Recombinant Human EGF Protein, CF 236-EG-200: R&D Systems

Recombinant Human EGF Protein, CF

(220 citations)
(6 Reviews)
  
  • Purity
    >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Endotoxin Level
    <0.10 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Rubin, J.S. et al. (1991) Proc. Natl. Acad. Sci. USA 88:415. The ED50 for this effect is 20-100 pg/mL.
    The specific activity of Recombinant Human EGF is approximately 1.4 x 103 IU/μg, which is calibrated against human EGF WHO International Standard (NIBSC code: 91/530).
  • Source
    E. coli-derived Asn971-Arg1023, with an N-terminal Met
  • Accession #
  • N-terminal Sequence
    Analysis
    Met
  • Predicted Molecular Mass
    6 kDa
  • SDS-PAGE
    6 kDa, reducing conditions
236-EG
 
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 500 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Data Images
Recombinant Human EGF (Catalog # 236‑EG) stimulates cell proliferation of the Balb/3T3 mouse embryonic fibroblast cell line. The ED50 for this effect is 20‑100 pg/mL.
1 µg/lane of Recombinant Human EGF was resolved with SDS-PAGE  and visualized by silver staining under reducing (R) conditions, showing a single band at 6 kDa.
Background: EGF
Epidermal growth factor (EGF) is the founding member of the EGF family that also includes TGF-alpha, amphiregulin (AR), betacellulin (BTC), epiregulin (EPR), heparin‑binding EGF‑like growth factor (HB‑EGF), epigen, and the neuregulins (NRG)-1 through -6 (1). Members of the EGF family share a structural motif, the EGF‑like domain, which is characterized by three intramolecular disulfide bonds that are formed by six similarly spaced conserved cysteine residues (2). All EGF family members are synthesized as type I transmembrane precursor proteins that may contain several EGF domains in the extracellular region. The mature proteins are released from the cell surface by regulated proteolysis (1). The 1207 amino acid (aa) human EGF precursor contains nine EGF domains and nine LDLR class B repeats. The mature protein consists of 53 aa and is generated by proteolytic excision of the EGF domain proximal to the transmembrane region (3). Mature human EGF shares 70% aa sequence identity with mature mouse and rat EGF. EGF is present in various body fluids, including blood, milk, urine, saliva, seminal fluid, pancreatic juice, cerebrospinal fluid, and amniotic fluid (4). Four ErbB (HER) family receptor tyrosine kinases including EGFR/ErbB1, ErbB2, ErbB3 and ErbB4, mediate responses to EGF family members (5). These receptors undergo a complex pattern of ligand induced homo- or hetero-dimerization to transduce EGF family signals (6, 7). EGF binds ErbB1 and depending on the context, induces the formation of homodimers or heterodimers containing ErbB2. Dimerization results in autophosphorylation of the receptor at specific tyrosine residues to create docking sites for a variety of signaling molecules (5, 8). Biological activities ascribed to EGF include epithelial development, angiogenesis, inhibition of gastric acid secretion, fibroblast proliferation, and colony formation of epidermal cells in culture.
  • References:
    1. Harris, R.C. et al. (2003) Exp. Cell Res. 284:2.
    2. Carpenter, G. and Cohen, S. (1990) J. Biol. Chem. 265:7709.
    3. Bell, G.I. et al. (1986) Nucl. Acids Res. 14:8427.
    4. Carpenter, G. and Zendegui, J.G. (1986) Exp. Cell Res. 164:1.
    5. Jorissen, R.N. et al. (2003) Exp. Cell Res. 284:31.
    6. Gamett, D.C. et al. (1997) J. Biol. Chem. 272:12052.
    7. Qian, X. et al. (1994) Proc. Natl. Acad. Sci. 91:1500.
    8. Qian, X. et al. (1999) J. Biol. Chem. 274:574.
  • Long Name:
    Epidermal Growth Factor
  • Entrez Gene IDs:
    1950 (Human); 13645 (Mouse); 25313 (Rat)
  • Alternate Names:
    beta-urogastrone; EGF; epidermal growth factor (beta-urogastrone); epidermal growth factor; HOMG4; pro-epidermal growth factor; URG; Urogastrone
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

220 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial-mesenchymal transition in cancer
    Authors: NV Sankpal, TP Fleming, PK Sharma, HJ Wiedner, WE Gillanders
    Oncogene, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  2. Applying phasor approach analysis of multiphoton FLIM measurements to probe the metabolic activity of three-dimensional in vitro cell culture models
    Authors: PH Lakner, MG Monaghan, Y Möller, MA Olayioye, K Schenke-La
    Sci Rep, 2017;7(0):42730.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  3. Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity
    Authors: S Fu, H Xu, M Gu, C Liu, Q Wang, X Wan, Y Chen, Q Chen, Y Peng, Z Cai, J Zhou, Z Wang
    Sci Rep, 2017;7(0):43771.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  4. A Core Regulatory Circuit in Glioblastoma Stem Cells Links MAPK Activation to a Transcriptional Program of Neural Stem Cell Identity
    Authors: G Riddick, S Kotliarova, V Rodriguez, HS Kim, A Linkous, AJ Storaska, S Ahn, J Walling, G Belova, HA Fine
    Sci Rep, 2017;7(0):43605.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  5. Heat Shock Factor 1 Depletion Sensitizes A172 Glioblastoma Cells to Temozolomide via Suppression of Cancer Stem Cell-Like Properties
    Authors: CN Im, HH Yun, JH Lee
    Int J Mol Sci, 2017;18(2):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  6. Human cytomegalovirus interleukin-10 enhances matrigel invasion of MDA-MB-231 breast cancer cells
    Authors: CA Valle Oseg, JV Spencer
    Cancer Cell Int, 2017;17(0):24.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  7. RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells
    Authors: HO King, T Brend, HL Payne, A Wright, TA Ward, K Patel, T Egnuni, LF Stead, A Patel, H Wurdak, SC Short
    Stem Cell Reports, 2017;8(1):125-139.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  8. Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma
    Authors: A Almazán-Mo, P Zarzosa, I Vidal, C Molist, I Giralt, N Navarro, A Soriano, MF Segura, A Alfranca, J Garcia-Cas, J Sánchez de, J Roma, S Gallego
    Stem Cells Int, 2017;2017(0):7507380.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  9. Geometry and network connectivity govern the mechanics of stress fibers
    Authors: E Kassianido, CA Brand, US Schwarz, S Kumar
    Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  10. Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3
    Authors: H He, AE Kuriyan, CW Su, M Mahabole, Y Zhang, YT Zhu, HW Flynn, JM Parel, SC Tseng
    Sci Rep, 2017;7(0):43736.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  11. Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy
    Authors: R Horibe, Y Hirohashi, T Asano, T Mariya, T Suzuki, A Takaya, H Saijo, Y Shionoya, T Kubo, M Nakatsugaw, T Kanaseki, T Tsukahara, K Watanabe, E Atsuyama, S Toji, H Hirano, T Hasegawa, H Takahashi, N Sato, T Torigoe
    PLoS ONE, 2017;12(3):e0171460.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  12. Regulation of stem-like cancer cells by glutamine through ?-catenin pathway mediated by redox signaling
    Authors: J Liao, PP Liu, G Hou, J Shao, J Yang, K Liu, W Lu, S Wen, Y Hu, P Huang
    Mol. Cancer, 2017;16(1):51.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  13. Dental pulp pluripotent-like stem cells (DPPSC), a new stem cell population with chromosomal stability and osteogenic capacity for biomaterials evaluation
    Authors: R Núñez-Told, E Martínez-S, C Gil-Recio, MÁ Carrasco, A Al Madhoun, S Montori, M Atari
    BMC Cell Biol., 2017;18(1):21.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  14. Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3K?-selective Inhibitors in Breast Cancer
    Authors: YC Xu, X Wang, Y Chen, SM Chen, XY Yang, YM Sun, MY Geng, J Ding, LH Meng
    Theranostics, 2017;7(4):974-986.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  15. Purine synthesis promotes maintenance of brain tumor initiating cells in glioma
    Authors: X Wang, K Yang, Q Xie, Q Wu, SC Mack, Y Shi, LJ Kim, BC Prager, WA Flavahan, X Liu, M Singer, CG Hubert, TE Miller, W Zhou, Z Huang, X Fang, A Regev, ML Suvà, TH Hwang, JW Locasale, S Bao, JN Rich
    Nat. Neurosci, 2017;0(0):.
    Species: Human
    Sample Type: Whole Tissue
    Application: Bioassay
  16. Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis
    Authors: S Lugert, T Kremer, R Jagasia, A Herrmann, S Aigner, C Giachino, I Mendez-Dav, AM Gardier, JP Carralot, H Meisterman, A Augustin, MD Saxe, J Lamerz, G Duran-Pach, A Ducret, V Taylor, DJ David, C Czech
    Sci Rep, 2017;7(0):46543.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  17. Aurora A-Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma
    Authors: J Wang, K Nikhil, K Viccaro, L Chang, M Jacobsen, G Sandusky, K Shah
    J. Cell. Sci, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  18. Targeting BMI1(+) Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma
    Authors: D Chen, M Wu, Y Li, I Chang, Q Yuan, M Ekimyan-Sa, P Deng, B Yu, Y Yu, J Dong, JM Szymanski, S Ramadoss, J Li, CY Wang
    Cell Stem Cell, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  19. Growth hormone is permissive for neoplastic colon growth
    Proc Natl Acad Sci USA, 2016;0(0):.
    Species: Human
    Sample Type: Whole Tissue
    Application: Bioassay
  20. LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer
    Oncotarget, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  21. SPINK6 promotes metastasis of nasopharyngeal carcinoma via binding and activation of epithelial growth factor receptor
    Cancer Res, 2016;0(0):.
    Species: Human
    Sample Type: recombinant protein
    Application: Bioassay
  22. Characterization of Neurogenic Potential of Dental Pulp Stem Cells Cultured in Xeno/Serum-Free Condition: In Vitro and In Vivo Assessment
    Stem Cells Int, 2016;2016(0):6921097.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  23. ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer
    Oncotarget, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  24. A Highly Diverse and Functional Na�ve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents
    J. Mol. Biol., 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  25. Glucocorticoids Suppress Mitochondrial Oxidant Production via Upregulation of Uncoupling Protein 2 in Hyperglycemic Endothelial Cells
    PLoS ONE, 2016;11(4):e0154813.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  26. Transcription factor-mediated regulation of kidney versus liver specification of Slc and Abc drug transporters, tight junction molecules and signature biomarkers
    Authors: G Martovetsk, KT Bush, SK Nigam
    Drug Metab Dispos, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  27. Treatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell Population
    Authors: Neil E Bhola
    Cancer Res, 2016;76(2):440-52.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  28. Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma
    Genome Biol, 2016;17(1):80.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  29. The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling
    J Cell Sci, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  30. Pituitary Adenlylate Cyclase Activating Peptide Protects Adult Neural Stem Cells from a Hypoglycaemic milieu
    Authors: Shiva Mansouri
    PLoS ONE, 2016;11(6):e0156867.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  31. Defined three-dimensional culture conditions mediate efficient induction of definitive endoderm lineage from human umbilical cord Wharton's jelly mesenchymal stem cells
    Stem Cell Res Ther, 2016;7(1):165.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  32. Cancer stem cell-secreted macrophage migration inhibitory factor stimulates myeloid derived suppressor cell function and facilitates glioblastoma immune evasion
    Stem Cells, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  33. Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking
    Nat. Genet., 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  34. Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models
    Authors: JK Dermawan, M Hitomi, DJ Silver, Q Wu, P Sandlesh, AE Sloan, AA Purmal, KV Gurova, JN Rich, JD Lathia, GR Stark, M Venere
    Cancer Res., 2016;76(8):2432-42.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  35. c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas
    Authors: DH Heiland, R Ferrarese, R Claus, F Dai, AP Masilamani, E Kling, A Weyerbrock, T Kling, S Nelander, MS Carro
    Oncotarget, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  36. A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo
    Authors: CG Hubert, M Rivera, LC Spangler, Q Wu, SC Mack, BC Prager, M Couce, RE McLendon, AE Sloan, JN Rich
    Cancer Res., 2016;76(8):2465-77.
    Species: Human
    Sample Type: Whole Tissue
    Application: Bioassay
  37. Brain tissue banking for stem cells for our future
    Sci Rep, 2016;6(0):39394.
    Species: Human
    Sample Type: Tissue Homogenates
    Application: Bioassay
  38. Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain.
    Authors: Lee S, Kang W, Yoon Y, Jin J, Song H, Her J, Kang S, Hwang Y, Kang K, Joo K, Nam D
    BMC Cancer, 2015;15(1):1011.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  39. Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents.
    Authors: Pasdar E, Smits M, Stapelberg M, Bajzikova M, Stantic M, Goodwin J, Yan B, Stursa J, Kovarova J, Sachaphibulkij K, Bezawork-Geleta A, Sobol M, Filimonenko A, Tomasetti M, Zobalova R, Hozak P, Dong L, Neuzil J
    PLoS ONE, 2015;10(5):e0119549.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  40. Mutation of androgen receptor N-terminal phosphorylation site Tyr-267 leads to inhibition of nuclear translocation and DNA binding.
    Authors: Karaca M, Liu Y, Zhang Z, De Silva D, Parker J, Earp H, Whang Y
    PLoS ONE, 2015;10(5):e0126270.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  41. Excision of Expanded GAA Repeats Alleviates the Molecular Phenotype of Friedreich's Ataxia.
    Authors: Li Y, Polak U, Bhalla A, Rozwadowska N, Butler J, Lynch D, Dent S, Napierala M
    Mol Ther, 2015;23(6):1055-65.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  42. Arf6 regulates EGF-induced internalization of E-cadherin in breast cancer cells.
    Authors: Xu R, Zhang Y, Gu L, Zheng J, Cui J, Dong J, Du J
    Cancer Cell Int, 2015;15(1):11.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  43. The Synergistic Local Immunosuppressive Effects of Neural Stem Cells Expressing Indoleamine 2,3-Dioxygenase (IDO) in an Experimental Autoimmune Encephalomyelitis (EAE) Animal Model.
    Authors: Lee Y, An J, Lee K, Kim S, Song H, Pyeon H, Nam H, Kang K, Joo K
    PLoS ONE, 2015;10(12):e0144298.
    Species: Rat
    Sample Type: Whole Cells
    Application: Bioassay
  44. mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis.
    Authors: Morrison M, Young C, Wang S, Sobolik T, Sanchez V, Hicks D, Cook R, Brantley-Sieders D
    PLoS Genet, 2015;11(7):e1005291.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  45. Let-7 Sensitizes KRAS Mutant Tumor Cells to Chemotherapy.
    Authors: Dai X, Jiang Y, Tan C
    PLoS ONE, 2015;10(5):e0126653.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  46. EphrinB2 controls vessel pruning through STAT1-JNK3 signalling.
    Authors: Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, Segarra M, Eberhart C, Acker-Palmer A, Tosato G
    Nat Commun, 2015;6(0):6576.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  47. Activin/nodal signaling switches the terminal fate of human embryonic stem cell-derived trophoblasts.
    Authors: Sarkar P, Randall S, Collier T, Nero A, Russell T, Muddiman D, Rao B
    J Biol Chem, 2015;290(14):8834-48.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  48. The evidence of glioblastoma heterogeneity.
    Authors: Soeda, Akio, Hara, Akira, Kunisada, Takahiro, Yoshimura, Shin-ich, Iwama, Toru, Park, Deric M
    Sci Rep, 2015;5(0):7979.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  49. Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors.
    Authors: All A, Gharibani P, Gupta S, Bazley F, Pashai N, Chou B, Shah S, Resar L, Cheng L, Gearhart J, Kerr C
    PLoS ONE, 2015;10(1):e0116933.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  50. Acetylation of the RhoA GEF Net1A controls its subcellular localization and activity.
    Authors: Song E, Oh W, Ulu A, Carr H, Zuo Y, Frost J
    J Cell Sci, 2015;128(5):913-22.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  51. Mitochondrial control by DRP1 in brain tumor initiating cells.
    Authors: Xie Q, Wu Q, Horbinski C, Flavahan W, Yang K, Zhou W, Dombrowski S, Huang Z, Fang X, Shi Y, Ferguson A, Kashatus D, Bao S, Rich J
    Nat Neurosci, 2015;18(4):501-10.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  52. Endothelial-mesenchymal transition of brain endothelial cells: possible role during metastatic extravasation.
    Authors: Krizbai I, Gasparics A, Nagyoszi P, Fazakas C, Molnar J, Wilhelm I, Bencs R, Rosivall L, Sebe A
    PLoS ONE, 2015;10(3):e0119655.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  53. Epigenetic regulation of Elf5 is associated with epithelial-mesenchymal transition in urothelial cancer.
    Authors: Wu, Bo, Cao, Xiaoming, Liang, Xuezhi, Zhang, Xuhui, Zhang, Wei, Sun, Guang, Wang, Dongwen
    PLoS ONE, 2015;10(1):e0117510.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  54. RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.
    Authors: Bogershausen N, Tsai I, Pohl E, Kiper P, Beleggia F, Percin E, Keupp K, Matchan A, Milz E, Alanay Y, Kayserili H, Liu Y, Banka S, Kranz A, Zenker M, Wieczorek D, Elcioglu N, Prontera P, Lyonnet S, Meitinger T, Stewart A, Donnai D, Strom T, Boduroglu K, Yigit G, Li Y, Katsanis N, Wollnik B
    J Clin Invest, 2015;125(9):3585-99.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  55. Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity.
    Authors: Jacobsen H, Poulsen T, Dahlman A, Kjaer I, Koefoed K, Sen J, Weilguny D, Bjerregaard B, Andersen C, Horak I, Pedersen M, Kragh M, Lantto J
    Clin Cancer Res, 2015;21(18):4110-22.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  56. Artificial human Met agonists based on macrocycle scaffolds.
    Authors: Ito, Kenichir, Sakai, Katsuya, Suzuki, Yoshinor, Ozawa, Naoya, Hatta, Tomohisa, Natsume, Tohru, Matsumoto, Kunio, Suga, Hiroaki
    Nat Commun, 2015;6(0):6373.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  57. Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
    Authors: Tabata T, Petitt M, Zydek M, Fang-Hoover J, Larocque N, Tsuge M, Gormley M, Kauvar L, Pereira L
    J Virol, 2015;89(9):5134-47.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  58. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
    Authors: Kim, Dohoon, Fiske, Brian P, Birsoy, Kivanc, Freinkman, Elizavet, Kami, Kenjiro, Possemato, Richard, Chudnovsky, Yakov, Pacold, Michael, Chen, Walter W, Cantor, Jason R, Shelton, Laura M, Gui, Dan Y, Kwon, Manjae, Ramkissoon, Shakti H, Ligon, Keith L, Kang, Seong Wo, Snuderl, Matija, Vander Heiden, Matthew, Sabatini, David M
    Nature, 2015;520(7547):363-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  59. Receptor-type protein tyrosine phosphatase kappa directly dephosphorylates CD133 and regulates downstream AKT activation.
    Authors: Shimozato O, Waraya M, Nakashima K, Souda H, Takiguchi N, Yamamoto H, Takenobu H, Uehara H, Ikeda E, Matsushita S, Kubo N, Nakagawara A, Ozaki T, Kamijo T
    Oncogene, 2015;34(15):1949-60.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  60. Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity.
    Authors: Ilkow C, Marguerie M, Batenchuk C, Mayer J, Ben Neriah D, Cousineau S, Falls T, Jennings V, Boileau M, Bellamy D, Bastin D, de Souza C, Alkayyal A, Zhang J, Le Boeuf F, Arulanandam R, Stubbert L, Sampath P, Thorne S, Paramanthan P, Chatterjee A, Strieter R, Burdick M, Addison C, Stojdl D, Atkins H, Auer R, Diallo J, Lichty B, Bell J
    Nat Med, 2015;21(5):530-6.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  61. The Rho-specific GAP protein DLC3 coordinates endocytic membrane trafficking.
    Authors: Braun A, Hendrick J, Eisler S, Schmid S, Hausser A, Olayioye M
    J Cell Sci, 2015;128(7):1386-99.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  62. High levels of KAP1 expression are associated with aggressive clinical features in ovarian cancer.
    Authors: Cui Y, Yang S, Fu X, Feng J, Xu S, Ying G
    Int J Mol Sci, 2015;16(1):363-77.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  63. Growth differentiation factor 15 (GDF-15) plasma levels increase during bleomycin- and cisplatin-based treatment of testicular cancer patients and relate to endothelial damage.
    Authors: Altena, Renske, Fehrmann, Rudolf S, Boer, Hink, de Vries, Elisabet, Meijer, Coby, Gietema, Jourik A
    PLoS ONE, 2015;10(1):e0115372.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  64. V-myc immortalizes human neural stem cells in the absence of pluripotency-associated traits.
    Authors: Pino-Barrio M, Garcia-Garcia E, Menendez P, Martinez-Serrano A
    PLoS ONE, 2015;10(3):e0118499.
  65. Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences.
    Authors: Sundnes O, Pietka W, Loos T, Sponheim J, Rankin A, Pflanz S, Bertelsen V, Sitek J, Hol J, Haraldsen G, Khnykin D
    J Invest Dermatol, 2015;135(7):1771-80.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  66. Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer.
    Authors: Liang Y, Hu J, Li J, Liu Y, Yu J, Zhuang X, Mu L, Kong X, Hong D, Yang Q, Hu G
    Cancer Res, 2015;75(17):3672-80.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  67. Patient-derived xenografts from non-small cell lung cancer brain metastases are valuable translational platforms for the development of personalized targeted therapy.
    Authors: Lee H, Lee J, Lee S, Cho H, Song H, Jeong D, Seo Y, Shin S, Joung J, Kwon Y, Choi Y, Park W, Lee H, Seol H, Shim Y, Joo K, Nam D
    Clin Cancer Res, 2015;21(5):1172-82.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  68. Constitutive activation of myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tissue invasion.
    Authors: Wong S, Ulrich T, Deleyrolle L, MacKay J, Lin J, Martuscello R, Jundi M, Reynolds B, Kumar S
    Cancer Res, 2015;75(6):1113-22.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  69. Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors.
    Authors: Edri, Reuven, Yaffe, Yakey, Ziller, Michael, Mutukula, Naresh, Volkman, Rotem, David, Eyal, Jacob-Hirsch, Jasmine, Malcov, Hagar, Levy, Carmit, Rechavi, Gideon, Gat-Viks, Irit, Meissner, Alexande, Elkabetz, Yechiel
    Nat Commun, 2015;6(0):6500.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  70. Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors.
    Authors: Chernyavsky A, Shchepotin I, Galitovkiy V, Grando S
    BMC Cancer, 2015;15(0):152.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  71. Two Isoforms of the RNA Binding Protein, Coding Region Determinant-binding Protein (CRD-BP/IGF2BP1), Are Expressed in Breast Epithelium and Support Clonogenic Growth of Breast Tumor Cells.
    Authors: Fakhraldeen S, Clark R, Roopra A, Chin E, Huang W, Castorino J, Wisinski K, Kim T, Spiegelman V, Alexander C
    J Biol Chem, 2015;290(21):13386-400.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  72. Functional genomic analysis identifies indoxyl sulfate as a major, poorly dialyzable uremic toxin in end-stage renal disease.
    Authors: Jhawar S, Singh P, Torres D, Ramirez-Valle F, Kassem H, Banerjee T, Dolgalev I, Heguy A, Zavadil J, Lowenstein J
    PLoS ONE, 2015;10(3):e0118703.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  73. Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function.
    Authors: Leslie J, Huang S, Opp J, Nagy M, Kobayashi M, Young V, Spence J
    Infect Immun, 2015;83(1):138-45.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  74. Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation.
    Authors: Chen X, Xie W, Gu P, Cai Q, Wang B, Xie Y, Dong W, He W, Zhong G, Lin T, Huang J
    Sci Rep, 2015;5(0):8293.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  75. Photodynamic therapy with 5-aminolevulinic acid (ALA) impairs tumor initiating and chemo-resistance property in head and neck cancer-derived cancer stem cells.
    Authors: Yu, Chuan-Ha, Yu, Cheng-Ch
    PLoS ONE, 2014;9(1):e87129.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  76. Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.
    Authors: Barmada, Sami J, Serio, Andrea, Arjun, Arpana, Bilican, Bilada, Daub, Aaron, Ando, D Michae, Tsvetkov, Andrey, Pleiss, Michael, Li, Xingli, Peisach, Daniel, Shaw, Christop, Chandran, Siddhart, Finkbeiner, Steven
    Nat Chem Biol, 2014;10(8):677-85.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  77. CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer.
    Authors: Lopez-Sanchez L, Jimenez C, Valverde A, Hernandez V, Penarando J, Martinez A, Lopez-Pedrera C, Munoz-Castaneda J, De la Haba-Rodriguez J, Aranda E, Rodriguez-Ariza A
    PLoS ONE, 2014;9(6):e99143.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  78. Micro-environment causes reversible changes in DNA methylation and mRNA expression profiles in patient-derived glioma stem cells.
    Authors: Baysan, Mehmet, Woolard, Kevin, Bozdag, Serdar, Riddick, Gregory, Kotliarova, Svetlana, Cam, Margaret, Belova, Galina I, Ahn, Susie, Zhang, Wei, Song, Hua, Walling, Jennifer, Stevenson, Holly, Meltzer, Paul, Fine, Howard A
    PLoS ONE, 2014;9(4):e94045.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  79. THY-1 receptor expression differentiates cardiosphere-derived cells with divergent cardiogenic differentiation potential.
    Authors: Gago-Lopez N, Awaji O, Zhang Y, Ko C, Nsair A, Liem D, Stempien-Otero A, MacLellan W
    Stem Cell Reports, 2014;2(5):576-91.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  80. Chondrogenesis of infrapatellar fat pad derived adipose stem cells in 3D printed chitosan scaffold.
    Authors: Ye K, Felimban R, Traianedes K, Moulton S, Wallace G, Chung J, Quigley A, Choong P, Myers D
    PLoS ONE, 2014;9(6):e99410.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  81. p38-Mediated phosphorylation of Eps15 endocytic adaptor protein.
    Authors: Zhou Y, Tanaka T, Sugiyama N, Yokoyama S, Kawasaki Y, Sakuma T, Ishihama Y, Saiki I, Sakurai H
    FEBS Lett, 2014;588(1):131-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  82. XBP1 promotes triple-negative breast cancer by controlling the HIF1alpha pathway.
    Authors: Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt M, Hatziapostolou M, Lim E, Tam W, Ni M, Chen Y, Mai J, Shen H, Hu D, Adoro S, Hu B, Song M, Tan C, Landis M, Ferrari M, Shin S, Brown M, Chang J, Liu X, Glimcher L
    Nature, 2014;508(7494):103-7.
  83. Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells.
    Authors: Sakanyan V, Angelini M, Le Bechec M, Lecocq M, Benaiteau F, Rousseau B, Gyulkhandanyan A, Gyulkhandanyan L, Loge C, Reiter E, Roussakis C, Fleury F
    Sci Rep, 2014;4(0):3977.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  84. Human marrow stromal cells downsize the stem cell fraction of lung cancers by fibroblast growth factor 10.
    Authors: Kanehira M, Kikuchi T, Santoso A, Tode N, Hirano T, Ohkouchi S, Tamada T, Sugiura H, Harigae H, Ichinose M
    Mol Cell Biol, 2014;34(15):2848-56.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  85. CCAAT/enhancer binding protein-mediated regulation of TGFbeta receptor 2 expression determines the hepatoblast fate decision.
    Authors: Takayama K, Kawabata K, Nagamoto Y, Inamura M, Ohashi K, Okuno H, Yamaguchi T, Tashiro K, Sakurai F, Hayakawa T, Okano T, Furue M, Mizuguchi H
    Development, 2014;141(1):91-100.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  86. Selective calcium sensitivity in immature glioma cancer stem cells.
    Authors: Wee S, Niklasson M, Marinescu V, Segerman A, Schmidt L, Hermansson A, Dirks P, Forsberg-Nilsson K, Westermark B, Uhrbom L, Linnarsson S, Nelander S, Andang M
    PLoS ONE, 2014;9(12):e115698.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  87. Dopaminergic-like neurons derived from oral mucosa stem cells by developmental cues improve symptoms in the hemi-parkinsonian rat model.
    Authors: Ganz, Javier, Arie, Ina, Buch, Sigal, Zur, Tali Ben, Barhum, Yael, Pour, Sammy, Araidy, Shareef, Pitaru, Sandu, Offen, Daniel
    PLoS ONE, 2014;9(6):e100445.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  88. High efficient differentiation of functional hepatocytes from porcine induced pluripotent stem cells.
    Authors: Ao, Ying, Mich-Basso, Jocelyn, Lin, Bo, Yang, Lei
    PLoS ONE, 2014;9(6):e100417.
    Species: Porcine
    Sample Type: Whole Cells
    Application: Bioassay
  89. Canine epidermal neural crest stem cells: characterization and potential as therapy candidate for a large animal model of spinal cord injury.
    Authors: Gericota B, Anderson J, Mitchell G, Borjesson D, Sturges B, Nolta J, Sieber-Blum M
    Stem Cells Transl Med, 2014;3(3):334-45.
    Species: Canine
    Sample Type: Whole Tissue
    Application: Bioassay
  90. The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration.
    Authors: Elloul, Sivan, Kedrin, Dmitriy, Knoblauch, Nicholas, Beck, Andrew H, Toker, Alex
    Mol Cancer Res, 2014;12(3):464-76.
  91. Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-beta-mediated migration of human lung and breast epithelial cells.
    Authors: Boudreau H, Casterline B, Burke D, Leto T
    Br J Cancer, 2014;110(10):2569-82.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  92. MicroRNA-224 is involved in the regulation of mouse cumulus expansion by targeting Ptx3.
    Authors: Yao G, Liang M, Liang N, Yin M, Lu M, Lian J, Wang Y, Sun F
    Mol Cell Endocrinol, 2014;382(1):244-53.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  93. Functional cross-talk between the cellular prion protein and the neural cell adhesion molecule is critical for neuronal differentiation of neural stem/precursor cells.
    Authors: Prodromidou K, Papastefanaki F, Sklaviadis T, Matsas R
    Stem Cells, 2014;32(6):1674-87.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  94. Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell-like side population cells.
    Authors: Zhu, Dingjun, Wan, Xuesi, Huang, Hai, Chen, Xu, Liang, Wu, Zhao, Fengjin, Lin, Tianxin, Han, Jinli, Xie, Wenlian
    Oncol Rep, 2014;31(2):727-36.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  95. Boundary cap neural crest stem cells homotopically implanted to the injured dorsal root transitional zone give rise to different types of neurons and glia in adult rodents.
    Authors: Trolle, Carl, Konig, Niclas, Abrahamsson, Ninnie, Vasylovska, Svitlana, Kozlova, Elena N
    BMC Neurosci, 2014;15(0):60.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  96. NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation.
    Authors: Fang, Di-Feng, He, Kun, Wang, Na, Sang, Zhi-Hong, Qiu, Xin, Xu, Guang, Jian, Zhao, Liang, Bing, Li, Tao, Li, Hui-Yan, Li, Ai-Ling, Zhou, Tao, Gong, Wei-Li, Yang, Baoli, Karin, Michael, Zhang, Xue-Min, Li, Wei-Hua
    Nat Commun, 2014;5(0):4513.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  97. Leptin-induced adhesion and invasion in colorectal cancer cell lines.
    Authors: Yoon K, Park S, Kim J, Lee S, Park C, Cho S, Lee W, Joo Y, Lee J, Kim H, Choi S, Rew J
    Oncol Rep, 2014;31(6):2493-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  98. MASP-1 induces a unique cytokine pattern in endothelial cells: a novel link between complement system and neutrophil granulocytes.
    Authors: Jani P, Kajdacsi E, Megyeri M, Dobo J, Doleschall Z, Futosi K, Timar C, Mocsai A, Mako V, Gal P, Cervenak L
    PLoS ONE, 2014;9(1):e87104.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  99. Molecular evidence for OCT4-induced plasticity in adult human fibroblasts required for direct cell fate conversion to lineage specific progenitors.
    Authors: Mitchell R, Szabo E, Shapovalova Z, Aslostovar L, Makondo K, Bhatia M
    Stem Cells, 2014;32(8):2178-87.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  100. MicroRNA-200b suppresses arsenic-transformed cell migration by targeting protein kinase Calpha and Wnt5b-protein kinase Calpha positive feedback loop and inhibiting Rac1 activation.
    Authors: Wang Z, Humphries B, Xiao H, Jiang Y, Yang C
    J Biol Chem, 2014;289(26):18373-86.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  101. Translational validation of personalized treatment strategy based on genetic characteristics of glioblastoma.
    Authors: Oh, Young Ta, Cho, Hee Jin, Kim, Jinkuk, Lee, Ji-Hyun, Rho, Kyoohyou, Seo, Yun-Jee, Choi, Yeon-Soo, Jung, Hye Jin, Song, Hyeon Su, Kong, Doo-Sik, Seol, Ho Jun, Lee, Jung-Il, Yoon, Yeup, Kim, Sunghoon, Nam, Do-Hyun, Joo, Kyeung M
    PLoS ONE, 2014;9(8):e103327.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  102. Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells.
    Authors: Yang, Ruifeng, Zheng, Ying, Burrows, Michelle, Liu, Shujing, Wei, Zhi, Nace, Arben, Guo, Wei, Kumar, Suresh, Cotsarelis, George, Xu, Xiaowei
    Nat Commun, 2014;5(0):3071.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  103. Control of a tumor suppressor PDCD4: Degradation mechanisms of the protein in hepatocellular carcinoma cells.
    Authors: Matsuhashi S, Hamajima H, Xia J, Zhang H, Mizuta T, Anzai K, Ozaki I
    Cell Signal, 2014;26(3):603-10.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  104. Ezrin expression and cell survival regulation in colorectal cancer.
    Authors: Leiphrakpam P, Rajput A, Mathiesen M, Agarwal E, Lazenby A, Are C, Brattain M, Chowdhury S
    Cell Signal, 2014;26(5):868-79.
  105. High glucose induces human endothelial dysfunction through an Axl-dependent mechanism.
    Authors: Lee C, Shieh Y, Hsiao F, Kuo F, Lin C, Hsieh C, Hung Y
    Cardiovasc Diabetol, 2014;13(0):53.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  106. The repressive effect of miR-148a on TGF beta-SMADs signal pathway is involved in the glabridin-induced inhibition of the cancer stem cells-like properties in hepatocellular carcinoma cells.
    Authors: Jiang F, Mu J, Wang X, Ye X, Si L, Ning S, Li Z, Li Y
    PLoS ONE, 2014;9(5):e96698.
  107. Porcupine is not required for the production of the majority of Wnts from primary human astrocytes and CD8+ T cells.
    Authors: Richards M, Seaton M, Wallace J, Al-Harthi L
    PLoS ONE, 2014;9(3):e92159.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  108. Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRbeta aptamer.
    Authors: Camorani S, Esposito C, Rienzo A, Catuogno S, Iaboni M, Condorelli G, de Franciscis V, Cerchia L
    Mol Ther, 2014;22(4):828-41.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  109. Three-dimensional lung tumor microenvironment modulates therapeutic compound responsiveness in vitro--implication for drug development.
    Authors: Ekert, Jason E, Johnson, Kjell, Strake, Brandy, Pardinas, Jose, Jarantow, Stephen, Perkinson, Robert, Colter, David C
    PLoS ONE, 2014;9(3):e92248.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  110. MicroRNA-608 and microRNA-34a regulate chordoma malignancy by targeting EGFR, Bcl-xL and MET.
    Authors: Zhang, Ying, Schiff, David, Park, Deric, Abounader, Roger
    PLoS ONE, 2014;9(3):e91546.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  111. In vivo analysis of insulin-like growth factor type 1 receptor humanized monoclonal antibody MK-0646 and small molecule kinase inhibitor OSI-906 in colorectal cancer.
    Authors: Leiphrakpam, Premila, Agarwal, Ekta, Mathiesen, Michelle, Haferbier, Katie L, Brattain, Michael, Chowdhury, Sanjib
    Oncol Rep, 2014;31(1):87-94.
  112. Butein suppresses breast cancer growth by reducing a production of intracellular reactive oxygen species.
    Authors: Cho, Sung-Goo, Woo, Sang-Mi, Ko, Seong-Gy
    J Exp Clin Cancer Res, 2014;33(0):51.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  113. Adult human nasal mesenchymal-like stem cells restore cochlear spiral ganglion neurons after experimental lesion.
    Authors: Bas E, Van De Water T, Lumbreras V, Rajguru S, Goss G, Hare J, Goldstein B
    Stem Cells Dev, 2014;23(5):502-14.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  114. miR-17 regulates the proliferation and differentiation of the neural precursor cells during mouse corticogenesis.
    Authors: Mao S, Li H, Sun Q, Zen K, Zhang C, Li L
    FEBS J, 2014;281(4):1144-58.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  115. A novel berbamine derivative inhibits cell viability and induces apoptosis in cancer stem-like cells of human glioblastoma, via up-regulation of miRNA-4284 and JNK/AP-1 signaling.
    Authors: Yang, Fan, Nam, Sangkil, Brown, Christin, Zhao, Robin, Starr, Renate, Ma, Yuelong, Xie, Jun, Horne, David A, Malkas, Linda H, Jove, Richard, Hickey, Robert J
    PLoS ONE, 2014;9(4):e94443.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  116. Influence of oxygen tension on dopaminergic differentiation of human fetal stem cells of midbrain and forebrain origin.
    Authors: Krabbe C, Bak S, Jensen P, von Linstow C, Martinez Serrano A, Hansen C, Meyer M
    PLoS ONE, 2014;9(5):e96465.
  117. Isolation of cancer stem cells from three human glioblastoma cell lines: characterization of two selected clones.
    Authors: Iacopino F, Angelucci C, Piacentini R, Biamonte F, Mangiola A, Maira G, Grassi C, Sica G
    PLoS ONE, 2014;9(8):e105166.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  118. EGF potentiation of VEGF production is cell density dependent in H292 EGFR wild type NSCLC cell line.
    Authors: Ranayhossaini D, Lu J, Mabus J, Gervais A, Lingham R, Fursov N
    Int J Mol Sci, 2014;15(10):17686-704.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  119. Additive effects of EGF and IL-1beta regulate tumor cell migration and invasion in gastric adenocarcinoma via activation of ERK1/2.
    Authors: Han J, Xie Y, Lan F, Yu Y, Liu W, Chen J, Zheng F, Ouyang X, Lin X, Lin Y, Huang Q, Wang L, Tan J
    Int J Oncol, 2014;45(1):291-301.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  120. Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation.
    Authors: Oleinik N, Helke K, Kistner-Griffin E, Krupenko N, Krupenko S
    J Biol Chem, 2014;289(38):26383-94.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  121. Chromatinized protein kinase C-theta directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells.
    Authors: Zafar A, Wu F, Hardy K, Li J, Tu W, McCuaig R, Harris J, Khanna K, Attema J, Gregory P, Goodall G, Harrington K, Dahlstrom J, Boulding T, Madden R, Tan A, Milburn P, Rao S
    Mol Cell Biol, 2014;34(16):2961-80.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  122. Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma.
    Authors: Zhang, Y, Kim, J, Mueller, A C, Dey, B, Yang, Y, Lee, D-h, Hachmann, J, Finderle, S, Park, D M, Christensen, J, Schiff, D, Purow, B, Dutta, A, Abounader, R
    Cell Death Differ, 2014;21(5):720-34.
    Species: Human
    Sample Type: whole cells
    Application: Bioassay
  123. Nestin regulates proliferation, migration, invasion and stemness of lung adenocarcinoma.
    Authors: Narita K, Matsuda Y, Seike M, Naito Z, Gemma A, Ishiwata T
    Int J Oncol, 2014;44(4):1118-30.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  124. The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines.
    Authors: Kirkegaard T, Yde C, Kveiborg M, Lykkesfeldt A
    Int J Oncol, 2014;45(1):393-400.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  125. Triptolide reverses hypoxia-induced epithelial-mesenchymal transition and stem-like features in pancreatic cancer by NF-kappaB downregulation.
    Authors: Liu L, Salnikov A, Bauer N, Aleksandrowicz E, Labsch S, Nwaeburu C, Mattern J, Gladkich J, Schemmer P, Werner J, Herr I
    Int J Cancer, 2014;134(10):2489-503.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  126. Transcriptional profiling of adult neural stem-like cells from the human brain.
    Authors: Sandberg C, Vik-Mo E, Behnan J, Helseth E, Langmoen I
    PLoS ONE, 2014;9(12):e114739.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  127. Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study.
    Authors: Zheng G, Huang L, Tong H, Shu Q, Hu Y, Ge M, Deng K, Zhang L, Zou B, Cheng B, Xu J
    Respir Res, 2014;15(0):39.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  128. Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition.
    Authors: Appari M, Babu K, Kaczorowski A, Gross W, Herr I
    Int J Oncol, 2014;45(4):1391-400.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  129. Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells.
    Authors: Labsch S, Liu L, Bauer N, Zhang Y, Aleksandrowicz E, Gladkich J, Schonsiegel F, Herr I
    Int J Oncol, 2014;44(5):1470-80.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  130. Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy.
    Authors: Yan K, Wu Q, Yan D, Lee C, Rahim N, Tritschler I, DeVecchio J, Kalady M, Hjelmeland A, Rich J
    Genes Dev, 2014;28(10):1085-100.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  131. An in vitro cord formation assay identifies unique vascular phenotypes associated with angiogenic growth factors.
    Authors: Falcon B, Swearingen M, Gough W, Lee L, Foreman R, Uhlik M, Hanson J, Lee J, McClure D, Chintharlapalli S
    PLoS ONE, 2014;9(9):e106901.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  132. mTOR-dependent proliferation defect in human ES-derived neural stem cells affected by myotonic dystrophy type 1.
    Authors: Denis J, Gauthier M, Rachdi L, Aubert S, Giraud-Triboult K, Poydenot P, Benchoua A, Champon B, Maury Y, Baldeschi C, Scharfmann R, Pietu G, Peschanski M, Martinat C
    J Cell Sci, 2013;126(0):1763-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  133. Epigenetic regulation of the miR142-3p/interleukin-6 circuit in glioblastoma.
    Authors: Chiou G, Chien C, Wang M, Chen M, Yang Y, Yu Y, Chien Y, Chang Y, Shen C, Chio C, Lu K, Ma H, Chen K, Liu D, Miller S, Chen Y, Huang P, Shih Y, Hung M, Chiou S
    Mol Cell, 2013;52(5):693-706.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  134. TGF-beta1 promotes lymphangiogenesis during peritoneal fibrosis.
    Authors: Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, Hattori R, Matsukawa Y, Mizuno T, Noda Y, Nishimura H, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y
    J Am Soc Nephrol, 2013;24(10):1627-42.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  135. Minimal residual disease monitoring in neuroblastoma patients based on the expression of a set of real-time RT-PCR markers in tumor-initiating cells.
    Authors: Hartomo T, Kozaki A, Hasegawa D, Van Huyen Pham T, Yamamoto N, Saitoh A, Ishida T, Kawasaki K, Kosaka Y, Ohashi H, Yamamoto T, Morikawa S, Hirase S, Kubokawa I, Mori T, Yanai T, Hayakawa A, Takeshima Y, Iijima K, Matsuo M, Nishio H, Nishimura N
    Oncol Rep, 2013;29(4):1629-36.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  136. Essential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells.
    Authors: Gourlaouen, Morgane, Welti, Jonathan, Vasudev, Naveen S, Reynolds, Andrew R
    J Biol Chem, 2013;288(11):7467-80.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  137. Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes.
    Authors: Takayama K, Nagamoto Y, Mimura N, Tashiro K, Sakurai F, Tachibana M, Hayakawa T, Kawabata K, Mizuguchi H
    Stem Cell Reports, 2013;1(4):322-35.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  138. Inhibition of PARP1 by small interfering RNA enhances docetaxel activity against human prostate cancer PC3 cells.
    Authors: Wu W, Kong Z, Duan X, Zhu H, Li S, Zeng S, Liang Y, Iliakis G, Gui Z, Yang D
    Biochem Biophys Res Commun, 2013;442(1):127-32.
    Species: Human
    Sample Type: whole cells
    Application: cell culture
  139. Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A.
    Authors: Lotti, Fiorenza, Jarrar, Awad M, Pai, Rish K, Hitomi, Masahiro, Lathia, Justin, Mace, Adam, Gantt, Gerald A, Sukhdeo, Kumar, DeVecchio, Jennifer, Vasanji, Amit, Leahy, Patrick, Hjelmeland, Anita B, Kalady, Matthew, Rich, Jeremy N
    J Exp Med, 2013;210(13):2851-72.
    Species: Human
    Sample Type: whole cells
    Application: Bioassay
  140. Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility.
    Authors: Zhang X, Lavoie G, Fort L, Huttlin E, Tcherkezian J, Galan J, Gu H, Gygi S, Carreno S, Roux P
    Mol Cell Biol, 2013;33(8):1657-70.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  141. Vaccination for invasive canine meningioma induces in situ production of antibodies capable of antibody-dependent cell-mediated cytotoxicity.
    Authors: Andersen B, Pluhar G, Seiler C, Goulart M, SantaCruz K, Schutten M, Meints J, O'Sullivan M, Bentley R, Packer R, Thomovsky S, Chen A, Faissler D, Chen W, Hunt M, Olin M, Ohlfest J
    Cancer Res, 2013;73(10):2987-97.
    Species: Canine
    Sample Type: Whole Cells
    Application: Bioassay
  142. P38/NF-kappaB/snail pathway is involved in caffeic acid-induced inhibition of cancer stem cells-like properties and migratory capacity in malignant human keratinocyte.
    Authors: Yang Y, Li Y, Wang K, Wang Y, Yin W, Li L
    PLoS ONE, 2013;8(3):e58915.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  143. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor.
    Authors: Smith, Christop, Berry, Donna M, McGlade, C Jane
    J Cell Sci, 2013;126(0):1366-80.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  144. Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma.
    Authors: Zheng Y, McFarland B, Drygin D, Yu H, Bellis S, Kim H, Bredel M, Benveniste E
    Clin Cancer Res, 2013;19(23):6484-94.
    Species: Human
    Sample Type: Whole Cells
    Application: cell culture
  145. Enhanced filopodium formation and stem-like phenotypes in a novel metastatic head and neck cancer cell model.
    Authors: Chen Y, Huang W, Chang S, Chang K, Kao S, Lo J, Su P
    Oncol Rep, 2013;30(6):2829-37.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  146. Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival.
    Authors: Huber, Roland M, Rajski, Michal, Sivasankaran, Balasubr, Moncayo, Gerald, Hemmings, Brian A, Merlo, Adrian
    PLoS ONE, 2013;8(2):e57793.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  147. Distinct effects of ligand-induced PDGFRalpha and PDGFRbeta signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments.
    Authors: Ehnman M, Missiaglia E, Folestad E, Selfe J, Strell C, Thway K, Brodin B, Pietras K, Shipley J, Ostman A, Eriksson U
    Cancer Res, 2013;73(7):2139-49.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  148. Generation of multipotent foregut stem cells from human pluripotent stem cells.
    Authors: Hannan, Nicholas, Fordham, Robert P, Syed, Yasir A, Moignard, Victoria, Berry, Andrew, Bautista, Ruben, Hanley, Neil A, Jensen, Kim B, Vallier, Ludovic
    Stem Cell Reports, 2013;1(4):293-306.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  149. The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer.
    Authors: Mimura, Kousaku, Shiraishi, Kensuke, Mueller, Anja, Izawa, Shinichi, Kua, Ley-Fang, So, Jimmy, Yong, Wei-Peng, Fujii, Hideki, Seliger, Barbara, Kiessling, Rolf, Kono, Koji
    J Immunol, 2013;191(12):6261-72.
    Species: Human
    Sample Type: Whole Cells
    Application: cell culture
  150. Diacylglycerol kinase delta modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2).
    Authors: Crotty T, Nakano T, Stafforini D, Topham M
    J Biol Chem, 2013;288(3):1439-47.
    Species: Human
    Sample Type: whole cells
    Application: Bioassay
  151. The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer.
    Authors: Hage C, Rausch V, Giese N, Giese T, Schonsiegel F, Labsch S, Nwaeburu C, Mattern J, Gladkich J, Herr I
    Cell Death Dis, 2013;4(0):e627.
    Species: Human
    Sample Type: whole cells
    Application: Bioassay
  152. Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation.
    Authors: Wolf A, Rietscher K, Glass M, Huttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M
    J Cell Sci, 2013;126(0):1832-44.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  153. Clinical-grade multipotent adult progenitor cells durably control pathogenic T cell responses in human models of transplantation and autoimmunity.
    Authors: Reading J, Yang J, Sabbah S, Skowera A, Knight R, Pinxteren J, Vaes B, Allsopp T, Ting A, Busch S, Raber A, Deans R, Tree T
    J Immunol, 2013;190(9):4542-52.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  154. Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking.
    Authors: Mehra A, Zahra A, Thompson V, Sirisaengtaksin N, Wells A, Porto M, Koster S, Penberthy K, Kubota Y, Dricot A, Rogan D, Vidal M, Hill D, Bean A, Philips J
    PLoS Pathog, 2013;9(10):e1003734.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  155. APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based gamma-secretase modulation.
    Authors: Mertens J, Stuber K, Wunderlich P, Ladewig J, Kesavan J, Vandenberghe R, Vandenbulcke M, Van Damme P, Walter J, Brustle O, Koch P
    Stem Cell Reports, 2013;1(6):491-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  156. Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-kappaB Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells.
    Authors: Bera A, Zhao S, Cao L, Chiao P, Freeman J
    PLoS ONE, 2013;8(12):e82282.
    Species: Human
    Sample Type: whole cells
    Application: Bioassay
  157. Neuronal differentiation and extensive migration of human neural precursor cells following co-culture with rat auditory brainstem slices.
    Authors: Novozhilova E, Olivius P, Siratirakun P, Lundberg C, Englund-Johansson U
    PLoS ONE, 2013;8(3):e57301.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  158. Silencing of reversion-inducing cysteine-rich protein with Kazal motifs stimulates hyperplastic phenotypes through activation of epidermal growth factor receptor and hypoxia-inducible factor-2alpha.
    Authors: Lee Y, Lee S, Lee K, Nguyen M, Lee M, Park G, Kwon M
    PLoS ONE, 2013;8(12):e84520.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  159. Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer.
    Authors: Tanizaki J, Okamoto I, Okabe T, Sakai K, Tanaka K, Hayashi H, Kaneda H, Takezawa K, Kuwata K, Yamaguchi H, Hatashita E, Nishio K, Nakagawa K
    Clin Cancer Res, 2012;18(22):6219-26.
    Species: Human
    Sample Type: whole cells
    Application: Bioassay
  160. Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c.
    Authors: Di Maggio N, Mehrkens A, Papadimitropoulos A, Schaeren S, Heberer M, Banfi A, Martin I
    Stem Cells, 2012;30(7):1455-64.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  161. The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1.
    Authors: Zelinka C, Scott M, Volkov L, Fischer A
    PLoS ONE, 2012;7(9):e44477.
    Species: Chicken
    Sample Type: In Vivo
    Application: In Vivo
  162. Regulation of IL-33 expression by IFN-gamma and tumor necrosis factor-alpha in normal human epidermal keratinocytes.
    J. Invest. Dermatol., 2012;132(11):2593-600.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  163. Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.
    Authors: Goel S, Chin EN, Fakhraldeen SA
    J. Biol. Chem., 2012;287(20):16454-66.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  164. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012;487(7408):505-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  165. Efficient differentiation of human embryonic and induced pluripotent stem cells into functional astrocytes.
    Authors: Emdad L, D'Souza SL, Kothari HP, Qadeer ZA, Germano IM
    Stem Cells Dev., 2012;21(3):404-10.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  166. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.
    Authors: Spence JR, Mayhew CN, Rankin SA
    Nature, 2011;470(7332):105-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  167. Vandetanib inhibits both VEGFR-2 and EGFR signalling at clinically relevant drug levels in preclinical models of human cancer.
    Authors: Brave SR, Odedra R, James NH
    Int. J. Oncol., 2011;39(1):271-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  168. CD133 positive embryonal rhabdomyosarcoma stem-like cell population is enriched in rhabdospheres.
    Authors: Walter D, Satheesha S, Albrecht P, Bornhauser BC, D'Alessandro V, Oesch SM, Rehrauer H, Leuschner I, Koscielniak E, Gengler C, Moch H, Bernasconi M, Niggli FK, Schafer BW
    PLoS ONE, 2011;6(5):e19506.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  169. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition.
    Authors: Yang MH, Hsu DS, Wang HW
    Nat. Cell Biol., 2010;12(10):982-92.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  170. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer.
    Authors: Hickinson DM, Klinowska T, Speake G
    Clin. Cancer Res., 2010;16(4):1159-69.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  171. Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid.
    Authors: Morizane S, Yamasaki K, Kabigting FD, Gallo RL
    J. Invest. Dermatol., 2010;130(5):1297-306.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  172. Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors.
    Authors: Nilsson MB, Zage PE, Zeng L, Xu L, Cascone T, Wu HK, Saigal B, Zweidler-McKay PA, Heymach JV
    Oncogene, 2010;29(20):2938-49.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  173. The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress.
    Authors: Park JA, Drazen JM, Tschumperlin DJ
    J. Biol. Chem., 2010;285(39):29817-25.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  174. Notch and Wnt signaling mediated rod photoreceptor regeneration by Muller cells in adult mammalian retina.
    Authors: Del Debbio CB, Balasubramanian S, Parameswaran S, Chaudhuri A, Qiu F, Ahmad I
    PLoS ONE, 2010;5(8):e12425.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  175. Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase.
    Authors: Riento K, Frick M, Schafer I, Nichols BJ
    J. Cell. Sci., 2009;122(0):912-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  176. Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity.
    Authors: Switzer CH, Ridnour LA, Cheng RY, Sparatore A, Del Soldato P, Moody TW, Vitek MP, Roberts DD, Wink DA
    Oncogene, 2009;28(43):3837-46.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  177. Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells.
    Authors: Katakura M, Hashimoto M, Shahdat HM, Gamoh S, Okui T, Matsuzaki K, Shido O
    Neuroscience, 2009;160(3):651-60.
    Species: Rat
    Sample Type: Whole Cells
    Application: Bioassay
  178. Purification and characterization of mouse lacrimal gland epithelial cells and reconstruction of an acinarlike structure in three-dimensional culture.
    Authors: Ueda Y, Karasawa Y, Satoh Y, Nishikawa S, Imaki J, Ito M
    Invest. Ophthalmol. Vis. Sci., 2009;50(5):1978-87.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  179. EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor.
    Authors: Li JJ, Liu DP, Liu GT, Xie D
    Oncogene, 2009;28(15):1759-68.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  180. Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression.
    Authors: Chang CJ, Hsu CC, Yung MC, Chen KY, Tzao C, Wu WF, Chou HY, Lee YY, Lu KH, Chiou SH, Ma HI
    Biochem. Biophys. Res. Commun., 2009;380(2):236-42.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  181. Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis.
    Authors: Lee HS, Myers A, Kim J
    Am. J. Respir. Crit. Care Med., 2009;180(11):1056-67.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  182. Mitogen-activated protein kinase-signaling regulates the ability of Muller glia to proliferate and protect retinal neurons against excitotoxicity.
    Authors: Fischer AJ, Scott MA, Ritchey ER, Sherwood P
    Glia, 2009;57(14):1538-52.
    Species: Chicken
    Sample Type: In Vivo
    Application: In Vivo
  183. Thalidomide inhibits epidermal growth factor-induced cell growth in mouse and human monocytic leukemia cells via Ras inactivation.
    Authors: Noman AS, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T
    Biochem. Biophys. Res. Commun., 2008;374(4):683-7.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  184. Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage.
    Authors: Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L
    Genes Dev., 2008;22(2):152-65.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  185. Characterization of human skin-derived mesenchymal stem cell proliferation rate in different growth conditions.
    Authors: Riekstina U, Muceniece R, Cakstina I, Muiznieks I, Ancans J
    Cytotechnology, 2008;58(3):153-62.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  186. Epidermal Growth Factor Receptor Blockade in Combination with Conventional Chemotherapy Inhibits Soft Tissue Sarcoma Cell Growth In vitro and In vivo.
    Authors: Ren W, Korchin B, Zhu QS, Wei C, Dicker A, Heymach J, Lazar A, Pollock RE, Lev D
    Clin. Cancer Res., 2008;14(9):2785-2795.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  187. Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.
    Authors: Bergin DA, Greene CM, Sterchi EE, Kenna C, Geraghty P, Belaaouaj A, Taggart CC, O'Neill SJ, McElvaney NG
    J. Biol. Chem., 2008;283(46):31736-44.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  188. Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons.
    Authors: Ladewig J, Koch P, Endl E, Meiners B, Opitz T, Couillard-Despres S, Aigner L, Brustle O
    Stem Cells, 2008;26(7):1705-12.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  189. Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts.
    Authors: Sarup J, Jin P, Turin L, Bai X, Beryt M, Brdlik C, Higaki JN, Jorgensen B, Lau FW, Lindley P, Liu J, Ni I, Rozzelle J, Kumari R, Watson SA, Zhang J, Shepard HM
    Mol. Cancer Ther., 2008;7(10):3223-36.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  190. Epidermal growth factor-like growth factors prevent apoptosis of alcohol-exposed human placental cytotrophoblast cells.
    Authors: Wolff GS, Chiang PJ, Smith SM, Romero R, Armant DR
    Biol. Reprod., 2007;77(1):53-60.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  191. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.
    Authors: Sa SM, Valdez PA, Wu J
    J. Immunol., 2007;178(4):2229-40.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  192. Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration.
    Authors: Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS
    J. Biol. Chem., 2007;282(43):31643-55.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  193. Long-term maintenance of brain tumor stem cell properties under at non-adherent and adherent culture conditions.
    Authors: Inagaki A, Soeda A, Oka N, Kitajima H, Nakagawa J, Motohashi T, Kunisada T, Iwama T
    Biochem. Biophys. Res. Commun., 2007;361(3):586-92.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  194. Atrial-radiofrequency catheter ablation mediated targeting of mesenchymal stromal cells.
    Authors: Schweizer PA, Krause U, Becker R, Seckinger A, Bauer A, Hardt C, Eckstein V, Ho AD, Koenen M, Katus HA, Zehelein J
    Stem Cells, 2007;25(6):1546-51.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  195. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases.
    Authors: Zhu J, Jia X, Xiao G, Kang Y, Partridge NC, Qin L
    J. Biol. Chem., 2007;282(37):26656-64.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  196. Tissue engineering for full-thickness burns: a dermal substitute from bench to bedside.
    Authors: Kellouche S, Martin C, Korb G, Rezzonico R, Bouard D, Benbunan M, Dubertret L, Soler C, Legrand C, Dosquet C
    Biochem. Biophys. Res. Commun., 2007;363(3):472-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  197. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer.
    Authors: Zhou BB, Peyton M, He B, Liu C, Girard L, Caudler E, Lo Y, Baribaud F, Mikami I, Reguart N, Yang G, Li Y, Yao W, Vaddi K, Gazdar AF, Friedman SM, Jablons DM, Newton RC, Fridman JS, Minna JD, Scherle PA
    Cancer Cell, 2006;10(1):39-50.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  198. Platelet-derived LIGHT induces inflammatory responses in endothelial cells and monocytes.
    Authors: Otterdal K, Smith C, Oie E, Pedersen TM, Yndestad A, Stang E, Endresen K, Solum NO, Aukrust P, Damas JK
    Blood, 2006;108(3):928-35.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  199. Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult rats.
    Authors: Kobayashi T, Ahlenius H, Thored P, Kobayashi R, Kokaia Z, Lindvall O
    Stroke, 2006;37(9):2361-7.
    Species: Rat
    Sample Type: Whole Cells
    Application: Bioassay
  200. The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines.
    Authors: Rhodes KE, Raivich G, Fawcett JW
    Neuroscience, 2006;140(1):87-100.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  201. Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor.
    Authors: Armant DR, Kilburn BA, Petkova A, Edwin SS, Duniec-Dmuchowski ZM, Edwards HJ, Romero R, Leach RE
    Development, 2006;133(4):751-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  202. Epidermal growth factor receptor expression regulates proliferation in the postnatal rat retina.
    Authors: Close JL, Liu J, Gumuscu B, Reh TA
    Glia, 2006;54(2):94-104.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  203. Effect of cytokine treatment on the neurogenesis process in the brain of soman-poisoned mice.
    Authors: Collombet JM, Four E, Burckhart MF, Masqueliez C, Bernabe D, Baubichon D, Herodin F, Lallement G
    Toxicology, 2005;210(1):9-23.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  204. Retinal neurons regulate proliferation of postnatal progenitors and Muller glia in the rat retina via TGF beta signaling.
    Authors: Close JL, Gumuscu B, Reh TA
    Development, 2005;132(13):3015-26.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  205. Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype.
    Authors: Leach RE, Kilburn B, Wang J, Liu Z, Romero R, Armant DR
    Dev. Biol., 2004;266(2):223-37.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  206. High-level expression of functional chemokine receptor CXCR4 on human neural precursor cells.
    Authors: Ni HT, Hu S, Sheng WS, Olson JM, Cheeran MC, Chan AS, Lokensgard JR, Peterson PK
    Brain Res. Dev. Brain Res., 2004;152(2):159-69.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  207. Human bronchial epithelial cells express and secrete MMP-12.
    Authors: Lavigne MC, Thakker P, Gunn J, Miyashiro JS, Wasserman AM, Wei SQ, Pelker JW
    Biochem. Biophys. Res. Commun., 2004;324(2):534-46.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  208. Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments.
    Authors: Oynebraten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G
    Blood, 2004;104(2):314-20.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  209. Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads.
    Authors: Wen FQ, Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T, Ertl R, Terasaki Y, Manouilova L, Rennard SI
    Am. J. Respir. Cell Mol. Biol., 2004;30(6):816-22.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  210. Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor.
    Authors: Lee D, Cross SH, Strunk KE, Morgan JE, Bailey CL, Jackson IJ, Threadgill DW
    Mamm. Genome, 2004;15(7):525-36.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  211. Different aspects of gliosis in retinal Muller glia can be induced by CNTF, insulin, and FGF2 in the absence of damage.
    Authors: Fischer AJ, Omar G, Eubanks J, McGuire CR, Dierks BD, Reh TA
    Mol. Vis., 2004;10(0):973-86.
    Species: Chicken
    Sample Type: In Vivo
    Application: In Vivo
  212. Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2.
    Authors: Viti J, Gulacsi A, Lillien L
    J. Neurosci., 2003;23(13):5919-27.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  213. Dual roles of IL-4 in lung injury and fibrosis.
    Authors: Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH
    J. Immunol., 2003;170(4):2083-92.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  214. Metabolic replacement of kidney function in uremic animals with a bioartificial kidney containing human cells.
    Authors: Humes HD, Fissell WH, Weitzel WF, Buffington DA, Westover AJ, MacKay SM, Gutierrez JM
    Am. J. Kidney Dis., 2002;39(5):1078-87.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  215. RGD-peptides for tissue engineering of articular cartilage.
    Authors: Jeschke B, Meyer J, Jonczyk A, Kessler H, Adamietz P, Meenen NM, Kantlehner M, Goepfert C, Nies B
    Biomaterials, 2002;23(16):3455-63.
    Species: Porcine
    Sample Type: Whole Cells
    Application: Bioassay
  216. A profibrotic function of IL-12p40 in experimental pulmonary fibrosis.
    Authors: Huaux F, Arras M, Tomasi D, Barbarin V, Delos M, Coutelier JP, Vink A, Phan SH, Renauld JC, Lison D
    J. Immunol., 2002;169(5):2653-61.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  217. Apical and basolateral EGF receptors regulate gastric mucosal paracellular permeability.
    Authors: Chen MC, Goliger J, Bunnett N, Soll AH
    Am. J. Physiol. Gastrointest. Liver Physiol., 2001;280(2):G264-72.
    Species: Canine
    Sample Type: Whole Cells
    Application: Bioassay
  218. Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I.
    Authors: Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM
    Cancer Res., 1998;58(17):4008-14.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  219. Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation.
    Authors: Barquilla A, Lamberto I, Heynen-Genel S, Brill L, Pasquale E
    Mol Biol Cell, 0;27(17):2757-70.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  220. alpha-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor.
    Authors: Sakane H, Horii Y, Nogami S, Kawano Y, Kaneko-Kawano T, Shirataki H
    PLoS ONE, 0;9(4):e93509.
    Species: Human
    Sample Type: Whole Cells
    Application: cell culture
Expand to show all 220 Citations
Animal-Free Recombinant Proteins
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Recombinant Human EGF, Animal-Free Protein

BA AFL236
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Average Rating: 4.8 (Based on 6 reviews)

Have you used Recombinant Human EGF Protein, CF?

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Read what people are saying who have used Recombinant Human EGF Protein, CF.

We have 6 reviews tested in 5 applications: In vitro bioactivity in cell culture, Induction of fibronectin production, Stem/Immune cell maintenance or differentiation , Manufacturing In vitro Products, Cell migration/motility.
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In vitro bioactivity in cell culture
(1)
Induction of fibronectin production
(1)
Stem/Immune cell maintenance or differentiation
(2)
Manufacturing In vitro Products
(1)
Cell migration/motility
(1)
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  Excellent
 In vitro bioactivity in cell culture Anonymous 07/20/2017
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Summary

ApplicationIn vitro bioactivity in cell culture
Induction of fibronectin production Recombinant Human EGF Protein, CF 236-EG
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Excellent
 Induction of fibronectin production Anonymous 04/12/2017
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Induction of fibronectin production Recombinant Human EGF Protein, CF 236-EG
Induction of fibronectin production: Recombinant Human EGF Protein, CF [236-EG]

Summary

ApplicationInduction of fibronectin production

Other Experimental Details

Other Experimental DetailsTo induce proliferation and EMT in ARPE-19 cells
Stem/Immune cell maintenance or differentiation  Recombinant Human EGF Protein, CF 236-EG
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Excellent
 Stem/Immune cell maintenance or differentiation Anonymous 03/31/2017
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Stem/Immune cell maintenance or differentiation  Recombinant Human EGF Protein, CF 236-EG
Stem/Immune cell maintenance or differentiation : Recombinant Human EGF Protein, CF [236-EG]

Summary

ApplicationStem/Immune cell maintenance or differentiation

Other Experimental Details

Other Experimental DetailsGrowth of MDA-MB-231 spheroids in serum-free condition in the absence (A) or presence (B) of Recombinant Human EGF (#236-EG) after 72 hours. Medium: RPMI + 2% B-27 supplement + 1% L-glutamine + 1% Pen/Strep.
Stem/Immune cell maintenance or differentiation  Recombinant Human EGF Protein, CF 236-EG
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Excellent
 Stem/Immune cell maintenance or differentiation Anonymous 08/17/2016
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Stem/Immune cell maintenance or differentiation  Recombinant Human EGF Protein, CF 236-EG
Stem/Immune cell maintenance or differentiation : Recombinant Human EGF Protein, CF [236-EG]

Summary

ApplicationStem/Immune cell maintenance or differentiation
Reason for RatingTested with the same application on different species and the result is always excellent

Other Experimental Details

Other Experimental DetailsRecombinant protein to induced sphere formation on olfactory stem cells
  Excellent
 Manufacturing In vitro Products Anonymous 07/21/2016
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Summary

ApplicationManufacturing In vitro Products
  Very Good
 Cell migration/motility Anonymous 05/18/2016
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Summary

ApplicationCell migration/motility

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