Human Aminopeptidase LRAP/ERAP2 Antibody Summary
Ala56-Thr960
Accession # Q6P179
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
View Larger
Detection of Human Aminopeptidase LRAP/ERAP2 by Western Blot Immunoblot analyses of ERAP2 using LCL protein extract.Two LCLs of each ERAP2 genotype (AA, AB, and BB) were tested for protein using primary antibodies specific to: A, ERAP2 (goat polyclonal); B, ERAP2 (mouse polyclonal); and C, beta -actin (see Materials and Methods). Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pgen.1001157), licensed under a CC-BY license. Not internally tested by R&D Systems.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Aminopeptidase LRAP/ERAP2
Leukocyte-derived arginine aminopeptidase (LRAP) and endoplasmic reticulum-aminopeptidase 2 (ERAP2) are the two names given to the protein encoded by the LRAP gene (1, 2). Induced by interferon-gamma, LRAP is able to trim various MHC class I antigenic peptide precursors. It belongs to the oxytocinase subfamily of M1 aminopeptidases, which also includes aminopeptidases PILS/ARTS1/ERAP1 and LNPEP/PLAP (1, 3). In addition to antigen presentation, the members of this subfamily are also important in maintenance of pregnancy, memory retention, and blood pressure regulation (3).
- Tanioka, T. et al. (2003) J. Biol. Chem. 278:32275.
- Tanioka, T. et al. (2005) FEBS J. 272:916.
- Tsujimoto, M. and A. Hattori (2005) Biochim. Biophys. Acta 1751:9.
Product Datasheets
Citations for Human Aminopeptidase LRAP/ERAP2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
16
Citations: Showing 1 - 10
Filter your results:
Filter by:
-
Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis
Authors: Jonas J W Kuiper, Jessica van van Setten, Matthew Devall, Mircea Cretu-Stancu, Sanne Hiddingh, Roel A Ophoff et al.
Human Molecular Genetics
-
A New ERAP2/Iso3 Isoform Expression Is Triggered by Different Microbial Stimuli in Human Cells. Could It Play a Role in the Modulation of SARS-CoV-2 Infection?
Authors: Irma Saulle, Claudia Vanetti, Sara Goglia, Chiara Vicentini, Enrico Tombetti, Micaela Garziano et al.
Cells
-
Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1)
Authors: Despoina Koumantou, Eilon Barnea, Adrian Martin-Esteban, Zachary Maben, Athanasios Papakyriakou, Anastasia Mpakali et al.
Cancer Immunology, Immunotherapy
-
Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells
Authors: IC Kuo, HK Kao, Y Huang, CI Wang, JS Yi, Y Liang, CT Liao, TC Yen, CC Wu, KP Chang
Oncotarget, 2017-06-27;8(37):61698-61708.
-
The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia
Authors: Kimberly Seamon, Lesia O. Kurlak, Michelle Warthan, Efstratios Stratikos, Jerome F. Strauss, Hiten D. Mistry et al.
Frontiers in Immunology
-
The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response
Authors: Sæterstad, S;Østvik, AE;Hansen, MD;Bruland, T;van Beelen Granlund, A;
Journal of translational medicine
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
ERAP2 Inhibition Induces Cell-Surface Presentation by MOLT-4 Leukemia Cancer Cells of Many Novel and Potentially Antigenic Peptides
Authors: I Temponeras, G Stamatakis, M Samiotaki, D Georgiadis, H Pratsinis, G Panayotou, E Stratikos
International Journal of Molecular Sciences, 2022-02-08;23(3):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29
Authors: Wouter J. Venema, Sanne Hiddingh, Joke H. de Boer, Frans H. J. Claas, Arend Mulder, Anneke I. den Hollander et al.
Frontiers in Immunology
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Interaction between ERAP Alleles and HLA Class I Types Support a Role of Antigen Presentation in Hodgkin Lymphoma Development
Authors: P Jiang, RN Veenstra, A Seitz, IM Nolte, BG Hepkema, L Visser, A van den Be, A Diepstra
Cancers, 2021-01-22;13(3):.
Species: Human
Sample Types: Cell Lysates, Whole Tissue
Applications: IHC, Western Blot -
Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection
Authors: Chun Jimmie Ye, Jenny Chen, Alexandra-Chloé Villani, Rachel E. Gate, Meena Subramaniam, Tushar Bhangale et al.
Genome Research
Species: Human
Sample Types: Protein
Applications: Western Blot -
The role of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in modulating immune detection of choriocarcinoma
Authors: MD Warthan, SL Washington, SE Franzese, RM Ramus, KR Kim, TP York, E Stratikos, JF Strauss, ED Lee
Biol. Reprod., 2018-03-01;0(0):.
Species: Human
Sample Types: Cell Lysates, Whole Cells, Whole Tissue
Applications: ICC, IHC-P, Western Blot -
Integrated analysis of fine-needle-aspiration cystic fluid proteome, cancer cell secretome, and public transcriptome datasets for papillary thyroid cancer biomarker discovery
Authors: CC Wu, JD Lin, JT Chen, CM Chang, HF Weng, C Hsueh, HP Chien, JS Yu
Oncotarget, 2018-01-04;9(15):12079-12100.
Species: Human
Sample Types: Cyst Fluid, Whole Tissue
Applications: IHC, Western Blot -
Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation
Authors: Aida M. Andrés, Megan Y. Dennis, Warren W. Kretzschmar, Jennifer L. Cannons, Shih-Queen Lee-Lin, Belen Hurle et al.
PLoS Genetics
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29
Authors: Wouter J. Venema, Sanne Hiddingh, Joke H. de Boer, Frans H. J. Claas, Arend Mulder, Anneke I. den Hollander et al.
Frontiers in Immunology
-
Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection
Authors: Chun Jimmie Ye, Jenny Chen, Alexandra-Chloé Villani, Rachel E. Gate, Meena Subramaniam, Tushar Bhangale et al.
Genome Research
-
Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation
Authors: Aida M. Andrés, Megan Y. Dennis, Warren W. Kretzschmar, Jennifer L. Cannons, Shih-Queen Lee-Lin, Belen Hurle et al.
PLoS Genetics
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsReviews for Human Aminopeptidase LRAP/ERAP2 Antibody
There are currently no reviews for this product. Be the first to review Human Aminopeptidase LRAP/ERAP2 Antibody and earn rewards!
Have you used Human Aminopeptidase LRAP/ERAP2 Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
