Recombinant Human EGF Protein, CF Summary
Product Specifications
Asn971-Arg1023, with an N-terminal Met
Analysis
Complete Your Research
Complete Your Experiment
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
236-EG
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
Reconstitution | Reconstitute at 500 μg/mL in sterile PBS. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Scientific Data

Recombinant Human EGF (Catalog # 236‑EG) stimulates cell proliferation of the Balb/3T3 mouse embryonic fibroblast cell line. The ED50 for this effect is 20‑100 pg/mL.

1 µg/lane of Recombinant Human EGF was resolved with SDS-PAGE and visualized by silver staining under reducing (R) conditions, showing a single band at 6 kDa.
Reconstitution Calculator
Background: EGF
Epidermal growth factor (EGF) is a small, potent growth factor capable of inducing cell proliferation, differentiation, and survival. EGF is the founding member of the EGF family that also includes TGF-alpha, amphiregulin (AR), betacellulin (BTC), epiregulin (EPR), heparin‑binding EGF‑like growth factor (HB‑EGF), epigen, and the neuregulins (NRG)-1 through -6 (1). Members of The EGF family are characterized by a shared structural motif, the EGF‑like domain, which contains three intramolecular disulfide bonds that are formed by six similarly spaced, conserved cysteine residues (2). These disulfide bonds are essential for proper protein conformation and receptor binding. All EGF family members are synthesized as type I transmembrane precursor proteins that may contain several EGF domains in the extracellular region. The mature proteins are released from the cell surface by regulated proteolysis (1). The full length EGF protein is 1207 amino acids (aa) (EGF precursor) containing nine EGF domains and nine LDLR class B repeats. However, the mature protein is much smaller, only 53 aa, and is generated by proteolytic cleavage of the EGF domain proximal to the transmembrane region (3). EGF is well conserved across mammals with mature human EGF 70% identical to mature mouse and rat EGF. Physiologically, EGF is found in various body fluids, including blood, milk, urine, saliva, seminal fluid, pancreatic juice, cerebrospinal fluid, and amniotic fluid (4). EGF is a high affinity ligand of the EGF receptor (ErbB). Four ErbB (HER) family receptor tyrosine kinases including EGFR/ErbB1, ErbB2, ErbB3 and ErbB4, mediate responses to EGF family members (5). EGF binding induces dimerization of the EGF receptor resulting in activation of the protein tyrosine kinase signaling pathway. These receptors undergo a complex pattern of ligand-induced homo- or hetero-dimerization to transduce EGF family signals (6, 7). EGF binds ErbB1 and depending on the context, induces the formation of homodimers or heterodimers containing ErbB2. Dimerization results in autophosphorylation of the receptor at specific tyrosine residues to create docking sites for a variety of signaling molecules (5, 8). Biological activities ascribed to EGF include epithelial development, angiogenesis, inhibition of gastric acid secretion, fibroblast proliferation, and colony formation of epidermal cells in culture.
- Harris, R.C. et al. (2003) Exp. Cell Res. 284:2.
- Carpenter, G. and Cohen, S. (1990) J. Biol. Chem. 265:7709.
- Bell, G.I. et al. (1986) Nucl. Acids Res. 14:8427.
- Carpenter, G. and Zendegui, J.G. (1986) Exp. Cell Res. 164:1.
- Jorissen, R.N. et al. (2003) Exp. Cell Res. 284:31.
- Gamett, D.C. et al. (1997) J. Biol. Chem. 272:12052.
- Qian, X. et al. (1994) Proc. Natl. Acad. Sci. 91:1500.
- Qian, X. et al. (1999) J. Biol. Chem. 274:574.
Citations for Recombinant Human EGF Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
684
Citations: Showing 1 - 10
Filter your results:
Filter by:
-
Effects of a monoclonal antibody against (pro)renin receptor on gliomagenesis
Authors: T Fujimori, Y Shibayama, T Kanda, K Suzuki, D Ogawa, R Ishikawa, K Kadota, T Matsunaga, T Tamiya, A Nishiyama, K Miyake
Scientific Reports, 2023;13(1):808.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Streptogramin A derivatives as mitochondrial translation inhibitors to suppress glioblastoma stem cell growth
Authors: D Sighel, G Battistini, EF Rosatti, J Vigna, M Pavan, R Belli, D Peroni, F Alessandri, S Longhi, M Pancher, J Rorbach, S Moro, A Quattrone, I Mancini
European Journal of Medicinal Chemistry, 2023;246(0):114979.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Counterintuitive production of tumor-suppressive secretomes from Oct4- and c-Myc-overexpressing tumor cells and MSCs
Authors: K Li, X Sun, R Zha, S Liu, Y Feng, T Sano, UK Aryal, A Sudo, BY Li, H Yokota
Theranostics, 2022;12(7):3084-3103.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cardioprotection of Klotho against myocardial infarction-induced heart failure through inducing autophagy
Authors: K Wang, Z Li, Y Li, X Liu, Y Sun, J Hong, Y Ding, W Zheng, L Qian, D Xu
Mechanisms of Ageing and Development, 2022;207(0):111714.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Differentially expression and function of circular RNAs in ovarian cancer stem cells
Authors: EJ Sohn
Journal of ovarian research, 2022;15(1):97.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Patient-Derived Tumor Organoids for Guidance of Personalized Drug Therapies in Recurrent Glioblastoma
Authors: M Ratliff, H Kim, H Qi, M Kim, B Ku, DD Azorin, D Hausmann, RK Khajuria, A Patel, E Maier, L Cousin, A Ogier, F Sahm, N Etminan, L Bunse, F Winkler, V El-Khoury, M Platten, YJ Kwon
International Journal of Molecular Sciences, 2022;23(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dynamics of Metabolic Pathways and Stress Response Patterns during Human Neural Stem Cell Proliferation and Differentiation
Authors: V Semkova, S Haupt, M Segschneid, C Bell, M Ingelman-S, M Hajo, B Weykopf, P Muthukotti, A Till, O Brüstle
Cells, 2022;11(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians
Authors: AK Nair, M Traurig, JR Sutherland, YL Muller, ED Grellinger, L Saporito, RG Nelson, C Bogardus, LJ Baier
Cells, 2022;11(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Activation of ADRB2/PKA Signaling Pathway Facilitates Lipid Synthesis in Meibocytes, and Beta-Blocker Glaucoma Drug Impedes PKA-Induced Lipid Synthesis by Inhibiting ADRB2
Authors: I Jun, YJ Choi, BR Kim, KY Seo, TI Kim
International Journal of Molecular Sciences, 2022;23(16):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
PIK3R3, a regulatory subunit of PI3K, modulates ovarian cancer stem cells and ovarian cancer development and progression by integrative analysis
Authors: EJ Sohn
BMC Cancer, 2022;22(1):708.
Species: Human
Sample Types: Organoid
Applications: Bioassay -
Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids
Authors: S Kim, S Min, YS Choi, SH Jo, JH Jung, K Han, J Kim, S An, YW Ji, YG Kim, SW Cho
Nature Communications, 2022;13(1):1692.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Kir4.2 Potassium Channels in Retinal Pigment Epithelial Cells In Vitro: Contribution to Cell Viability and Proliferation, and Down-Regulation by Vascular Endothelial Growth Factor
Authors: MC Beer, H Kuhrt, L Kohen, P Wiedemann, A Bringmann, M Hollborn
Biomolecules, 2022;12(6):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC
Authors: H Sun, J Zheng, J Xiao, J Yue, Z Shi, Z Xuan, C Chen, Y Zhao, W Tang, S Ye, J Li, Q Deng, L Zhang, F Zhu, C Shao
Cell Death & Disease, 2022;13(5):450.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Epithelial JAM-A is fundamental for intestinal wound repair in-vivo
Authors: S Fan, K Boerner, CK Muraleedha, A Nusrat, M Quiros, CA Parkos
JCI Insight, 2022;0(0):.
Species: Mouse
Sample Types: Organoid
Applications: Bioassay -
Equine Oviductal Organoid Generation and Cryopreservation
Authors: RE Thompson, MA Meyers, DNR Veeramacha, BS Pukazhenth, FK Hollinshea
Methods and protocols, 2022;5(3):.
Species: Equine
Sample Types: Organoid
Applications: Bioassay -
Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair
Authors: D Hao, L Lu, H Song, Y Duan, J Chen, R Carney, JJ Li, P Zhou, J Nolta, KS Lam, JK Leach, DL Farmer, A Panitch, A Wang
Theranostics, 2022;12(13):6021-6037.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissues
Authors: M Wang, W Li, J Hao, A Gonzales, Z Zhao, RS Flores, X Kuang, X Mu, T Ching, G Tang, Z Luo, CE Garciamend, JK Sahoo, MF Wells, G Niu, P Agrawal, A Quiñones-H, K Eggan, YS Zhang
Nature Communications, 2022;13(1):3317.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
JMJD3 intrinsically disordered region links the 3D-genome structure to TGFbeta-dependent transcription activation
Authors: M Vicioso-Ma, R Fueyo, C Navarro, S Cruz-Molin, WFJ van Ijcken, E Rebollo, Á Rada-Igles, MA Martínez-B
Nature Communications, 2022;13(1):3263.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
EGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association
Authors: Y Wang, H Shu, J Liu, X Jin, L Wang, Y Qu, M Xia, P Peng, Y Feng, M Wei
The Journal of Biological Chemistry, 2022;0(0):102340.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cooperative regulation of adherens junction expansion through Epidermal Growth Factor Receptor (EGFR) activation
Authors: C Fu, A Arora, W Engl, M Sheetz, V Viasnoff
Journal of Cell Science, 2022;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Integrative analysis of cell adhesion molecules in glioblastoma identified prostaglandin F2 receptor inhibitor (PTGFRN) as an essential gene
Authors: U Mala, TK Baral, K Somasundar
BMC Cancer, 2022;22(1):642.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Increased Expression and Altered Cellular Localization of Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) Are Associated with Prostate Cancer Progression
Authors: L Yu, M Toriseva, S Afshan, M Cangiano, V Fey, A Erickson, H Seikkula, K Alanen, P Taimen, O Ettala, M Nurmi, PJ Boström, M Kallajoki, J Tuomela, T Mirtti, IJ Beumer, M Nees, P Härkönen
Cancers, 2022;14(2):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Microwell bag culture for large-scale production of homogeneous islet-like clusters
Authors: R Suenaga, S Konagaya, J Yamaura, R Ito, S Tanaka, Y Ishizaki, T Toyoda
Scientific Reports, 2022;12(1):5221.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
HER2-CDH1 Interaction via Wnt/B-Catenin Is Associated with Patients' Survival in HER2-Positive Metastatic Gastric Adenocarcinoma
Authors: V De Re, L Alessandri, G Brisotto, L Caggiari, M De Zorzi, M Casarotto, G Miolo, F Puglisi, SK Garattini, S Lonardi, R Cannizzaro, V Canzonieri, M Fassan, A Steffan
Cancers, 2022;14(5):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids
Authors: K Uehara, M Koyanagi-A, T Koide, T Itoh, T Aoi
Stem Cell Reports, 2022;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Engineering brain assembloids to interrogate human neural circuits
Authors: Y Miura, MY Li, O Revah, SJ Yoon, G Narazaki, SP Pa?ca
Nature Protocols, 2022;17(1):15-35.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Conversion of Human Fibroblasts into Induced Neural Stem Cells by Small Molecules
Authors: D Liu, G Rychkov, P Hurtado, HY Luo, T Zhang, L Bobrovskay, XF Zhou
International Journal of Molecular Sciences, 2022;23(3):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer
Authors: SH Gao, GZ Wang, LP Wang, L Feng, YC Zhou, XJ Yu, F Liang, FY Yang, Z Wang, BB Sun, D Wang, LJ Liang, DW Xie, S Zhao, HP Feng, X Li, KK Li, TS Tang, YC Huang, SQ Wang, GB Zhou
Cell Calcium, 2022;102(0):102527.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Phosphoproteomic profiling of influenza virus entry reveals infection-triggered filopodia induction counteracted by dynamic cortactin phosphorylation
Authors: A Hunziker, I Glas, MO Pohl, S Stertz
Cell Reports, 2022;38(4):110306.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Degradation of DRAK1 by CUL3/SPOP E3 Ubiquitin ligase promotes tumor growth of paclitaxel-resistant cervical cancer cells
Authors: K Pang, J Lee, J Kim, J Park, Y Park, E Hong, H An, A Ooshima, M Son, KS Park, JH Cho, C Lee, YS Song, KM Yang, SJ Kim
Cell Death & Disease, 2022;13(2):169.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3
Authors: Z Pan, R Zhao, B Li, Y Qi, W Qiu, Q Guo, S Zhang, S Zhao, H Xu, M Li, Z Gao, Y Fan, J Xu, H Wang, S Wang, J Qiu, Q Wang, X Guo, L Deng, P Zhang, H Xue, G Li
Molecular Cancer, 2022;21(1):16.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MicroRNA 3928 Suppresses Glioblastoma through Downregulation of Several Oncogenes and Upregulation of p53
Authors: EQX Mulcahy, Y Zhang, RR Col?n, SR Cain, MK Gibert, CJ Dube, M Hafner, R Abounader
International Journal of Molecular Sciences, 2022;23(7):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CERS6-AS1 contributes to the malignant phenotypes of colorectal cancer cells by interacting with miR-15b-5p to regulate SPTBN2
Authors: SY Zhao, Z Wang, XB Wu, S Zhang, Q Chen, DD Wang, QF Tan
The Kaohsiung journal of medical sciences, 2022;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Suspension culture promotes serosal mesothelial development in human intestinal organoids
Authors: MM Capeling, S Huang, CJ Childs, JH Wu, YH Tsai, A Wu, N Garg, EM Holloway, N Sundaram, C Bouffi, M Helmrath, JR Spence
Cell Reports, 2022;38(7):110379.
Species: Human
Sample Types: Organoids
Applications: Bioassay -
Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias
Authors: C Hu, CA Leche, A Kiyatkin, Z Yu, SE Stayrook, KM Ferguson, MA Lemmon
Nature, 2022;602(7897):518-522.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis
Authors: H Han, Y Wang, J Curto, S Gurrapu, S Laudato, A Rumandla, G Chakrabort, X Wang, H Chen, Y Jiang, D Kumar, EG Caggiano, M Capogiri, B Zhang, Y Ji, SN Maity, M Hu, S Bai, AM Aparicio, E Efstathiou, CJ Logothetis, N Navin, NM Navone, Y Chen, FG Giancotti
Cell Reports, 2022;39(1):110595.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals
Authors: DA Eagles, NJ Saez, B Krishnarju, JJ Bradford, YK Chin, H Starobova, A Mueller, ME Reichelt, EAB Undheim, RS Norton, WG Thomas, I Vetter, GF King, SD Robinson
Proceedings of the National Academy of Sciences of the United States of America, 2022;119(7):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IQGAP1 is positively correlated with PD-L1 and regulates its expression via mediating STAT proteins phosphorylation
Authors: Y Chen, J Mei, P Zhang, J Liu, L Chen, L Wu, Y Zhang
Oncogene, 2022;108(0):108897.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity
Authors: D Bernareggi, Q Xie, BC Prager, J Yun, LS Cruz, TV Pham, W Kim, X Lee, M Coffey, C Zalfa, P Azmoon, H Zhu, P Tamayo, JN Rich, DS Kaufman
Nature Communications, 2022;13(1):1899.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cytoplasmic LMO2-LDB1 Complex Activates STAT3 Signaling through Interaction with gp130-JAK in Glioma Stem Cells
Authors: CG Park, SH Choi, SY Lee, K Eun, MG Park, J Jang, HJ Jeong, SJ Kim, S Jeong, K Lee, H Kim
Cells, 2022;11(13):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Influence of the Postmortem/Storage Time of Human Corneas on the Properties of Cultured Limbal Epithelial Cells
Authors: G Le-Bel, P Desjardins, C Gross, S Cortez Ghi, C Couture, L Germain, SL Guérin
Cells, 2022;11(17):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Combination of Ad-SGE-REIC and bevacizumab modulates glioma progression by suppressing tumor invasion and angiogenesis
Authors: Y Hattori, K Kurozumi, Y Otani, A Uneda, N Tsuboi, K Makino, S Hirano, K Fujii, Y Tomita, T Oka, Y Matsumoto, Y Shimazu, H Michiue, H Kumon, I Date
PLoS ONE, 2022;17(8):e0273242.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Exposure to e-cigarette vapor extract induces vocal fold epithelial injury and triggers intense mucosal remodeling
Authors: V Lungova, K Wendt, SL Thibeault
Oncogene, 2022;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Efficient Gene Expression in Human Stem Cell Derived-Cortical Organoids Using Adeno Associated Virus
Authors: AN Cho, F Bright, N Morey, C Au, LM Ittner, YD Ke
Cells, 2022;11(20):.
Species: Human
Sample Types: Organoid
Applications: Bioassay -
Estrone, the major postmenopausal estrogen, binds ERa to induce SNAI2, epithelial-to-mesenchymal transition, and ER+ breast cancer metastasis
Authors: R Qureshi, M Picon-Ruiz, M Sho, D Van Booven, V Nunes de P, AB Diaz-Ruano, TA Ince, J Slingerlan
Cell Reports, 2022;41(7):111672.
-
7beta-22 Dihydroxyhopane, Isolated from the Sub-Antarctic Lichen, Inhibits the Viability and Stemness in Glioma Stem Like Cells
Authors: HJ Kim, SS Suh, J Park, MJ Shin, MH Koo, SJ Lee, YJ Jeon, S Lee, UJ Youn, SH Kim
OncoTargets and Therapy, 2022;15(0):1375-1383.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Stem-Cell-Derived beta-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity
Authors: TM Triolo, JQ Matuschek, R Castro-Gut, AH Shilleh, SPM Williams, MS Hansen, K McDaniel, JM Barra, A Michels, HA Russ
Cells, 2022;11(23):.
Species: Human
Sample Types: Whole Cells
Applications: Differentiation -
Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy
Authors: L Liu, S Han, X Xiao, X An, J Gladkich, U Hinz, S Hillmer, T Hoppe-Tich, Y Xu, M Schaefer, O Strobel, I Herr
Cell Death & Disease, 2022;13(12):1052.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Long noncoding RNA-mediated activation of PROTOR1/PRR5-AKT signaling shunt downstream of PI3K in�triple-negative breast cancer
Authors: Z Tu, Y Hu, D Raizada, MA Bassal, DG Tenen, AE Karnoub
Proceedings of the National Academy of Sciences of the United States of America, 2022;119(43):e2203180119.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes
Authors: H Wang, B Keepers, Y Qian, Y Xie, M Colon, J Liu, L Qian
Cell Stem Cell, 2022;29(10):1491-1504.e9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The oncogenic JAG1 intracellular domain is a transcriptional cofactor that acts in concert with DDX17/SMAD3/TGIF2
Authors: EJ Kim, JY Kim, SO Kim, N Hong, SH Choi, MG Park, J Jang, SW Ham, S Seo, SY Lee, K Lee, HJ Jeong, SJ Kim, S Jeong, K Min, SC Kim, X Jin, SH Kim, SH Kim, H Kim
Cell Reports, 2022;41(8):111626.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Crocetin protects against mitochondrial damage induced by UV-A irradiation in corneal epithelial cell line HCE-T cells
Authors: W Otsu, T Yako, E Sugisawa, S Nakamura, H Tsusaki, N Umigai, M Shimazawa, H Hara
Journal of pharmacological sciences, 2022;150(4):279-288.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells via Tryptophan 2,3 Dioxygenase
Authors: M Cecchi, A Mannini, A Lapucci, A Silvano, M Lulli, C Luceri, M D'Ambrosio, A Chiarugi, AH Eid, A Parenti
Frontiers in Pharmacology, 2022;13(0):911019.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Generation and cryopreservation of feline oviductal organoids
Authors: RE Thompson, MA Meyers, C Premananda, FK Hollinshea
Theriogenology, 2022;196(0):167-173.
Species: Feline
Sample Types: Organoids
Applications: Bioassay -
Effects of a novel hepatitis B anti-viral drug E-CFCP in renal organic acid transporters
Authors: M Ishibane, H Hashimoto, M Kaneko, S Saito, S Pae, S Saito, Y Reien, Y Hirayama, N Higashi-Ku, H Mitsuya, N Anzai
Journal of pharmacological sciences, 2022;150(4):201-203.
Species: Transgenic Mouse
Sample Types: Cells
Applications: Bioassay -
The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A
Authors: A Beucher, I Miguel-Esc, D Balboa, MG De Vas, MA Maestro, J Garcia-Hur, A Bernal, R Gonzalez-F, P Vargiu, H Heyn, P Ravassard, S Ortega, J Ferrer
Nature Cell Biology, 2022;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity
Authors: JE Kaserman, RB Werder, F Wang, T Matte, MI Higgins, M Dodge, J Lindstrom-, P Bawa, A Hinds, E Bullitt, IS Caballero, X Shi, RE Gerszten, N Brunetti-P, M Liesa, C Villacorta, AN Hollenberg, DN Kotton, AA Wilson
Cell Reports, 2022;41(10):111775.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Glioblastoma cells have increased capacity to repair radiation-induced DNA damage after migration to the olfactory bulb
Authors: C Degorre, IC Sutton, SL Lehman, UT Shankavara, K Camphausen, PJ Tofilon
Cancer Cell International, 2022;22(1):389.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Maturation and circuit integration of transplanted human cortical organoids
Authors: O Revah, F Gore, KW Kelley, J Andersen, N Sakai, X Chen, MY Li, F Birey, X Yang, NL Saw, SW Baker, ND Amin, S Kulkarni, R Mudipalli, B Cui, S Nishino, GA Grant, JK Knowles, M Shamloo, JR Huguenard, K Deisseroth, SP Pa?ca
Nature, 2022;610(7931):319-326.
Species: Human
Sample Types: Spheroid
Applications: Bioassay -
Long noncoding RNA Smyca coactivates TGF-beta/Smad and Myc pathways to drive tumor progression
Authors: HY Chen, SJ Chan, X Liu, AC Wei, RI Jian, KW Huang, YD Lang, JH Shih, CC Liao, CL Luan, YT Kao, SY Chiang, PW Hsiao, YS Jou, Y Chen, RH Chen
Journal of hematology & oncology, 2022;15(1):85.
Species: Human
Sample Types: Spheroids
Applications: Bioassay -
Antibody targeting of E3 ubiquitin ligases for receptor degradation
Authors: H Marei, WK Tsai, YS Kee, K Ruiz, J He, C Cox, T Sun, S Penikalapa, P Dwivedi, M Choi, D Kan, P Saenz-Lope, K Dorighi, P Zhang, YT Kschonsak, N Kljavin, D Amin, I Kim, AG Mancini, T Nguyen, C Wang, E Janezic, A Doan, E Mai, H Xi, C Gu, M Heinlein, B Biehs, J Wu, I Lehoux, S Harris, L Comps-Agra, D Seshasayee, FJ de Sauvage, M Grimmer, J Li, NJ Agard, F de Sousa E
Nature, 2022;610(7930):182-189.
Species: Human
Sample Types: Organoid
Applications: Bioassay -
Neutralizing Antibodies to Human Cytomegalovirus Recombinant Proteins Reduce Infection in an Ex Vivo Model of Developing Human Placentas
Authors: T Tabata, M Petitt, J Li, X Chi, W Chen, I Yurgelonis, S Wellnitz, S Bredl, T Vicente, X Yang, PR Dormitzer, L Pereira
Vaccines, 2022;10(7):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Organoids capture tissue-specific innate lymphoid cell development in mice and humans
Authors: GM Jowett, E Read, LB Roberts, D Coman, M Vilà Gonzá, T Zabinski, U Niazi, R Reis, TJ Trieu, D Danovi, E Gentleman, L Vallier, MA Curtis, GM Lord, JF Neves
Cell Reports, 2022;40(9):111281.
Species: Mouse
Sample Types: Organoid
Applications: Bioassay -
In-Vitro Use of Verteporfin for Photodynamic Therapy in Glioblastoma
Authors: S Jeising, G Geerling, R Guthoff, D Hänggi, M Sabel, M Rapp, AC Nickel
Photodiagnosis and photodynamic therapy, 2022;0(0):103049.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cells
Authors: DS Lee, YJ Song, HR Gug, JH Lee, HS Bae, JC Park
Stem Cells International, 2022;2022(0):1092184.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Synchronous intracellular delivery of EGFR-targeted antibody-drug conjugates by p38-mediated non-canonical endocytosis
Authors: JI Takahashi, S Nakamura, I Onuma, Y Zhou, S Yokoyama, H Sakurai
Scientific Reports, 2022;12(1):11561.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
PI3K drives the de novo synthesis of coenzyme A from vitamin B5
Authors: CC Dibble, SA Barritt, GE Perry, EC Lien, RC Geck, SE DuBois-Coy, D Bartee, TT Zengeya, EB Cohen, M Yuan, BD Hopkins, JL Meier, JG Clohessy, JM Asara, LC Cantley, A Toker
Nature, 2022;608(7921):192-198.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tumor-associated macrophages promote resistance of hepatocellular carcinoma cells against sorafenib by activating CXCR2 signaling
Authors: HC Wang, LY Haung, CJ Wang, YJ Chao, YC Hou, CJ Yen, YS Shan
Journal of Biomedical Science, 2022;29(1):99.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Computational modeling implicates protein scaffolding in p38 regulation of Akt
Authors: PC Kinnunen, GD Luker, KE Luker, JJ Linderman
Journal of theoretical biology, 2022;555(0):111294.
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay -
Long-term maintenance of human endometrial epithelial stem cells and their therapeutic effects on intrauterine adhesion
Authors: W He, X Zhu, A Xin, H Zhang, Y Sun, H Xu, H Li, T Yang, D Zhou, H Yan, X Sun
Cell & bioscience, 2022;12(1):175.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Sox9 directs divergent epigenomic states in brain tumor subtypes
Authors: D Sardar, HC Chen, A Reyes, S Varadharaj, A Jain, C Mohila, R Curry, B Lozzi, K Rajendran, A Cervantes, K Yu, A Jalali, G Rao, SC Mack, B Deneen
Oncogene, 2022;119(29):e2202015119.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CDK4/6 inhibition enhances oncolytic virus efficacy by potentiating tumor-selective cell killing and T cell activation in refractory glioblastoma
Authors: D Guo, J Xiao, J Liang, J Fan, P Hou, X Li, H Zhang, K Li, L Bu, P Li, M He, Y Zhong, L Guo, P Jia, Q Xiao, J Wu, H Peng, C Li, F Xing
Cancer Research, 2022;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pharmacological targeting of TFIIH suppresses KRAS mutant pancreatic ductal adenocarcinoma and synergizes with TRAIL
Authors: R Moser, J Annis, O Nikolova, CJ Whatcott, KE Gurley, E Mendez, K Moran-Jone, C Dorrell, RC Sears, CJ Kuo, H Han, AV Biankin, C Grandori, DD Von Hoff, CJ Kemp
Cancer Research, 2022;0(0):.
Species: Human
Sample Types: Organoids
Applications: Bioassay -
beta2-microglobulin maintains glioblastoma stem cells and induces M2-like polarization of tumor-associated macrophages
Authors: D Li, Q Zhang, L Li, K Chen, J Yang, D Dixit, RC Gimple, S Ci, C Lu, L Hu, J Gao, D Shan, Y Li, J Zhang, ZM Shi, D Gu, W Yuan, Q Wu, K Yang, L Zhao, Z Qiu, D Lv, W Gao, H Yang, F Lin, Q Wang, J Man, C Li, W Tao, S Agnihotri, X Qian, Y Shi, Y You, N Zhang, JN Rich, X Wang
Oncogene, 2022;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CXCR4 Regulates Temporal Differentiation via PRC1 Complex in Organogenesis of Epithelial Glands
Authors: J Kim, SW Lee, K Park
International Journal of Molecular Sciences, 2021;22(2):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
alpha-glucosyl-rutin activates immediate early genes in human induced pluripotent stem cells
Authors: T Miyake, M Kuge, Y Matsumoto, M Shimada
Stem Cell Research, 2021;56(0):102511.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection
Authors: AV Parent, G Faleo, J Chavez, M Saxton, DI Berrios, NR Kerper, Q Tang, M Hebrok
Cell Reports, 2021;36(7):109538.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Gintonin influences the morphology and motility of adult brain neurons via LPA receptors
Authors: DG Kim, HJ Kim, SH Choi, SM Nam, HC Kim, H Rhim, IH Cho, MH Rhee, SY Nah
Journal of Ginseng Research, 2021;45(3):401-407.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function
Authors: S Bahl, H Ling, NPN Acharige, I Santos-Bar, MKH Pflum, E Seto
Cell Death & Disease, 2021;12(5):469.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease
Authors: A Tarallo, C Damiano, S Strollo, N Minopoli, A Indrieri, E Polishchuk, F Zappa, E Nusco, S Fecarotta, C Porto, M Coletta, R Iacono, M Moracci, R Polishchuk, DL Medina, P Imbimbo, DM Monti, MA De Matteis, G Parenti
Embo Molecular Medicine, 2021;0(0):e14434.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage
Authors: Q Zhu, F Sang, S Withey, W Tang, S Dietmann, D Klisch, P Ramos-Ibea, H Zhang, CE Requena, P Hajkova, M Loose, MA Surani, R Alberio
Cell Reports, 2021;34(6):108735.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma
Authors: E Jung, M Osswald, M Ratliff, H Dogan, R Xie, S Weil, DC Hoffmann, FT Kurz, T Kessler, S Heiland, A von Deimli, F Sahm, W Wick, F Winkler
Nature Communications, 2021;12(1):1014.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effects of selected hormones and their combination on progesterone and estradiol production and proliferation of feline granulosa cells cultured in�vitro
Authors: M Chiara Per, N Bellitto, ERS Maylem, F Caloni, LJ Spicer
Theriogenology, 2021;168(0):1-12.
Species: Feline
Sample Types: Whole Cells
Applications: Bioassay -
CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance
Authors: C Wang, Y Li, L Jia, JK Kim, J Li, P Deng, W Zhang, PH Krebsbach, CY Wang
Cell Stem Cell, 2021;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models
Authors: Y Aghazadeh, F Poon, F Sarangi, FTM Wong, ST Khan, X Sun, R Hatkar, BJ Cox, SS Nunes, MC Nostro
Cell Stem Cell, 2021;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Glioma cells require one-carbon metabolism to survive glutamine starvation
Authors: K Tanaka, T Sasayama, H Nagashima, Y Irino, M Takahashi, Y Izumi, T Uno, N Satoh, A Kitta, K Kyotani, Y Fujita, M Hashiguchi, T Nakai, M Kohta, Y Uozumi, M Shinohara, K Hosoda, T Bamba, E Kohmura
Acta neuropathologica communications, 2021;9(1):16.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth
Authors: M Niu, J Xu, Y Liu, Y Li, T He, L Ding, Y He, Y Yi, F Li, R Guo, Y Gao, R Li, L Li, M Fu, Q Hu, Y Luo, C Zhang, K Qin, J Yi, S Yu, J Yang, H Chen, L Wang, Z Li, B Dong, S Qi, L Ouyang, Y Zhang, Y Cao, ZJ Xiao
Nature Communications, 2021;12(1):5919.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells
Authors: S Ghatak, VC Hascall, RR Markwald, S Misra
International Journal of Molecular Sciences, 2021;22(2):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The Chemokine-Based Peptide, CXCL9(74-103), Inhibits Angiogenesis by Blocking Heparan Sulfate Proteoglycan-Mediated Signaling of Multiple Endothelial Growth Factors
Authors: A De Zutter, H Crijns, N Berghmans, M García-Cab, L Vanbrabant, N Pörtner, V Vanheule, P Verscheure, MM Siddiquei, AM Abu El-Asr, P Carmeliet, P Van Wielen, I De Meester, J Van Damme, P Proost, S Struyf
Cancers, 2021;13(20):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells
Authors: T Kobayashi, A Castillo-V, CA Penfold, M Morgan, N Mizuno, WWC Tang, Y Osada, M Hirao, F Yoshida, H Sato, H Nakauchi, M Hirabayash, MA Surani
Cell Reports, 2021;37(2):109812.
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay -
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors
Authors: T Gebregiwor, Y Kano, J St-Germain, N Radulovich, ML Udaskin, A Mentes, R Huang, BPK Poon, W He, I Valencia-S, CM Robinson, M Huestis, J Miao, JJ Yeh, ZY Zhang, MS Irwin, JE Lee, MS Tsao, B Raught, CB Marshall, M Ohh, M Ikura
Nature Communications, 2021;12(1):6274.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CD200 -dependent and -independent immune-modulatory functions of neural stem cells
Authors: T Arad, N Fainstein, S Goldfarb, M Lachish, T Ganz, T Ben-Hur
Stem Cell Research, 2021;56(0):102559.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
CD44v6 Defines a New Population of Circulating Tumor Cells Not Expressing EpCAM
Authors: G Belthier, Z Homayed, F Grillet, C Duperray, J Vendrell, I Krol, S Bravo, JC Boyer, O Villeronce, J Vitre-Boub, D Heaug-Wane, F Macari-Fin, J Smith, M Merlot, G Lossaint, T Mazard, F Portales, J Solassol, M Ychou, N Aceto, E Mamessier, F Bertucci, JM Pascussi, E Samalin, F Hollande, J Pannequin
Cancers, 2021;13(19):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation
Authors: S van der Po, GMH Birchenoug, JM Held
Cell Reports, 2021;35(1):108949.
Species: Mouse
Sample Types: Organoid
Applications: Bioassay -
CRMP2 as a Candidate Target to Interfere with Lung Cancer Cell Migration
Authors: X Morales, R Peláez, S Garasa, C Ortiz de S, A Rouzaut
Biomolecules, 2021;11(10):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Measuring the elastic modulus of soft culture surfaces and three-dimensional hydrogels using atomic force microscopy
Authors: MDA Norman, SA Ferreira, GM Jowett, L Bozec, E Gentleman
Nature Protocols, 2021;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer
Authors: JA Sninsky, KS Bishnupuri, I González, NA Trikalinos, L Chen, BK Dieckgraef
Oncotarget, 2021;12(4):278-291.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Primate cell fusion disentangles gene regulatory divergence in neurodevelopment
Authors: RM Agoglia, D Sun, F Birey, SJ Yoon, Y Miura, K Sabatini, SP Pa?ca, HB Fraser
Nature, 2021;0(0):.
Species: Human
Sample Types: Organoid
Applications: Bioassay -
Heterozygous APC germline mutations impart predisposition to colorectal cancer
Authors: L Preisler, A Habib, G Shapira, L Kuznitsov-, Y Mayshar, I Carmel-Gro, M Malcov, F Azem, N Shomron, R Kariv, D Hershkovit, D Ben-Yosef
Scientific Reports, 2021;11(1):5113.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Abnormally elevated ubiquilin?1 expression in breast cancer regulates metastasis and stemness via AKT signaling
Authors: X Feng, A Cao, T Qin, Q Zhang, S Fan, B Wang, B Song, X Yu, L Li
Oncology reports, 2021;46(5):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Chronic intermittent hypoxia promoted lung cancer stem cell-like properties via enhancing Bach1 expression
Authors: S Hao, X Zhu, Z Liu, X Wu, S Li, P Jiang, L Jiang
Respiratory Research, 2021;22(1):58.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease
Authors: KA Lidberg, AJ Annalora, M Jozic, DJ Elson, L Wang, TK Bammler, S Ramm, MB Monteiro, J Himmelfarb, CB Marcus, PL Iversen, EJ Kelly
Scientific Reports, 2021;11(1):4722.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Sex-Specific Isolation and Propagation of Human Premeiotic Fetal Germ Cells and Germ Cell-Like Cells
Authors: S Mishra, J Taelman, YW Chang, A Boel, P De Sutter, B Heindryckx, SM Chuva De S
Cells, 2021;10(5):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Two distinct trophectoderm lineage stem cells from human pluripotent stem cells
Authors: A Mischler, V Karakis, J Mahinthaku, CK Carberry, A San Miguel, JE Rager, RC Fry, BM Rao
The Journal of Biological Chemistry, 2021;0(0):100386.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The histone demethylase KDM2B regulates human primordial germ cell-like cells specification
Authors: W Yuan, Z Yao, V Veerapandi, X Yang, X Wang, D Chen, L Ma, C Li, Y Zheng, F Luo, XY Zhao
International journal of biological sciences, 2021;17(2):527-538.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth
Authors: D Sighel, M Notarangel, S Aibara, A Re, G Ricci, M Guida, A Soldano, V Adami, C Ambrosini, F Broso, EF Rosatti, S Longhi, M Buccarelli, QG D'Alessand, S Giannetti, S Pacioni, L Ricci-Viti, J Rorbach, R Pallini, S Roulland, A Amunts, I Mancini, A Modelska, A Quattrone
Cell Reports, 2021;35(4):109024.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional
Authors: IT Stancil, JE Michalski, D Davis-Hall, HW Chu, JA Park, CM Magin, IV Yang, BJ Smith, E Dobrinskik, DA Schwartz
Nature Communications, 2021;12(1):4566.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effects of islatravir (4'-ethynyl-2-fluoro-2'-deoxyadenosine or EFdA) on renal tubular cells and islatravir's interactions with organic anion transporters
Authors: M Kaneko, Y Reien, H Morio, T Fukuuchi, K Kaneko, Y Hirayama, H Hashimoto, N Kuwata, H Mitsuya, N Anzai
Journal of pharmacological sciences, 2021;146(2):82-87.
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Capturing human trophoblast development with naive pluripotent stem cells in�vitro
Authors: S Io, M Kabata, Y Iemura, K Semi, N Morone, A Minagawa, B Wang, I Okamoto, T Nakamura, Y Kojima, C Iwatani, H Tsuchiya, B Kaswandy, E Kondoh, S Kaneko, K Woltjen, M Saitou, T Yamamoto, M Mandai, Y Takashima
Cell Stem Cell, 2021;28(6):1023-1039.e13.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The translocon-associated protein (TRAP) complex regulates quality control of N-linked glycosylation during ER stress
Authors: C Phoomak, W Cui, TJ Hayman, SH Yu, P Zhao, L Wells, R Steet, JN Contessa
Science Advances, 2021;7(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The development of a functional human small intestinal epithelium model for drug absorption
Authors: O Kwon, KB Jung, KR Lee, YS Son, H Lee, JJ Kim, K Kim, S Lee, YK Song, J Jung, K Park, DS Kim, MJ Son, MO Lee, TS Han, HS Cho, SJ Oh, H Chung, SH Kim, KS Chung, J Kim, CR Jung, MY Son
Science Advances, 2021;7(23):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
Authors: J Dong, J Li, Y Li, Z Ma, Y Yu, CY Wang
Nature Communications, 2021;12(1):3974.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting
Authors: R Wang, ST Wu, X Yang, Y Qian, JP Choi, R Gao, S Song, Y Wang, T Zhuang, JJ Wong, Y Zhang, Z Han, HA Lu, SI Alexander, R Liu, Y Xia, X Zheng
JCI Insight, 2021;6(12):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Biomarkers for Comorbidities Modulate the Activity of T-Cells in COPD
Authors: K Jamal Jame, WJ Gallert, SD Yanik, S Panek, J Kronsbein, D Jungck, A Koch, J Knobloch
International Journal of Molecular Sciences, 2021;22(13):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
D-Propranolol Impairs EGFR Trafficking and Destabilizes Mutant p53 Counteracting AKT Signaling and Tumor Malignancy
Authors: J Barra, J Cerda-Infa, L Sandoval, P Gajardo-Me, JF Henriquez, M Labarca, C Metz, J Venegas, C Retamal, C Oyanadel, J Cancino, A Soza, MA Cuello, JC Roa, VP Montecinos, A Gonzalez
Cancers, 2021;13(14):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anti-Angiogenic Treatment in Pseudomyxoma Peritonei-Still a Strong Preclinical Rationale
Authors: Y Andersson, KG Fleten, TW Abrahamsen, W Reed, B Davidson, K Flatmark
Cancers, 2021;13(11):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
Authors: MO Lee, SG Lee, CR Jung, YS Son, JW Ryu, KB Jung, JH Ahn, JH Oh, HA Lee, JH Lim, J Kim, I Jang, J Choi, J Jung, K Park, B Lee, DS Kim, MY Son, HS Cho
Nature Communications, 2021;12(1):4492.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays
Authors: X Dolde, C Karreman, M Wiechers, S Schildknec, M Leist
International Journal of Molecular Sciences, 2021;22(18):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Myogenic Differentiation of iPS Cells Shows Different Efficiency in Simultaneous Comparison of Protocols
Authors: A Ulman, M Kot, K Skrzypek, B Szewczyk, M Majka
Cells, 2021;10(7):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma
Authors: L Jerby-Arno, C Neftel, ME Shore, HR Weisman, ND Mathewson, MJ McBride, B Haas, B Izar, A Volorio, G Boulay, L Cironi, AR Richman, LC Broye, JM Gurski, CC Luo, R Mylvaganam, L Nguyen, S Mei, JC Melms, C Georgescu, O Cohen, JE Buendia-Bu, A Segerstolp, M Sud, MS Cuoco, D Labes, S Gritsch, DR Zollinger, N Ortogero, JM Beechem, G Petur Niel, I Chebib, T Nguyen-Ngo, M Montemurro, GM Cote, E Choy, I Letovanec, S Cherix, N Wagle, PK Sorger, AB Haynes, JT Mullen, I Stamenkovi, MN Rivera, C Kadoch, KW Wucherpfen, O Rozenblatt, ML Suvà, N Riggi, A Regev
Nature Medicine, 2021;0(0):.
Species: Human
Sample Types: Spheroid
Applications: Bioassay -
Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype
Authors: RR Madsen, EC Erickson, OM Rueda, X Robin, C Caldas, A Toker, RK Semple, B Vanhaesebr
PloS Genetics, 2021;17(11):e1009876.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
In Vitro Study of Human Immune Responses to Hyaluronic Acid Hydrogels, Recombinant Spidroins and Human Neural Progenitor Cells of Relevance to Spinal Cord Injury Repair
Authors: C Lin, Å Ekblad-Nor, J Michaëlsso, C Götherströ, CC Hsu, H Ye, J Johansson, A Rising, E Sundström, E Åkesson
Cells, 2021;10(7):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anaphylatoxins orchestrate Th17 response via interactions between CD16+ monocytes and pleural mesothelial cells in tuberculous pleural effusion
Authors: S Deng, X Hu, L Luo, W Tang, Y Jiang, F Yin, C Hu, J Feng, X Li
PloS Neglected Tropical Diseases, 2021;15(7):e0009508.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Neurodegeneration Induced by Anti-IgLON5 Antibodies Studied in Induced Pluripotent Stem Cell-Derived Human Neurons
Authors: M Ryding, M Gamre, MS Nissen, AC Nilsson, J Okarmus, AAE Poulsen, M Meyer, M Blaabjerg
Cells, 2021;10(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling
Authors: A Abdullah, C Herdenberg, H Hedman
Scientific Reports, 2021;11(1):8585.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer
Authors: SM Dieter, C Siegl, PL Codó, M Huerta, AL Ostermann-, E Schulz, MK Zowada, S Martin, K Laaber, A Nowrouzi, M Blatter, S Kreth, F Westermann, A Benner, U Uhrig, K Putzker, J Lewis, A Haegebarth, D Mumberg, SJ Holton, J Weiske, LM Toepper, U Scheib, G Siemeister, CR Ball, B Kuster, G Stoehr, H Hahne, S Johannes, M Lange, F Herbst, H Glimm
Cell Reports, 2021;36(3):109394.
Species: Human
Sample Types: Organoid
Applications: Bioassay -
Repositioning Trimebutine Maleate as a Cancer Treatment Targeting Ovarian Cancer Stem Cells
Authors: H Lee, OB Kwon, JE Lee, YH Jeon, DS Lee, SH Min, JW Kim
Cells, 2021;10(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells
Authors: M Yoshimatsu, H Ohnishi, C Zhao, Y Hayashi, F Kuwata, S Kaba, H Okuyama, Y Kawai, N Hiwatashi, Y Kishimoto, T Sakamoto, M Ikeya, K Omori
Stem Cell Research, 2021;52(0):102233.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Simultaneous readout of multiple FRET pairs using photochromism
Authors: T Roebroek, W Vandenberg, F Sipieter, S Hugelier, C Stove, J Zhang, P Dedecker
Nature Communications, 2021;12(1):2005.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A pan-cancer organoid platform for precision medicine
Authors: BM Larsen, M Kannan, LF Langer, BD Leibowitz, A Bentaieb, A Cancino, I Dolgalev, BE Drummond, JR Dry, CS Ho, G Khullar, BA Krantz, B Mapes, KE McKinnon, J Metti, JF Perera, TA Rand, V Sanchez-Fr, JM Shaxted, MM Stein, MA Streit, YC Tan, Y Zhang, E Zhao, J Venkataram, MC Stumpe, JA Borgia, A Masood, DVT Catenacci, JV Mathews, DB Gursel, JJ Wei, TH Welling, DM Simeone, KP White, AA Khan, C Igartua, AA Salahudeen
Cell Reports, 2021;36(4):109429.
Species: Human
Sample Types: Organoid
Applications: Bioassay -
TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation
Authors: C Tu, H Li, X Liu, Y Wang, W Li, L Meng, W Wang, Y Li, D Li, J Du, G Lu, G Lin, YQ Tan
Autophagy, 2021;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Long-term maturation of human cortical organoids matches key early postnatal transitions
Authors: A Gordon, SJ Yoon, SS Tran, CD Makinson, JY Park, J Andersen, AM Valencia, S Horvath, X Xiao, JR Huguenard, SP Pa?ca, DH Geschwind
Nature Neuroscience, 2021;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
D-Mannose Slows Glioma Growth by Modulating Myeloperoxidase Activity
Authors: N Jalali Mot, C Wang, EG Kuellenber, GR Wojtkiewic, S Schmidt, JW Chen
Cancers, 2021;13(24):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs
Authors: K Nomi, R Hayashi, Y Ishikawa, Y Kobayashi, T Katayama, AJ Quantock, K Nishida
Cell Reports, 2021;34(5):108715.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity
Authors: SK Sarvestani, S Signs, B Hu, Y Yeu, H Feng, Y Ni, DR Hill, RC Fisher, S Ferrandon, RK DeHaan, J Stiene, M Cruise, TH Hwang, X Shen, JR Spence, EH Huang
Nature Communications, 2021;12(1):262.
Species: Human
Sample Types: Organoid
Applications: Bioassay -
hnRNPA2B1 regulates the alternative splicing of BIRC5 to promote gastric cancer progression
Authors: WZ Peng, J Zhao, X Liu, CF Li, S Si, R Ma
Cancer Cell International, 2021;21(1):281.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IDH1 mutations induce organelle defects via dysregulated phospholipids
Authors: A Lita, A Pliss, A Kuzmin, T Yamasaki, L Zhang, T Dowdy, C Burks, N de Val, O Celiku, V Ruiz-Rodad, ER Nicoli, M Kruhlak, T Andresson, S Das, C Yang, R Schmitt, C Herold-Men, MR Gilbert, PN Prasad, M Larion
Nature Communications, 2021;12(1):614.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Conversion of Osteoclasts into Bone-Protective, Tumor-Suppressing Cells
Authors: KX Li, X Sun, BY Li, H Yokota
Cancers, 2021;13(22):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cross-Talk between Probiotic Nissle 1917 and Human Colonic Epithelium Affects the Metabolite Composition and Demonstrates Host Antibacterial Effect
Authors: K Dokladny, JK Crane, AJ Kassicieh, JB Kaper, O Kovbasnjuk
Metabolites, 2021;11(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells
Authors: AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells
Cell Stem Cell, 2021;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors
Authors: RJ Geusz, A Wang, DK Lam, NK Vinckier, KD Alysandrat, DA Roberts, J Wang, S Kefalopoul, A Ramirez, Y Qiu, J Chiou, KJ Gaulton, B Ren, DN Kotton, M Sander
Nature Communications, 2021;12(1):6636.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation
Authors: Y Gu, Y Chen, L Wei, S Wu, K Shen, C Liu, Y Dong, Y Zhao, Y Zhang, C Zhang, W Zheng, J He, Y Wang, Y Li, X Zhao, H Wang, J Tan, L Wang, Q Zhou, G Xie, H Liang, J Ou
Nature Communications, 2021;12(1):6711.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Substratum stiffness regulates Erk signaling dynamics through receptor-level control
Authors: PE Farahani, SB Lemke, E Dine, G Uribe, JE Toettcher, CM Nelson
Cell Reports, 2021;37(13):110181.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Concomitant activation of GLI1 and Notch1 contributes to racial disparity of human triple negative breast cancer progression
Authors: S Siddharth, S Parida, N Muniraj, S Hercules, D Lim, A Nagalingam, C Wang, B Gyorffy, JM Daniel, D Sharma
Elife, 2021;10(0):.
Species: Human
Sample Types: Spheroid
Applications: Bioassay -
Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage
Authors: V Chesnokova, S Zonis, A Apostolou, HQ Estrada, S Knott, K Wawrowsky, K Michelsen, A Ben-Shlomo, R Barrett, V Gorbunova, K Karalis, S Melmed
Cell Reports, 2021;37(11):110068.
Species: Human
Sample Types: Organoid
Applications: Bioassay -
Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients
Authors: AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles
Cells, 2021;10(11):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity
Authors: X Wu, S Xiao, M Zhang, L Yang, J Zhong, B Li, F Li, X Xia, X Li, H Zhou, D Liu, N Huang, X Yang, F Xiao, N Zhang
Genome Biology, 2021;22(1):33.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Combined Targeting of AKT and mTOR Inhibits Proliferation of Human NF1-Associated Malignant Peripheral Nerve Sheath Tumour Cells In Vitro but not in a Xenograft Mouse Model In Vivo
Authors: A Schulte, F Ewald, M Spyra, DJ Smit, W Jiang, J Salamon, M Jücker, VF Mautner
Int J Mol Sci, 2020;21(4):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Human primary endothelial label-free biochip assay reveals unpredicted functions of plasma serine proteases
Authors: ML Debreczeni, I Szekacs, B Kovacs, A Saftics, S Kurunczi, P Gál, J Dobó, L Cervenak, R Horvath
Sci Rep, 2020;10(1):3303.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma
Authors: DJH Shih, N Nayyar, I Bihun, I Dagogo-Jac, CM Gill, E Aquilanti, M Bertalan, A Kaplan, MR D'Andrea, U Chukwueke, FM Ippen, C Alvarez-Br, ND Camarda, M Lastrapes, D McCabe, B Kuter, B Kaufman, MR Strickland, JC Martinez-G, D Nagabhusha, M De Sauvage, MD White, BA Castro, K Hoang, A Kaneb, ED Batchelor, SH Paek, SH Park, M Martinez-L, AS Berghoff, P Merrill, ER Gerstner, TT Batchelor, MP Frosch, RP Frazier, DR Borger, AJ Iafrate, BE Johnson, S Santagata, M Preusser, DP Cahill, SL Carter, PK Brastianos
Nat. Genet., 2020;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
EB1-dependent long survival of glioblastoma-grafted mice with the oral tubulin-binder BAL101553 is associated with inhibition of tumor angiogenesis
Authors: R Bergès, A Tchoghandj, A Sergé, S Honoré, D Figarella-, F Bachmann, HA Lane, D Braguer
Oncotarget, 2020;11(8):759-774.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
EGF released from human placental mesenchymal stem cells improves premature ovarian insufficiency via NRF2/HO-1 activation
Authors: C Ding, Q Zou, Y Wu, J Lu, C Qian, H Li, B Huang
Aging (Albany NY), 2020;12(3):2992-3009.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation
Authors: C Sieben, E Sezgin, C Eggeling, S Manley
PLoS Pathog., 2020;16(7):e1008656.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection
Authors: SK Ryan, MV Gonzalez, JP Garifallou, FC Bennett, KS Williams, NP Sotuyo, E Mironets, K Cook, H Hakonarson, SA Anderson, KL Jordan-Sci
Stem Cell Reports, 2020;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals
Authors: S Findakly, A Choudhury, V Daggubati, M Pekmezci, UE Lang, DR Raleigh
Acta Neuropathol Commun, 2020;8(1):114.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Analysis of multi-lineage gene expression dynamics during primordial germ cell induction from human induced pluripotent stem cells
Authors: F Fang, Z Li, Q Zhao, C Xiong, K Ni
Stem Cell Res Ther, 2020;11(1):100.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Replication Protein A (RPA) Mediates Radio-Resistance of Glioblastoma Cancer Stem-Like Cells
Authors: H Pedersen, E Anne Adanm, KJ Elbæk, K Vitting-Se, P Hamerlik
Int J Mol Sci, 2020;21(5):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Microenvironmentally-driven Plasticity of CD44 isoform expression determines Engraftment and Stem-like Phenotype in CRC cell lines
Authors: TF Dinger, O Chen, C Dittfeld, L Hetze, M Hüther, M Wondrak, S Löck, W Eicheler, G Breier, LA Kunz-Schug
Theranostics, 2020;10(17):7599-7621.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Mucus layer modeling of human colonoids during infection with enteroaggragative E. coli
Authors: L Liu, W Saitz-Roja, R Smith, L Gonyar, JG In, O Kovbasnjuk, NC Zachos, M Donowitz, JP Nataro, F Ruiz-Perez
Sci Rep, 2020;10(1):10533.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Human multipotent adult progenitor cell-conditioned medium improves wound healing through modulating inflammation and angiogenesis in mice
Authors: P Ahangar, SJ Mills, LE Smith, XL Strudwick, AE Ting, B Vaes, AJ Cowin
Stem Cell Res Ther, 2020;11(1):299.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Quantitative Efficacy and Fate of Mesenchymal Stromal Cells Targeted to Cardiac Sites by Radiofrequency Catheter Ablation
Authors: R Malik, FA Darche, R Rivinius, A Seckinger, U Krause, M Koenen, D Thomas, HA Katus, PA Schweizer
Cell Transplant, 2020;29(0):9636897209142.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Generation of Otic Lineages from Integration-Free Human-Induced Pluripotent Stem Cells Reprogrammed by mRNAs
Authors: SL Boddy, R Romero-Gue, AR Ji, C Unger, L Corns, W Marcotti, MN Rivolta
Stem Cells Int, 2020;2020(0):3692937.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells
Authors: Y Wang, L Lifshitz, K Gellatly, CL Vinton, K Busman-Sah, S McCauley, P Vangala, K Kim, A Derr, S Jaiswal, A Kucukural, P McDonel, PW Hunt, T Greenough, J Houghton, M Somsouk, JD Estes, JM Brenchley, M Garber, SG Deeks, J Luban
Nat. Immunol., 2020;21(3):274-286.
Species: Human
Sample Types: Cells
Applications: Cell Culture -
Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential
Authors: SI Mae, M Ryosaka, S Sakamoto, K Matsuse, A Nozaki, M Igami, R Kabai, A Watanabe, K Osafune
Cell Rep, 2020;32(4):107963.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Soy Isoflavone Genistein Impedes Cancer Stemness and Mesenchymal Transition in Head and Neck Cancer through Activating miR-34a/RTCB Axis
Authors: PL Hsieh, YW Liao, CW Hsieh, PN Chen, CC Yu
Nutrients, 2020;12(7):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
WNT7A Promotes EGF-Induced Migration of Oral Squamous Cell Carcinoma Cells by Activating &beta-Catenin/MMP9-Mediated Signaling
Authors: H Xie, Y Ma, J Li, H Chen, Y Xie, M Chen, X Zhao, S Tang, S Zhao, Y Zhang, J Du, F Zhang, L Gu
Front Pharmacol, 2020;11(0):98.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells
Authors: NJ Hogrebe, P Augsornwor, KG Maxwell, L Velazco-Cr, JR Millman
Nat. Biotechnol., 2020;0(0):.
Species: Human
Sample Types: Cells
Applications: Cell Culture -
Calcium Channels as Novel Therapeutic Targets for Ovarian Cancer Stem Cells
Authors: H Lee, JW Kim, DK Kim, DK Choi, S Lee, JH Yu, OB Kwon, J Lee, DS Lee, JH Kim, SH Min
Int J Mol Sci, 2020;21(7):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Generation of intestinal organoids derived from human pluripotent stem cells for drug testing
Authors: S Yoshida, H Miwa, T Kawachi, S Kume, K Takahashi
Sci Rep, 2020;10(1):5989.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
DLL4 restores damaged liver by enhancing hBMSC differentiation into cholangiocytes
Authors: S Sun, L Yuan, Z An, D Shi, J Xin, J Jiang, K Ren, J Chen, B Guo, X Zhou, Q Zhou, X Jin, S Ruan, T Cheng, N Xia, J Li
Stem Cell Res, 2020;47(0):101900.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells
Authors: K Takeishi, A Collin de, Y Wang, K Handa, J Guzman-Lep, K Matsubara, K Morita, S Jang, N Haep, RM Florentino, F Yuan, K Fukumitsu, K Tobita, W Sun, J Franks, ER Delgado, EM Shapiro, NA Fraunhoffe, AW Duncan, H Yagi, T Mashimo, IJ Fox, A Soto-Gutie
Cell Rep, 2020;31(9):107711.
Species: Human
Sample Types: cell culture
-
Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies
Authors: K Kawai, R Negoro, M Ichikawa, T Yamashita, S Deguchi, K Harada, K Hirata, K Takayama, H Mizuguchi
Mol Ther Methods Clin Dev, 2020;17(0):49-57.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Clozapine protects adult neural stem cells from ketamine-induced cell death in correlation with decreased apoptosis and autophagy
Authors: M Lundberg, S Curbo, H Bohman, I Agartz, SO Ögren, C Patrone, S Mansouri
Biosci. Rep., 2020;0(0):.
Species: Mouse
Sample Types: Whole Cell
Applications: Cell Culture -
SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner
Authors: H Ramos, J Calheiros, J Almeida, V Barcherini, S Santos, ATP Carvalho, MMM Santos, L Saraiva
Int J Mol Sci, 2020;21(2):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Glioblastoma Exhibits Inter-Individual Heterogeneity of TSPO and LAT1 Expression in Neoplastic and Parenchymal Cells
Authors: L Cai, SV Kirchleitn, D Zhao, M Li, JC Tonn, R Glass, RE Kälin
Int J Mol Sci, 2020;21(2):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells
Authors: AR Nickolls, MM Lee, DF Espinoza, M Szczot, RM Lam, Q Wang, J Beers, J Zou, MQ Nguyen, HJ Solinski, AA AlJanahi, KR Johnson, ME Ward, AT Chesler, CG Bönnemann
Cell Rep, 2020;30(3):932-946.e7.
Species: Human
Sample Types: Whole Cells
Applications: Differentiation -
Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer
Authors: S Yomtoubian, SB Lee, A Verma, F Izzo, G Markowitz, H Choi, L Cerchietti, L Vahdat, KA Brown, E Andreopoul, O Elemento, J Chang, G Inghirami, D Gao, S Ryu, V Mittal
Cell Rep, 2020;30(3):755-770.e6.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Control of protein function through oxidation and reduction of persulfidated states
Authors: É Dóka, T Ida, M Dagnell, Y Abiko, NC Luong, N Balog, T Takata, B Espinosa, A Nishimura, Q Cheng, Y Funato, H Miki, JM Fukuto, JR Prigge, EE Schmidt, ESJ Arnér, Y Kumagai, T Akaike, P Nagy
Sci Adv, 2020;6(1):eaax8358.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Epithelial-mesenchymal transition suppresses ERas to activate autophagy in retinal pigment epithelial cells in proliferative vitreoretinopathy
Authors: J Pan, LX Zhao
Eur Rev Med Pharmacol Sci, 2020;24(9):4627-4634.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Spatial�organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers
Authors: T Verheyen, T Fang, D Lindenhofe, Y Wang, K Akopyan, A Lindqvist, B Högberg, AI Teixeira
Nucleic Acids Res., 2020;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
In vitro and in vivo Anti-Tumor Effects of Pan-HER Inhibitor Varlitinib on Cholangiocarcinoma Cell Lines
Authors: H Dokduang, W Jamnongkar, B Promraksa, M Suksawat, S Padthaison, M Thanee, J Phetcharab, N Namwat, S Sangkhaman, A Titapun, N Khuntikeo, P Klanrit, W Loilome
Drug Des Devel Ther, 2020;14(0):2319-2334.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tissue Responses to Shiga Toxin in Human Intestinal Organoids
Authors: S Pradhan, SS Karve, AA Weiss, J Hawkins, HM Poling, MA Helmrath, JM Wells, HA McCauley
Cell Mol Gastroenterol Hepatol, 2020;0(0):.
Species: Human
Sample Types: Organoid
Applications: Cell Culture -
In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids
Authors: Y Yuan, L Li, Q Cheng, F Diao, Q Zeng, X Yang, Y Wu, H Zhang, M Huang, J Chen, Q Zhou, Y Zhu, R Hua, J Tian, X Wang, Z Zhou, J Hao, J Yu, D Hua, J Liu, X Guo, Q Zhou, J Sha
Cell Res., 2020;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
X-ray irradiated cultures of mouse cortical neural stem/progenitor cells recover cell viability and proliferation with dose-dependent kinetics
Authors: V Licursi, S Anzellotti, J Favaro, S Sineri, N Carucci, E Cundari, M Fiore, G Guarguagli, S Pippa, PS Nisi, F Vernì, S Biagioni, E Cacci, R Amendola, G Lupo, R Negri
Sci Rep, 2020;10(1):6562.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Enhancing Antitumor Efficacy of Heavily Vascularized Tumors by RAMBO Virus through Decreased Tumor Endothelial Cell Activation
Authors: M Nair, M Khosla, Y Otani, M Yeh, F Park, T Shimizu, JM Kang, C Bolyard, JG Yu, Y Kumar Bana, G Lopez, B Kaur, RE Pollock, TJ Lee, M Old, JY Yoo
Cancers (Basel), 2020;12(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development
Authors: NK Vinckier, NA Patel, RJ Geusz, A Wang, J Wang, I Matta, AR Harrington, M Wortham, N Wetton, J Wang, US Jhala, MG Rosenfeld, CW Benner, HP Shih, M Sander
Nat Commun, 2020;11(1):2082.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Generation of human oogonia from induced pluripotent stem cells in culture
Authors: C Yamashiro, K Sasaki, S Yokobayash, Y Kojima, M Saitou
Nat Protoc, 2020;15(4):1560-1583.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Nitidine Chloride Is a Potential Alternative Therapy for Glioma Through Inducing Endoplasmic Reticulum Stress and Alleviating Epithelial-Mesenchymal Transition
Authors: Z Chen, J Zhang, H Xue, M Qian, X Guo, X Gao, J Xu, Y Qi, X Sun, G Li
Integr Cancer Ther, 2020;19(0):1534735419900.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Metabolic pathway alterations in microvascular endothelial cells in response to hypoxia
Authors: EB Cohen, RC Geck, A Toker
PLoS ONE, 2020;15(7):e0232072.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Astrocytes influence medulloblastoma phenotypes and CD133 surface expression
Authors: E Gronseth, A Gupta, C Koceja, S Kumar, RG Kutty, K Rarick, L Wang, R Ramchandra
PLoS ONE, 2020;15(7):e0235852.
Species: Zebrafish
Sample Types: Whole Cells
Applications: Cell Culture -
Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells
Authors: R Lucero, V Zappulli, A Sammarco, OD Murillo, PS Cheah, S Srinivasan, E Tai, DT Ting, Z Wei, ME Roth, LC Laurent, AM Krichevsky, XO Breakefiel, A Milosavlje
Cell Rep, 2020;30(7):2065-2074.e4.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy
Authors: L Song, Z Liu, HH Hu, Y Yang, TY Li, ZZ Lin, J Ye, J Chen, X Huang, DT Liu, J Zhou, Y Shi, H Zhao, C Xie, L Chen, E Song, SY Lin, SC Lin
Nat Commun, 2020;11(1):5842.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types
Authors: JK Khalsa, N Cheng, J Keegan, A Chaudry, J Driver, WL Bi, J Lederer, K Shah
Nat Commun, 2020;11(1):3912.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Formation of alginate microspheres prepared by optimized microfluidics parameters for high encapsulation of bioactive molecules
Authors: LM Caballero, S Duchi, C Onofrillo, CD O'Connell, C Di Bella, SE Moulton
Journal of colloid and interface science, 2020;587(0):240-251.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
The Fragile X Mental Retardation Protein regulates RIP1K and colorectal cancer resistance to necroptosis
Authors: A Di Grazia, I Marafini, G Pedini, D Di Fusco, F Laudisi, V Dinallo, E Rosina, C Stolfi, E Franzè, P Sileri, G Sica, G Monteleone, C Bagni, I Monteleone
Cell Mol Gastroenterol Hepatol, 2020;0(0):.
Species: Human
Sample Types: Organoid
Applications: Bioassay -
Isolation and characterization of neural crest-like progenitor cells in human umbilical cord blood
Authors: Z Al-Bakri, M Ishige-Wad, N Fukuda, C Yoshida-No, N Nagoshi, H Okano, H Mugishima, T Matsumoto
Regenerative Therapy, 2020;15(0):53-63.
Species: Human
Sample Types: Organoid
Applications: Bioassay -
Modeling Intestinal Epithelial Response to Interferon-&gamma in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids
Authors: MJ Workman, E Troisi, SR Targan, CN Svendsen, RJ Barrett
International Journal of Molecular Sciences, 2020;22(1):.
Species: Human
Sample Types: Organoid
Applications: Bioassay -
Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta
Authors: G Meinhardt, S Haider, V Kunihs, L Saleh, J Pollheimer, C Fiala, S Hetey, Z Feher, A Szilagyi, NG Than, M Knöfler
Proc. Natl. Acad. Sci. U.S.A., 2020;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The Deubiquitinase USP4 Stabilizes Twist1 Protein to Promote Lung Cancer Cell Stemness
Authors: F Li, Q Hu, T He, J Xu, Y Yi, S Xie, L Ding, M Fu, R Guo, ZJ Xiao, M Niu
Cancers (Basel), 2020;12(6):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature
Authors: BN Sheikh, S Guhathakur, TH Tsang, M Schwabenla, G Renschler, B Herquel, V Bhardwaj, H Holz, T Stehle, O Bondareva, N Aizarani, O Mossad, O Kretz, W Reichardt, A Chatterjee, LJ Braun, J Thevenon, H Sartelet, T Blank, D Grün, D von Elverf, TB Huber, D Vestweber, S Avilov, M Prinz, JM Buescher, A Akhtar
Nat. Cell Biol., 2020;0(0):.
Species: Mouse
Sample Types: Organoid
Applications: Bioassay -
Characterization and oncolytic virus targeting of FAP-expressing tumor-associated pericytes in glioblastoma
Authors: M Li, G Li, J Kiyokawa, Z Tirmizi, LG Richardson, J Ning, S Das, RL Martuza, A Stemmer-Ra, SD Rabkin, H Wakimoto
Acta neuropathologica communications, 2020;8(1):221.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Generation and validation of a PITX2-EGFP reporter line of human induced pluripotent stem cells enables isolation of periocular mesenchymal cells
Authors: T Okubo, R Hayashi, S Shibata, Y Kudo, Y Ishikawa, S Inoue, Y Kobayashi, A Honda, Y Honma, S Kawasaki, K Nishida
J. Biol. Chem., 2020;295(11):3456-3465.
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay -
MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK
Authors: Y Na, A Hall, K Choi, L Hu, J Rose, RA Coover, A Miller, RF Hennigan, E Dombi, MO Kim, S Subramania, N Ratner, J Wu
Oncogene, 2020;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells
Authors: YS Hwang, S Suzuki, Y Seita, J Ito, Y Sakata, H Aso, K Sato, BP Hermann, K Sasaki
Nat Commun, 2020;11(1):5656.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
CPEB1 orchestrates a fine-tuning of miR-145-5p tumor-suppressive activity on TWIST1 translation in prostate cancer cells
Authors: F Rajabi, WY Liu-Bordes, M Pinskaya, F Dominika, G Kratassiou, G Pinna, S Nanni, A Farsetti, C Gespach, A Londoño-Va, I Groisman
Oncotarget, 2020;11(45):4155-4168.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways
Authors: C Zhong, P Li, S Argade, L Liu, A Chilla', W Liang, H Xin, B Eliceiri, B Choudhury, N Ferrara
Nature Communications, 2020;11(1):6330.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
EGFR targeting enhances the efficiency of chemotherapy through inhibiting IRE1alpha-XBP1s pathway in colorectal cancer cells
Authors: M Huo, Y Zhao, X Liu, Y Gao, D Zhang, M Chang, M Liu, N Xu, H Zhu
J Cancer, 2020;11(15):4464-4473.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types
Authors: JK Khalsa, N Cheng, J Keegan, A Chaudry, J Driver, WL Bi, J Lederer, K Shah
Nat Commun, 2020;11(1):3912.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of Notch pathway enhances the anti-tumor effect of docetaxel in prostate cancer stem-like cells
Authors: L Wang, H Zi, Y Luo, T Liu, H Zheng, C Xie, X Wang, X Huang
Stem Cell Res Ther, 2020;11(1):258.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Notch signalling drives synovial fibroblast identity and arthritis pathology
Authors: K Wei, I Korsunsky, JL Marshall, A Gao, GFM Watts, T Major, AP Croft, J Watts, PE Blazar, JK Lange, TS Thornhill, A Filer, K Raza, LT Donlin,, CW Siebel, CD Buckley, S Raychaudhu, MB Brenner
Nature, 2020;582(7811):259-264.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Neutrophils produce proinflammatory or anti-inflammatory extracellular vesicles depending on the environmental conditions
Authors: F Kolonics, E Kajdácsi, VJ Farkas, DS Veres, D Khamari, Á Kittel, ML Merchant, KR McLeish, ÁM L?rincz, E Ligeti
J. Leukoc. Biol., 2020;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways
Authors: MH Hancock, J Mitchell, FD Goodrum, JA Nelson
mSphere, 2020;5(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma
Authors: SJ Liu, ST Magill, HN Vasudevan, S Hilz, JE Villanueva, S Lastella, V Daggubati, J Spatz, A Choudhury, BA Orr, B Demaree, K Seo, SP Ferris, AR Abate, NA Oberheim B, AW Bollen, MW McDermott, JF Costello, DR Raleigh
Cell Rep, 2020;30(5):1300-1309.e5.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer
Authors: BA Humphries, AC Cutter, JM Buschhaus, YC Chen, T Qyli, DSW Palagama, S Eckley, TH Robison, A Bevoor, B Chiang, HR Haley, S Sahoo, PC Spinosa, DB Neale, J Boppisetti, D Sahoo, P Ghosh, J Lahann, BD Ross, E Yoon, KE Luker, GD Luker
Breast Cancer Res., 2020;22(1):60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways
Authors: MH Hancock, J Mitchell, FD Goodrum, JA Nelson
mSphere, 2020;5(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease
Authors: MMA Verstegen, FJM Roos, K Burka, H Gehart, M Jager, M de Wolf, MJC Bijvelds, HR de Jonge, AI Ardisasmit, NA van Huizen, HP Roest, J de Jonge, M Koch, F Pampaloni, SA Fuchs, IF Schene, TM Luider, HPJ van der Do, FAJA Bodewes, RHJ de Kleine, B Spee, GJ Kremers, H Clevers, JNM IJzermans, E Cuppen, LJW van der La
Scientific Reports, 2020;10(1):21900.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation
Authors: T Chitiashvi, I Dror, R Kim, FM Hsu, R Chaudhari, E Pandolfi, D Chen, S Liebscher, K Schenke-La, K Plath, A Clark
Nature Cell Biology, 2020;22(12):1436-1446.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Polarization of ADAM17-driven EGFR signalling in electric field-guided collective migration of epidermal sheets
Authors: N Jia, J Liu, G Zhu, Y Liang, Y Wang, W Wang, Y Chen, J Yang, W Zhang, J Zhang
J Cell Mol Med, 2020;0(0):.
Species: Human
Sample Types: cell culture
Applications: Cell Culture -
Combined Poziotinib with Manidipine Treatment Suppresses Ovarian Cancer Stem-Cell Proliferation and Stemness
Authors: H Lee, JW Kim, DS Lee, SH Min
Int J Mol Sci, 2020;21(19):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Mapping Development of the Human Intestinal Niche at Single-Cell Resolution
Authors: EM Holloway, M Czerwinski, YH Tsai, JH Wu, A Wu, CJ Childs, KD Walton, CW Sweet, Q Yu, I Glass, B Treutlein, JG Camp, JR Spence
Cell Stem Cell, 2020;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures
Authors: D Tabari, C Scholl, M Steffens, S Weickhardt, F Elgner, D Bender, ML Herrlein, C Sabino, V Semkova, M Peitz, A Till, O Brüstle, E Hildt, J Stingl
Viruses, 2020;12(11):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Transplantation Efficacy of Human Ciliary Epithelium Cells from Fetal Eye and Lin-ve Stem Cells from Umbilical Cord Blood in the Murine Retinal Degeneration Model of Laser Injury
Authors: S Bammidi, P Bali, J Kalra, A Anand
Cell Transplant, 2020;29(0):9636897209460.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
PI3K p110&alpha Blockade Enhances Anti-Tumor Efficacy of Abemaciclib in Human Colorectal Cancer Cells
Authors: HJ Lee, KJ Kim, JH Sung, M Nam, KJ Suh, JW Kim, SH Kim, JW Kim, YJ Kim, KW Lee, JS Lee, JH Kim
Cancers, 2020;12(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Characterization of zika virus infection of human fetal cardiac mesenchymal stromal cells
Authors: F Rossi, B Josey, EC Sayitoglu, R Potens, T Sultu, AD Duru, V Beljanski
PLoS ONE, 2020;15(9):e0239238.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
EREG-driven oncogenesis of Head and Neck Squamous Cell Carcinoma exhibits higher sensitivity to Erlotinib therapy
Authors: S Liu, Y Wang, Y Han, W Xia, L Zhang, S Xu, H Ju, X Zhang, G Ren, L Liu, W Ye, Z Zhang, J Hu
Theranostics, 2020;10(23):10589-10605.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer
Authors: SR Lin, YC Wen, HL Yeh, KC Jiang, WH Chen, N Mokgautsi, J Huang, WY Chen, YN Liu
Oncogene, 2020;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Alternative splicing and cleavage of GLUT8
Authors: CM Alexander, JA Martin, E Oxman, I Kasza, KA Senn, H Dvinge
Mol Cell Biol, 2020;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease
Authors: K Lloyd, S Papoutsopo, E Smith, P Stegmaier, F Bergey, L Morris, M Kittner, H England, D Spiller, MHR White, CA Duckworth, BJ Campbell, V Poroikov, VAP Martins Do, A Kel, W Muller, DM Pritchard, C Probert, MD Burkitt, SysmedIBD
Dis Model Mech, 2020;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
GOLPH3 Regulates EGFR in T98G Glioblastoma Cells by Modulating Its Glycosylation and Ubiquitylation
Authors: C Arriagada, VA Cavieres, C Luchsinger, AE González, VC Muñoz, J Cancino, PV Burgos, GA Mardones
Int J Mol Sci, 2020;21(22):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
P300-dependent acetylation of histone H3 is required for EGFR-mediated HMGA2 transcription in hepatocellular carcinoma
Authors: C Liang, J Niu, X Wang, ZS Zhang, RH Yang, X Yao, FY Liu, WQ Li, SH Pei, H Sun, CJ Wang, D Fang, SQ Xie
Cancer Sci, 2020;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma
Authors: ST Magill, HN Vasudevan, K Seo, JE Villanueva, A Choudhury, S John Liu, M Pekmezci, S Findakly, S Hilz, S Lastella, B Demaree, SE Braunstein, NAO Bush, MK Aghi, PV Theodosopo, PK Sneed, AR Abate, MS Berger, MW McDermott, DA Lim, EM Ullian, JF Costello, DR Raleigh
Nat Commun, 2020;11(1):4803.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
Authors: EAA Obara, D Aguilar-Mo, RD Rasmussen, A Frias, K Vitting-Se, YC Lim, KJ Elbæk, H Pedersen, L Vardouli, KE Jensen, J Skjoth-Ras, J Brennum, L Tuckova, R Strauss, C Dinant, J Bartek, P Hamerlik
Nat Commun, 2020;11(1):4709.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Polyelectrolyte complex templated synthesis of monodisperse, sub-100�nm porous silica nanoparticles for cancer targeted and stimuli-responsive drug delivery
Authors: G Newham, RK Mathew, H Wurdak, SD Evans, ZY Ong
J Colloid Interface Sci, 2020;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
Authors: KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar
Cell Stem Cell, 2020;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Development of a Cx46 Targeting Strategy for Cancer Stem Cells
Authors: EE Mulkearns-, LA Torre-Heal, DJ Silver, JT Eurich, D Bayik, E Serbinowsk, M Hitomi, J Zhou, B Przychodze, R Zhang, SA Sprowls, JS Hale, TJ Alban, A Berezovsky, BA Bell, PR Lockman, BK Jha, JD Lathia
Cell Rep, 2019;27(4):1062-1072.e5.
Species: Xenograft
Sample Types: Whole Cells
Applications: Bioassay -
Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies
Authors: S An, I Raju, B Surenkhuu, JE Kwon, S Gulati, M Karaman, A Pradeep, S Sinha, C Mun, S Jain
Ocul Surf, 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Organoid culture media formulated with growth factors of defined cellular activity
Authors: M Urbischek, H Rannikmae, T Foets, K Ravn, M Hyvönen, M de la Roch
Sci Rep, 2019;9(1):6193.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Activation of MAPK signaling by CXCR7 leads to enzalutamide resistance in prostate cancer
Authors: S Li, KW Fong, G Gritsina, A Zhang, JC Zhao, J Kim, A Sharp, W Yuan, C Aversa, XJ Yang, PS Nelson, FY Feng, AM Chinnaiyan, JS de Bono, C Morrissey, MB Rettig, J Yu
Cancer Res., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration
Authors: T Hirose, A Cabrera-So, D Chitayat, T Lemonnier, O Féraud, C Cifuentes-, N Gervasi, C Mombereau, T Ghosh, L Stoica, JDA Bacha, H Yamada, MA Lauterbach, M Guillon, K Kaneko, JW Norris, K Siriwarden, S Blasér, J Teillon, R Mendoza-Lo, M Russeau, J Hadoux, S Ito, P Corvol, MG Matheus, KR Holden, K Takei, V Emiliani, A Bennaceur-, CE Schwartz, G Nguyen, M Groszer
J. Clin. Invest., 2019;130(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD
Authors: N Kawai, Y Hirohashi, Y Ebihara, T Saito, A Murai, T Saito, T Shirosaki, T Kubo, M Nakatsugaw, T Kanaseki, T Tsukahara, T Shichinohe, L Li, S Hirano, T Torigoe
PLoS ONE, 2019;14(5):e0216503.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Immunomodulation with Human Umbilical Cord Blood Stem Cells Ameliorates Ischemic Brain Injury - A Brain Transcriptome Profiling Analysis
Authors: ML Shiao, C Yuan, AT Crane, JP Voth, M Juliano, LLH Stone, Z Nan, Y Zhang, N Kuzmin-Nic, PR Sanberg, AW Grande, WC Low
Cell Transplant, 2019;0(0):9636897198367.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A Potential Antitumor Effect of Dendritic Cells Fused with Cancer Stem Cells in Hepatocellular Carcinoma
Authors: YB Pang, J He, BY Cui, S Xu, XL Li, MY Wu, R Liang, Y Feng, X Guo, XH Zhang, XL Luo
Stem Cells Int, 2019;2019(0):5680327.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue
Authors: OC Tysoe, AW Justin, T Brevini, SE Chen, KT Mahbubani, AK Frank, H Zedira, E Melum, K Saeb-Parsy, AE Markaki, L Vallier, F Sampazioti
Nat Protoc, 2019;14(6):1884-1925.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Relevance of a TCGA-derived Glioblastoma Subtype Gene-Classifier among Patient Populations
Authors: WY Teo, K Sekar, P Seshachala, J Shen, WY Chow, CC Lau, H Yang, J Park, SG Kang, X Li, DH Nam, KM Hui
Sci Rep, 2019;9(1):7442.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MICAL-L2 potentiates Cdc42-dependent EGFR stability and promotes gastric cancer cell migration
Authors: P Min, S Zhao, L Liu, Y Zhang, Y Ma, X Zhao, Y Wang, Y Song, C Zhu, H Jiang, L Gu, J Du
J. Cell. Mol. Med., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Aging, rather than Parkinson's disease, affects the responsiveness of PBMCs to the immunosuppression of bone marrow mesenchymal stem cells
Authors: YQ Guan, CS Zhao, HQ Zou, XM Yan, LL Luo, JL Wu, X Li, YA Zhang
Mol Med Rep, 2019;19(1):165-176.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Encapsulated human mesenchymal stem cells (eMSCs) as a novel anti-cancer agent targeting breast cancer stem cells: development of 3D primed therapeutic MSCs
Authors: S Mandal, F Arfuso, G Sethi, A Dharmaraja, S Warrier
Int. J. Biochem. Cell Biol., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Metformin Results in Diametrically Opposed Effects by Targeting Non-Stem Cancer Cells but Protecting Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma
Authors: SZ Kuo, CO Honda, WT Li, TK Honda, E Kim, X Altuna, E Abhold, J Wang-Rodri, WM Ongkeko
Int J Mol Sci, 2019;20(1):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Novel Gastric Cancer Stem Cell-Related Marker LINGO2 Is Associated with Cancer Cell Phenotype and Patient Outcome
Authors: JH Jo, SB Park, S Park, HS Lee, C Kim, DE Jung, SY Song
Int J Mol Sci, 2019;20(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Impaired Regeneration Potential in Urinary Stem Cells Diagnosed from the Patients with Diabetic Nephropathy
Authors: G Xiong, W Tang, D Zhang, D He, G Wei, A Atala, XJ Liang, AJ Bleyer, ME Bleyer, J Yu, JA Aloi, JX Ma, CM Furdui, Y Zhang
Theranostics, 2019;9(14):4221-4232.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells
Authors: JA Bernatchez, M Coste, S Beck, GA Wells, LA Luna, AE Clark, Z Zhu, D Hecht, JN Rich, CD Sohl, BW Purse, JL Siqueira-N
Viruses, 2019;11(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model
Authors: J Klose, S Trefz, T Wagner, L Steffen, A Prei beta endör, P Radhakrish, C Volz, T Schmidt, A Ulrich, SM Dieter, C Ball, H Glimm, M Schneider
PLoS ONE, 2019;14(2):e0211916.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells
Authors: T Kijima, H Nakagawa, M Shimonoson, PM Chandramou, T Hara, V Sahu, Y Kasagi, O Kikuchi, K Tanaka, V Giroux, AB Muir, KA Whelan, S Ohashi, S Naganuma, AJ Klein-Szan, Y Shinden, K Sasaki, I Omoto, Y Kita, M Muto, AJ Bass, JA Diehl, GG Ginsberg, Y Doki, M Mori, Y Uchikado, T Arigami, NG Avadhani, D Basu, AK Rustgi, S Natsugoe
Cell Mol Gastroenterol Hepatol, 2019;7(1):73-91.
Species: Human
Sample Types: Organoids
Applications: Bioassay -
Connexin 43 plays an important role in the transformation of cholangiocytes with Clonochis sinensis excretory-secretory protein and N-nitrosodimethylamine
Authors: EM Kim, YM Bae, MH Choi, ST Hong
PLoS Negl Trop Dis, 2019;13(4):e0006843.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation
Authors: Z Wang, L Kang, H Zhang, Y Huang, L Fang, M Li, PJ Brown, CH Arrowsmith, J Li, J Wong
Oncogene, 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Co-Transplantation of Human Umbilical Cord Mesenchymal Stem Cells and Human Neural Stem Cells Improves the Outcome in Rats with Spinal Cord Injury
Authors: L Sun, F Wang, H Chen, D Liu, T Qu, X Li, D Xu, F Liu, Z Yin, Y Chen
Cell Transplant, 2019;0(0):9636897198445.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Nanoparticle delivery of miR-708 mimetic impairs breast cancer metastasis
Authors: D Ramchandan, SK Lee, S Yomtoubian, MS Han, CH Tung, V Mittal
Mol. Cancer Ther., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Src and SHP2 coordinately regulate the dynamics and organization of vimentin filaments during cell migration
Authors: CY Yang, PW Chang, WH Hsu, HC Chang, CL Chen, CC Lai, WT Chiu, HC Chen
Oncogene, 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Targeting APLN/APLNR improves anti-angiogenic efficiency and blunts pro-invasive side effects of VEGFA/VEGFR2-blockade in glioblastoma
Authors: G Mastrella, M Hou, M Li, VM Stoecklein, N Zdouc, MNM Volmar, H Miletic, S Reinhard, CC Herold-Men, S Kleber, K Eisenhut, G Gargiulo, M Synowitz, AL Vescovi, PN Harter, JM Penninger, E Wagner, M Mittelbron, R Bjerkvig, D Hambardzum, U Schüller, JC Tonn, J Radke, R Glass, RE Kälin
Cancer Res., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Generation of human antral and fundic gastric organoids from pluripotent stem cells
Authors: TR Broda, KW McCracken, JM Wells
Nat Protoc, 2019;14(1):28-50.
Species: Human
Sample Types: Organoids
Applications: Bioassay -
CIC protein instability contributes to tumorigenesis in glioblastoma
Authors: S Bunda, P Heir, J Metcalf, ASC Li, S Agnihotri, S Pusch, M Yasin, M Li, K Burrell, S Mansouri, O Singh, M Wilson, A Alamsahebp, R Nejad, B Choi, D Kim, A von Deimli, G Zadeh, K Aldape
Nat Commun, 2019;10(1):661.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
Authors: Y Kano, T Gebregiwor, CB Marshall, N Radulovich, BPK Poon, J St-Germain, JD Cook, I Valencia-S, BMM Grant, SG Herrera, J Miao, B Raught, MS Irwin, JE Lee, JJ Yeh, ZY Zhang, MS Tsao, M Ikura, M Ohh
Nat Commun, 2019;10(1):224.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Isolation and characterization of myogenic precursor cells from human cremaster muscle
Authors: N Naldaiz-Ga, M Goicoechea, IM Aragón, V Pérez-Lópe, S Fuertes-Al, B Herrera-Im, A López de M, R de Luna-Di, PM Baptista, MA Fernández, MF Lara, A Izeta
Sci Rep, 2019;9(1):3454.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway
Authors: Z Shen, C Zhang, L Qu, C Lu, M Xiao, R Ni, J Liu
Cancer Cell Int., 2019;19(0):61.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death
Authors: MA Ajmone-Cat, A Onori, C Toselli, E Stronati, M Morlando, I Bozzoni, E Monni, Z Kokaia, G Lupo, L Minghetti, S Biagioni, E Cacci
Sci Rep, 2019;9(1):4572.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation
Authors: L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn
Mol. Vis., 2019;25(0):329-344.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids
Authors: YP Xu, Y Qiu, B Zhang, G Chen, Q Chen, M Wang, F Mo, J Xu, J Wu, RR Zhang, ML Cheng, NN Zhang, B Lyu, WL Zhu, MH Wu, Q Ye, D Zhang, JH Man, XF Li, J Cui, Z Xu, B Hu, X Zhou, CF Qin
Cell Res., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
PTPRK suppresses progression and chemo-resistance of colon cancer cells via direct inhibition of pro-oncogenic CD133
Authors: M Matsushita, Y Mori, K Uchiumi, T Ogata, M Nakamura, H Yoda, H Soda, N Takiguchi, Y Nabeya, O Shimozato, T Ozaki
FEBS Open Bio, 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Modeling Patient-Derived Glioblastoma with Cerebral Organoids
Authors: A Linkous, D Balamatsia, M Snuderl, L Edwards, K Miyaguchi, T Milner, B Reich, L Cohen-Goul, A Storaska, Y Nakayama, E Schenkein, R Singhania, S Cirigliano, T Magdeldin, Y Lin, G Nanjangud, K Chadalavad, D Pisapia, C Liston, HA Fine
Cell Rep, 2019;26(12):3203-3211.e5.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth
Authors: X Feng, Y Jia, Y Zhang, F Ma, Y Zhu, X Hong, Q Zhou, R He, H Zhang, J Jin, D Piao, H Huang, Q Li, X Qiu, Z Zhang
Autophagy, 2019;0(0):1-20.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
Authors: X Ma, L Zhang, J Song, E Nguyen, RS Lee, SJ Rodgers, F Li, C Huang, RB Schittenhe, H Chan, C Chheang, J Wu, KK Brown, CA Mitchell, KJ Simpson, RJ Daly
Nat Commun, 2019;10(1):296.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Autonomous trisomic rescue of Down syndrome cells
Authors: M Inoue, K Kajiwara, A Yamaguchi, T Kiyono, O Samura, H Akutsu, H Sago, A Okamoto, A Umezawa
Lab. Invest., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
Authors: G Wang, J Long, Y Gao, W Zhang, F Han, C Xu, L Sun, SC Yang, J Lan, Z Hou, Z Cai, G Jin, CC Hsu, YH Wang, J Hu, TY Chen, H Li, MG Lee, HK Lin
Nat. Cell Biol., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures
Authors: RM Marton, Y Miura, SA Sloan, Q Li, O Revah, RJ Levy, JR Huguenard, SP Pa?ca
Nat. Neurosci., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Differentiation and isolation of iPSC-derived remodeling ductal plate-like cells by use of an AQP1-GFP reporter human iPSC line
Authors: S Matsui, M Ochiai, K Yasuda, SI Mae, M Kotaka, T Toyoda, T Yamamoto, K Osafune
Stem Cell Res, 2019;35(0):101400.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
RUNX represses Pmp22 to drive neurofibromagenesis
Authors: A Hall, K Choi, W Liu, J Rose, C Zhao, Y Yu, Y Na, Y Cai, RA Coover, Y Lin, E Dombi, M Kim, D Levanon, Y Groner, E Boscolo, D Pan, PP Liu, QR Lu, N Ratner, G Huang, J Wu
Sci Adv, 2019;5(4):eaau8389.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
c-Myc maintains the self-renewal and chemoresistance properties of colon cancer stem cells
Authors: HL Zhang, P Wang, MZ Lu, SD Zhang, L Zheng
Oncol Lett, 2019;17(5):4487-4493.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells
Authors: KB Jung, O Kwon, MO Lee, H Lee, YS Son, O Habib, JH Oh, HS Cho, CR Jung, J Kim, MY Son
J Clin Med, 2019;8(7):.
Species: Human
Sample Types: Organoid
Applications: Bioassay -
Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals
Authors: T Yung, F Poon, M Liang, S Coquenlorg, EC McGaugh, CC Hui, MD Wilson, MC Nostro, TH Kim
Nat Commun, 2019;10(1):4647.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS)
Authors: MR Wu, L Nissim, D Stupp, E Pery, A Binder-Nis, K Weisinger, C Enghuus, SR Palacios, M Humphrey, Z Zhang, E Maria Novo, M Kellis, R Weiss, SD Rabkin, Y Tabach, TK Lu
Nat Commun, 2019;10(1):2880.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Cardiac Magnetic Resonance Imaging used for Evaluation of Adipose-Derived Stromal Cell Therapy in Patients with Chronic Ischemic Heart Disease
Authors: AA Qayyum, AB Mathiasen, ND Mygind, NG Vejlstrup, J Kastrup
Cell Transplant, 2019;0(0):9636897198835.
Species: Human
Sample Types: Whole Cells
Applications: Stimulation -
MicroRNA-548 regulates high mobility group box 1 expression in patients with preterm birth and chorioamnionitis
Authors: GH Son, Y Kim, JJ Lee, KY Lee, H Ham, JE Song, ST Park, YH Kim
Sci Rep, 2019;9(1):19746.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Non-proliferative neurogenesis in human periodontal ligament stem cells
Authors: C Bueno, M Martínez-M, S Martínez
Sci Rep, 2019;9(1):18038.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen
Authors: D De Silva, Z Zhang, Y Liu, JS Parker, C Xu, L Cai, GG Wang, HS Earp, YE Whang
Sci Rep, 2019;9(1):18637.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Immunomodulatory effects of interferon-gamma on human fetal cardiac mesenchymal stromal cells
Authors: KH Grinnemo, M Löfling, L Nathanson, R Baumgartne, DFJ Ketelhuth, V Beljanski, LC Davies, C Österholm
Stem Cell Res Ther, 2019;10(1):371.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The oncogenic and druggable hPG80 (Progastrin) is overexpressed in multiple cancers and detected in the blood of patients
Authors: B You, F Mercier, E Assenat, C Langlois-J, O Glehen, J Soulé, L Payen, V Kepenekian, M Dupuy, F Belouin, E Morency, V Saywell, M Flacelière, P Elies, P Liaud, T Mazard, D Maucort-Bo, W Tan, B Vire, L Villeneuve, M Ychou, M Kohli, D Joubert, A Prieur
EBioMedicine, 2019;51(0):102574.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer
Authors: D Parashar, A Geethadevi, MR Aure, J Mishra, J George, C Chen, MK Mishra, A Tahiri, W Zhao, B Nair, Y Lu, LS Mangala, C Rodriguez-, G Lopez-Bere, AKS Camara, M Liang, JS Rader, R Ramchandra, M You, AK Sood, VN Kristensen, GB Mills, S Pradeep, P Chaluvally
Cell Rep, 2019;29(13):4389-4406.e10.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors
Authors: D Chen, N Sun, L Hou, R Kim, J Faith, M Aslanyan, Y Tao, Y Zheng, J Fu, W Liu, M Kellis, A Clark
Cell Rep, 2019;29(13):4568-4582.e5.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis
Authors: L Zhu, Y Li, X Xie, X Zhou, M Gu, Z Jie, CJ Ko, T Gao, BE Hernandez, X Cheng, SC Sun
Nat. Cell Biol., 2019;21(12):1604-1614.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering
Authors: D Hao, C He, B Ma, L Lankford, L Reynaga, DL Farmer, F Guo, A Wang
Stem Cells Int, 2019;2019(0):9695239.
Species: Human
Sample Types: Whole Tissue
Applications: Tissue Culture -
Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR
Authors: F Du, C Qiao, X Li, Z Chen, H Liu, S Wu, S Hu, Z Qiu, M Qian, D Tian, K Wu, D Fan, Y Nie, L Xia
Theranostics, 2019;9(13):3879-3902.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Efficient One-Step Induction of Human Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs) Produces MSC-Derived Neurospheres (MSC-NS) with Unique Transcriptional Profile and Enhanced Neurogenic and Angiogenic Secretomes
Authors: C Peng, Y Li, L Lu, J Zhu, H Li, J Hu
Stem Cells Int, 2019;2019(0):9208173.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Supplementation of vitamin C promotes early germ cell specification from human embryonic stem cells
Authors: Z Li, F Fang, Q Zhao, H Li, C Xiong
Stem Cell Res Ther, 2019;10(1):324.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation
Authors: V Costa, V Carina, L Raimondi, A De Luca, D Bellavia, A Conigliaro, F Salamanna, R Alessandro, M Fini, G Giavaresi
Cells, 2019;8(12):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression
Authors: L Hu, Y Sun, J Luo, X He, M Ye, G Li, Y Zhang, J Bai, D Zhang, C Chang
Oncogene, 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking
Authors: L Yammine, A Zablocki, W Baron, F Terzi, M Gallazzini
Cell Rep, 2019;29(7):2067-2077.e6.
Species: Human
Sample Types: Whole Cell
Applications: Cell Culture -
Pharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers
Authors: JK Sa, JR Hwang, YJ Cho, JY Ryu, JJ Choi, SY Jeong, J Kim, MS Kim, ES Paik, YY Lee, CH Choi, TJ Kim, BG Kim, DS Bae, Y Lee, NG Her, YJ Shin, HJ Cho, JY Kim, YJ Seo, H Koo, JW Oh, T Lee, HS Kim, SY Song, JS Bae, WY Park, HD Han, HJ Ahn, AK Sood, R Rabadan, JK Lee, DH Nam, JW Lee
Genome Biol., 2019;20(1):253.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Mechanism of Action of Methotrexate Against Zika Virus
Authors: S Beck, Z Zhu, MF Oliveira, DM Smith, JN Rich, JA Bernatchez, JL Siqueira-N
Viruses, 2019;11(4):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-na�ve glioblastoma
Authors: E Skaga, E Kulesskiy, A Fayzullin, CJ Sandberg, S Potdar, A Kyttälä, IA Langmoen, A Laakso, E Gaál-Paavo, M Perola, K Wennerberg, EO Vik-Mo
BMC Cancer, 2019;19(1):628.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo
Authors: M Reed, AC Luissint, V Azcutia, S Fan, MN O'Leary, M Quiros, J Brazil, A Nusrat, CA Parkos
Nat Commun, 2019;10(1):5004.
Species: Mouse
Sample Types: Cells
Applications: Cell Culture -
Neurospheres induced from human adipose-derived stem cells as a new source of neural progenitor cells
Authors: C Peng, L Lu, Y Li, J Hu
Cell Transplant, 2019;0(0):9636897198886.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo
Authors: S Weber, SE Koschade, CM Hoffmann, TD Dubash, KM Giessler, SM Dieter, F Herbst, H Glimm, CR Ball
BMC Cancer, 2019;19(1):1181.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Enteroendocrine progenitor cell enriched miR-7 regulates intestinal epithelial proliferation in an Xiap-dependent manner
Authors: AP Singh, YH Hung, MT Shanahan, M Kanke, A Bonfini, MK Dame, M Biraud, BCE Peck, OO Oyesola, JM Freund, RL Cubitt, EG Curry, LM Gonzalez, GA Bewick, ED Tait-Wojno, NA Kurpios, S Ding, JR Spence, CM Dekaney, N Buchon, P Sethupathy
Cell Mol Gastroenterol Hepatol, 2019;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: Tissue Culture -
Neurobiological roots of psychopathy
Authors: J Tiihonen, M Koskuvi, M Lähteenvuo, PLJ Virtanen, I Ojansuu, O Vaurio, Y Gao, I Hyötyläine, KA Puttonen, E Repo-Tiiho, T Paunio, MR Rautiainen, S Tyni, J Koistinaho, Š Lehtonen
Mol. Psychiatry, 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms
Authors: V Ravi, AB Madhankuma, T Abraham, B Slagle-Web, JR Connor
PLoS ONE, 2019;14(9):e0221952.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
High Expression of Acid-Sensing Ion Channel 2 (ASIC2) in Bone Cells in Osteoporotic Vertebral Fractures
Authors: CY Lee, TJ Huang, MH Wu, YY Li, KD Lee
Biomed Res Int, 2019;2019(0):4714279.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Phosphorylation of adducin-1 by cyclin-dependent kinase 5 is important for epidermal growth factor-induced cell migration
Authors: CY Su, RL Yan, WH Hsu, CT Chu, HC Chang, CC Lai, HP Hsu, HC Chen
Sci Rep, 2019;9(1):13703.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Differentially Expressed microRNAs in MIA PaCa-2 and PANC-1 Pancreas Ductal Adenocarcinoma Cell Lines are Involved in Cancer Stem Cell Regulation
Authors: Y Shen, K Pu, K Zheng, X Ma, J Qin, L Jiang, J Li
Int J Mol Sci, 2019;20(18):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Repurposing Penfluridol in Combination with Temozolomide for the Treatment of Glioblastoma
Authors: H Kim, K Chong, BK Ryu, KJ Park, MO Yu, J Lee, S Chung, S Choi, MJ Park, YG Chung, SH Kang
Cancers (Basel), 2019;11(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
Authors: L Jin, H Tao, A Karachi, Y Long, AY Hou, M Na, KA Dyson, AJ Grippin, LP Deleyrolle, W Zhang, DA Rajon, QJ Wang, JC Yang, JL Kresak, EJ Sayour, M Rahman, FJ Bova, Z Lin, DA Mitchell, J Huang
Nat Commun, 2019;10(1):4016.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness
Authors: SFB Fadhlullah, NBA Halim, JYT Yeo, RLY Ho, P Um, BT Ang, C Tang, WH Ng, DM Virshup, IAW Ho
Oncogene, 2019;38(27):5367-5380.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells
Authors: KB Jung, O Kwon, MO Lee, H Lee, YS Son, O Habib, JH Oh, HS Cho, CR Jung, J Kim, MY Son
J Clin Med, 2019;8(7):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Excess growth hormone suppresses DNA damage repair in epithelial cells
Authors: V Chesnokova, S Zonis, R Barrett, H Kameda, K Wawrowsky, A Ben-Shlomo, M Yamamoto, J Gleeson, C Bresee, V Gorbunova, S Melmed
JCI Insight, 2019;4(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Evaluating S. flexneri pathogenesis in the human enteroid model
Authors: S Ranganatha, M Doucet, CL Grassel, B Delaine-El, NC Zachos, EM Barry
Infect. Immun., 2019;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale
Authors: X Wang, T Liao, C Wan, X Yang, J Zhao, R Fu, Z Yao, Y Huang, Y Shi, G Chang, Y Zheng, F Luo, Z Liu, Y Wang, X Mao, XY Zhao
PeerJ, 2019;6(0):e6143.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
Authors: K Shik Mun, K Arora, Y Huang, F Yang, S Yarlagadda, Y Ramananda, M Abu-El-Hai, JJ Palermo, BN Appakalai, JD Nathan, AP Naren
Nat Commun, 2019;10(1):3124.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Reliability of human cortical organoid generation
Authors: SJ Yoon, LS Elahi, AM Pa?ca, RM Marton, A Gordon, O Revah, Y Miura, EM Walczak, GM Holdgate, HC Fan, JR Huguenard, DH Geschwind, SP Pa?ca
Nat. Methods, 2019;16(1):75-78.
Species: Human
Sample Types: Organoids
Applications: Bioassay -
Identification and Classification of Hubs in microRNA Target Gene Networks in Human Neural Stem/Progenitor Cells following Japanese Encephalitis Virus Infection
Authors: S Mukherjee, I Akbar, R Bhagat, B Hazra, A Bhattachar, P Seth, D Roy, A Basu
mSphere, 2019;4(5):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas
Authors: T Tabata, M Petitt, J Fang-Hoove, DC Freed, F Li, Z An, D Wang, TM Fu, L Pereira
Vaccines (Basel), 2019;7(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrPC signaling
Authors: YH Lee, HT Lee, CL Chen, CH Chang, CY Hsu, WC Shyu
Theranostics, 2019;9(22):6443-6465.
Species: Human
Sample Types: Tissue Explants
Applications: Cell Culture -
Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion
Authors: J Chen, B Ananthanar, KS Springer, KJ Wolf, SM Sheyman, VD Tran, S Kumar
Cancer Res., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus
Authors: Y Koutmani, IA Gampieraki, A Polissidis, M Ximerakis, PN Koutsoudak, A Polyzos, G Agrogianni, S Karaliota, D Thomaidou, LL Rubin, PK Politis, KP Karalis
Cell Rep, 2019;29(4):932-945.e7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma
Authors: JH Wang, ST Huang, L Zhang, ZG Liu, RX Liang, SW Jiang, YN Jiang, XJ Yu, YC Jiang, XZ Li, PF Zhang, ZS Wen, M Zheng
Cancer Med, 2019;0(0):.
Species: Human
Sample Types:
Applications: Bioassay -
Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ
Authors: Z Liu, Y Wei, L Zhang, PP Yee, M Johnson, X Zhang, M Gulley, JM Atkinson, M Trebak, HG Wang, W Li
Oncogene, 2019;38(1):120-139.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
Authors: ML Schulte, A Fu, P Zhao, J Li, L Geng, ST Smith, J Kondo, RJ Coffey, MO Johnson, JC Rathmell, JT Sharick, MC Skala, JA Smith, J Berlin, MK Washington, ML Nickels, HC Manning
Nat. Med., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Characterization of a novel OTX2-driven stem cell program in Group 3 and Group 4 medulloblastoma
Authors: M Stromecki, N Tatari, LC Morrison, R Kaur, J Zagozewski, G Palidwor, V Ramaswamy, P Skowron, M Wölfl, T Milde, MR Del Bigio, MD Taylor, TE Werbowetsk
Mol Oncol, 2018;12(4):495-513.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips.
Authors: Michael J Workman, John P Gleeson, Elissa J Troisi, Hannah Q Estrada, S Jordan Kerns, Christopher D Hinojosa, Geraldine A Hamilton, Stephan R Targan, Clive N Svendsen, Robert J Barrett
Cellular and Molecular Gastroenterology and Hepatology, 2018;0(0):2352-345X.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Natural molecules induce and synergize to boost expression of the human antimicrobial peptide ?-defensin-3
Authors: E Sechet, E Telford, C Bonamy, PJ Sansonetti, B Sperandio
Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.
Species: Human
Sample Types: Organoids
Applications: Bioassay -
Umbilical cord mesenchymal stem cell transplantation in the treatment of multiple sclerosis
Authors: M Meng, Y Liu, W Wang, C Wei, F Liu, Z Du, Y Xie, W Tang, Z Hou, Q Li
Am J Transl Res, 2018;10(1):212-223.
Species: Human
Sample Types: Whole Cells
Applications: Differentiation -
Implementation of a Multiplex and Quantitative Proteomics Platform for Assessing Protein Lysates Using DNA-Barcoded Antibodies
Authors: J Lee, GK Geiss, G Demirkan, CP Vellano, B Fila