Monitoring Cell and Gene Therapy - Efficacy and Toxicity

Monitoring Cell and Gene Therapy Efficacy and Toxicity

Monitoring Cell and Gene Therapy Efficacy and Toxicity

Bring your research to the clinic with Bio-Techne’s comprehensive solutions for Cell and Gene Therapy Manufacturing. To view our complete solutions for Cell and Gene Therapy including GMP-grade reagents and 21 CFR Part 11-compliant analytical instrumentation, visit bio-techne.com.

 
 
 
Monitoring Stem Cell Engraftment

Stem Cell Engraftment After Infusion

Keep a close eye on how your cell or gene therapy performs in vivo. Track cell homing to the target tissue, cell persistence in the target tissue, and continued cell function.

 

RNAscope® in situ Hybridization Assays (at acd.com)
    Single-cell RNA expression analysis to localize your cell therapy in the target tissue
Epitope Tag Antibodies
    For detection of tagged molecules in your genetic construct
Monitoring T Cell Exhaustion
    Reagents and assays to confirm that your cells don’t become over-activated in vivo
Reagents and Assays for Exosome Research (at novusbio.com)
    To monitor microvesicles released by your cell or gene therapy
Suicide Switch Triggering and Monitoring for Cell Therapy Inactivation
    Apoptosis Inducer Compounds (at tocris.com)
    Apoptosis Detection Kits and Reagents
 
 
Systemic Host Response

Systemic Host Response

Analyze how the host responds to your cell therapy. Our multiple assay platforms will give you flexibility to monitor circulating biomarkers of cytokine release syndrome, tissue and organ damage, and immunogenicity.

 

Proteome Profiler Antibody Arrays
    No specialized equipment required; affordable screening tool for discovery-level research
DuoSet® ELISA Development Reagents
    Flexible and economical for discovery-level research; over 1,000 available
Quantikine® ELISA Kits
    Industry gold standard ELISAs as you transition to clinical-level research; over 450 available
Luminex® Assays and Luminex High Performance Assays
    Quantitative multiplex for up to 100 analytes and for translational medicine applications
Simple Plex Assays (at proteinsimple.com)
    Automated, parallel immunoassays for translational medicine applications; results in < 1 hour
Simple Western Assays (at proteinsimple.com)
    Automated, 3-hour capillary-based immunoassays and size assays for translational medicine applications
Antibodies for Disease Biomarkers (at biospacific.com)
 
 
Host Tissue Response

Host Tissue Response to Cell Therapy

Evaluate the efficacy of your cell therapy in the tissue you’re targeting. Determine if your treatment is inducing tumor regression, tissue regeneration, angiogenesis, immune cell infiltration, apoptosis, fibrosis, or other relevant measures.

 

 
Custom Services

Custom Services

Our Custom Services team will work closely with you and expert R&D Systems scientists to develop effective methods for monitoring the host response to your cell or gene therapy. We can help you adopt a robust host monitoring system that will be valuable as you move toward and into clinical testing.

Learn more about Custom Services for Cell Therapy.