Mouse THRSP Antibody

THRSP (Thyroid hormone inducible hepatic protein; also S14/SPOT 14) is an 18-20 kDa acidic nuclear protein that belongs to the SPOT14 family of molecules. It is expressed by lactating mammary epithelium, adipocytes and hepatocytes, and appears to promote the synthesis of long-chain fatty acids. Its synthesis is induced by thyroid hormone, insulin and carbohydrates. Mouse THRSP is 150 amino acids (aa) in length. The residues between aa 10-66 contain a Leu-zipper domain that mediates noncovalent homodimerization plus heterodimerization with MIG12. Other proteins known to bind to THRSP include the thyroid hormone receptor and Zac51. Heterointeractions are posited to positively influence p53-dependent gene activation. Two potential isoforms are reported. One contains a seven aa extension at the C-terminus, while another shows a deletion of aa 31-64. Over aa 47-150, mouse THRSP shares 78% and 94% aa identity with human and rat THRSP, respectively.