20 results for "Caspase Inhibitors Small Molecules and Peptides" in Products
Caspase Inhibitors Small Molecules and Peptides
Caspases (cysteinyl aspartate proteases) are involved in the signal transduction pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED.
Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are ...
| Reactivity: | Multi-Species |
| Reactivity: | Multi-Species |
| Reactivity: | Multi-Species |
| Reactivity: | Multi-Species |
| Reactivity: | Multi-Species |
| Reactivity: | Multi-Species |
| Reactivity: | Multi-Species |
Cell-permeable, irreversible caspase inhibitor
| Chemical Name: | Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone |
| Purity: | ≥95% |
| Reactivity: | Multi-Species |
| Reactivity: | Multi-Species |
| Reactivity: | Multi-Species |
| Reactivity: | Multi-Species |
Potent pan-caspase inhibitor
| Chemical Name: | N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide |
| Purity: | ≥98% |
| Reactivity: | Multi-Species |
Caspase-1 and NLRP3 inflammasome inhibitor
| Chemical Name: | Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate |
| Purity: | ≥98% |
High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable
| Alternate Names: | Belnacasan |
| Chemical Name: | N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide |
| Purity: | ≥98% |
NLRP3 inhibitor; active in vivo
| Chemical Name: | 4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid |
| Purity: | ≥98% |
Potent and selective inhibitor of caspases 1, 5 and 4
| Purity: | ≥95% |
| Reactivity: | Multi-Species |
Caspase-3 Inhibitor
| Purity: | ≥95% |
