Recombinant Human Wnt-3a Protein

GMP Version Available: 5036-GMP
GMP

Carrier Free

Catalog # Availability Size / Price Qty
5036-WN-010/CF
5036-WN-500/CF

With Carrier

Catalog # Availability Size / Price Qty
5036-WN-010
5036-WN-500
Recombinant Human Wnt-3a Protein Bioactivity
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Product Details
Citations (242)
FAQs
Supplemental Products
Reviews (18)

Recombinant Human Wnt-3a Protein Summary

Product Specifications

Purity
>75%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to induce alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. The ED50 for this effect is 5-25 ng/mL. Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The ED50 for this effect is <500 ng/mL. Protein concentrations should be titrated based on cell type and if appropriate, passage number of the cell line.
Optimal concentrations should be determined by each laboratory for each application.
Source
Chinese Hamster Ovary cell line, CHO-derived human Wnt-3a protein
Ser19-Lys352
Accession #
N-terminal Sequence
Analysis
Ser19
Predicted Molecular Mass
37.4 kDa
SDS-PAGE
40 kDa, reducing conditions

Product Datasheets

5036-WN (with carrier)

5036-WN/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

5036-WN

Formulation Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS with BSA as a carrier protein.
Reconstitution Reconstitute at 200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

5036-WN/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS.
Reconstitution Reconstitute at 200 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Image

Bioactivity Recombinant Human Wnt-3a Protein Bioactivity View Larger

Recombinant Human Wnt-3a (Catalog # 5036-WN) induces alkaline phosphatase production by the MC3T3-E1 mouse preosteoblast cell line. The ED50 is 1.7-fold better with more than twice the maximum response compared to the top competitor's Wnt-3a.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Wnt-3a

Wnt-3a is one of 19 vertebrate members of the Wingless-type MMTV integration site (Wnt) family of highly conserved cysteine-rich secreted glycoproteins important for normal developmental processes (1). Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). As intracellular beta -catenin levels rise, beta -catenin binds to TCF/LEF transcription factors leading to expression of Wnt target genes (3). Endo-IWR 1 (Catalog # 3532, # PSM1324) is a cell-permeant small molecule inhibitor of Axin turnover that suppresses Wnt signal transduction by stabilizing the beta -catenin destruction complex (4). Wnt-3a is a 44 kDa secreted hydrophobic glycoprotein containing a conserved pattern of 24 cysteine residues (5). Wnt-3a has two N-linked glycosylation sites (Asn 87, Asn 298), and Ser 209 is modified with palmitoleic acid (6). Glycosylation and acylation are essential for efficient Wnt secretion and biological activity, respectively (6, 7). Human Wnt-3a shares 96% amino acid (aa) identity with mouse mouse, bovine and canine Wnt-3a, and 89%, 86% and 84% aa identity with chicken, Xenopus and zebrafish Wnt-3a, respectively. It also shares 87% aa identity with Wnt3. During embryonic development, Wnt-3a is necessary for proper development of the hippocampus, anterior-posterior patterning, somite development, and tailbud formation (9-12). Wnt-3a also promotes self-renewal of hematopoietic stem cells, neural stem cells, and embryonic stem cells (13, 14).

References
  1. Willert, K. and Nusse, R. (2012) Cold Spring Harb. Perspect. Biol. 4:a007864.
  2. MacDonald, B.T. and X. He (2012) Cold Spring Harb. Perspect. Biol. 4:a007880.
  3. Korinek, V. et al. (1997) Science 275:1784.
  4. Chen, B. et al. (2009) Nat. Chem. Biol. 5:100.
  5. Smolich, B.D. et al. (1993) Mol. Biol. Cell 4:1267.
  6. Takada, R. et al. (2006) Dev. Cell 11:791.
  7. Komekado, H. (2007) Genes Cells 12:521.
  8. Dunty Jr. W. C. et al. (2008) Development 135:85.
  9. Ikeya, M. and S. Takada (2001) Mech. Dev. 103:27.
  10. Lee, S. M. et al. (2000) Development 127:457.
  11. Takada, S. et al. (1994) Genes Dev. 8:174.
  12. Willert, K. et al. (2003) Nature 423:6938.
  13. Kalani, M.Y. et al. (2008) Proc. Natl. Acad. Sci. USA 105:16970.
  14. Ten Berge, D. et al. (2011) Nat. Cell Biol. 13:1070.
Long Name
Wingless-type MMTV Integration Site Family, Member 3a
Entrez Gene IDs
89780 (Human); 22416 (Mouse)
Alternate Names
MGC119418; MGC119419; MGC119420; protein Wnt-3a; wingless-type MMTV integration site family, member 3A; Wnt3a; Wnt-3a

Citations for Recombinant Human Wnt-3a Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

242 Citations: Showing 1 - 10
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  1. Propionate Enhances Cell Speed and Persistence to Promote Intestinal Epithelial Turnover and Repair
    Authors: AJ Bilotta, C Ma, W Yang, Y Yu, Y Yu, X Zhao, Z Zhou, S Yao, SM Dann, Y Cong
    Cell Mol Gastroenterol Hepatol, 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  2. Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription
    Authors: Q Li, Y Sun, GK Jarugumill, S Liu, K Dang, JL Cotton, J Xiol, PY Chan, M DeRan, L Ma, R Li, LJ Zhu, JH Li, AB Leiter, YT Ip, FD Camargo, X Luo, RL Johnson, X Wu, J Mao
    Cell Stem Cell, 2020;26(5):675-692.e8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  3. Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma
    Authors: WY Liao, CC Hsu, TS Chan, CJ Yen, WY Chen, HW Pan, KK Tsai
    Stem Cell Reports, 2020;14(3):462-477.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Induced pluripotent stem cell-derived tenocyte-like cells promote the regeneration of injured tendons in mice
    Authors: S Komura, T Satake, A Goto, H Aoki, H Shibata, K Ito, A Hirakawa, Y Yamada, H Akiyama
    Sci Rep, 2020;10(1):3992.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. The Transcription Factor-microRNA Regulatory Network during hESC-chondrogenesis
    Authors: R Griffiths, S Woods, A Cheng, P Wang, S Griffiths-, M Ronshaugen, SJ Kimber
    Sci Rep, 2020;10(1):4744.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Generation and characterization of human induced pluripotent stem cells (iPSCs) from hand osteoarthritis patient-derived fibroblasts
    Authors: R Castro-Viñ, C Sanjurjo-R, M Piñeiro-Ra, T Hermida-Gó, S Rodríguez-, N Oreiro, J de Toro, I Fuentes, FJ Blanco, S Díaz-Prado
    Sci Rep, 2020;10(1):4272.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  7. Expression of MALAT1 Promotes Trastuzumab Resistance in HER2 Overexpressing Breast Cancers
    Authors: Y Wu, M Sarkissyan, O Ogah, J Kim, JV Vadgama
    Cancers (Basel), 2020;12(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  8. Identification and validation of the phosphorylation sites on Aristaless-related homeobox protein
    Authors: X Shi, W Lin, X Gao, W Xie, JA Golden, T Tao
    Biosci. Rep., 2020;40(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. LSD1 inhibition yields functional insulin-producing cells from human embryonic stem cells
    Authors: F He, N Li, HB Huang, JB Wang, XF Yang, HD Wang, W Huang, FR Li
    Stem Cell Res Ther, 2020;11(1):163.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets
    Authors: M Liu, Q Yan, Y Sun, Y Nam, L Hu, JH Loong, Q Ouyang, Y Zhang, HL Li, FE Kong, L Li, Y Li, MM Li, W Cheng, LX Jiang, S Fang, XD Yang, JQ Mo, YF Gong, YQ Tang, Y Li, YF Yuan, NF Ma, G Lin, S Ma, JG Wang, XY Guan
    Proc. Natl. Acad. Sci. U.S.A., 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  11. Generation of intestinal organoids derived from human pluripotent stem cells for drug testing
    Authors: S Yoshida, H Miwa, T Kawachi, S Kume, K Takahashi
    Sci Rep, 2020;10(1):5989.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Canonical and non-canonical Wnt signaling are simultaneously activated by Wnts in colon cancer cells
    Authors: E Flores-Her, DM Velázquez, MC Castañeda-, G Fuentes-Ga, G Fonseca-Ca, JK Yamamoto-F, MT Romero-Avi, JA García-Sái, M Robles-Flo
    Cell. Signal., 2020;72(0):109636.
    Species: Human
    Sample Types: Whole Cell
    Applications: Bioassay
  13. FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits
    Authors: M Bowers, T Liang, D Gonzalez-B, S Zocher, BN Jaeger, WJ Kovacs, C Röhrl, KML Cramb, J Winterer, M Kruse, S Dimitrieva, RW Overall, T Wegleiter, H Najmabadi, CF Semenkovic, G Kempermann, C Földy, S Jessberger
    Cell Stem Cell, 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. iPSC-Derived Intestinal Organoids from Cystic Fibrosis Patients Acquire CFTR Activity upon TALEN-Mediated Repair of the p.F508del Mutation
    Authors: A Fleischer, S Vallejo-Dí, JM Martín-Fer, A Sánchez-Gi, M Castresana, A Del Pozo, A Esquisabel, S Ávila, JL Castrillo, E Gaínza, JL Pedraz, M Viñas, D Bachiller
    Mol Ther Methods Clin Dev, 2020;17(0):858-870.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  15. SULF1 suppresses Wnt3A-driven growth of bone metastatic prostate cancer in perlecan-modified 3D cancer-stroma-macrophage triculture models
    Authors: FH Brasil da, MS Lewis, A Truong, DD Carson, MC Farach-Car
    PLoS ONE, 2020;15(5):e0230354.
    Species: Human
    Sample Types:
    Applications: Cell Culture
  16. Structural insight into small molecule action on Frizzleds
    Authors: P Kozielewic, A Turku, CF Bowin, J Petersen, J Valnohova, MCA Cañizal, Y Ono, A Inoue, C Hoffmann, G Schulte
    Nat Commun, 2020;11(1):414.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  17. Wnt-3a Induces Epigenetic Remodeling in Human Dental Pulp Stem Cells
    Authors: V Uribe-Etxe, P García-Gal, M Pérez-Garr, M Casado-And, I Irastorza, F Unda, G Ibarretxe, N Subirán
    Cells, 2020;9(3):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  18. Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency
    Authors: W Kawarazaki, R Mizuno, M Nishimoto, N Ayuzawa, D Hirohama, K Ueda, F Kawakami-M, S Oba, T Marumo, T Fujita
    J. Clin. Invest., 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  19. Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and WNT
    Authors: A El-Sehemy, HJ Selvadurai, A Ortin-Mart, NT Pokrajac, Y Mamatjan, N Tachibana, KJ Rowland, L Lee, NI Park, KD Aldape, P Dirks, VA Wallace
    J. Clin. Invest., 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  20. Wnt/&beta-catenin signaling pathway inhibits porcine reproductive and respiratory syndrome virus replication by enhancing the nuclear factor-&kappaB-dependent innate immune response
    Authors: J Wang, L Gong, W Zhang, W Chen, H Pan, Y Zeng, X Liang, J Ma, G Zhang, H Wang
    Veterinary Microbiology, 2020;251(0):108904.
    Species: Chlorocebus aethiops (green monkey)
    Sample Types: Whole Cells
    Applications: Cell Culture
  21. Aquaporin 1 promotes sensitivity of anthracycline chemotherapy in breast cancer by inhibiting &beta-catenin degradation to enhance TopoII&alpha activity
    Authors: W Chong, H Zhang, Z Guo, L Yang, Y Shao, X Liu, Y Zhao, Z Wang, M Zhang, C Guo, L Fu, Y Ma, F Gu
    Cell Death Differ., 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia
    Authors: S Nagel, C Pommerenke, C Meyer, RAF MacLeod, HG Drexler
    PLoS ONE, 2020;15(10):e0240120.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  23. Familial hypercholesterolemia class II low density lipoprotein-receptor response to statin treatment
    Authors: L Omer, L Hindi, G Militello, KB Stivers, KC Tien, NL Boyd
    Dis Model Mech, 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  24. Elevated Dkk1 Mediates Downregulation of the Canonical Wnt Pathway and Lysosomal Loss in an iPSC Model of Neuronopathic Gaucher Disease
    Authors: MP Srikanth, RA Feldman
    Biomolecules, 2020;10(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Generation of a human iPSC line CIBi008-A from amniotic fluid-derived cells of a fetus with &beta-thalassemia carrying variants of -28A�>�G and IVS-II-654C�>�T in HBB
    Authors: S Wu, H Wei, M Chu, Z Weng
    Stem Cell Res, 2020;49(0):102074.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  26. Fallopian Tube Basal Stem Cells Reproducing the Epithelial Sheets In Vitro-Stem Cell of Fallopian Epithelium
    Authors: M Zhu, T Iwano, S Takeda
    Biomolecules, 2020;10(9):.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  27. PWP1 Promotes the Malignant Phenotypes of Lung Cancer Cells by Interacting with DVL2 and Merlin
    Authors: L Wei, P Li, Y Luo, M Zhang, T Yan, Y Yang, Y Han, S Liu, E Wang
    Onco Targets Ther, 2020;13(0):10025-10037.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids
    Authors: T Sawada, TE Chater, Y Sasagawa, M Yoshimura, N Fujimori-T, K Tanaka, KJM Benjamin, ACM Paquola, JA Erwin, Y Goda, I Nikaido, T Kato
    Mol. Psychiatry, 2020;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  29. Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology
    Authors: Z Dantes, HY Yen, N Pfarr, C Winter, K Steiger, A Muckenhube, A Hennig, S Lange, T Engleitner, R Öllinger, R Maresch, F Orben, I Heid, G Kaissis, K Shi, G Topping, F Stögbauer, M Wirth, K Peschke, A Papargyrio, M Rezaee-Ogh, K Feldmann, AP Schäfer, R Ranjan, C Lubeseder-, DE Stange, T Welsch, M Martignoni, GO Ceyhan, H Friess, A Herner, L Liotta, M Treiber, G von Figura, M Abdelhafez, P Klare, C Schlag, H Algül, J Siveke, R Braren, G Weirich, W Weichert, D Saur, R Rad, RM Schmid, G Schneider, M Reichert
    JCI Insight, 2020;5(15):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Cell Culture
  30. Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1
    Authors: K Dunbar, A Valanciute, A Lima, PF Vinuela, T Jamieson, V Rajasekara, J Blackmur, AM Ochocka-Fo, A Guazzelli, P Cammareri, MJ Arends, OJ Sansom, KB Myant, SM Farrington, MG Dunlop, FVN Din
    Cell Mol Gastroenterol Hepatol, 2020;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Cell Culture
  31. Activation of &beta-catenin by TGF-&beta1 promotes ligament-fibroblastic differentiation and inhibits cementoblastic differentiation of human periodontal ligament cells
    Authors: JC Lim, SH Bae, G Lee, CJ Ryu, YJ Jang
    Stem Cells, 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  32. R-Spondin 2 Induces Odontogenic Differentiation of Dental Pulp Stem/Progenitor Cells via Regulation of Wnt/&beta-Catenin Signaling
    Authors: Y Gong, S Yuan, J Sun, Y Wang, S Liu, R Guo, W Dong, R Li
    Front Physiol, 2020;11(0):918.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  33. Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability
    Authors: M Díaz-Corán, CM Lin, S Liebner, DA Antonetti
    J. Biol. Chem., 2020;0(0):.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair
    Authors: T Colunga, M Hayworth, S Kre beta, DM Reynolds, L Chen, KL Nazor, J Baur, AM Singh, JF Loring, M Metzger, S Dalton
    Cell Rep, 2019;26(10):2566-2579.e10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification
    Authors: CP Nielsen, KK Jernigan, NL Diggins, DJ Webb, JA MacGurn
    Cell Rep, 2019;28(4):1074-1089.e5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  36. Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells
    Authors: KB Jung, O Kwon, MO Lee, H Lee, YS Son, O Habib, JH Oh, HS Cho, CR Jung, J Kim, MY Son
    J Clin Med, 2019;8(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis
    Authors: Z Yan, K Ohuchida, S Fei, B Zheng, W Guan, H Feng, S Kibe, Y Ando, K Koikawa, T Abe, C Iwamoto, K Shindo, T Moriyama, K Nakata, Y Miyasaka, T Ohtsuka, K Mizumoto, M Hashizume, M Nakamura
    J. Exp. Clin. Cancer Res., 2019;38(1):221.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  38. WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis
    Authors: K Kaiser, D Gyllborg, J Procházka, A Salašová, P Kompaníkov, FL Molina, R Laguna-Goy, T Radaszkiew, J Harnoš, M Procházkov, D Pot?šil, RA Barker, ÁG Casado, Z Zdráhal, R Sedlá?ek, E Arenas, JC Villaescus, V Bryja
    Nat Commun, 2019;10(1):1498.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite
    Authors: K Abe, A Shimada, S Tayama, H Nishikawa, T Kaneko, S Tsuda, A Karaiwa, T Matsui, T Ishitani, H Takeda
    Cell Rep, 2019;27(3):928-939.e4.
    Species: Fish - Oryzias latipes (Medaka/Rice Fish)
    Sample Types: In Vivo
    Applications: In Vivo
  40. An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos
    Authors: L Liu, L Leng, C Liu, C Lu, Y Yuan, L Wu, F Gong, S Zhang, X Wei, M Wang, L Zhao, L Hu, J Wang, H Yang, S Zhu, F Chen, G Lu, Z Shang, G Lin
    Nat Commun, 2019;10(1):364.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. In-depth characterization of the Wnt-signaling/?-catenin pathway in an in vitro model of Barrett's sequence
    Authors: K Götzel, O Chemnitzer, L Maurer, A Dietrich, U Eichfeld, O Lyros, Y Moulla, S Niebisch, M Mehdorn, B Jansen-Win, M Vieth, A Hoffmeiste, I Gockel, R Thieme
    BMC Gastroenterol, 2019;19(1):38.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Gfi1b regulates the level of Wnt/?-catenin signaling in hematopoietic stem cells and megakaryocytes
    Authors: P Shooshtari, A Helness, C Vadnais, N Brouwer, H Beauchemin, R Chen, H Bagci, FJT Staal, JF Coté, T Möröy
    Nat Commun, 2019;10(1):1270.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Point mutations in the PDX1 transactivation domain impair human ?-cell development and function
    Authors: X Wang, M Sterr, Ansarullah, I Burtscher, A Böttcher, J Beckenbaue, J Siehler, T Meitinger, HU Häring, H Staiger, FM Cernilogar, G Schotta, M Irmler, J Beckers, CVE Wright, M Bakhti, H Lickert
    Mol Metab, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
  44. Dickkopf-1 (DKK1) promotes tumor growth via Akt-phosphorylation and independently of Wnt-axis in Barrett's associated esophageal adenocarcinoma
    Authors: O Lyros, AK Lamprecht, L Nie, R Thieme, K Götzel, M Gasparri, G Haasler, P Rafiee, R Shaker, I Gockel
    Am J Cancer Res, 2019;9(2):330-346.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. ZNF326 promotes malignant phenotype of glioma by up-regulating HDAC7 expression and activating Wnt pathway
    Authors: X Yu, M Wang, J Wu, Q Han, X Zhang
    J. Exp. Clin. Cancer Res., 2019;38(1):40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors
    Authors: H Noguchi, C Miyagi-Shi, Y Nakashima, T Kinjo, N Kobayashi, I Saitoh, M Watanabe, AMJ Shapiro, T Kin
    Mol Ther Methods Clin Dev, 2019;13(0):243-252.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells
    Authors: T Kijima, H Nakagawa, M Shimonoson, PM Chandramou, T Hara, V Sahu, Y Kasagi, O Kikuchi, K Tanaka, V Giroux, AB Muir, KA Whelan, S Ohashi, S Naganuma, AJ Klein-Szan, Y Shinden, K Sasaki, I Omoto, Y Kita, M Muto, AJ Bass, JA Diehl, GG Ginsberg, Y Doki, M Mori, Y Uchikado, T Arigami, NG Avadhani, D Basu, AK Rustgi, S Natsugoe
    Cell Mol Gastroenterol Hepatol, 2019;7(1):73-91.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  48. Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor
    Authors: CL Hammond, E Roztocil, RP Phipps, SE Feldon, CF Woeller
    PLoS ONE, 2019;14(9):e0222779.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Excess growth hormone suppresses DNA damage repair in epithelial cells
    Authors: V Chesnokova, S Zonis, R Barrett, H Kameda, K Wawrowsky, A Ben-Shlomo, M Yamamoto, J Gleeson, C Bresee, V Gorbunova, S Melmed
    JCI Insight, 2019;4(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. COL4A2 in the tissue-specific extracellular matrix plays important role on osteogenic differentiation of periodontal ligament stem cells
    Authors: Y Wen, H Yang, J Wu, A Wang, X Chen, S Hu, Y Zhang, D Bai, Z Jin
    Theranostics, 2019;9(15):4265-4286.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  51. Enhanced chondrogenesis from human embryonic stem cells
    Authors: T Wang, P Nimkingrat, CA Smith, A Cheng, TE Hardingham, SJ Kimber
    Stem Cell Res, 2019;39(0):101497.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Microenvironmental Factors Drive Tenascin C and Src Cooperation to Promote Invadopodia Formation in Ewing Sarcoma
    Authors: AG Hawkins, CM Julian, S Konzen, S Treichel, ER Lawlor, KM Bailey
    Neoplasia, 2019;21(10):1063-1072.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells
    Authors: C Praça, SC Rosa, E Sevin, R Cecchelli, MP Dehouck, LS Ferreira
    Stem Cell Reports, 2019;13(4):599-611.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Wnt Glycation Inhibits Canonical Signaling
    Authors: Z Ye, S Mittag, M Schmidt, A Simm, R Horstkorte, O Huber
    Cells, 2019;8(11):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  55. Microenvironmental IL1beta promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
    Authors: R Eyre, DG Alférez, A Santiago-G, K Spence, JC McConnell, C Hart, BM Simões, D Lefley, C Tulotta, J Storer, A Gurney, N Clarke, M Brown, SJ Howell, AH Sims, G Farnie, PD Ottewell, RB Clarke
    Nat Commun, 2019;10(1):5016.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  56. Immunomodulatory effects of interferon-gamma on human fetal cardiac mesenchymal stromal cells
    Authors: KH Grinnemo, M Löfling, L Nathanson, R Baumgartne, DFJ Ketelhuth, V Beljanski, LC Davies, C Österholm
    Stem Cell Res Ther, 2019;10(1):371.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Enteroendocrine progenitor cell enriched miR-7 regulates intestinal epithelial proliferation in an Xiap-dependent manner
    Authors: AP Singh, YH Hung, MT Shanahan, M Kanke, A Bonfini, MK Dame, M Biraud, BCE Peck, OO Oyesola, JM Freund, RL Cubitt, EG Curry, LM Gonzalez, GA Bewick, ED Tait-Wojno, NA Kurpios, S Ding, JR Spence, CM Dekaney, N Buchon, P Sethupathy
    Cell Mol Gastroenterol Hepatol, 2019;0(0):.
    Species: Porcine
    Sample Types: Whole Tissue
    Applications: Tissue Culture
  58. PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism
    Authors: RR Stine, AP Sakers, T TeSlaa, M Kissig, ZE Stine, CW Kwon, L Cheng, HW Lim, KH Kaestner, JD Rabinowitz, P Seale
    Cell Stem Cell, 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  59. Controlled modelling of human epiblast and amnion development using stem cells
    Authors: Y Zheng, X Xue, Y Shao, S Wang, SN Esfahani, Z Li, JM Muncie, JN Lakins, VM Weaver, DL Gumucio, J Fu
    Nature, 2019;573(7774):421-425.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
    Authors: V Lungova, X Chen, Z Wang, C Kendziorsk, SL Thibeault
    Nat Commun, 2019;10(1):4161.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells
    Authors: KB Jung, O Kwon, MO Lee, H Lee, YS Son, O Habib, JH Oh, HS Cho, CR Jung, J Kim, MY Son
    J Clin Med, 2019;8(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. In vitro metabolic zonation through oxygen gradient on a chip
    Authors: F Tonon, GG Giobbe, A Zambon, C Luni, O Gagliano, A Floreani, G Grassi, N Elvassore
    Sci Rep, 2019;9(1):13557.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling
    Authors: S Akbari, GG Sevinç, N Ersoy, O Basak, K Kaplan, K Sevinç, E Ozel, B Sengun, E Enustun, B Ozcimen, A Bagriyanik, N Arslan, TT Önder, E Erdal
    Stem Cell Reports, 2019;13(4):627-641.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  64. IKK? is a ?-catenin kinase that regulates mesenchymal stem cell differentiation
    Authors: Y Sui, Z Liu, SH Park, SE Thatcher, B Zhu, JP Fernandez, H Molina, PA Kern, C Zhou
    JCI Insight, 2018;3(2):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Tissue transglutaminase regulates interactions between ovarian cancer stem cells and the tumor niche
    Authors: S Condello, LE Sima, C Ivan, H Cardenas, GE Schiltz, RK Mishra, D Matei
    Cancer Res., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells
    Authors: BA Brown, GM Connolly, CEJ Mill, H Williams, GD Angelini, JL Johnson, SJ George
    Aging Cell, 2018;0(0):e12844.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Expression of the human antimicrobial peptide ?-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells
    Authors: C Bonamy, E Sechet, A Amiot, A Alam, M Mourez, L Fraisse, PJ Sansonetti, B Sperandio
    Sci Rep, 2018;8(1):18043.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  68. A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family
    Authors: J Li, C Narayanan, J Bian, D Sambo, T Brickler, W Zhang, S Chetty
    PLoS ONE, 2018;13(12):e0208110.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In�Vitro
    Authors: A Sarkar, A Mei, ACM Paquola, S Stern, C Bardy, JR Klug, S Kim, N Neshat, HJ Kim, M Ku, MN Shokhirev, DH Adamowicz, MC Marchetto, R Jappelli, JA Erwin, K Padmanabha, M Shtrahman, X Jin, FH Gage
    Cell Stem Cell, 2018;22(5):684-697.e9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages
    Authors: J Li, F Xing, F Chen, L He, KF So, Y Liu, J Xiao
    Cell Transplant, 2018;0(0):9636897187803.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors
    Authors: H Ida, T Akiyama, K Ishiguro, SK Goparaju, Y Nakatake, N Chikazawa-, S Sato, H Kimura, Y Yokoyama, M Nagino, MSH Ko, SBH Ko
    Stem Cell Res Ther, 2018;9(1):277.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Genome-wide analysis of PDX1 target genes in human pancreatic progenitors
    Authors: X Wang, M Sterr, I Burtscher, S Chen, A Hieronimus, F Machicao, H Staiger, HU Häring, G Lederer, T Meitinger, FM Cernilogar, G Schotta, M Irmler, J Beckers, M Hrab? de A, M Ray, CVE Wright, M Bakhti, H Lickert
    Mol Metab, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids
    Authors: E Magro-Lope, C Palmer, J Manso, I Liste, A Zambrano
    Stem Cell Res Ther, 2018;9(1):186.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. The Wnt-?-catenin signaling regulated MRTF-A transcription to activate migration-related genes in human breast cancer cells
    Authors: H He, F Du, Y He, Z Wei, C Meng, Y Xu, H Zhou, N Wang, XG Luo, W Ma, TC Zhang
    Oncotarget, 2018;9(20):15239-15251.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies
    Authors: M Russo, S Lamba, A Lorenzato, A Sogari, G Corti, G Rospo, B Mussolin, M Montone, L Lazzari, S Arena, D Oddo, M Linnebache, A Sartore-Bi, F Pietranton, S Siena, F Di Nicolan, A Bardelli
    Nat Commun, 2018;9(1):2287.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling
    Authors: S Kokabu, V Rosen
    FEBS Open Bio, 2018;8(2):168-176.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells
    Authors: S Yamada, Y Kubo, D Yamazaki, Y Sekino, Y Nomura, S Yoshida, Y Kanda
    Sci Rep, 2018;8(1):12155.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Cardiotrophic Growth Factor-Driven Induction of Human Muse Cells Into Cardiomyocyte-Like Phenotype
    Authors: M Amin, Y Kushida, S Wakao, M Kitada, K Tatsumi, M Dezawa
    Cell Transplant, 2018;27(2):285-298.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. EPH receptor A2 governs a feedback loop that activates Wnt/?-catenin signaling in gastric cancer
    Authors: Q Peng, L Chen, W Wu, J Wang, X Zheng, Z Chen, Q Jiang, J Han, L Wei, L Wang, J Huang, J Ma
    Cell Death Dis, 2018;9(12):1146.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips
    Authors: MJ Workman, JP Gleeson, EJ Troisi, HQ Estrada, SJ Kerns, CD Hinojosa, GA Hamilton, SR Targan, CN Svendsen, RJ Barrett
    Cell Mol Gastroenterol Hepatol, 2018;5(4):669-677.e2.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  81. An essential role for Wnt/?-catenin signaling in mediating hypertensive heart disease
    Authors: Y Zhao, C Wang, C Wang, X Hong, J Miao, Y Liao, L Zhou, Y Liu
    Sci Rep, 2018;8(1):8996.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation
    Authors: R Diacou, Y Zhao, D Zheng, A Cvekl, W Liu
    Cell Rep, 2018;25(9):2510-2523.e4.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  83. A20 regulates canonical wnt-signaling through an interaction with RIPK4
    Authors: BN Nakamura, A Glazier, MG Kattah, B Duong, Y Jia, D Campo, L Shao
    PLoS ONE, 2018;13(5):e0195893.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips.
    Authors: Michael J Workman, John P Gleeson, Elissa J Troisi, Hannah Q Estrada, S Jordan Kerns, Christopher D Hinojosa, Geraldine A Hamilton, Stephan R Targan, Clive N Svendsen, Robert J Barrett
    Cellular and Molecular Gastroenterology and Hepatology, 2018;0(0):2352-345X.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/?-catenin Pathway
    Authors: HJ Lee, J Li, RE Vickman, J Li, R Liu, A Durkes, BD Elzey, S Yue, X Liu, TL Ratliff, JX Cheng
    Mol. Cancer Res., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma
    Authors: M Szemes, A Greenhough, Z Melegh, S Malik, A Yuksel, D Catchpoole, K Gallacher, M Kollareddy, JH Park, K Malik
    Neoplasia, 2018;20(4):335-350.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. TGF? activation primes canonical Wnt signaling through the downregulation of AXIN2
    Authors: J Gillespie, RL Ross, C Corinaldes, F Esteves, E Derrett-Sm, MF McDermott, GM Doody, CP Denton, P Emery, F Del Galdo
    Arthritis & rheumatology (Hoboken, N.J.), 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  88. PBX3 is part of an EMT regulatory network and indicates poor outcome in colorectal cancer
    Authors: S Lamprecht, M Kaller, EM Schmidt, C Blaj, TS Schiergens, J Engel, A Jung, H Hermeking, TGP Grünewald, T Kirchner, D Horst
    Clin. Cancer Res., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Stimulation
  89. The Ewing sarcoma secretome and its response to activation of Wnt/beta-catenin signaling
    Authors: AG Hawkins, V Basrur, F da Veiga L, E Pedersen, C Sperring, AI Nesvizhski, ER Lawlor
    Mol. Cell Proteomics, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
  90. GLIS3 Transcriptionally Activates WNT Genes to Promote Differentiation of Human Embryonic Stem Cells into Posterior Neural Progenitors
    Authors: K Jeon, D Kumar, AE Conway, K Park, R Jothi, AM Jetten
    Stem Cells, 2018;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Immunoassay Development
  91. Natural molecules induce and synergize to boost expression of the human antimicrobial peptide ?-defensin-3
    Authors: E Sechet, E Telford, C Bonamy, PJ Sansonetti, B Sperandio
    Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  92. Ubiquitylation and degradation of adenomatous polyposis coli by MKRN1 enhances Wnt/?-catenin signaling
    Authors: HK Lee, EW Lee, J Seo, M Jeong, SH Lee, SY Kim, EH Jho, CH Choi, JY Chung, J Song
    Oncogene, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. LGR5 and BMI1 Increase Pig Intestinal Epithelial Cell Proliferation by Stimulating WNT/?-Catenin Signaling
    Authors: XG Li, Z Wang, RQ Chen, HL Fu, CQ Gao, HC Yan, GX Xing, XQ Wang
    Int J Mol Sci, 2018;19(4):.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  94. Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system
    Authors: D Garnier, R Li, F Delbos, A Fourrier, C Collet, C Guguen-Gui, C Chesné, TH Nguyen
    Sci Rep, 2018;8(1):8222.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  95. Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma
    Authors: A Ogorodniko, M Levin, S Tattikota, S Tokalov, M Hoque, D Scherzinge, F Marini, A Poetsch, H Binder, S Macher-Göp, HC Probst, B Tian, M Schaefer, KJ Lackner, F Westermann, S Danckwardt
    Nat Commun, 2018;9(1):5331.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. A simple and scalable hydrogel-based system for culturing protein-producing cells
    Authors: Q Li, Q Wang, O Wang, K Shao, H Lin, Y Lei
    PLoS ONE, 2018;13(1):e0190364.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/?-Catenin Signaling
    Authors: B Cha, X Geng, MR Mahamud, JY Zhang, L Chen, W Kim, EH Jho, Y Kim, D Choi, JB Dixon, H Chen, YK Hong, L Olson, TH Kim, BJ Merrill, MJ Davis, RS Srinivasan
    Cell Rep, 2018;25(3):571-584.e5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Lineage-Specific Chiral Biases of Human Embryonic Stem Cells during Differentiation
    Authors: KE Worley, AS Chin, LQ Wan
    Stem Cells Int, 2018;2018(0):1848605.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Wnt3a Induces the Expression of Acetylcholinesterase during Osteoblast Differentiation via the Runx2 Transcription Factor
    Authors: ML Xu, CWC Bi, EYL Liu, TTX Dong, KWK Tsim
    J. Biol. Chem., 2017;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  100. Surrogate Wnt agonists that phenocopy canonical Wnt and ?-catenin signalling
    Authors: CY Janda, LT Dang, C You, J Chang, W de Lau, ZA Zhong, KS Yan, O Marecic, D Siepe, X Li, JD Moody, BO Williams, H Clevers, J Piehler, D Baker, CJ Kuo, KC Garcia
    Nature, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Donor-Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells
    Authors: JA Heslop, R Kia, CS Pridgeon, RL Sison-Youn, T Liloglou, M Elmasry, SW Fenwick, JS Mills, NR Kitteringh, CE Goldring, BK Park
    Stem Cells Transl Med, 2017;6(5):1321-1331.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Wnt/?-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells
    Authors: Y Kishimoto, B Ohkawara, T Sakai, M Ito, A Masuda, N Ishiguro, C Shukunami, D Docheva, K Ohno
    PLoS ONE, 2017;12(7):e0182051.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Wnt/?-catenin signaling contributes to tumor malignancy and is targetable in gastrointestinal stromal tumor
    Authors: S Zeng, AM Seifert, JQ Zhang, MJ Cavnar, TS Kim, VP Balachandr, JA Santamaria, NA Cohen, MJ Beckman, B Medina, F Rossi, MH Crawley, JK Loo, JH Maltbaek, P Besmer, CR Antonescu, RP DeMatteo
    Mol. Cancer Ther., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells
    Authors: B Lucendo-Vi, P Filis, MJ Swortwood, MA Huestis, J Meseguer-R, K Cameron, JP Iredale, PJ O'Shaughne, PA Fowler, DC Hay
    Arch. Toxicol., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. DOT1L safeguards cartilage homeostasis and protects against osteoarthritis
    Authors: S Monteagudo, FMF Cornelis, C Aznar-Lope, P Yibmantasi, LA Guns, P Carmeliet, F Cailotto, RJ Lories
    Nat Commun, 2017;8(0):15889.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling
    Authors: KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton
    Cell Stem Cell, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. A process engineering approach to increase organoid yield
    Authors: N Arora, J Imran Also, JW Guggenheim, M Mak, J Munera, JM Wells, RD Kamm, HH Asada, SY Shvartsman, LG Griffith
    Development, 2017;144(6):1128-1136.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Suppression of Wnt Signaling and Osteogenic Changes in Vascular Smooth Muscle Cells by Eicosapentaenoic Acid.
    Authors: Yukihiro Saito, Kazufumi Nakamura, Daiji Miura, Kei Yunoki, Toru Miyoshi, Masashi Yoshida, Norifumi Kawakita, Tomonari Kimura, Megumi Kondo, Toshihiro Sarashina, Satoshi Akagi, Atsuyuki Watanabe, Nobuhiro Nishii, Hiroshi Morita, Hiroshi Ito
    Nutrients, 2017;0(0):2072-6643.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  109. Dishevelled stability is positively regulated by PKC?-mediated phosphorylation induced by Wnt agonists
    Authors: DM Velázquez, MC Castañeda-, M Robles-Flo
    Cell. Signal., 2017;35(0):107-117.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Wnts contribute to neuromuscular junction formation through distinct signaling pathways
    Authors: J Messéant, J Ezan, P Delers, K Glebov, C Marchiol, F Lager, G Renault, F Tissir, M Montcouqui, N Sans, C Legay, L Strochlic
    Development, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells
    Authors: T Nakamura, T Hosoyama, J Murakami, M Samura, K Ueno, H Kurazumi, R Suzuki, A Mikamo, K Hamano
    Biochem. Biophys. Res. Commun., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming
    Authors: S Miura, A Suzuki
    Cell Stem Cell, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  113. The LncRNA ZBED3-AS1 induces chondrogenesis of human synovial fluid mesenchymal stem cells
    Authors: F Ou, K Su, J Sun, W Liao, Y Yao, Y Zheng, Z Zhang
    Biochem. Biophys. Res. Commun., 2017;487(2):457-463.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  114. AKAP2 is upregulated in ovarian cancer, and promotes growth and migration of cancer cells
    Authors: X Li, C Wang, G Zhang, M Liang, B Zhang
    Mol Med Rep, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Multilineage communication regulates human liver bud development from pluripotency
    Authors: JG Camp, K Sekine, T Gerber, H Loeffler-W, H Binder, M Gac, S Kanton, J Kageyama, G Damm, D Seehofer, L Belicova, M Bickle, R Barsacchi, R Okuda, E Yoshizawa, M Kimura, H Ayabe, H Taniguchi, T Takebe, B Treutlein
    Nature, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Physico-electrochemical Characterization of Pluripotent Stem Cells during Self-Renewal or Differentiation by a Multi-modal Monitoring System
    Authors: K Low, LY Wong, M Maldonado, C Manjunath, CB Horner, M Perez, NV Myung, J Nam
    Stem Cell Reports, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Effects of hepatitis C virus core protein and nonstructural protein 4B on the Wnt/?-catenin pathway
    Authors: XH Jiang, YT Xie, YP Cai, J Ren, T Ma
    BMC Microbiol., 2017;17(1):124.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  118. The N-glycome of embryonic stem cells and thereof differentiated hepatic cells
    Authors: H Montacir, N Freyer, F Knoespel, T Urbaniak, T Dedova, M Berger, G Damm, R Tauber, K Zeilinger, V Blanchard
    Chembiochem, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  119. LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974
    Authors: J Jang, Y Jung, Y Kim, EH Jho, Y Yoon
    Sci Rep, 2017;7(0):41612.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Establishment of a refined culture method for rat colon organoids
    Authors: H Isshiki, Y Arimura, K Nagaishi, K Kawakami, K Onodera, K Yamashita, Y Naishiro, M Fujimiya, K Imai, Y Shinomura
    Biochem. Biophys. Res. Commun., 2017;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Notch/Wnt cross-signalling regulates stemness of dental pulp stem cells through expression of neural crest and core pluripotency factors
    Authors: V Uribe-Etxe, J Luzuriaga, P García-Gal, A Agliano, F Unda, G Ibarretxe
    Eur Cell Mater, 2017;34(0):249-270.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Beta-catenin inhibitor BC2059 is efficacious as monotherapy or in combination with proteasome inhibitor bortezomib in multiple myeloma
    Authors: I Savvidou, T Khong, A Cuddihy, C McLean, S Horrigan, A Spencer
    Mol. Cancer Ther., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  123. A Novel Positive Feedback Loop Between NTSR1 and Wnt/?-Catenin Contributes to Tumor Growth of Glioblastoma
    Authors: H Xiao, Y Zeng, Q Wang, S Wei, X Zhu
    Cell. Physiol. Biochem., 2017;43(5):2133-2142.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  124. SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/?-catenin signaling through stabilization of the WNT-receptor complex
    Authors: SJ Zhao, YQ Jiang, NW Xu, Q Li, Q Zhang, SY Wang, J Li, YH Wang, YL Zhang, SH Jiang, YJ Wang, YJ Huang, XX Zhang, GA Tian, CC Zhang, YY Lv, M Dai, F Liu, R Zhang, D Zhou, ZG Zhang
    Oncogene, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations
    Authors: Q Gu, J Wang, L Wang, ZX Liu, WW Zhu, YQ Tan, WF Han, J Wu, CJ Feng, JH Fang, L Liu, L Wang, W Li, XY Zhao, BY Hu, J Hao, Q Zhou
    Stem Cell Reports, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  126. Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma
    Authors: PC Sanchez-Di, JC Chang, ES Moses, T Dao, Y Chen, JY Hung
    PLoS ONE, 2017;12(5):e0176879.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  127. WNT/?-catenin pathway modulates the TNF-?-induced inflammatory response in bronchial epithelial cells
    Authors: J Jang, Y Jung, S Chae, SI Chung, SM Kim, Y Yoon
    Biochem. Biophys. Res. Commun, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting ROR?
    Authors: Z Wen, T Pan, S Yang, J Liu, H Tao, Y Zhao, D Xu, W Shao, J Wu, X Liu, Y Wang, J Mao, Y Zhu
    Mol. Cancer, 2017;16(1):20.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Gelatin device for the delivery of growth factors involved in endochondral ossification
    Authors: LA Ahrens, D Vonwil, J Christense, VP Shastri
    PLoS ONE, 2017;12(4):e0175095.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  130. Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity
    Authors: Y Choudhury, YC Toh, J Xing, Y Qu, J Poh, L Huan, HS Tan, R Kanesvaran, H Yu, MH Tan
    Sci Rep, 2017;7(0):41238.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  131. Aristaless Related Homeobox (ARX) Interacts with ?-Catenin, BCL9, and P300 to Regulate Canonical Wnt Signaling
    Authors: IT Cho, Y Lim, JA Golden, G Cho
    PLoS ONE, 2017;12(1):e0170282.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  132. Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors
    Authors: S Premarathn, M Murtaza, N Matigian, LA Jolly, SA Wood
    Sci Rep, 2017;7(1):8109.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  133. Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation In Vitro
    Authors: DS Varghese, S Parween, MT Ardah, BS Emerald, SA Ansari
    Stem Cells Int, 2017;2017(0):2451927.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  134. A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking
    Authors: K Minegishi, M Hashimoto, R Ajima, K Takaoka, K Shinohara, Y Ikawa, H Nishimura, AP McMahon, K Willert, Y Okada, H Sasaki, D Shi, T Fujimori, T Ohtsuka, Y Igarashi, TP Yamaguchi, A Shimono, H Shiratori, H Hamada
    Dev. Cell, 2017;40(5):439-452.e4.
    Species: Mouse
    Sample Types: Whole Embryo
    Applications: Bioassay
  135. Galectin-1 inhibition attenuates profibrotic signaling in hypoxia-induced pulmonary fibrosis
    Authors: JJ Kathiriya, N Nakra, J Nixon, PS Patel, V Vaghasiya, A Alhassani, Z Tian, D Allen-Gips, V Davé
    Cell Death Discov, 2017;3(0):17010.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium
    Authors: N Yucer, M Holzapfel, T Jenkins Vo, L Lenaeus, L Ornelas, A Laury, D Sareen, R Barrett, BY Karlan, CN Svendsen
    Sci Rep, 2017;7(1):10741.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  137. Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells
    Authors: A Asai, E Aihara, C Watson, R Mourya, T Mizuochi, P Shivakumar, K Phelan, C Mayhew, M Helmrath, T Takebe, J Wells, JA Bezerra
    Development, 2017;144(6):1056-1064.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  138. Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells
    Authors: J Yang, Y Wang, T Zhou, LY Wong, XY Tian, X Hong, WH Lai, KW Au, R Wei, Y Liu, LH Cheng, G Liang, Z Huang, W Fan, P Zhao, X Wang, DP Ibañez, Z Luo, Y Li, X Zhong, S Chen, D Wang, L Li, L Lai, B Qin, X Bao, AP Hutchins, CW Siu, Y Huang, MA Esteban, HF Tse
    Stem Cell Reports, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  139. Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth
    Authors: Ronald A DePinho
    Cell, 2016;167(5):1281-1295.e18.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  140. Oncogenic retinoic acid receptor ? promotes human colorectal cancer growth through simultaneously regulating p21 transcription and GSK3?/?-catenin signaling
    Authors: Gui-Li Huang
    Cancer Lett, 2016;388(0):118-129.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  141. Altering the Proteoglycan State of Transforming Growth Factor ? Type III Receptor (T?RIII)/Betaglycan Modulates Canonical Wnt/?-Catenin Signaling
    Authors: Karthikeyan Mythreye
    J. Biol. Chem., 2016;291(49):25716-25728.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  142. Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration
    Stem Cells Transl Med, 2016;5(5):694-702.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  143. Quantifying ?-catenin subcellular dynamics and cyclin D1 mRNA transcription during Wnt signaling in single living cells
    Elife, 2016;5(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  144. Icariin attenuates titanium-particle inhibition of bone formation by activating the Wnt/?-catenin signaling pathway in vivo and in vitro.
    Authors: Junhua Wang, Yunxia Tao, Zichuan Ping, Wen Zhang, Xuanyang Hu, Yijun Wang, Liangliang Wang, Jiawei Shi, Xiexing Wu, Huilin Yang, Yaozeng Xu, Dechun Geng
    Scientific Reports, 2016;0(0):2045-2322.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  145. Expression of adipokines in osteoarthritis osteophytes and their effect on osteoblasts
    Authors: Elena Neumann
    Matrix Biol., 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  146. Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration
    Authors: Yasuhiro Ikeda
    Stem Cells Transl Med, 2016;5(5):694-702.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  147. PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells
    Sci Rep, 2016;6(0):36795.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  148. TNIK inhibition abrogates colorectal cancer stemness
    Nat Commun, 2016;7(0):12586.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  149. Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins
    Proc. Natl. Acad. Sci. U.S.A, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  150. Activation of endothelial ?-catenin signaling induces heart failure
    Sci Rep, 2016;6(0):25009.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  151. Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/?-catenin defects in neuronal cholesterol synthesis phenotypes
    Nat. Med., 2016;22(4):388-96.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  152. ROCK inhibitor primes human induced pluripotent stem cells to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation
    Stem Cell Res, 2016;17(2):222-227.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  153. G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications
    Authors: L J Spicer
    Domest. Anim. Endocrinol, 2016;59(0):90-99.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  154. Active ?-catenin is regulated by the PTEN/PI3 kinase pathway: a role for protein phosphatase PP2A
    Authors: A Persad, G Venkateswa, L Hao, ME Garcia, J Yoon, J Sidhu, S Persad
    Genes Cancer, 2016;7(12):368-382.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  155. Growth hormone is permissive for neoplastic colon growth
    Proc Natl Acad Sci USA, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  156. Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD
    Authors: Hoeke A Baarsma
    J. Exp. Med, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  157. Anthelmintic niclosamide disrupts the interplay of p65 and FOXM1/?-catenin and eradicates leukemia stem cells in chronic myelogenous leukemia
    Clin Cancer Res, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  158. The AKAP GSKIP regulates beta-catenin through both its interactions with PKA and GSK3beta
    J Biol Chem, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  159. Wnt signaling promotes breast cancer by blocking ITCH-mediated degradation of the YAP/TAZ transcriptional coactivator WBP2
    Cancer Res, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  160. The Aryl Hydrocarbon Receptor and Its Ligands Inhibit Myofibroblast Formation and Activation: Implications for Thyroid Eye Disease
    Authors: Richard P Phipps
    Am. J. Pathol., 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  161. A Regulatory Network Involving beta-Catenin, e-Cadherin, PI3k/Akt, and Slug Balances Self-Renewal and Differentiation of Human Pluripotent Stem Cells In Response to Wnt Signaling.
    Authors: Huang T, Li L, Moalim-Nour L, Jia D, Bai J, Yao Z, Bennett S, Figeys D, Wang L
    Stem Cells, 2015;33(5):1419-33.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  162. Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy.
    Authors: Williams K, Bundred N, Landberg G, Clarke R, Farnie G
    Stem Cells, 2015;33(2):327-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  163. A protein kinase A (PKA)/beta-catenin pathway sustains the BMP2/DLX3-induced osteogenic differentiation in dental follicle cells (DFCs).
    Authors: Viale-Bouroncle S, Klingelhoffer C, Ettl T, Reichert T, Morsczeck C
    Cell Signal, 2015;27(3):598-605.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  164. Tumour suppressor TRIM33 targets nuclear beta-catenin degradation.
    Authors: Xue J, Chen Y, Wu Y, Wang Z, Zhou A, Zhang S, Lin K, Aldape K, Majumder S, Lu Z, Huang S
    Nat Commun, 2015;6(0):6156.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  165. Hepcidin regulation in prostate and its disruption in prostate cancer.
    Authors: Tesfay L, Clausen K, Kim J, Hegde P, Wang X, Miller L, Deng Z, Blanchette N, Arvedson T, Miranti C, Babitt J, Lin H, Peehl D, Torti F, Torti S
    Cancer Res, 2015;75(11):2254-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  166. Canonical Wnt pathway inhibitor ICG-001 induces cytotoxicity of multiple myeloma cells in Wnt-independent manner.
    Authors: Grigson E, Ozerova M, Pisklakova A, Liu H, Sullivan D, Nefedova Y
    PLoS ONE, 2015;10(1):e0117693.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  167. Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia.
    Authors: Kuhnl A, Valk P, Sanders M, Ivey A, Hills R, Mills K, Gale R, Kaiser M, Dillon R, Joannides M, Gilkes A, Haferlach T, Schnittger S, Duprez E, Linch D, Delwel R, Lowenberg B, Baldus C, Solomon E, Burnett A, Grimwade D
    Blood, 2015;125(19):2985-94.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  168. Endogenously produced Indian Hedgehog regulates TGFbeta-driven chondrogenesis of human bone marrow stromal/stem cells.
    Authors: Handorf A, Chamberlain C, Li W
    Stem Cells Dev, 2015;24(8):995-1007.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  169. Characterization and propagation of tumor initiating cells derived from colorectal liver metastases: trials, tribulations and a cautionary note.
    Authors: James M, Howells L, Karmokar A, Higgins J, Greaves P, Cai H, Dennison A, Metcalfe M, Garcea G, Lloyd D, Berry D, Steward W, Brown K
    PLoS ONE, 2015;10(2):e0117776.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  170. Resveratrol ameliorates the maturation process of beta-cell-like cells obtained from an optimized differentiation protocol of human embryonic stem cells.
    Authors: Pezzolla D, Lopez-Beas J, Lachaud C, Dominguez-Rodriguez A, Smani T, Hmadcha A, Soria B
    PLoS ONE, 2015;10(3):e0119904.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  171. Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells.
    Authors: Iyer D, Gambardella L, Bernard W, Serrano F, Mascetti V, Pedersen R, Talasila A, Sinha S
    Development, 2015;142(8):1528-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  172. Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells.
    Authors: Wong, Amy P, Chin, Stephani, Xia, Sunny, Garner, Jodi, Bear, Christin, Rossant, Janet
    Nat Protoc, 2015;10(3):363-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  173. microRNA-103/107 Family Regulates Multiple Epithelial Stem Cell Characteristics.
    Authors: Peng H, Park J, Katsnelson J, Kaplan N, Yang W, Getsios S, Lavker R
    Stem Cells, 2015;33(5):1642-56.
  174. Transcription factor binding dynamics during human ES cell differentiation.
    Authors: Tsankov, Alexande, Gu, Hongcang, Akopian, Veronika, Ziller, Michael, Donaghey, Julie, Amit, Ido, Gnirke, Andreas, Meissner, Alexande
    Nature, 2015;518(7539):344-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  175. Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis.
    Authors: Kim M, Horst A, Blinka S, Stamm K, Mahnke D, Schuman J, Gundry R, Tomita-Mitchell A, Lough J
    PLoS ONE, 2015;10(2):e0118670.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  176. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D'Souza S, Snoeck H
    Nat Protoc, 2015;10(3):413-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  177. Novel cancer chemotherapy hits by molecular topology: dual Akt and Beta-catenin inhibitors.
    Authors: Zanni R, Galvez-Llompart M, Morell C, Rodriguez-Henche N, Diaz-Laviada I, Recio-Iglesias M, Garcia-Domenech R, Galvez J
    PLoS ONE, 2015;10(4):e0124244.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  178. Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development.
    Authors: Chang B, Tessneer K, McManus J, Liu X, Hahn S, Pasula S, Wu H, Song H, Chen Y, Cai X, Dong Y, Brophy M, Rahman R, Ma J, Xia L, Chen H
    Nat Commun, 2015;6(0):6380.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  179. Transcriptome analysis of wnt3a-treated triple-negative breast cancer cells.
    Authors: Maubant S, Tesson B, Maire V, Ye M, Rigaill G, Gentien D, Cruzalegui F, Tucker G, Roman-Roman S, Dubois T
    PLoS ONE, 2015;10(4):e0122333.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  180. Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1.
    Authors: Tamminen K, Balboa D, Toivonen S, Pakarinen M, Wiener Z, Alitalo K, Otonkoski T
    PLoS ONE, 2015;10(7):e0134551.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  181. WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells.
    Authors: Ekstrom E, Bergenfelz C, von Bulow V, Serifler F, Carlemalm E, Jonsson G, Andersson T, Leandersson K
    Mol Cancer, 2014;13(0):88.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  182. A synthetic peptide-acrylate surface for production of insulin-producing cells from human embryonic stem cells.
    Authors: Lin P, Hung S, Yang Y, Liao L, Hsieh Y, Yen H, Lu H, Lee M, Chu I, Hwang S
    Stem Cells Dev, 2014;23(4):372-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  183. A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells.
    Authors: Cecchelli R, Aday S, Sevin E, Almeida C, Culot M, Dehouck L, Coisne C, Engelhardt B, Dehouck M, Ferreira L
    PLoS ONE, 2014;9(6):e99733.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  184. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers.
    Authors: Lam A, Freedman B, Morizane R, Lerou P, Valerius M, Bonventre J
    J Am Soc Nephrol, 2014;25(6):1211-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  185. Brivanib attenuates hepatic fibrosis in vivo and stellate cell activation in vitro by inhibition of FGF, VEGF and PDGF signaling.
    Authors: Nakamura I, Zakharia K, Banini B, Mikhail D, Kim T, Yang J, Moser C, Shaleh H, Thornburgh S, Walters I, Roberts L
    PLoS ONE, 2014;9(4):e92273.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  186. WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment.
    Authors: Hwang Y, Suk S, Shih Y, Seo T, Du B, Xie Y, Li Z, Varghese S
    Sci Rep, 2014;4(0):5916.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  187. Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility.
    Authors: Meinhardt G, Haider S, Haslinger P, Proestling K, Fiala C, Pollheimer J, Knofler M
    Endocrinology, 2014;155(5):1908-20.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  188. High efficient differentiation of functional hepatocytes from porcine induced pluripotent stem cells.
    Authors: Ao, Ying, Mich-Basso, Jocelyn, Lin, Bo, Yang, Lei
    PLoS ONE, 2014;9(6):e100417.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  189. Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation.
    Authors: Hirata, Naoya, Yamada, Shigeru, Shoda, Takuji, Kurihara, Masaaki, Sekino, Yuko, Kanda, Yasunari
    Nat Commun, 2014;5(0):4806.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  190. Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro.
    Authors: Pethe, Prasad, Nagvenkar, Punam, Bhartiya, Deepa
    BMC Cell Biol, 2014;15(0):18.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  191. Whole-exome sequencing reveals LRP5 mutations and canonical Wnt signaling associated with hepatic cystogenesis.
    Authors: Cnossen W, te Morsche R, Hoischen A, Gilissen C, Chrispijn M, Venselaar H, Mehdi S, Bergmann C, Veltman J, Drenth J
    Proc Natl Acad Sci U S A, 2014;111(14):5343-8.
  192. Efficient programming of human eye conjunctiva-derived induced pluripotent stem (ECiPS) cells into definitive endoderm-like cells.
    Authors: Massumi M, Hoveizi E, Baktash P, Hooti A, Ghazizadeh L, Nadri S, Pourasgari F, Hajarizadeh A, Soleimani M, Nabiuni M, Khorramizadeh M
    Exp Cell Res, 2014;322(1):51-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  193. An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells.
    Authors: Listerman I, Gazzaniga F, Blackburn E
    Mol Cell Biol, 2014;34(2):280-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  194. Drugging a stem cell compartment using Wnt3a protein as a therapeutic.
    Authors: Dhamdhere, Girija R, Fang, Mark Y, Jiang, Jie, Lee, Katherin, Cheng, Du, Olveda, Rebecca, Liu, Bo, Mulligan, Kimberle, Carlson, Jeffery, Ransom, Ryan C, Weis, William, Helms, Jill A
    PLoS ONE, 2014;9(1):e83650.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  195. Interleukin-1beta-induced Wnt5a enhances human corneal endothelial cell migration through regulation of Cdc42 and RhoA.
    Authors: Lee J, Heur M
    Mol Cell Biol, 2014;34(18):3535-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  196. Pigment epithelium-derived factor 34-mer peptide prevents liver fibrosis and hepatic stellate cell activation through down-regulation of the PDGF receptor.
    Authors: Tsai T, Shih S, Ho T, Ma H, Liu M, Chen S, Tsao Y
    PLoS ONE, 2014;9(4):e95443.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  197. Wnts enhance neurotrophin-induced neuronal differentiation in adult bone-marrow-derived mesenchymal stem cells via canonical and noncanonical signaling pathways.
    Authors: Tsai H, Deng W, Lai W, Chiu W, Yang C, Tsai Y, Hwang S, Renshaw P
    PLoS ONE, 2014;9(8):e104937.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  198. Differentiation of human pluripotent stem cells into nephron progenitor cells in a serum and feeder free system.
    Authors: Kang, Minyong, Han, Yong-Mah
    PLoS ONE, 2014;9(4):e94888.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  199. Type I collagen as an extracellular matrix for the in vitro growth of human small intestinal epithelium.
    Authors: Jabaji Z, Brinkley G, Khalil H, Sears C, Lei N, Lewis M, Stelzner M, Martin M, Dunn J
    PLoS ONE, 2014;9(9):e107814.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  200. RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer.
    Authors: Wu C, Qiu S, Lu L, Zou J, Li W, Wang O, Zhao H, Wang H, Tang J, Chen L, Xu T, Sun Z, Liao W, Luo G, Lu X
    Nat Commun, 2014;5(0):3149.
  201. Tissue-engineered vascular grafts created from human induced pluripotent stem cells.
    Authors: Sundaram S, One J, Siewert J, Teodosescu S, Zhao L, Dimitrievska S, Qian H, Huang A, Niklason L
    Stem Cells Transl Med, 2014;3(12):1535-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  202. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
    Authors: Carmon K, Gong X, Yi J, Thomas A, Liu Q
    Proc Natl Acad Sci U S A, 2014;111(13):E1221-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  203. Zrf1 is required to establish and maintain neural progenitor identity.
    Authors: Aloia L, Di Stefano B, Sessa A, Morey L, Santanach A, Gutierrez A, Cozzuto L, Benitah S, Graf T, Broccoli V, Di Croce L
    Genes Dev, 2014;28(2):182-97.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  204. miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFbeta and Wnt signaling.
    Authors: Emmrich S, Rasche M, Schoning J, Reimer C, Keihani S, Maroz A, Xie Y, Li Z, Schambach A, Reinhardt D, Klusmann J
    Genes Dev, 2014;28(8):858-74.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  205. Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity.
    Authors: Kilander M, Dahlstrom J, Schulte G
    Cell Signal, 2014;26(9):1943-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  206. CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis.
    Authors: Todaro M, Gaggianesi M, Catalano V, Benfante A, Iovino F, Biffoni M, Apuzzo T, Sperduti I, Volpe S, Cocorullo G, Gulotta G, Dieli F, De Maria R, Stassi G
    Cell Stem Cell, 2014;14(3):342-56.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  207. sRNA-seq analysis of human embryonic stem cells and definitive endoderm reveals differentially expressed microRNAs and novel IsomiRs with distinct targets.
    Authors: Hinton A, Hunter S, Afrikanova I, Jones G, Lopez A, Fogel G, Hayek A, King C
    Stem Cells, 2014;32(9):2360-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  208. Luminal microbes promote monocyte-stem cell interactions across a healthy colonic epithelium.
    Authors: Skoczek D, Walczysko P, Horn N, Parris A, Clare S, Williams M, Sobolewski A
    J Immunol, 2014;193(1):439-51.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  209. beta-catenin promotes the type I IFN synthesis and the IFN-dependent signaling response but is suppressed by influenza A virus-induced RIG-I/NF-kappaB signaling.
    Authors: Hillesheim A, Nordhoff C, Boergeling Y, Ludwig S, Wixler V
    Cell Commun Signal, 2014;12(0):29.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  210. Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells.
    Authors: Lin, I-Ying, Chiu, Feng-Lan, Yeang, Chen-Hsi, Chen, Hsin-Fu, Chuang, Ching-Yu, Yang, Shii-Yi, Hou, Pei-Shan, Sintupisut, Nardnisa, Ho, Hong-Ner, Kuo, Hung-Chi, Lin, Kuo-I
    Stem Cell Reports, 2014;2(2):189-204.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  211. Generation of bladder urothelium from human pluripotent stem cells under chemically defined serum- and feeder-free system.
    Authors: Kang, Minyong, Kim, Hyeon Ho, Han, Yong-Mah
    Int J Mol Sci, 2014;15(5):7139-57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  212. Glycogen synthase kinase 3 inhibitors induce the canonical WNT/beta-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma.
    Authors: Chen E, DeRan M, Ignatius M, Grandinetti K, Clagg R, McCarthy K, Lobbardi R, Brockmann J, Keller C, Wu X, Langenau D
    Proc Natl Acad Sci U S A, 2014;111(14):5349-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  213. Canonical Wnt signaling skews TGF-beta signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8.
    Authors: van den Bosch M, Blom A, van Lent P, van Beuningen H, Blaney Davidson E, van der Kraan P, van den Berg W
    Cell Signal, 2014;26(5):951-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  214. Nodal.Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation.
    Authors: Fuerer C, Nostro M, Constam D
    J Biol Chem, 2014;289(25):17854-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  215. Influence of in vitro and in vivo oxygen modulation on beta cell differentiation from human embryonic stem cells.
    Authors: Cechin S, Alvarez-Cubela S, Giraldo J, Molano R, Villate S, Ricordi C, Pileggi A, Inverardi L, Fraker C, Dominguez-Bendala J
    Stem Cells Transl Med, 2014;3(3):277-89.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  216. Modulation of stemness in a human normal intestinal epithelial crypt cell line by activation of the WNT signaling pathway.
    Authors: Guezguez A, Pare F, Benoit Y, Basora N, Beaulieu J
    Exp Cell Res, 2014;322(2):355-64.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  217. The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of beta-catenin through mechanisms involving FRAT1 and PAK4.
    Authors: Jin R, Liu W, Menezes S, Yue F, Zheng M, Kovacevic Z, Richardson D
    J Cell Sci, 2014;127(0):3116-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  218. Wnt/beta-catenin signaling regulates the proliferation and differentiation of mesenchymal progenitor cells through the p53 pathway.
    Authors: Peng X, Yang L, Chang H, Dai G, Wang F, Duan X, Guo L, Zhang Y, Chen G
    PLoS ONE, 2014;9(5):e97283.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  219. Protein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell lines.
    Authors: Hernandez-Maqueda J, Luna-Ulloa L, Santoyo-Ramos P, Castaneda-Patlan M, Robles-Flores M
    PLoS ONE, 2013;8(3):e58540.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  220. Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer.
    Authors: Rasmussen N, Wright T, Brooks S, Hacker K, Debebe Z, Sendor A, Walker M, Major M, Green J, Wahl G, Rathmell W
    J Biol Chem, 2013;288(36):26301-10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  221. Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo.
    Authors: Rezania A, Bruin J, Xu J, Narayan K, Fox J, O'Neil J, Kieffer T
    Stem Cells, 2013;31(11):2432-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  222. Caveolin-1-LRP6 signaling module stimulates aerobic glycolysis in prostate cancer.
    Authors: Tahir S, Yang G, Goltsov A, Song K, Ren C, Wang J, Chang W, Thompson T
    Cancer Res, 2013;73(6):1900-11.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  223. Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells.
    Authors: Thatava T, Kudva Y, Edukulla R, Squillace K, De Lamo J, Khan Y, Sakuma T, Ohmine S, Terzic A, Ikeda Y
    Mol Ther, 2013;21(1):228-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  224. Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors.
    Cell Signal, 2013;25(1):178-89.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  225. IQGAP1 protein regulates nuclear localization of beta-catenin via importin-beta5 protein in Wnt signaling.
    Authors: Goto T, Sato A, Adachi S, Iemura S, Natsume T, Shibuya H
    J Biol Chem, 2013;288(51):36351-60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  226. Generation of multipotent foregut stem cells from human pluripotent stem cells.
    Authors: Hannan, Nicholas, Fordham, Robert P, Syed, Yasir A, Moignard, Victoria, Berry, Andrew, Bautista, Ruben, Hanley, Neil A, Jensen, Kim B, Vallier, Ludovic
    Stem Cell Reports, 2013;1(4):293-306.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  227. Atypical protein kinase Ciota is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2.
    Authors: Greer Y, Fields A, Brown A, Rubin J
    J Biol Chem, 2013;288(13):9438-46.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  228. The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer.
    Authors: Loh Y, Hedditch E, Baker L, Jary E, Ward R, Ford C
    BMC Cancer, 2013;13(0):174.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  229. Activation of the Wnt pathway through AR79, a GSK3beta inhibitor, promotes prostate cancer growth in soft tissue and bone.
    Authors: Jiang Y, Dai J, Zhang H, Sottnik J, Keller J, Escott K, Sanganee H, Yao Z, McCauley L, Keller E
    Mol Cancer Res, 2013;11(12):1597-610.
  230. The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells.
    Authors: Ichii, Michiko, Frank, Mark Bar, Iozzo, Renato V, Kincade, Paul W
    Blood, 2012;119(7):1683-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  231. Wnt5a and Wnt11 are essential for second heart field progenitor development.
    Authors: Cohen E, Miller M, Wang Z, Moon R, Morrisey E
    Development, 2012;139(11):1931-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  232. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012;487(7408):505-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  233. FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells.
    Authors: Sui L, Mfopou J, Geens M, Sermon K, Bouwens L
    Biochem Biophys Res Commun, 2012;426(3):380-5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  234. The hedgehog system in ovarian follicles of cattle selected for twin ovulations and births: evidence of a link between the IGF and hedgehog systems.
    Authors: Aad, Pauline, Echternkamp, Sherrill, Sypherd, David D, Schreiber, Nicole B, Spicer, Leon J
    Biol Reprod, 2012;87(4):79.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  235. Derivation of cerebellar neurons from human pluripotent stem cells.
    Authors: Erceg S, Lukovic D, Moreno-Manzano V, Stojkovic M, Bhattacharya S
    Curr Protoc Stem Cell Biol, 2012;20(0):1H.51.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  236. Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells.
    Authors: Prabakar K, Dominguez-Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, Inverardi L
    Cell Transplant, 2012;21(6):1321-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  237. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.
    Authors: Spence JR, Mayhew CN, Rankin SA
    Nature, 2011;470(7332):105-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  238. High levels of beta-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway.
    Authors: Liu N, Shi S, Deng M, Tang L, Zhang G, Liu N, Ding B, Liu W, Liu Y, Shi H, Liu L, Jin Y
    J. Bone Miner. Res., 2011;26(9):2082-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  239. NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis.
    Authors: Kohler EE, Cowan CE, Chatterjee I
    Blood, 2011;117(5):1761-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  240. Evidence for altered Wnt signaling in psoriatic skin.
    Authors: Gudjonsson JE, Johnston A, Stoll SW
    J. Invest. Dermatol., 2010;130(7):1849-59.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  241. Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells.
    Authors: Liu G, Vijayakumar S, Grumolato L, Arroyave R, Qiao H, Akiri G, Aaronson SA
    J. Cell Biol., 2009;185(1):67-75.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  242. Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion.
    Authors: Henry C, Llamosas E, Knipprath-Meszaros A, Schoetzau A, Obermann E, Fuenfschilling M, Caduff R, Fink D, Hacker N, Ward R, Heinzelmann-Schwarz V, Ford C
    Oncotarget, 0;6(37):40310-26.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. Can I reconstitute Recombinant Human Wnt-3a Protein (catalog # 5036-WN) at a different concentration than recommended?

     

     

    • We cannot guarantee the performance if the protein is reconstituted at a different concentration than recommended in the product datasheet. Please contact Technical Service if you have any questions or concerns about reconstitution.

  2. Can I reconstitute Recombinant Human Wnt-3a Protein (catalog # 5036-WN) in a different buffer than recommended?

    • For best recovery, stability, and activity, the protein should be reconstituted in the buffer recommended on the product datasheet. Stability testing has been evaluated under these conditions; we can support the performance under these reconstitution conditions.

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Reviews for Recombinant Human Wnt-3a Protein

Average Rating: 4.6 (Based on 18 Reviews)

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Recombinant Human Wnt-3a Protein
By Anonymous on 07/20/2021
Application: CellProlif
Reason for Rating: This product works good.

Use the final concentration that is recommended, don't make the final concentration very low. Hek293SFT cells were treated with different concentrations of wnt3a, and topflash assay was performed to detect the luciferase activity of wnt3a.


Recombinant Human Wnt-3a Protein
By Anonymous on 01/02/2021
Application: Cell Culture

Recombinant Human Wnt-3a Protein
By Anonymous on 11/06/2020
Application: Enzymatic activity in vitro

HepG2 cells were treated with 100 ng/ml Wnt3a for 2 days, following which the LDH activity of cell culture medium samples were assayed. The result shows that Wnt3a increased LDH release in HepG2 cells.


Recombinant Human Wnt-3a Protein
By Anonymous on 02/16/2020
Application: SDS-PAGE Control
Reason for Rating: Recombinant Wnt3a product was added to activate Wnt/ beta -catenin signaling pathway.

Recombinant Human Wnt-3a Protein
By Anonymous on 12/16/2018
Application: In vitro bioactivity in cell culture
Reason for Rating: This protein (200 ng/mL) works well for activating Wnt signaling as shown by Topflash luciferase activity.

Recombinant Human Wnt-3a Protein
By Anonymous on 10/27/2018
Application: In vitro bioactivity in cell culture
Reason for Rating: The product worked to activate Wnt signaling in breast cancer cells with a Wnt reporter, however performed less well than supernatants from L cell Wnt3a lines.

Recombinant Wnt3a product was added at 100 ng/mL for 2 days on 7TGC reporter cell lines. Activation was measured with GFP levels by Flow.


Recombinant Human Wnt-3a Protein
By Anonymous on 10/17/2018
Application: CellProlif

Recombinant Human Wnt-3a Protein
By Anonymous on 12/06/2017
Application: In vitro bioactivity in cell culture

Recombinant Human Wnt-3a Protein
By Anonymous on 06/07/2017
Application: In vitro bioactivity in cell culture

Recombinant Human Wnt-3a Protein
By Anonymous on 03/14/2017
Application: Cell migration/motility

Cell motility assay performed with MA-11 cells untreated (A) and treated (B) for 72 hours with R&D Recombinant Human Wnt-3a (#5036-WN/CF) at 250 ng/mL.


Recombinant Human Wnt-3a Protein
By Anonymous on 12/15/2016
Application: Stem/Immune cell maintenance or differentiation

We use for stem cell maintenance and differentiation.


Recombinant Human Wnt-3a Protein
By Anonymous on 12/15/2016
Application: Stem/Immune cell maintenance or differentiation

We use this product for our neuron stem cells studies.


Recombinant Human Wnt-3a Protein
By Anonymous on 11/11/2016
Application: In vitro bioactivity in cell culture
Reason for Rating: It works well.

I tested the activity of the recombinant protein in the HEK293 Top Flash Reporter cell lines. LiCl was used as a positive control.


Recombinant Human Wnt-3a Protein
By Anonymous on 08/08/2016
Application: Luciferase reporter activity (TOPFlash for Wnt activity) was performed in cultured cells.

Luciferase reporter activity by TOPFlash/FOPFlash for Wnt/B-catenin activity was performed in cultured cells. Cells were transfected for 48 hours with plasmid and treated with Wnt3a for 24 hours prior to performing Dual-Glo luciferase assay.


Recombinant Human Wnt-3a Protein
By Anonymous on 05/13/2016
Application: Stem/Immune cell maintenance or differentiation
Reason for Rating: We attempted to use the product to induce skeletal muscle differentiation in Mus musculus stem cells, but our results suggest differentiation to cardiomyocytes.

Recombinant Human Wnt-3a Protein
By Anonymous on 01/15/2016
Application: CellProlif

Recombinant Human Wnt-3a Protein
By Anonymous on 01/13/2016
Application: SDS-PAGE Control
Reason for Rating: I have used Wnt3a routinely to stimulate primary cells in culture. I have obtained consistent results with reproducible data.

Recombinant Human Wnt-3a Protein
By Anonymous on 01/13/2016
Application: Media additive for protein or antibody production
Reason for Rating: This protein works very well for activating Wnt signaling as shown by B-catenin expression.