13 results for "Cell Adhesion Inhibitors" in Products

Cell Adhesion Inhibitors

Cellular adhesion molecules (CAMs) are a large family of transmembrane proteins that link the cytoskeleton and intracellular signaling cascades with the extracellular environment. Cell adhesion molecules have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common in cancer.

There are four major families of cell adhesion molecules:

  1. Immunoglobulin Superfamily (IgSF) CAMs - bind to integrins and members of this ...
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Glycoprotein IIb/IIIa (integrin αIIbβ3) receptor antagonist. Antithrombotic

Chemical Name: 4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid trihydrochloride
Purity: ≥98%
Glycoprotein IIb/IIIa (integrin αIIbβ3) receptor antagonist. Antithrombotic
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Integrin binding sequence; inhibits integrin receptor function

Purity: ≥95%
Integrin binding sequence; inhibits integrin receptor function
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Selective α4β1 (VLA-4) inhibitor

Purity: ≥95%
Selective α4β1 (VLA-4) inhibitor
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Potent and selective α1β1 inhibitor

Purity: ≥95%
Potent and selective α1β1 inhibitor
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Sialic acid analog; sialyltransferase inhibitor

Chemical Name: 5-(Acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-α-L-manno-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate
Purity: ≥97%
Sialic acid analog; sialyltransferase inhibitor
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Selective inhibitor of E-selectin and ICAM-1 expression

Chemical Name: 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
Purity: ≥98%
Selective inhibitor of E-selectin and ICAM-1 expression
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Potent α2β1 inhibitor; displays antithrombotic activity in vivo

Chemical Name: N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine
Purity: ≥98%
Potent α2β1 inhibitor; displays antithrombotic activity in vivo
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αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor

Purity: ≥95%
αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor
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α4β1 (VLA-4) antagonist

Chemical Name: 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid
Purity: ≥98%
α4β1 (VLA-4) antagonist
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Potent inhibitor of the LFA-1/ICAM-1 interaction

Chemical Name: (2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one
Purity: ≥98%
Potent inhibitor of the LFA-1/ICAM-1 interaction
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Potent inhibitor of the LFA-1/ICAM interaction

Chemical Name: 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid
Purity: ≥98%
Potent inhibitor of the LFA-1/ICAM interaction
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Disrupts MTDH and SND1 interaction, enhances immune surveillance

Chemical Name: 5-Chloro-2-methoxy-N-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-8-yl)benzenesulfonamide
Purity: ≥98%
Disrupts MTDH and SND1 interaction, enhances immune surveillance
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Potent integrin inhibitor (αvβ3/αvβ6); also improves stem cell attachment in 3D cell culture scaffolds

Purity: ≥95%
Potent integrin inhibitor (αVβ3/αVβ5); also improves stem cell attachment in 3D cell culture scaffolds
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