p38: Products

The p38 Mitogen-activated Protein Kinases (MAPKs) are a family of four related Ser/Thr kinases activated by proinflammatory cytokines and environmental stresses.

The most frequently analyzed family member, p38 alpha, also known as SAPK2a and MAPK14, was initially purified as a kinase critical to the signaling cascade linking IL-1 to MAPKAPK-2 and the small heat shock protein HSP27. Ubiquitously expressed, p38 alpha is dually phosphorylated by MKK3 and MKK6 at Thr180 and Tyr182. Once activated, p38 alpha phosphorylates a number of targets, including the cytoplasmic kinases MNK 4 and PRAK5 and the nuclear transcription factors ATF2 1 and STAT1. Several promising compounds that inhibit p38 alpha are being investigated as potential therapies for arthritic and inflammatory diseases.

"p38" has 25 results in Products.
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SB 202190

Potent, selective inhibitor of p38 MAPK

SB 203580

Selective inhibitor of p38 MAPK

Anisomycin

JNK, SAPK and p38 activator

SB 203580 hydrochloride

Selective inhibitor of p38 MAPK; water-soluble

BIRB 796

High affinity and selective p38 kinase inhibitor

p38 MAPK Inhibitor Tocriset™

Selection of 3 p38 MAPK inhibitors (Cat. Nos. 1264, 1202 and 1962)

SB 239063

Potent, selective p38 MAPK inhibitor; orally active

SKF 86002 dihydrochloride

p38 MAPK inhibitor; anti-inflammatory agent

CMPD-1

Selective inhibitor of p38α-mediated MK2a phosphorylation; also tubulin polymerization inhibitor

CGH 2466 dihydrochloride

A1, A2B and A3 antagonist and inhibitor of p38 MAPK and PDE4

JX 401

Potent, reversible p38α inhibitor

EO 1428

Selective inhibitor of p38α and p38β2

RWJ 67657

Potent, selective p38α and p38β inhibitor

SCIO 469 hydrochloride

Selective p38 MAPK inhibitor

SX 011

p38 MAPK inhibitor

VX 745

Potent and selective p38α inhibitor

VX 702

Orally active p38α and p38β inhibitor

AMG 548

Potent and selective p38α inhibitor

TAK 715

Potent p38 MAPK inhibitor; anti-inflammatory

ML 3403

p38 inhibitor

SB 706504

p38 MAPK inhibitor

DBM 1285 dihydrochloride

p38 MAPK inhibitor; anti-inflammatory

PH 797804

Potent and selective p38α/β inhibitor

Org 48762-0

Selective p38α/β inhibitor; orally bioavailable

Proteome Profiler Human Cell Stress Array Kit

Contains 4 membranes - each spotted in duplicate with 26 different cell stress antibodies
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