Mouse PDGF R alpha Antibody Summary
Leu25-Glu524 (Asp65Glu, Gly439Ala, Thr440Ala)
Accession # P26618
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples

Detection of Mouse PDGF R alpha by Western Blot. Western blot shows lysates of mouse uterus tissue and mouse lung tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Mouse PDGF Ra Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1062) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). Specific bands were detected for PDGF Ra at approximately 160-200 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

PDGF R alpha in Mouse Embryo. PDGF Ra was detected in immersion fixed frozen sections of mouse embryo using 15 µg/mL Goat Anti-Mouse PDGF Ra Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1062) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific labeling was localized to the plasma membrane of mesenchymal cells. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

PDGF R alpha in Mouse Embryo. PDGF Ra was detected in immersion fixed frozen sections of mouse embryo using Goat Anti-Mouse PDGF Ra Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1062) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Cell Proliferation Induced by PDGF‑AA and Neutralization by Mouse PDGF R alpha Antibody. Recombinant Human PDGF-AA (Catalog # 221-AA) stimulates proliferation in the NR6R-3T3 mouse fibroblast cell line in a dose-dependent manner (orange line), as measured by Resazurin (Catalog # AR002. Proliferation elicited by Recombinant Human PDGF-AA (250 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse PDGF Ra Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1062). The ND50is typically 0.2-1.6 µg/mL.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: PDGF R alpha
The platelet-derived growth factor (PDGF) family consists of proteins derived from four genes (PDGF-A, -B, -C, and -D) that form disulfide-linked homodimers (PDGF-AA, -BB, -CC, and -DD) and a heterodimer (PDGF-AB) (1, 2). These proteins regulate diverse cellular functions by binding to and inducing the homo- or hetero-dimerization of two receptors (PDGF R alpha and R beta ). Whereas alpha / alpha homo-dimerization is induced by PDGF-AA, -BB, -CC, and -AB, alpha / beta hetero-dimerization is induced by PDGF-AB, -BB, -CC, and -DD, and beta / beta homo-dimerization is induced only by PDGF-BB and -DD (1-4). Both PDGF R alpha and R beta are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, SCF, and Flt-3 ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. Ligand-induced receptor dimerization results in autophosphorylation in trans resulting in the activation of several intracellular signaling pathways that can lead to cell proliferation, cell survival, cytoskeletal rearrangement, and cell migration. Many cell types, including fibroblasts and smooth muscle cells, express both the alpha and beta receptors. Others have only the alpha receptors (oligodendrocyte progenitor cells, mesothelial cells, liver sinusoidal endothelial cells, astrocytes, platelets, and megakaryocytes) or only the beta receptors (myoblasts, capillary endothelial cells, pericytes, T cells, myeloid hematopoietic cells, and macrophages) (1, 2). Recombinant mouse and human soluble PDGF R beta bind PDGF with high affinity and are potent PDGF antagonists.
- Betsholtz, C. et al. (2001) BioEssays 23:494.
- Ostman, A. and A.H. Heldin (2001) Advances in Cancer Research 80:1.
- Gilbertson, D. et al. (2001) J. Biol. Chem. 276:27406.
- LaRochells, W.J. et al. (2001) Nature Cell Biol. 3:517.
Product Datasheets
Citations for Mouse PDGF R alpha Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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BCAS1-positive immature oligodendrocytes are affected by the &alpha-synuclein-induced pathology of multiple system atrophy
Authors: S Kaji, T Maki, J Ueda, T Ishimoto, Y Inoue, K Yasuda, M Sawamura, R Hikawa, T Ayaki, H Yamakado, R Takahashi
Acta Neuropathol Commun, 2020;8(1):120.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles
Authors: J Camps, N Breuls, A Sifrim, N Giarratana, M Corvelyn, L Danti, H Grosemans, S Vanuytven, I Thiry, M Belicchi, M Meregalli, K Platko, ME MacDonald, RC Austin, R Gijsbers, G Cossu, Y Torrente, T Voet, M Sampaolesi
Cell Rep, 2020;31(5):107597.
Species: Human
Sample Types: Whole Cells
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Lgr5+�telocytes are a signaling source at the intestinal villus tip
Authors: K Bahar Halp, H Massalha, RK Zwick, AE Moor, D Castillo-A, M Rozenberg, L Farack, A Egozi, DR Miller, I Averbukh, Y Harnik, N Weinberg-C, FJ de Sauvage, I Amit, OD Klein, M Shoshkes-C, S Itzkovitz
Nat Commun, 2020;11(1):1936.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Variation of Human Neural Stem Cells Generating Organizer States In�Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates
Authors: N Micali, SK Kim, M Diaz-Busta, G Stein-O'Br, S Seo, JH Shin, BG Rash, S Ma, Y Wang, NA Olivares, JI Arellano, KR Maynard, EJ Fertig, AJ Cross, RW Bürli, NJ Brandon, DR Weinberger, JG Chenoweth, DJ Hoeppner, N Sestan, P Rakic, C Colantuoni, RD McKay
Cell Rep, 2020;31(5):107599.
Species: Human
Sample Types:
Applications: IF -
The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination
Authors: A Pu, MK Mishra, Y Dong, S Ghorbaniga, EL Stephenson, KS Rawji, C Silva, H Kitagawa, S Sawcer, VW Yong
J Neuroinflammation, 2020;17(1):220.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Embryonic microglia influence developing hypothalamic glial populations
Authors: CM Marsters, D Nesan, R Far, N Klenin, QJ Pittman, DM Kurrasch
J Neuroinflammation, 2020;17(1):146.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth
Authors: S Davidson, M Efremova, A Riedel, B Mahata, J Pramanik, J Huuhtanen, G Kar, R Vento-Torm, T Hagai, X Chen, MA Haniffa, JD Shields, SA Teichmann
Cell Rep, 2020;31(7):107628.
Species: Mouse
Sample Types: Whole Cell
Applications: Flow Cytometry -
Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle
Authors: MN Wosczyna, CT Konishi, EE Perez Carb, TT Wang, RA Walsh, Q Gan, MW Wagner, TA Rando
Cell Rep, 2019;27(7):2029-2035.e5.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds
Authors: CF Guerrero-J, PH Dedhia, S Jin, R Ruiz-Vega, D Ma, Y Liu, K Yamaga, O Shestova, DL Gay, Z Yang, K Kessenbroc, Q Nie, WS Pear, G Cotsarelis, MV Plikus
Nat Commun, 2019;10(1):650.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice
Authors: X Zhang, X Wang, H Yin, L Zhang, A Feng, QX Zhang, Y Lin, B Bao, LL Hernandez, GP Shi, J Liu
Cell Rep, 2019;28(3):792-803.e4.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation
Authors: A Grund, M Szaroszyk, M Korf-Kling, M Malek Moha, FA Trogisch, U Schrameck, A Gigina, C Tiedje, M Gaestel, T Kraft, J Hegermann, S Batkai, T Thum, A Perrot, CD Remedios, E Riechert, M Völkers, S Doroudgar, A Jungmann, R Bauer, X Yin, M Mayr, KC Wollert, A Pich, H Xiao, HA Katus, J Bauersachs, OJ Müller, J Heineke
EMBO Mol Med, 2019;0(0):e10018.
Species: Rat
Sample Types: Whole Cells
Applications: ICC -
TBX2-positive cells represent a multi-potent mesenchymal progenitor pool in the developing lung
Authors: I Wojahn, TH Lüdtke, VM Christoffe, MO Trowe, A Kispert
Respir. Res., 2019;20(1):292.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration
Authors: X Han, Y Wang, W Pu, X Huang, L Qiu, Y Li, W Yu, H Zhao, X Liu, L He, L Zhang, Y Ji, J Lu, KO Lui, B Zhou
Stem Cell Reports, 2019;12(3):624-638.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
Authors: D Aran, AP Looney, L Liu, E Wu, V Fong, A Hsu, S Chak, RP Naikawadi, PJ Wolters, AR Abate, AJ Butte, M Bhattachar
Nat. Immunol., 2019;20(2):163-172.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors
Authors: L Lukjanenko, S Karaz, P Stuelsatz, U Gurriaran-, J Michaud, G Dammone, F Sizzano, O Mashinchia, S Ancel, E Migliavacc, S Liot, G Jacot, S Metairon, F Raymond, P Descombes, A Palini, B Chazaud, MA Rudnicki, CF Bentzinger, JN Feige
Cell Stem Cell, 2019;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Myelin repair stimulated by CNS-selective thyroid hormone action
Authors: MD Hartley, T Banerji, IJ Tagge, LL Kirkemo, P Chaudhary, E Calkins, D Galipeau, MD Shokat, MJ DeBell, S Van Leuven, H Miller, G Marracci, E Pocius, T Banerji, SJ Ferrara, JM Meinig, B Emery, D Bourdette, TS Scanlan
JCI Insight, 2019;4(8):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
PDGFR?+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland
Authors: PA Joshi, PD Waterhouse, K Kasaian, H Fang, O Gulyaeva, HS Sul, PC Boutros, R Khokha
Nat Commun, 2019;10(1):1760.
Species: Mouse
Sample Types: Whole Tissues
Applications: IHC -
In Situ Modification of Tissue Stem and Progenitor Cell Genomes
Authors: JM Goldstein, M Tabebordba, K Zhu, LD Wang, KA Messemer, B Peacker, S Ashrafi Ka, M Gonzalez-C, Y Shwartz, JKW Cheng, R Xiao, T Barungi, C Albright, YC Hsu, LH Vandenberg, AJ Wagers
Cell Rep, 2019;27(4):1254-1264.e7.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
Authors: S Mitew, I Gobius, LR Fenlon, SJ McDougall, D Hawkes, YL Xing, H Bujalka, AL Gundlach, LJ Richards, TJ Kilpatrick, TD Merson, B Emery
Nat Commun, 2018;9(1):306.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Perfect chronic skeletal muscle regeneration in adult spiny mice, Acomys cahirinus
Authors: M Maden, JO Brant, A Rubiano, AGW Sandoval, C Simmons, R Mitchell, H Collin-Hoo, J Jacobson, S Omairi, K Patel
Sci Rep, 2018;8(1):8920.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Myelination of the developing lateral olfactory tract and anterior commissure
Authors: LN Collins, DL Hill, PC Brunjes
J. Comp. Neurol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
AMPK Activation Regulates LTBP4-Dependent TGF-?1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy
Authors: G Juban, M Saclier, H Yacoub-You, A Kernou, L Arnold, C Boisson, S Ben Larbi, M Magnan, S Cuvellier, M Théret, BJ Petrof, I Desguerre, J Gondin, R Mounier, B Chazaud
Cell Rep, 2018;25(8):2163-2176.e6.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration
Authors: MJ Carr, JS Toma, APW Johnston, PE Steadman, SA Yuzwa, N Mahmud, PW Frankland, DR Kaplan, FD Miller
Cell Stem Cell, 2018;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Profiling proliferative cells and their progeny in damaged murine hearts
Authors: K Kretzschma, Y Post, M Bannier-Hé, A Mattiotti, J Drost, O Basak, VSW Li, M van den Bo, QD Gunst, D Versteeg, L Kooijman, S van der El, JH van Es, E van Rooij, MJB van den Ho, H Clevers
Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Heterozygosity for Nuclear Factor One X in mice models features of Malan syndrome
Authors: S Oishi, D Harkins, ND Kurniawan, M Kasherman, L Harris, O Zalucki, RM Gronostajs, THJ Burne, M Piper
EBioMedicine, 2018;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice
Authors: SN Kim, S Akindehin, HJ Kwon, YH Son, A Saha, YS Jung, JK Seong, KM Lim, JH Sung, KR Maddipati, YH Lee
Sci Rep, 2018;8(1):8856.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1?
Authors: SK Jensen, NJ Michaels, S Ilyntskyy, MB Keough, O Kovalchuk, VW Yong
Cell Rep, 2018;24(12):3167-3179.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Role of P2XReceptor in Mouse Voiding Function
Authors: W Yu, WG Hill, SC Robson, ML Zeidel
Sci Rep, 2018;8(1):1838.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Pulmonary pericytes regulate lung morphogenesis
Authors: K Kato, R Diéguez-Hu, DY Park, SP Hong, S Kato-Azuma, S Adams, M Stehling, B Trappmann, JL Wrana, GY Koh, RH Adams
Nat Commun, 2018;9(1):2448.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
B-1a lymphocytes promote oligodendrogenesis during brain development
Authors: S Tanabe, T Yamashita
Nat. Neurosci., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
Colonic PDGFR? Overexpression Accompanied Forkhead Transcription Factor FOXO3 Up-Regulation in STZ-Induced Diabetic Mice
Authors: H Lu, C Zhang, N Song, C Lu, L Tong, X Huang, YC Kim, J Chen, W Xu
Cell. Physiol. Biochem., 2017;43(1):158-171.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Physiologically activated mammary fibroblasts promote postpartum mammary cancer
Authors: Q Guo, J Minnier, J Burchard, K Chiotti, P Spellman, P Schedin
JCI Insight, 2017;2(6):e89206.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Pdgfr? functions in endothelial-derived cells to regulate neural crest cells and development of the great arteries
Authors: H Aghajanian, YK Cho, NW Rizer, Q Wang, L Li, K Degenhardt, R Jain
Dis Model Mech, 2017;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Leptin sustains spontaneous remyelination in the adult central nervous system
Authors: K Matoba, R Muramatsu, T Yamashita
Sci Rep, 2017;7(0):40397.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Transcriptome analysis of PDGFR?+ cells identifies T-type Ca2+ channel CACNA1G as a new pathological marker for PDGFR?+ cell hyperplasia
Authors: SE Ha, MY Lee, M Kurahashi, L Wei, BG Jorgensen, C Park, PJ Park, D Redelman, KC Sasse, LS Becker, KM Sanders, S Ro
PLoS ONE, 2017;12(8):e0182265.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
ALS skeletal muscle shows enhanced TGF-? signaling, fibrosis and induction of fibro/adipogenic progenitor markers
Authors: D Gonzalez, O Contreras, DL Rebolledo, JP Espinoza, B van Zunder, E Brandan
PLoS ONE, 2017;12(5):e0177649.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination
Authors: Y Chen, W Zhen, T Guo, Y Zhao, A Liu, JP Rubio, D Krull, JC Richardson, H Lu, R Wang
PLoS ONE, 2017;12(12):e0189380.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion
Authors: S Begolly, JA Olschowka, T Love, JP Williams, MK O'Banion
Glia, 2017;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In�Vivo
Authors: N Guimar?es-, P Cattaneo, Y Sun, T Moore-Morr, Y Gu, ND Dalton, E Rockenstei, E Masliah, KL Peterson, WB Stallcup, J Chen, SM Evans
Cell Stem Cell, 2017;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Spatio-Temporal Patterns of Demyelination and Remyelination in the Cuprizone Mouse Model
Authors: I Tagge, A O'Connor, P Chaudhary, J Pollaro, Y Berlow, M Chalupsky, D Bourdette, R Woltjer, M Johnson, W Rooney
PLoS ONE, 2016;11(4):e0152480.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to ?-adrenergic signalling
Authors: JH Shin, SH Lee, YN Kim, IY Kim, YJ Kim, DS Kyeong, HJ Lim, SY Cho, J Choi, YJ Wi, JH Choi, YS Yoon, YS Bae, JK Seong
Sci Rep, 2016;6(0):23426.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Real-time and Non-invasive Monitoring of Embryonic Stem Cell Survival during the Development of Embryoid Bodies with Smart Nanosensor
Authors: Dong-An Wang
Acta Biomater, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development
Authors: K Noda, M Kitami, K Kitami, M Kaku, Y Komatsu
Proc Natl Acad Sci USA, 2016;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
USP9X deletion elevates the density of oligodendrocytes within the postnatal dentate gyrus
Authors: Michael Piper
Neurogenesis (Austin), 2016;3(1):e1235524.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation
Cell Rep, 2016;17(9):2312-2325.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Efficient derivation of extraembryonic endoderm stem cell lines from mouse postimplantation embryos
Sci Rep, 2016;6(0):39457.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
Depletion of white adipocyte progenitors induces beige adipocyte differentiation and suppresses obesity development.
Authors: Daquinag, A C, Tseng, C, Salameh, A, Zhang, Y, Amaya-Manzanares, F, Dadbin, A, Florez, F, Xu, Y, Tong, Q, Kolonin, M G
Cell Death Differ, 2015;22(2):351-63.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Double minute amplification of mutant PDGF receptor alpha in a mouse glioma model.
Authors: Zou H, Feng R, Huang Y, Tripodi J, Najfeld V, Tsankova N, Jahanshahi M, Olson L, Soriano P, Friedel R
Sci Rep, 2015;5(0):8468.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Transplanted bone marrow-derived circulating PDGFRalpha+ cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft.
Authors: Iinuma S, Aikawa E, Tamai K, Fujita R, Kikuchi Y, Chino T, Kikuta J, McGrath J, Uitto J, Ishii M, Iizuka H, Kaneda Y
J Immunol, 2015;194(4):1996-2003.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling.
Authors: Fan J, Ponferrada V, Sato T, Vemaraju S, Fruttiger M, Gerhardt H, Ferrara N, Lang R
Development, 2014;141(2):448-59.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain.
Authors: Gibson, Erin M, Purger, David, Mount, Christop, Goldstein, Andrea K, Lin, Grant L, Wood, Lauren S, Inema, Ingrid, Miller, Sarah E, Bieri, Gregor, Zuchero, J Bradle, Barres, Ben A, Woo, Pamelyn, Vogel, Hannes, Monje, Michelle
Science, 2014;344(6183):1252304.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Nitric oxide controls fat deposition in dystrophic skeletal muscle by regulating fibro-adipogenic precursor differentiation.
Authors: Cordani N, Pisa V, Pozzi L, Sciorati C, Clementi E
Stem Cells, 2014;32(4):874-85.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Hypoxia inducible factor-2alpha regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors.
Authors: Duan L, Takeda K, Fong G
PLoS ONE, 2014;9(1):e84736.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Malignant stroma increases luminal breast cancer cell proliferation and angiogenesis through platelet-derived growth factor signaling.
Authors: Pinto, Mauricio, Dye, Wendy W, Jacobsen, Britta M, Horwitz, Kathryn
BMC Cancer, 2014;14(0):735.
Species: Mouse
Sample Types: Whole Cells
Applications: IHC -
Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells.
Authors: Ettle B, Reiprich S, Deusser J, Schlachetzki J, Xiang W, Prots I, Masliah E, Winner B, Wegner M, Winkler J
Mol Cell Neurosci, 2014;62(0):68-78.
Species: Rat
Sample Types: Whole Cells
Applications: ICC -
Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis.
Authors: Moore-Morris T, Guimaraes-Camboa N, Banerjee I, Zambon A, Kisseleva T, Velayoudon A, Stallcup W, Gu Y, Dalton N, Cedenilla M, Gomez-Amaro R, Zhou B, Brenner D, Peterson K, Chen J, Evans S
J Clin Invest, 2014;124(7):2921-34.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Distinct fibroblast lineages determine dermal architecture in skin development and repair.
Authors: Driskell R, Lichtenberger B, Hoste E, Kretzschmar K, Simons B, Charalambous M, Ferron S, Herault Y, Pavlovic G, Ferguson-Smith A, Watt F
Nature, 2013;504(7479):277-81.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Abnormal development of NG2+PDGFR-alpha+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model.
Authors: Carter C, Vogel T, Zhang Q, Seo S, Swiderski R, Moninger T, Cassell M, Thedens D, Keppler-Noreuil K, Nopoulos P, Nishimura D, Searby C, Bugge K, Sheffield V
Nat Med, 2012;18(12):1797-804.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Immunoprecipitation -
Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation.
Authors: Tang Z, Arjunan P, Lee C, Li Y, Kumar A, Hou X, Wang B, Wardega P, Zhang F, Dong L, Zhang Y, Zhang SZ, Ding H, Fariss RN, Becker KG, Lennartsson J, Nagai N, Cao Y, Li X
J. Exp. Med., 2010;207(4):867-80.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke.
Authors: Su EJ, Fredriksson L, Geyer M, Folestad E, Cale J, Andrae J, Gao Y, Pietras K, Mann K, Yepes M, Strickland DK, Betsholtz C, Eriksson U, Lawrence DA
Nat. Med., 2008;14(7):731-7.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Stem cell based delivery of IFN-beta reduces relapses in experimental autoimmune encephalomyelitis.
Authors: Makar TK, Trisler D, Bever CT, Goolsby JE, Sura KT, Balasubramanian S, Sultana S, Patel N, Ford D, Singh IS, Gupta A, Valenzuela RM, Dhib-Jalbut S
J. Neuroimmunol., 2008;196(1):67-81.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma.
Authors: Tejada ML, Yu L, Dong J, Jung K, Meng G, Peale FV, Frantz GD, Hall L, Liang X, Gerber HP, Ferrara N
Clin. Cancer Res., 2006;12(9):2676-88.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Oligodendroglial metabotropic glutamate receptors are developmentally regulated and involved in the prevention of apoptosis.
Authors: Luyt K, Varadi A, Durant CF, Molnar E
J. Neurochem., 2006;99(2):641-56.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC
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3 mice hearts extractions after MI.
HSP60 was used as loading control.
There is a non specific band around 80 kDa.
rat primary cardiac fibroblasts, PDGFRa in red, DAPI in blue
mouse heart post MI, troponin I in green, PDGFRa in red, DAPI in blue
Dilution 1:200
differentiation assay using e12.5 mouse neural stem cells.
PDGFR (red)/ Dapi (blue)