors: PA Joshi, PD Waterhouse, K Kasaian, H Fang, O Gulyaeva, HS Sul, PC Boutros, R Khokha
    Nat Commun, 2019;10(1):1760.
    Species: Mouse
    Sample Types: Whole Tissues
    Applications: IHC
  19. Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle
    Authors: MN Wosczyna, CT Konishi, EE Perez Carb, TT Wang, RA Walsh, Q Gan, MW Wagner, TA Rando
    Cell Rep, 2019;27(7):2029-2035.e5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  20. TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation
    Authors: A Grund, M Szaroszyk, M Korf-Kling, M Malek Moha, FA Trogisch, U Schrameck, A Gigina, C Tiedje, M Gaestel, T Kraft, J Hegermann, S Batkai, T Thum, A Perrot, CD Remedios, E Riechert, M Völkers, S Doroudgar, A Jungmann, R Bauer, X Yin, M Mayr, KC Wollert, A Pich, H Xiao, HA Katus, J Bauersachs, OJ Müller, J Heineke
    EMBO Mol Med, 2019;0(0):e10018.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  21. TBX2-positive cells represent a multi-potent mesenchymal progenitor pool in the developing lung
    Authors: I Wojahn, TH Lüdtke, VM Christoffe, MO Trowe, A Kispert
    Respir. Res., 2019;20(1):292.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  22. Myelination of the developing lateral olfactory tract and anterior commissure
    Authors: LN Collins, DL Hill, PC Brunjes
    J. Comp. Neurol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  23. Profiling proliferative cells and their progeny in damaged murine hearts
    Authors: K Kretzschma, Y Post, M Bannier-Hé, A Mattiotti, J Drost, O Basak, VSW Li, M van den Bo, QD Gunst, D Versteeg, L Kooijman, S van der El, JH van Es, E van Rooij, MJB van den Ho, H Clevers
    Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  24. Heterozygosity for Nuclear Factor One X in mice models features of Malan syndrome
    Authors: S Oishi, D Harkins, ND Kurniawan, M Kasherman, L Harris, O Zalucki, RM Gronostajs, THJ Burne, M Piper
    EBioMedicine, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  25. Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1?
    Authors: SK Jensen, NJ Michaels, S Ilyntskyy, MB Keough, O Kovalchuk, VW Yong
    Cell Rep, 2018;24(12):3167-3179.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  26. B-1a lymphocytes promote oligodendrogenesis during brain development
    Authors: S Tanabe, T Yamashita
    Nat. Neurosci., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  27. Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
    Authors: S Mitew, I Gobius, LR Fenlon, SJ McDougall, D Hawkes, YL Xing, H Bujalka, AL Gundlach, LJ Richards, TJ Kilpatrick, TD Merson, B Emery
    Nat Commun, 2018;9(1):306.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  28. Pulmonary pericytes regulate lung morphogenesis
    Authors: K Kato, R Diéguez-Hu, DY Park, SP Hong, S Kato-Azuma, S Adams, M Stehling, B Trappmann, JL Wrana, GY Koh, RH Adams
    Nat Commun, 2018;9(1):2448.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  29. Perfect chronic skeletal muscle regeneration in adult spiny mice, Acomys cahirinus
    Authors: M Maden, JO Brant, A Rubiano, AGW Sandoval, C Simmons, R Mitchell, H Collin-Hoo, J Jacobson, S Omairi, K Patel
    Sci Rep, 2018;8(1):8920.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  30. Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration
    Authors: MJ Carr, JS Toma, APW Johnston, PE Steadman, SA Yuzwa, N Mahmud, PW Frankland, DR Kaplan, FD Miller
    Cell Stem Cell, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  31. Role of P2XReceptor in Mouse Voiding Function
    Authors: W Yu, WG Hill, SC Robson, ML Zeidel
    Sci Rep, 2018;8(1):1838.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  32. Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice
    Authors: SN Kim, S Akindehin, HJ Kwon, YH Son, A Saha, YS Jung, JK Seong, KM Lim, JH Sung, KR Maddipati, YH Lee
    Sci Rep, 2018;8(1):8856.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  33. AMPK Activation Regulates LTBP4-Dependent TGF-?1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy
    Authors: G Juban, M Saclier, H Yacoub-You, A Kernou, L Arnold, C Boisson, S Ben Larbi, M Magnan, S Cuvellier, M Théret, BJ Petrof, I Desguerre, J Gondin, R Mounier, B Chazaud
    Cell Rep, 2018;25(8):2163-2176.e6.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  34. ALS skeletal muscle shows enhanced TGF-? signaling, fibrosis and induction of fibro/adipogenic progenitor markers
    Authors: D Gonzalez, O Contreras, DL Rebolledo, JP Espinoza, B van Zunder, E Brandan
    PLoS ONE, 2017;12(5):e0177649.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  35. Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In�Vivo
    Authors: N Guimar?es-, P Cattaneo, Y Sun, T Moore-Morr, Y Gu, ND Dalton, E Rockenstei, E Masliah, KL Peterson, WB Stallcup, J Chen, SM Evans
    Cell Stem Cell, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  36. Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination
    Authors: Y Chen, W Zhen, T Guo, Y Zhao, A Liu, JP Rubio, D Krull, JC Richardson, H Lu, R Wang
    PLoS ONE, 2017;12(12):e0189380.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  37. Physiologically activated mammary fibroblasts promote postpartum mammary cancer
    Authors: Q Guo, J Minnier, J Burchard, K Chiotti, P Spellman, P Schedin
    JCI Insight, 2017;2(6):e89206.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  38. Leptin sustains spontaneous remyelination in the adult central nervous system
    Authors: K Matoba, R Muramatsu, T Yamashita
    Sci Rep, 2017;7(0):40397.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  39. Pdgfr? functions in endothelial-derived cells to regulate neural crest cells and development of the great arteries
    Authors: H Aghajanian, YK Cho, NW Rizer, Q Wang, L Li, K Degenhardt, R Jain
    Dis Model Mech, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  40. Colonic PDGFR? Overexpression Accompanied Forkhead Transcription Factor FOXO3 Up-Regulation in STZ-Induced Diabetic Mice
    Authors: H Lu, C Zhang, N Song, C Lu, L Tong, X Huang, YC Kim, J Chen, W Xu
    Cell. Physiol. Biochem., 2017;43(1):158-171.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  41. Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion
    Authors: S Begolly, JA Olschowka, T Love, JP Williams, MK O'Banion
    Glia, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  42. Transcriptome analysis of PDGFR?+ cells identifies T-type Ca2+ channel CACNA1G as a new pathological marker for PDGFR?+ cell hyperplasia
    Authors: SE Ha, MY Lee, M Kurahashi, L Wei, BG Jorgensen, C Park, PJ Park, D Redelman, KC Sasse, LS Becker, KM Sanders, S Ro
    PLoS ONE, 2017;12(8):e0182265.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  43. Efficient derivation of extraembryonic endoderm stem cell lines from mouse postimplantation embryos
    Sci Rep, 2016;6(0):39457.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  44. Spatio-Temporal Patterns of Demyelination and Remyelination in the Cuprizone Mouse Model
    Authors: I Tagge, A O'Connor, P Chaudhary, J Pollaro, Y Berlow, M Chalupsky, D Bourdette, R Woltjer, M Johnson, W Rooney
    PLoS ONE, 2016;11(4):e0152480.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  45. USP9X deletion elevates the density of oligodendrocytes within the postnatal dentate gyrus
    Authors: Michael Piper
    Neurogenesis (Austin), 2016;3(1):e1235524.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  46. Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development
    Authors: K Noda, M Kitami, K Kitami, M Kaku, Y Komatsu
    Proc Natl Acad Sci USA, 2016;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  47. AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to ?-adrenergic signalling
    Authors: JH Shin, SH Lee, YN Kim, IY Kim, YJ Kim, DS Kyeong, HJ Lim, SY Cho, J Choi, YJ Wi, JH Choi, YS Yoon, YS Bae, JK Seong
    Sci Rep, 2016;6(0):23426.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  48. Real-time and Non-invasive Monitoring of Embryonic Stem Cell Survival during the Development of Embryoid Bodies with Smart Nanosensor
    Authors: Dong-An Wang
    Acta Biomater, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  49. Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation
    Cell Rep, 2016;17(9):2312-2325.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  50. Depletion of white adipocyte progenitors induces beige adipocyte differentiation and suppresses obesity development.
    Authors: Daquinag, A C, Tseng, C, Salameh, A, Zhang, Y, Amaya-Manzanares, F, Dadbin, A, Florez, F, Xu, Y, Tong, Q, Kolonin, M G
    Cell Death Differ, 2015;22(2):351-63.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  51. Transplanted bone marrow-derived circulating PDGFRalpha+ cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft.
    Authors: Iinuma S, Aikawa E, Tamai K, Fujita R, Kikuchi Y, Chino T, Kikuta J, McGrath J, Uitto J, Ishii M, Iizuka H, Kaneda Y
    J Immunol, 2015;194(4):1996-2003.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  52. Double minute amplification of mutant PDGF receptor alpha in a mouse glioma model.
    Authors: Zou H, Feng R, Huang Y, Tripodi J, Najfeld V, Tsankova N, Jahanshahi M, Olson L, Soriano P, Friedel R
    Sci Rep, 2015;5(0):8468.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  53. Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells.
    Authors: Ettle B, Reiprich S, Deusser J, Schlachetzki J, Xiang W, Prots I, Masliah E, Winner B, Wegner M, Winkler J
    Mol Cell Neurosci, 2014;62(0):68-78.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  54. Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling.
    Authors: Fan J, Ponferrada V, Sato T, Vemaraju S, Fruttiger M, Gerhardt H, Ferrara N, Lang R
    Development, 2014;141(2):448-59.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  55. Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain.
    Authors: Gibson, Erin M, Purger, David, Mount, Christop, Goldstein, Andrea K, Lin, Grant L, Wood, Lauren S, Inema, Ingrid, Miller, Sarah E, Bieri, Gregor, Zuchero, J Bradle, Barres, Ben A, Woo, Pamelyn, Vogel, Hannes, Monje, Michelle
    Science, 2014;344(6183):1252304.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  56. Malignant stroma increases luminal breast cancer cell proliferation and angiogenesis through platelet-derived growth factor signaling.
    Authors: Pinto, Mauricio, Dye, Wendy W, Jacobsen, Britta M, Horwitz, Kathryn
    BMC Cancer, 2014;14(0):735.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  57. Hypoxia inducible factor-2alpha regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors.
    Authors: Duan L, Takeda K, Fong G
    PLoS ONE, 2014;9(1):e84736.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  58. Nitric oxide controls fat deposition in dystrophic skeletal muscle by regulating fibro-adipogenic precursor differentiation.
    Authors: Cordani N, Pisa V, Pozzi L, Sciorati C, Clementi E
    Stem Cells, 2014;32(4):874-85.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  59. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis.
    Authors: Moore-Morris T, Guimaraes-Camboa N, Banerjee I, Zambon A, Kisseleva T, Velayoudon A, Stallcup W, Gu Y, Dalton N, Cedenilla M, Gomez-Amaro R, Zhou B, Brenner D, Peterson K, Chen J, Evans S
    J Clin Invest, 2014;124(7):2921-34.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  60. Distinct fibroblast lineages determine dermal architecture in skin development and repair.
    Authors: Driskell R, Lichtenberger B, Hoste E, Kretzschmar K, Simons B, Charalambous M, Ferron S, Herault Y, Pavlovic G, Ferguson-Smith A, Watt F
    Nature, 2013;504(7479):277-81.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  61. Abnormal development of NG2+PDGFR-alpha+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model.
    Authors: Carter C, Vogel T, Zhang Q, Seo S, Swiderski R, Moninger T, Cassell M, Thedens D, Keppler-Noreuil K, Nopoulos P, Nishimura D, Searby C, Bugge K, Sheffield V
    Nat Med, 2012;18(12):1797-804.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Immunoprecipitation
  62. Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation.
    Authors: Tang Z, Arjunan P, Lee C, Li Y, Kumar A, Hou X, Wang B, Wardega P, Zhang F, Dong L, Zhang Y, Zhang SZ, Ding H, Fariss RN, Becker KG, Lennartsson J, Nagai N, Cao Y, Li X
    J. Exp. Med., 2010;207(4):867-80.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  63. Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke.
    Authors: Su EJ, Fredriksson L, Geyer M, Folestad E, Cale J, Andrae J, Gao Y, Pietras K, Mann K, Yepes M, Strickland DK, Betsholtz C, Eriksson U, Lawrence DA
    Nat. Med., 2008;14(7):731-7.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  64. Stem cell based delivery of IFN-beta reduces relapses in experimental autoimmune encephalomyelitis.
    Authors: Makar TK, Trisler D, Bever CT, Goolsby JE, Sura KT, Balasubramanian S, Sultana S, Patel N, Ford D, Singh IS, Gupta A, Valenzuela RM, Dhib-Jalbut S
    J. Neuroimmunol., 2008;196(1):67-81.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  65. Oligodendroglial metabotropic glutamate receptors are developmentally regulated and involved in the prevention of apoptosis.
    Authors: Luyt K, Varadi A, Durant CF, Molnar E
    J. Neurochem., 2006;99(2):641-56.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  66. Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma.
    Authors: Tejada ML, Yu L, Dong J, Jung K, Meng G, Peale FV, Frantz GD, Hall L, Liang X, Gerber HP, Ferrara N
    Clin. Cancer Res., 2006;12(9):2676-88.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P

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Cell and Tissue Staining Kits

Anti-Goat HRP-DAB Cell & Tissue Staining Kit

CTS008
25 Citations
6 Reviews

Immunohistochemistry Reagents

Antigen Retrieval Reagent Sampler (50 mL each)

CTS016
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Antigen Retrieval Reagent-Acidic

CTS014
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Antigen Retrieval Reagent-Basic

CTS013
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Antigen Retrieval Reagent-Universal

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VisUCyte Antigen Retrieval Reagent-Acidic

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VisUCyte Antigen Retrieval Reagent-Basic

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VisUCyte Antigen Retrieval Reagent-Universal

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Isotype Controls

Normal Goat IgG Control

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Ctrl

Reconstitution Buffers

Reconstitution Buffer 1 (PBS)

RB01
2 Reviews

Secondary Antibodies

Chicken Anti-Goat IgG Biotinylated Antibody

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Donkey Anti-Goat IgG (H+L) PerCP-conjugated Antibody

F0124
Flow

Donkey Anti-Goat IgG Antibody

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Donkey Anti-Goat IgG Biotinylated Antibody

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Donkey Anti-Goat IgG NorthernLights™ NL637-conjugated Antibody

NL002
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Goat IgG (H+L) APC-conjugated Antibody

F0108
9 Citations
1 Image
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Goat IgG (H+L) Fluorescein-conjugated Antibody

F0109
2 Citations
1 Image
Flow

Goat IgG (H+L) PE-conjugated Antibody

F0107
5 Citations
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Flow

Goat IgG HRP-conjugated Antibody

HAF109
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WB,Simple Western

Goat IgG HRP-conjugated Antibody

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Goat IgG Horseradish Peroxidase-conjugated Antibody

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Goat IgG VisUCyte HRP Polymer

VC004
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IHC

Rabbit Anti-Goat IgG (H+L) Antibody, X Absorbed

R-401-C-ABS
WB,ELISA

Rabbit Anti-Goat IgG Biotinylated Antibody

BAF017
1 Citations
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Reviews for Mouse PDGF R alpha Antibody

Average Rating: 4.4 (Based on 9 Reviews)

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Mouse PDGF R alpha Antibody
By Anonymous on 05/10/2020
Application: WB Sample Tested: Adult heart Species: Mouse

3 mice hearts extractions after MI.
HSP60 was used as loading control.
There is a non specific band around 80 kDa.

Western Blot Mouse PDGF R alpha Antibody AF1062
Mouse PDGF R alpha Antibody
By Anonymous on 05/10/2020
Application: ICC/IF Sample Tested: primary cardiac fibroblasts Species: Rat

rat primary cardiac fibroblasts, PDGFRa in red, DAPI in blue

Immunocytochemistry/Immunofluorescence Mouse PDGF R alpha Antibody AF1062
Mouse PDGF R alpha Antibody
By Anonymous on 05/10/2020
Application: IHC Sample Tested: Adult heart Species: Mouse

mouse heart post MI, troponin I in green, PDGFRa in red, DAPI in blue

Immunohistochemistry Mouse PDGF R alpha Antibody AF1062
Mouse PDGF R alpha Antibody
By Anonymous on 10/20/2019
Application: ICC/IF Sample Tested: Adult brain Species: Mouse

Dilution 1:200

Immunocytochemistry/Immunofluorescence Mouse PDGF R alpha Antibody AF1062
Mouse PDGF R alpha Antibody
By Anonymous on 01/16/2019
Application: ICC/IF Sample Tested: Spinal cord tissue Species: Mouse
Mouse PDGF R alpha Antibody
By Anonymous on 07/27/2018
Application: ICC/IF Sample Tested: IPS2 induced pluripotent stem cells Species: Mouse
Immunocytochemistry/Immunofluorescence Mouse PDGF R alpha Antibody AF1062
Mouse PDGF R alpha Antibody
By Anonymous on 01/25/2018
Application: WB Sample Tested: IPS2 induced pluripotent stem cells Species: Mouse
Western Blot Mouse PDGF R alpha Antibody AF1062
Mouse PDGF R alpha Antibody
By Anonymous on 01/13/2018
Application: ICC/IF Sample Tested: Embryo Species: Mouse

differentiation assay using e12.5 mouse neural stem cells.
PDGFR (red)/ Dapi (blue)

Immunocytochemistry/Immunofluorescence Mouse PDGF R alpha Antibody AF1062
Mouse PDGF R alpha Antibody
By Anonymous on 08/10/2017
Application: IHC Sample Tested: Brain (cerebellum) tissue Species: Mouse