Recombinant Human BMP-7 Protein

GMP Version Available: 354-GMP
GMP

Carrier Free

Catalog # Availability Size / Price Qty
354-BP-010/CF
354-BP-500/CF

With Carrier

Catalog # Availability Size / Price Qty
354-BP-010

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Graph showing dose-dependent bioactivity of Human BMP-7 protein
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Product Details
Citations (88)
FAQs
Reviews (2)

Recombinant Human BMP-7 Protein Summary

Product Specifications

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al. (1999) Exp. Cell Res. 250:351. The ED50 for this effect is 0.1-0.6 µg/mL.
Source
Chinese Hamster Ovary cell line, CHO-derived human BMP-7 protein
Ser293-His431
Accession #
N-terminal Sequence
Analysis
Ser293
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
15.7 kDa (monomer)
SDS-PAGE
18-20 kDa, reducing conditions

Product Datasheets

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354-BP (with carrier)

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354-BP/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

354-BP

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution Reconstitute at 100-200 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

354-BP/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution Reconstitute at 100-200 μg/mL in sterile 4 mM HCl.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Image

Bioactivity Bioactivity of Human BMP-7 View Larger

Recombinant human BMP-7 (354-BP) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED50 for this effect is 0.1-0.6 µg/mL.

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Reconstitution Calculator

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Background: BMP-7

Bone morphogenetic protein 7 (BMP-7), also known as osteogenic protein 1 (OP-1), is a widely expressed TGF-beta superfamily member with important functions during embryogenesis, in the adult, and in disease (1, 2). Human BMP-7 is synthesized with a 29 amino acid (aa) signal sequence, a 263 aa propeptide, and a 139 aa growth factor domain (3, 4). The growth factor domain of human BMP-7 shares 98% aa sequence identity with mouse and rat BMP-7. The BMP-7 propeptide is cleaved intracellularly but remains in association with the growth factor domain. BMP-7 is subsequently secreted as a tetramer that consists of two propeptides and two disulfide-linked growth factor domains (5, 6). Mature BMP-7 can also form disulfide-linked heterodimers with BMP-2 or BMP-4, complexes that show increased potency and range of activity compared to BMP-7 homodimers (7-9). The presence of the propeptides in the BMP-7 tetramer does not diminish the bioactivity of the growth factor domains (6). Secreted BMP-7 is immobilized in the extracellular matrix as a result of interactions between the propeptide and matrix Fibrillin (5). BMP-7 exerts its biological effects through the type 2 receptors Activin RIIA, Activin RIIB, and BMPR-II and the type 1 receptors Activin RIA, BMPR-IA, and BMPR-IB (2, 6). BMP-7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development (10, 11), inhibits the branching of prostate epithelium (12), and antagonizes epithelial-mesenchymal transition (EMT) (13-15). In pathological conditions, BMP-7 inhibits tumor growth and metastasis (14), ameliorates fibrotic damage in nephritis (13), and promotes neuroregeneration following brain ischemia (16).

References
  1. Carreira, A.C. et al. (2015) J. Dent. Res. 93:335.
  2. Weiskirchen, R. and S.K. Meurer (2013) Front. Biosci. (Landmark Ed.) 18:1407.
  3. Ozkaynak, E. et al. (1990) EMBO J. 9:2085.
  4. Celeste, A.J. et al. (1990) Proc. Natl. Acad. Sci. USA 87:9843.
  5. Gregory, K.E. et al. (2005) J. Biol. Chem. 280:27970.
  6. Sengle, G. et al. (2008) J. Mol. Biol. 381:1025.
  7. Israel, D.I. et al. (1996) Growth Factors 13:291.
  8. Aono, A. et al. (1995) Biochem. Biophys. Res. Commun. 210:670.
  9. Nishimatsu, S. and G.H. Thomsen (1998) Mech. Dev. 74:75.
  10. Sampath, T.K. et al. (1992) J. Biol. Chem. 267:20352.
  11. Kazama, I. et al. (2008) J. Am. Soc. Nephrol. 19:2181.
  12. Grishina, I.B. et al. (2005) Dev. Biol. 288:334.
  13. Zeisberg, M. et al. (2003) Nat. Med. 9:964.
  14. Buijs, J.T. et al. (2007) Am. J. Pathol. 171:1047.
  15. Yu, M.-A. et al. (2009) J. Am. Soc. Nephrol. 20:567.
  16. Chou, J. et al. (2006) J. Neurol. Sci. 240:21.
Long Name
Bone Morphogenetic Protein 7
Entrez Gene IDs
655 (Human); 12162 (Mouse); 85272 (Rat)
Alternate Names
BMP7; BMP-7; bone morphogenetic protein 7; Eptotermin alfa; OP-1; OP-1OP1; Osteogenic protein 1

Citations for Recombinant Human BMP-7 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

88 Citations: Showing 1 - 10
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  1. Elimination of Reprogramming Transgenes Facilitates the Differentiation of Induced Pluripotent Stem Cells into Hepatocyte-like Cells and Hepatic Organoids
    Authors: J Jeong, TH Kim, M Kim, YK Jung, KS Kim, S Shim, H Jang, WI Jang, SB Lee, D Choi
    Biology, 2022;11(4):.
    Species: Human
    Sample Types: Transduced Whole Cells
    Applications: Bioassay
  2. A novel renal perivascular mesenchymal cell subset gives rise to fibroblasts distinct from classic myofibroblasts
    Authors: S Minatoguch, S Saito, K Furuhashi, Y Sawa, M Okazaki, Y Shimamura, AB Kaihan, Y Hashimoto, Y Yasuda, A Hara, Y Mizutani, R Ando, N Kato, T Ishimoto, N Tsuboi, N Esaki, M Matsuyama, Y Shiraki, H Kobayashi, N Asai, A Enomoto, S Maruyama
    Scientific Reports, 2022;12(1):5389.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
    Authors: J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, R Roverts, D Daviran, LAS Fermin, B Willemsen, M Beukenboom, S Djudjaj, S von Stillf, LE van Eijk, M Mastik, M Bulthuis, WD Dunnen, H van Goor, JL Hillebrand, SH Triana, T Alexandrov, MC Timm, BT van den Be, M van den Br, Q Nlandu, J Heijnert, EMJ Bindels, RM Hoogenboez, F Mooren, C Kuppe, P Miesen, K Grünberg, T Ijzermans, EJ Steenberge, J Czogalla, MF Schreuder, N Sommerdijk, A Akiva, P Boor, VG Puelles, J Floege, TB Huber, COVID Moon, RP van Rij, IG Costa, RK Schneider, B Smeets, R Kramann
    Cell Stem Cell, 2021;29(2):217-231.e8.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  4. Functionally diverse heteromeric traps for ligands of the transforming growth factor-beta superfamily
    Authors: R Kumar, AV Grinberg, H Li, TH Kuo, D Sako, L Krishnan, K Liharska, J Li, R Grenha, MC Maguire, SD Briscoe, RS Pearsall, BR Herrin, RNVS Suragani, R Castonguay
    Scientific Reports, 2021;11(1):18341.
    Species: Human
    Sample Types: Recombinant Proteins
    Applications: Bioassay
  5. Microenvironment Influences on Human Umbilical Cord Mesenchymal Stem Cell-Based Bone Regeneration
    Authors: L E, R Lu, J Sun, H Li, W Xu, H Xing, X Wang, T Cheng, S Zhang, X Ma, R Zhang, H Liu
    Stem Cells International, 2021;2021(0):4465022.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells
    Authors: Y Soejima, N Iwata, Y Nakano, K Yamamoto, A Suyama, T Nada, F Otsuka
    International Journal of Molecular Sciences, 2021;22(20):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  7. Altered pattern of circulating miRNAs in HIV lipodystrophy perturb key adipose differentiation and inflammation pathways
    Authors: S Srinivasa, R Garcia-Mar, M Torriani, KV Fitch, AR Carlson, CR Kahn, SK Grinspoon
    JCI Insight, 2021;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture
    Authors: T Nakajima, A Nakahata, N Yamada, K Yoshizawa, TM Kato, M Iwasaki, C Zhao, H Kuroki, M Ikeya
    Nature Communications, 2021;12(1):5012.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. BMP7 reduces the fibrocartilage chondrocyte phenotype
    Authors: EGJ Ripmeester, MMJ Caron, GGH van den Ak, J Steijns, DAM Surtel, A Cremers, LCW Peeters, LW van Rhijn, TJM Welting
    Scientific Reports, 2021;11(1):19663.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Impaired chondrocyte U3 snoRNA expression in osteoarthritis impacts the chondrocyte protein translation apparatus
    Authors: EGJ Ripmeester, MMJ Caron, GGH van den Ak, DAM Surtel, A Cremers, P Balaskas, P Dyer, BAC Housmans, A Chabronova, A Smagul, Y Fang, LW van Rhijn, MJ Peffers, TJM Welting
    Sci Rep, 2020;10(1):13426.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Impaired chondrocyte U3 snoRNA expression in osteoarthritis impacts the chondrocyte protein translation apparatus
    Authors: EGJ Ripmeester, MMJ Caron, GGH van den Ak, DAM Surtel, A Cremers, P Balaskas, P Dyer, BAC Housmans, A Chabronova, A Smagul, Y Fang, LW van Rhijn, MJ Peffers, TJM Welting
    Sci Rep, 2020;10(1):13426.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration
    Authors: A Krouwels, JD Iljas, AHM Kragten, WJA Dhert, FC Öner, MA Tryfonidou, LB Creemers
    Int J Mol Sci, 2020;21(8):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  13. A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells
    Authors: H Tsujimoto, T Kasahara, SI Sueta, T Araoka, S Sakamoto, C Okada, SI Mae, T Nakajima, N Okamoto, D Taura, M Nasu, T Shimizu, M Ryosaka, Z Li, M Sone, M Ikeya, A Watanabe, K Osafune
    Cell Rep, 2020;31(1):107476.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State
    Authors: L Zhang, J Avery, A Yin, AM Singh, TS Cliff, H Yin, S Dalton
    Cell Stem Cell, 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State
    Authors: L Zhang, J Avery, A Yin, AM Singh, TS Cliff, H Yin, S Dalton
    Cell Stem Cell, 2020;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  16. Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis
    Authors: M Huang, J Tailor, Q Zhen, AH Gillmor, ML Miller, H Weishaupt, J Chen, T Zheng, EK Nash, LK McHenry, Z An, F Ye, Y Takashima, J Clarke, H Ayetey, FMG Cavalli, B Luu, BS Moriarity, S Ilkhanizad, L Chavez, C Yu, KM Kurian, T Magnaldo, N Sevenet, P Koch, SM Pollard, P Dirks, MP Snyder, DA Largaespad, YJ Cho, JJ Phillips, FJ Swartling, AS Morrissy, M Kool, SM Pfister, MD Taylor, A Smith, WA Weiss
    Cell Stem Cell, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway
    Authors: D Seo, SM Jung, JS Park, J Lee, J Ha, M Kim, SH Park
    EBioMedicine, 2019;49(0):55-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  18. Comparative transcriptome analysis of hESC- and iPSC-derived lentoid bodies
    Authors: M Ali, F Kabir, JJ Thomson, Y Ma, C Qiu, M Delannoy, SY Khan, SA Riazuddin
    Sci Rep, 2019;9(1):18552.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD signaling pathway
    Authors: M Omi, V Kaartinen, Y Mishina
    J. Biol. Chem., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs
    Authors: T Kamperman, M Koerselman, C Kelder, J Hendriks, JF Crispim, X de Peuter, PJ Dijkstra, M Karperien, J Leijten
    Nat Commun, 2019;10(1):4347.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA Capture
  21. Human adipose stromal-vascular fraction self-organizes to form vascularized adipose tissue in 3D cultures
    Authors: S Muller, I Ader, J Creff, H Leménager, P Achard, L Casteilla, L Sensebé, A Carrière, F Deschaseau
    Sci Rep, 2019;9(1):7250.
    Species: Human
    Sample Types: Whole Cells
  22. Differentiating SGBS adipocytes respond to PPAR? stimulation, irisin and BMP7 by functional browning and beige characteristics
    Authors: Á Klusóczki, Z Veréb, A Vámos, P Fischer-Po, M Wabitsch, Z Bacso, L Fésüs, E Kristóf
    Sci Rep, 2019;9(1):5823.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes
    Authors: MJ Harms, Q Li, S Lee, C Zhang, B Kull, S Hallen, A Thorell, I Alexanders, CE Hagberg, XR Peng, A Mardinoglu, KL Spalding, J Boucher
    Cell Rep, 2019;27(1):213-225.e5.
    Species: Human
    Sample Types: Tissue Explants
    Applications: Bioassay
  24. Feather arrays are patterned by interacting signalling and cell density waves
    Authors: WKW Ho, L Freem, D Zhao, KJ Painter, TE Woolley, EA Gaffney, MJ McGrew, A Tzika, MC Milinkovit, P Schneider, A Drusko, F Matthäus, JD Glover, KL Wells, JA Johansson, MG Davey, HM Sang, M Clinton, DJ Headon
    PLoS Biol., 2019;17(2):e3000132.
    Species: Chicken
    Sample Types: Tissue Explants
    Applications: Bioassay
  25. Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain
    Authors: M Kijewska, C Viski, F Turrell, A Fitzpatric, A van Weverw, Q Gao, M Iravani, CM Isacke
    Breast Cancer Res., 2019;21(1):4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Local injection of bone morphogenetic protein 7 promotes neuronal regeneration and motor function recovery after acute spinal cord injury
    Authors: C Chen, GC Bai, HL Jin, K Lei, KX Li
    Neural Regen Res, 2018;13(6):1054-1060.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  27. Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis
    Authors: CC Weng, PY Ding, YH Liu, JR Hawse, M Subramania, CC Wu, YC Lin, CY Chen, WC Hung, KH Cheng
    Oncogene, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Co-treatment of TGF-?3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments
    Authors: X Huang, L Zhong, JN Post, M Karperien
    Sci Rep, 2018;8(1):10251.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Supraphysiological levels of GDF11 induce striated muscle atrophy
    Authors: DW Hammers, M Merscham-B, JY Hsiao, S Engst, JJ Hartman, HL Sweeney
    EMBO Mol Med, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells
    Authors: C Sallon, I Callebaut, I Boulay, J Fontaine, D Logeart-Av, C Henriquet, M Pugnière, X Cayla, P Monget, G Harichaux, V Labas, S Canepa, C Taragnat
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Bone morphogenetic protein-7 (BMP-7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K/AKT pathway
    Authors: T Chattopadh, RR Singh, S Gupta, A Surolia
    Biofactors, 2017;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  32. Osteogenic differentiation of mesenchymal stem cells is impaired by bone morphogenetic protein 7
    Authors: P Wongwitwic, J Kaewsricha
    Adv Med Sci, 2017;62(2):266-272.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
    Authors: K Hino, K Horigome, M Nishio, S Komura, S Nagata, C Zhao, Y Jin, K Kawakami, Y Yamada, A Ohta, J Toguchida, M Ikeya
    J. Clin. Invest., 2017;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  34. Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells
    Authors: E Raja, A Komuro, R Tanabe, S Sakai, Y Ino, N Saito, T Todo, M Morikawa, H Aburatani, D Koinuma, C Iwata, K Miyazono
    Oncogene, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Generation of thalamic neurons from mouse embryonic stem cells
    Authors: A Shiraishi, K Muguruma, Y Sasai
    Development, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-? receptor type I ALK5
    Authors: LK Bollum, K Huse, MP Oksvold, B Bai, VI Hilden, L Forfang, SO Yoon, S Wälchli, EB Smeland, JH Myklebust
    PLoS ONE, 2017;12(5):e0177188.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis
    PLoS Genet, 2016;12(12):e1006474.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Clinical-scale expansion of Adipose derived Stromal Cells starting from Stromal Vascular Fraction in a single-use bioreactor: Proof of concept for autologous applications
    Authors: Mélanie Gadelorge
    J Tissue Eng Regen Med, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication
    PLoS ONE, 2016;11(12):e0168334.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Functional Langerinhigh-Expressing Langerhans-like Cells Can Arise from CD14highCD16- Human Blood Monocytes in Serum-Free Condition
    Authors: G Picarda, C Chéneau, JM Humbert, G Bériou, P Pilet, J Martin, F Duteille, P Perrot, F Bellier-Wa, M Heslan, F Haspot, F Guillon, R Josien, FA Halary
    J Immunol, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Endogenously produced Indian Hedgehog regulates TGFbeta-driven chondrogenesis of human bone marrow stromal/stem cells.
    Authors: Handorf A, Chamberlain C, Li W
    Stem Cells Dev, 2015;24(8):995-1007.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. White-to-brown metabolic conversion of human adipocytes by JAK inhibition.
    Authors: Moisan A, Lee Y, Zhang J, Hudak C, Meyer C, Prummer M, Zoffmann S, Truong H, Ebeling M, Kiialainen A, Gerard R, Xia F, Schinzel R, Amrein K, Cowan C
    Nat Cell Biol, 2015;17(1):57-67.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. A Combination of Culture Conditions and Gene Expression Analysis Can Be Used to Investigate and Predict hES Cell Differentiation Potential towards Male Gonadal Cells.
    Authors: Kjartansdottir K, Reda A, Panula S, Day K, Hultenby K, Soder O, Hovatta O, Stukenborg J
    PLoS ONE, 2015;10(12):e0144029.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Doublecortin may play a role in defining chondrocyte phenotype.
    Authors: Ge D, Zhang Q, Zabaleta J, Zhang Q, Liu S, Reiser B, Bunnell B, Braun S, O'Brien M, Savoie F, You Z
    Int J Mol Sci, 2014;15(4):6941-60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.
    Authors: Thiede B, Mann Z, Chang W, Ku Y, Son Y, Lovett M, Kelley M, Corwin J
    Nat Commun, 2014;5(0):3840.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: Bioassay
  46. Brown fat determination and development from muscle precursor cells by novel action of bone morphogenetic protein 6.
    Authors: Sharma A, Huard C, Vernochet C, Ziemek D, Knowlton K, Tyminski E, Paradis T, Zhang Y, Jones J, von Schack D, Brown C, Milos P, Coyle A, Tremblay F, Martinez R
    PLoS ONE, 2014;9(3):e92608.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury.
    Authors: Yamada, Sachiko, Nakamura, Jin, Asada, Misako, Takase, Masayuki, Matsusaka, Taiji, Iguchi, Taku, Yamada, Ryo, Tanaka, Mari, Higashi, Atsuko Y, Okuda, Tomohiko, Asada, Nariaki, Fukatsu, Atsushi, Kawachi, Hiroshi, Graf, Daniel, Muso, Eri, Kita, Toru, Kimura, Takeshi, Pastan, Ira, Economides, Aris N, Yanagita, Motoko
    PLoS ONE, 2014;9(2):e89135.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Essential roles of epithelial bone morphogenetic protein signaling during prostatic development.
    Authors: Omori, Akiko, Miyagawa, Shinichi, Ogino, Yukiko, Harada, Masayo, Ishii, Kenichir, Sugimura, Yoshiki, Ogino, Hajime, Nakagata, Naomi, Yamada, Gen
    Endocrinology, 2014;155(7):2534-44.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro.
    Authors: Lorda-Diez C, Montero J, Choe S, Garcia-Porrero J, Hurle J
    J Bone Miner Res, 2014;29(3):735-48.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes.
    Authors: Xue, Ruidan, Wan, Yun, Zhang, Shuo, Zhang, Qiongyue, Ye, Hongying, Li, Yiming
    Am J Physiol Endocrinol Metab, 2014;306(4):E363-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear.
    Authors: Mann Z, Thiede B, Chang W, Shin J, May-Simera H, Lovett M, Corwin J, Kelley M
    Nat Commun, 2014;5(0):3839.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  52. SDF-1 enhances wound healing of critical-sized calvarial defects beyond self-repair capacity.
    Authors: Jin, Qiming, Giannobile, William
    PLoS ONE, 2014;9(5):e97035.
    Species: Mouse
    Sample Types: Complex Sample Type
    Applications: Bioassay
  53. Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis.
    Authors: Brady K, Dickinson S, Guillot P, Polak J, Blom A, Kafienah W, Hollander A
    Stem Cells Dev, 2014;23(5):541-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney.
    Authors: Long, Jianyin, Badal, Shawn S, Wang, Yin, Chang, Benny H, Rodriguez, Antony, Danesh, Farhad R
    J Biol Chem, 2013;288(51):36202-14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production.
    Authors: Glister C, Satchell L, Bathgate R, Wade J, Dai Y, Ivell R, Anand-Ivell R, Rodgers R, Knight P
    Proc Natl Acad Sci U S A, 2013;110(15):E1426-35.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Generation of human induced pluripotent stem cells using epigenetic regulators reveals a germ cell-like identity in partially reprogrammed colonies.
    Authors: Goyal, Akshi, Chavez, Shawn L, Reijo Pera, Renee A
    PLoS ONE, 2013;8(12):e82838.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  57. Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells.
    Authors: Mae, Shin-Ich, Shono, Akemi, Shiota, Fumihiko, Yasuno, Tetsuhik, Kajiwara, Masatosh, Gotoda-Nishimura, Nanaka, Arai, Sayaka, Sato-Otubo, Aiko, Toyoda, Taro, Takahashi, Kazutosh, Nakayama, Naoki, Cowan, Chad A, Aoi, Takashi, Ogawa, Seishi, McMahon, Andrew P, Yamanaka, Shinya, Osafune, Kenji
    Nat Commun, 2013;4(0):1367.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Inhibition of TGF-beta signaling enables human corneal endothelial cell expansion in vitro for use in regenerative medicine.
    Authors: Okumura N, Kay E, Nakahara M, Hamuro J, Kinoshita S, Koizumi N
    PLoS ONE, 2013;8(2):e58000.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue.
    Authors: Deschaseaux F, Gaillard J, Langonne A, Chauveau C, Naji A, Bouacida A, Rosset P, Heymann D, De Pinieux G, Rouas-Freiss N, Sensebe L
    FASEB J, 2013;27(8):2977-87.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Human embryonic stem cells differentiate into functional renal proximal tubular-like cells.
    Authors: Narayanan, Karthike, Schumacher, Karl M, Tasnim, Farah, Kandasamy, Karthike, Schumacher, Annegret, Ni, Ming, Gao, Shujun, Gopalan, Began, Zink, Daniele, Ying, Jackie Y
    Kidney Int, 2013;83(4):593-603.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Gremlin-1 induces BMP-independent tumor cell proliferation, migration, and invasion.
    Authors: Kim M, Yoon S, Lee S
    PLoS ONE, 2012;7(4):e35100.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Binding Assay
  62. Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma.
    Authors: Huse K, Bakkebo M, Walchli S, Oksvold M, Hilden V, Forfang L, Bredahl M, Liestol K, Alizadeh A, Smeland E, Myklebust J
    PLoS ONE, 2012;7(10):e46117.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15.
    Authors: Mottershead D, Ritter L, Gilchrist R
    Mol Hum Reprod, 2012;18(3):121-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs).
    Authors: Wu, Qifang, Sun, Chia Chi, Lin, Herbert, Babitt, Jodie L
    PLoS ONE, 2012;7(9):e46307.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Surface Plasmon Resonance
  65. Sertoli cell-conditioned medium induces germ cell differentiation in human embryonic stem cells.
    Authors: Geens M, Sermon KD
    J. Assist. Reprod. Genet., 2011;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
    Authors: Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV
    J. Biol. Chem., 2011;286(34):30034-46.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Surface Plasmon Resonance
  67. Regulation of chemotropic guidance of nerve growth cones by microRNA.
    Mol Brain, 2011;4(0):40.
    Species: Xenopus
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7.
    Authors: Huse K, Bakkebo M, Oksvold MP, Forfang L, Hilden VI, Stokke T, Smeland EB, Myklebust JH
    Eur. J. Immunol., 2011;41(11):3135-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1.
    Authors: Hackett TL, Warner SM, Stefanowicz D, Shaheen F, Pechkovsky DV, Murray LA, Argentieri R, Kicic A, Stick SM, Bai TR, Knight DA
    Am. J. Respir. Crit. Care Med., 2009;180(2):122-33.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum.
    Authors: Herrera B, Inman GJ,
    BMC Cell Biol., 2009;10(0):20.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis.
    Authors: Little SC, Mullins MC
    Nat. Cell Biol., 2009;11(5):637-43.
    Species: Zebrafish
    Sample Types: Whole Tissue
    Applications: Bioassay
  72. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.
    Authors: Sengle G, Ono RN, Lyons KM, Bachinger HP, Sakai LY
    J. Mol. Biol., 2008;381(4):1025-39.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA (Capture)
  73. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.
    Authors: Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR
    Nature, 2008;454(7207):1000-4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Adenoviral expression of vascular endothelial growth factor splice variants differentially regulate bone marrow-derived mesenchymal stem cells.
    Authors: Lin H, Shabbir A, Molnar M, Yang J, Marion S, Canty JM, Lee T
    J. Cell. Physiol., 2008;216(2):458-68.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm.
    Authors: Shiraki N, Yoshida T, Araki K, Umezawa A, Higuchi Y, Goto H, Kume K, Kume S
    Stem Cells, 2008;26(4):874-85.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Targeting of bone morphogenetic protein growth factor complexes to fibrillin.
    Authors: Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bachinger HP, Sakai LY
    J. Biol. Chem., 2008;283(20):13874-88.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Binding Assay
  77. Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions.
    Authors: Fuller ML, DeChant AK, Rothstein B, Caprariello A, Wang R, Hall AK, Miller RH
    Ann. Neurol., 2007;62(3):288-300.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  78. Differentiation of ES cells into cerebellar neurons.
    Authors: Salero E, Hatten ME
    Proc. Natl. Acad. Sci. U.S.A., 2007;104(8):2997-3002.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  79. BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin.
    Authors: Wen Z, Han L, Bamburg JR, Shim S, Ming GL, Zheng JQ
    J. Cell Biol., 2007;178(1):107-19.
    Species: Xenopus
    Sample Types: Whole Cells
    Applications: Bioassay
  80. A rapid and sensitive bioassay to measure bone morphogenetic protein activity.
    Authors: Zilberberg L, ten Dijke P, Sakai L, Rifkin D
    BMC Cell Biol, 2007;8(0):41.
    Applications: Bioassay
  81. Inhibitory Smad transcription factors protect arterial endothelial cells from apoptosis induced by BMP4.
    Authors: Kiyono M, Shibuya M
    Oncogene, 2006;25(54):7131-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct.
    Authors: Maeshima A, Vaughn DA, Choi Y, Nigam SK
    Dev. Biol., 2006;295(2):473-85.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: Bioassay
  83. Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish.
    Authors: Holzschuh J, Wada N, Wada C, Schaffer A, Javidan Y, Tallafuss A, Bally-Cuif L, Schilling TF
    Development, 2005;132(16):3731-42.
    Species: Xenopus
    Sample Types: In Vivo
    Applications: In Vivo
  84. FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis.
    Authors: Steinberg Z, Myers C, Heim VM, Lathrop CA, Rebustini IT, Stewart JS, Larsen M, Hoffman MP
    Development, 2005;132(6):1223-34.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  85. CD44 modulates Smad1 activation in the BMP-7 signaling pathway.
    Authors: Peterson RS, Andhare RA, Rousche KT, Knudson W, Wang W, Grossfield JB, Thomas RO, Hollingsworth RE, Knudson CB
    J. Cell Biol., 2004;166(7):1081-91.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  86. HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis.
    Authors: Knosp WM, Scott V, Bachinger HP, Stadler HS
    Development, 2004;131(18):4581-92.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  87. FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis.
    Authors: Jaskoll T, Witcher D, Toreno L, Bringas P, Moon AM, Melnick M
    Dev. Biol., 2004;268(2):457-69.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids.
    Authors: Kumar Gupta A, Sarkar P, Wertheim J, Pan X, Carroll T, Oxburgh L
    Commun Biol, 0;3(1):231.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. What is the half-life of a recombinant or natural protein in culture at 37 °C?

    • R&D Systems has not determined the half-life of recombinant or natural proteins in culture. For cell-based bioassays, the incubation period of the protein with the cells typically ranges from 48 to 96 hours. Assay conditions for each protein will need to be optimized by each researcher.

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