Rat MuSK Antibody
Rat MuSK Antibody Summary
Complete Your Research
Complete Your Experiment
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
View Larger
Acetylcholine Receptor Clustering Mediated by MuSK and Neutralization by Rat MuSK Antibody. Recombinant Rat Agrin (Catalog # 550-AG) induces MuSK-dependent acetylcholine receptor clustering on myotubes differentiated from the C2C12 mouse myoblast cell line in a dose-dependent manner (orange line). Acetylcholine Receptor Clustering elicited by Recombinant Rat Agrin (16 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Rat MuSK Antigen Affinity-purified Polyclonal Antibody (Catalog # AF562). The ND50 is typically 0.5-2 µg/mL.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: MuSK
MuSK (Muscle-Specific Kinase) is a receptor tyrosine kinase expressed in muscle that regulates the formation of the neuromuscular junction. It binds the heparin sulfate proteoglycan Agrin to promote Acetylcholine Receptor clustering.
Product Datasheets
Citations for Rat MuSK Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
11
Citations: Showing 1 - 10
Filter your results:
Filter by:
-
Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia
Authors: J Oury, W Zhang, N Leloup, A Koide, AD Corrado, G Ketavarapu, T Hattori, S Koide, SJ Burden
Nature, 2021;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot -
Characterization of pathogenic monoclonal autoantibodies derived from muscle-specific kinase myasthenia gravis patients
Authors: K Takata, P Stathopoul, M Cao, M Mané-Damas, ML Fichtner, ES Benotti, L Jacobson, P Waters, SR Irani, P Martinez-M, D Beeson, M Losen, A Vincent, RJ Nowak, KC O'Connor
JCI Insight, 2019;4(12):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Immunoprecipitation -
IgG-specific cell-based assay detects potentially pathogenic MuSK-Abs in seronegative MG
Authors: S Huda, P Waters, M Woodhall, MI Leite, L Jacobson, A De Rosa, M Maestri, R Ricciardi, JM Heckmann, A Maniaol, A Evoli, J Cossins, D Hilton-Jon, A Vincent
Neurol Neuroimmunol Neuroinflamm, 2017;4(4):e357.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
DOK7 gene therapy enhances motor activity and life span in ALS model mice
Authors: S Miyoshi, T Tezuka, S Arimura, T Tomono, T Okada, Y Yamanashi
EMBO Mol Med, 2017;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Laminin is Instructive and Calmodulin Dependent Kinase II is Non-Permissive for the Formation of Complex Aggregates of Acetylcholine Receptors on Myotubes in Culture
Authors: Raphael Vezina-Aud
Matrix Biol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
MuSK myasthenia gravis IgG4 disrupts the interaction of LRP4 with MuSK but both IgG4 and IgG1-3 can disperse preformed agrin-independent AChR clusters.
Authors: Koneczny, Inga, Cossins, Judith, Waters, Patrick, Beeson, David, Vincent, Angela
PLoS ONE, 2013;8(11):e80695.
Species: Human
Sample Types: Cell Lysates
Applications: Immunoprecipitation -
Immunocapture and identification of cell membrane protein antigenic targets of serum autoantibodies.
Authors: Littleton E, Dreger M, Palace J
Mol. Cell Proteomics, 2009;8(7):1688-96.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Mutations causing DOK7 congenital myasthenia ablate functional motifs in Dok-7.
Authors: Hamuro J, Higuchi O, Okada K, Ueno M, Iemura S, Natsume T, Spearman H, Beeson D, Yamanashi Y
J. Biol. Chem., 2007;283(9):5518-24.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot -
MuSK expressed in the brain mediates cholinergic responses, synaptic plasticity, and memory formation.
Authors: Garcia-Osta A, Tsokas P, Pollonini G, Landau EM, Blitzer R, Alberini CM
J. Neurosci., 2006;26(30):7919-32.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
14-3-3 gamma associates with muscle specific kinase and regulates synaptic gene transcription at vertebrate neuromuscular synapse.
Authors: Strochlic L, Cartaud A, Mejat A, Grailhe R, Schaeffer L, Changeux JP, Cartaud J
Proc. Natl. Acad. Sci. U.S.A., 2004;101(52):18189-94.
Species: Rat
Sample Types: Cell Lysates
Applications: Immunoprecipitation -
Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction.
Authors: Finn AJ, Feng G, Pendergast AM
Nat. Neurosci., 2003;6(7):717-23.
Species: Mouse
Sample Types: Cell Lysates
Applications: Immunoprecipitation
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsIsotype Controls
Reconstitution Buffers
Secondary Antibodies
Reviews for Rat MuSK Antibody
There are currently no reviews for this product. Be the first to review Rat MuSK Antibody and earn rewards!
Have you used Rat MuSK Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
