Rat μ Opioid R/OPRM1 Antibody

Recombinant Monoclonal Antibody
Catalog # Availability Size / Price Qty
MAB86291
MAB86291-SP
Detection of Rat μ Opioid R/OPRM1 by Western Blot.
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Rat μ Opioid R/OPRM1 Antibody Summary

Species Reactivity
Rat
Specificity
Detects rat μ Opioid R/OPRM1 in direct ELISAs.
Source
Recombinant Monoclonal Rabbit IgG Clone # 1126D
Purification
Protein A or G purified from cell culture supernatant
Immunogen
Synthetic peptide with a short amino acid sequence from the N-terminus of rat μ Opioid R/OPRM1
Accession # P33535
Formulation
Supplied as a solution in PBS containing BSA, Glycerol and Sodium Azide. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1:1000 dilution
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Western Blot Detection of Rat μ Opioid R/OPRM1 by Western Blot. View Larger

Detection of Rat μ Opioid R/OPRM1 by Western Blot. Western blot shows lysates of rat spinal cord tissue and rat brain (cerebellum) tissue (negative control). PVDF membrane was probed with 1:1000 dilution of Rabbit Anti-Rat μ Opioid R/OPRM1 Monoclonal Antibody (Catalog # MAB86291) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # HAF008). A specific band was detected for μ Opioid R/OPRM1 at approximately 70 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 °C, as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after opening.
  • 6 months, -20 to -70 °C under sterile conditions after opening.

Background: mu Opioid R/OPRM1

The mu-type opioid receptor (MOR), also known as OPRM1, is a 60‑70 kDa variably glycosylated G protein-coupled receptor that mediates the biological effects of many alkaloid and peptide opioids including morphine. MOR is primarily expressed on neurons in the brain, spinal cord, and gastrointestinal tract as well as on immune cells. MOR activation induces analgesia, euphoria, sedation, respiratory depression, and reduced intestinal motility. Following agonist binding, MOR is phosphorylated and internalized which contributes to opioid tolerance and desensitization. OPRM1 can form heterdimers with several other 7TM GPCRs including the delta-type Opioid Receptor (DOR), Nociceptin/Orphanin Receptor (ORL1), Neurokinin 1 Receptor (NK1), Somatostatin Receptor 2 (SSTR2), Cannabinoid Receptor 1, CCR5, and the alpha 2A-Adrenergic Receptor (ADRA2A). Rat MOR shares 94% and 98% aa sequence identity with human and mouse MOR, respectively.

Long Name
mu Opioid Receptor
Entrez Gene IDs
4988 (Human); 18390 (Mouse); 25601 (Rat)
Alternate Names
hMOP; KIAA0403; LMOR; MOP; mOpioidR; MOR; MOR1; M-OR-1; MOR-1; MOR1MOR; Mu opiate receptor; mu Opioid R; Mu opioid receptor; mu-type opioid receptor; opioid receptor, mu 1; OPRM; OPRM1

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