12 results for "Protein Kinase C Inhibitors" in Products

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Protein Kinase C Inhibitors

Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Classical or conventional PKCs (cPKC α-, βI- , βII- and γ-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive novel PKCs (nPKCs ε-, δ-, θ- and η- isotypes) are also activated by DAG and phosphatidylserine.

The atypical PKCs (aPKCs ι- and ζ-) are insensitive to ...

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Go 6983

Catalog #: 2285
(2)
Citations (182)
Product Documents

Broad spectrum PKC inhibitor

Alternate Names: Goe 6983
Chemical Name: 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Purity: ≥98%
Broad spectrum PKC inhibitor

GF 109203X

Catalog #: 0741
(1)
Citations (317)
Product Documents

Protein kinase C inhibitor

Alternate Names: Gö 6850,Bisindolylmaleimide I
Chemical Name: 2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide
Purity: ≥98%
Protein kinase C inhibitor

Go 6976

Catalog #: 2253
Citations (75)
Product Documents

Potent protein kinase C inhibitor; selective for α and β isozymes

Chemical Name: 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
Purity: ≥95%
Potent protein kinase C inhibitor; selective for α and β isozymes

Calphostin C

Catalog #: 1626
Citations (57)
Product Documents

Potent, selective and photo-dependent PKC inhibitor

Alternate Names: UCN 1028C,PKF 115584
Chemical Name: (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester
Purity: ≥95%
Potent, selective and photo-dependent PKC inhibitor

Chelerythrine chloride

Catalog #: 1330
Citations (58)
Product Documents

Cell-permeable protein kinase C inhibitor

Chemical Name: 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
Purity: ≥98%
Cell-permeable protein kinase C inhibitor

ZIP

Catalog #: 2549
Citations (15)
Product Documents

Cell-permeable inhibitor of atypical PKC isozyme PKMζ

Alternate Names: z-Pseudosubstrate inhibitory peptide
Purity: ≥95%
Cell-permeable inhibitor of atypical PKC isozyme PKMζ

Melittin

Catalog #: 1193
Citations (13)
Product Documents

Inhibits Gs and stimulates Gi activity

Purity: ≥95%
Inhibits Gs and stimulates Gi activity

CRT 0066854 hydrochloride

Catalog #: 5922
Citations (2)
Product Documents

PKCι and PKCζ inhibitor

Chemical Name: (2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine dihydrochloride
Purity: ≥95%
PKCι and PKCζ inhibitor

Ro 32-0432 hydrochloride

Catalog #: 1587
Citations (2)
Product Documents

Potent, orally active PKC inhibitor

Chemical Name: 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride
Purity: ≥98%
Potent, orally active PKC inhibitor

Rottlerin

Catalog #: 1610
Citations (49)
Product Documents

Reported PKCδ inhibitor

Chemical Name: 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
Purity: ≥95%
Reported PKCδ inhibitor

CGP 53353

Catalog #: 2442
Citations (17)
Product Documents

Selective inhibitor of PKCβII

Chemical Name: 5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione
Purity: ≥98%
Selective inhibitor of PKCβII

Staurosporine

Catalog #: TB1285-RMU
Product Documents

Staurosporine synthesized to Ancillary Material Grade

Chemical Name: [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
Purity: ≥98%
Staurosporine synthesized to Ancillary Material Grade
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