21 results for "TAG Degradation Platforms Small Molecules and Peptides" in Products

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TAG Degradation Platforms Small Molecules and Peptides

The TAG Degradation Platform enables the knockdown of your protein of interest (POI) by adding a tag (or degron tag), via genetic modification, which can then be targeted by a small molecule Degrader.

The dTAG technique involves the expression of a protein of interest as a fusion with mutant FKBP12F36V via transgene expression or CRISPR-mediated locus-specific knock-in. dTAG Degraders are heterobifunctional, comprising a synthetic ligand (AP1836), that selectively binds FKBP12F36V linked to an ...

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dTAGV-1

Catalog #: 6914
(2)
Citations (69)
Product Documents

Potent and selective degrader of mutant FKBP12F36V fusion proteins

Chemical Name: (R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate trifluoroacetate
Purity: ≥98%
Potent and selective degrader of mutant FKBP12F36V fusion proteins

dTAG-13

Catalog #: 6605
(4)
Citations (127)
Product Documents

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Chemical Name: 1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester
Purity: ≥98%
Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

dTAGV-1-NEG

Catalog #: 6915
(1)
Citations (8)
Product Documents

Negative control for dTAGV-1 (Cat. No. 6914)

Chemical Name: (R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2R,4S)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥98%
Negative control for dTAGV-1 (Cat. No. 6914)

5-Ph-IAA

Catalog #: 7392
Citations (9)
Product Documents

Selective and potent TAG Degrader for auxin-inducible degron 2 system

Chemical Name: 5-Phenyl-1H-indole-3-acetic acid
Purity: ≥98%
Selective and potent TAG Degrader for auxin-inducible degron 2 system

dTAG-13-NEG

Catalog #: 6916
Citations (2)
Product Documents

Negative control for dTAG-13 (Cat. No. 6605)

Chemical Name: 1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester
Purity: ≥97%
Negative control for dTAG-13 (Cat. No. 6605)

dTAG-47

Catalog #: 7530
Citations (4)
Product Documents

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Chemical Name: (1R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥97%
Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

aTAG 4531

Catalog #: 6971
Citations (1)
Product Documents

Degrader of MTH1 fusion proteins for use within the aTAG system

Alternate Names: CFT 4531
Chemical Name: N-Cyclopropyl-6-(4-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)butyl)carbamoyl)-3-fluorophenyl)-7-fluoro-4-(phenylamino)quinoline-3-carboxamide
Purity: ≥98%
Degrader of MTH1 fusion proteins for use within the aTAG system

dTAG-7

Catalog #: 6912
Citations (10)
Product Documents

First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Chemical Name: (1R)-3-(3,4-Dimethoxyphenyl)-1-(2-((19-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadecyl)oxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥98%
First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

dTAGV-1 hydrochloride

Catalog #: 7374
(1)
Citations (3)
Product Documents

Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use

Chemical Name: (R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate hydrochloride
Purity: ≥98%
Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use

dTAG-47-NEG

Catalog #: 7531
Product Documents

Negative control for dTAG-47 (Cat. No. 7530)

Chemical Name: (1R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((8-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥97%
Negative control for dTAG-47 (Cat. No. 7530)

BromoTag® AGB1

Catalog #: 7686
Citations (8)
Product Documents

Potent and selective Degrader of Brd4BD2 L387A fusion proteins (BromoTag®)

Chemical Name: (S)-13-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecyl (R)-2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)butanoate
Purity: ≥98%
Live-cell luminescent kinetic degradation assay
(2)

aTAG 2139

Catalog #: 6970
Citations (1)
Product Documents

Degrader of MTH1 fusion proteins for use within the aTAG system

Alternate Names: CFT 2139
Chemical Name: 6-(6-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)carbamoyl)pyridin-3-yl)-N-methyl-4-(phenylamino)quinoline-3-carboxamide
Purity: ≥98%
Degrader of MTH1 fusion proteins for use within the aTAG system

aTAG 2139-NEG

Catalog #: 7575
Product Documents

Negative control for aTAG 2139 (Cat. No. 6970)

Chemical Name: 6-(6-((4-(2-((2-(1-Methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)carbamoyl)pyridin-3-yl)-N-methyl-4-(phenylamino)quinoline-3-carboxamide
Purity: ≥98%
Negative control for aTAG 2139 (Cat. no. 6970)

XY-06-007

Catalog #: 7669
Product Documents

Potent and selective Degrader of Brd4BD1 L94V fusion proteins

Chemical Name: (2R)-2-((S)-6-(4-Chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-(5-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)pentyl)propanamide
Purity: ≥98%
Potent and selective Degrader of Brd4BD1 L94V fusion proteins

BromoTag® cis-AGB1

Catalog #: 7687
Citations (4)
Product Documents

Negative control for BromoTag® AGB1 (Cat. No. 7686)

Chemical Name: (S)-13-((2S,4S)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecyl (R)-2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)butanoate
Purity: ≥98%
Negative control for BromoTag® AGB1 (Cat.No. 7686)

BromoTag® AGB3

Catalog #: 7688
Product Documents

Selective Degrader of Brd4BD2 L387A fusion proteins (BromoTag®)

Chemical Name: (2S,4R)-1-((2S,17R)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazanonadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98%
Selective Degrader of Brd4BD2 L387A fusion proteins (BromoTag®)

AP 1867

Catalog #: 6207
Product Documents

Selective binding ligand for FKBP12F36V

Chemical Name: (1R)-1-[3-(Carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate
Purity: ≥98%
Selective binding ligand for FKBP12F36V

Ortho AP 1867

Catalog #: 7787
Product Documents

Selective binding ligand for FKBP12F36V; precursor for dTAG compounds

Chemical Name: 2-(2-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid
Purity: ≥98%
Selective binding ligand for FKBP12F36V; precursor for dTAG compounds

dTAG-Biotin

Catalog #: 7883
Product Documents

Affinity probe for mutant FKBP12F36V proteins

Chemical Name: (R)-3-(3,4-Dimethoxyphenyl)-1-(2-((2,16-dioxo-20-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-6,9,12-trioxa-3,15-diazaicosyl)oxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥98%
Affinity probe for mutant FKBP12F36V proteins

dTAG-Fluorescein

Catalog #: 7892
Product Documents

Fluorescent probe for labeling mutant FKBP12 (F36V) proteins

Chemical Name: (R)-1-(2-(2-((3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)amino)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥95%
Fluorescent probe for labeling mutant FKBP12F36V proteins

5-Ph-IAA-AM

Catalog #: 7893
Citations (1)
Product Documents

Selective and potent TAG Degrader for auxin-inducible degron 2 system; 5-Ph-IAA analog

Chemical Name: Acetoxymethyl 2-(5-phenyl-1H-indol-3-yl)acetate
Purity: ≥98%
Selective and potent TAG Degrader for auxin-inducible degron 2 system; 5-Ph-IAA analog
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