Angiogenesis is the tightly regulated process by which new blood vessels form from the existing vasculature. This process is important for development and wound healing, and is also a common controlling factor in multiple diseases including rheumatoid arthritis, atherosclerosis, macular degeneration, and cancer. Angiogenesis occurs in response to a variety of molecular cues. Generally, the angiogenic process includes endothelial cell proliferation, chemotactic endothelial cell migration through the extracellular matrix, and the formation of capillary tubes. Physiological and pathological angiogenesis utilize many of the same cellular processes and molecular signaling networks, but the structures that form during pathological angiogenesis are often functionally abnormal. R&D Systems offers several in vitro and in vivo assay kits for assessing angiogenesis. These kits allow researchers to easily determine whether different molecules can activate or inhibit angiogenic processes.
For optimizing assay conditions and gaining practical experience using angioreactors.
For the assessment of angiogenesis activation under in vivo experimental conditions.
For the assessment of angiogenesis inhibitors under in vivo experimetal conditions.
For the accelerated screening of compounds that influence vascular endothelial cellular digestion of and migration across the basement extracellular membrane.
For the detection of inducers and inhibitors of endothelial cell tube formation.