13 results for "p53 Small Molecules and Peptides" in Products
p53 Small Molecules and Peptides
p53 is well known for its key role as a tumor suppressor protein. It is 393 amino acids (aa) in length with a predicted molecular weight of 44 kDa. It belongs to the p53 family that also includes p63 and p73. Structurally, p53 is characterized by an N-terminal transactivation domain, central DNA-binding and oligomerization domains, and a C-terminal regulatory domain. It is thought to exist as a homotetramer, and it exhibits approximately 72% and 76% aa identity with its mouse and rat ...
Restores mutant p53 activity; proapoptotic
| Chemical Name: | 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione |
Restores mutant p53 activity
| Alternate Names: | APR-246 |
| Chemical Name: | 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one |
| Purity: | ≥98% |
MDM2 antagonist; inhibits MDM2-p53 interaction
| Chemical Name: | (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one |
| Purity: | ≥98% |
p53 inhibitor. Also aryl hydrocarbon receptor agonist
| Chemical Name: | 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide |
Potent and selective allosteric inhibitor of Wip1 phosphatase
| Chemical Name: | 5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide |
| Purity: | ≥98% |
p53 inhibitor
| Alternate Names: | Pifithrin-β |
| Chemical Name: | 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole hydrobromide |
| Purity: | ≥98% |
Hdm2 inhibitor; activates p53-dependent transcription
| Chemical Name: | 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride |
| Purity: | ≥98% |
MDM2-p53 interaction inhibitor
| Alternate Names: | NSC 652287 |
| Chemical Name: | 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol |
| Purity: | ≥97% |
Cyclooxygenase inhibitor; NSAID
| Chemical Name: | 2-Acetoxybenzoic acid |
| Purity: | ≥98% |
High affinity MDM2 inhibitor
| Chemical Name: | 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole |
| Purity: | ≥98% |
RNA polymerase I inhibitor; also p53 pathway activator
| Chemical Name: | N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide |
| Purity: | ≥98% |
Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
| Chemical Name: | 4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid |
| Purity: | ≥98% |
Potent and selective Wee1 inhibitor
| Alternate Names: | AZD 1775,MK 1775 |
| Chemical Name: | 1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one |
| Purity: | ≥98% |
