Human Adrenomedullin/ADM Antibody

Catalog # Availability Size / Price Qty
Adrenomedullin/ADM in Human Heart.
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Human Adrenomedullin/ADM Antibody Summary

Species Reactivity
Detects human Adrenomedullin/ADM in direct ELISAs.
Monoclonal Mouse IgG1 Clone # 357923
Protein A or G purified from hybridoma culture supernatant
E. coli-derived recombinant human Adrenomedullin/ADM
Accession # P35318
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
8-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry Adrenomedullin/ADM antibody in Human Heart by Immunohistochemistry (IHC-P). View Larger

Adrenomedullin/ADM in Human Heart. Adrenomedullin/ADM was detected in immersion fixed paraffin-embedded sections of human heart using Human Adrenomedullin/ADM Monoclonal Antibody (Catalog # MAB6108) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to sarcoplasma in cardiomyocytes. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Sterile PBS to a final concentration of 0.5 mg/mL.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Adrenomedullin/ADM

Adrenomedullin (ADM) is a secreted, monomeric, 6 kDa member of the adrenomedullin family of molecules.  It is widely expressed, being found in smooth muscle cells, endothelium, adrenal medulla chromaffin cells, fibroblasts and keratinocytes.  Adrenomedullin has multiple functions including vasodilation, the maintenance of vascular integrity, and the suppression of inflammatory mediator secretion.  The human Adrenomedullin preproprecursor is 185 amino acids (aa) in length.  It contains a 21 aa signal sequence, a processed 20 aa peptide termed PAMP (aa 22-41), an N-terminal propeptide (aa 45-92), the Adrenomedullin precursor (amidation is required for maturation) (aa 95-147), and a C-terminal propeptide (aa 148-185).  The Adrenomedullin precursor with a terminal Gly147 circulates naturally with bioactive, mature amidated Adrenomedullin (aa 95-146).  Depending upon the tissue, truncated forms of Adrenomedullin likely also occur, including variants spanning aa 120-146 and 128-146.  Over aa 22-147, the human Adrenomedullin proprecursor shares 70% aa identity with mouse Adrenomedullin proprecursor.       

Entrez Gene IDs
133 (Human); 11535 (Mouse); 25026 (Rat)
Alternate Names
ADM; Adrenomedullin; AMpreproadrenomedullin

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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

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Human Adrenomedullin/ADM Antibody
By Anonymous on 02/23/2022
Application: IHC Sample Tested: Prostate tissue Species: Human

Strong positivity is observed in smooth muscle cells.