Mouse TL1A/TNFSF15 Antibody MAB1896: R&D Systems

Mouse TL1A/TNFSF15 Antibody

  
  • Species Reactivity
    Mouse
  • Specificity
    Detects mouse TL1A/TNFSF15 in ELISA.
  • Source
    Monoclonal Rat IgG1 Clone # 820446
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    E. coli-derived recombinant mouse TL1A/TNFSF15
    Ile76-Leu252
    Accession # Q5UBV8
  • Formulation
    Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
  • Label
    Unconjugated
Applications
  •  
    Recommended
    Concentration
    Sample
  • Neutralization
    Measured by its ability to neutralize TL1A/TNFSF15-induced apoptosis in the TF‑1 human erythroleukemic cell line. Migone, T. et al. (2002) Immunity 16:479. The Neutralization Dose (ND50) is typically 0.8-4 μg/ml in the presence of 500 ng/mL Recombinant Mouse TL1A/TNFSF15.
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Apoptosis Induced by TL1A/ TNFSF15 and Neutralization by Mouse TL1A/TNFSF15 Antibody. Recombinant Mouse TL1A/TNFSF15 (Catalog # 1896-TL) induces apoptosis in the TF‑1 human erythroleukemic cell line in a dose-dependent manner (orange line). Apoptosis elicited by Recombinant Mouse TL1A/TNFSF15 (500 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse TL1A/TNFSF15 Monoclonal Antibody (Catalog # MAB1896). The ND50 is typically 0.8-4 μg/ml.
Preparation and Storage
  • Reconstitution
    Sterile PBS to a final concentration of 0.5 mg/mL.
  • Shipping
    The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
  • Stability & Storage
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TL1A/TNFSF15
TL1A is a type II transmembrane protein belonging to the TNF superfamily and has been designated TNFSF15. It is expressed predominantly in endothelial cells, and its expression is inducible by TNF-alpha and IL-1 alpha. TL1A binds with high affinity to DR3/TNFRSF25 on activated T cells.
  • Long Name:
    TNF-like 1
  • Entrez Gene IDs:
    9966 (Human); 326623 (Mouse)
  • Alternate Names:
    MGC129934; MGC129935; TL1A; TL1Vascular endothelial cell growth inhibitor; TNF superfamily ligand TL1A; TNFSF15; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand superfamily member 15; vascular endothelial growth inhibitor-192A; VEGI; VEGI192A; VEGITNF ligand-related molecule 1
Related Research Areas
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Rat IgG1 Isotype Control

Ctrl MAB005 37  
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Normal Rat IgG Control (Azide Free)

Ctrl 6-001-F 1
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Rat IgG1 Isotype Control

Ctrl MAB005R
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WB, Simple Western HAF005 7  
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APC-conjugated Antibody

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Goat Anti-Rat IgG NorthernLights™ NL493-conjugated Antibody

Flow, IHC, ICC NL015 1
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WB BAF005 2
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Goat Anti-Rat IgG Antibody

WB AF005 1
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Rat IgG VisUCyte HRP Polymer Antibody

IHC VC005  
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Rat F(ab)2 IgG (H+L) Fluorescein-conjugated Antibody

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Goat Anti-Rat IgG NorthernLights™ NL637-conjugated Antibody

Flow, IHC, ICC NL014
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Goat Anti-Rat F(ab)2 IgG (H+L) PerCP-conjugated Antibody

Flow F0115 1
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