Human CXCR4 Antibody

(31 citations)   
  • Species Reactivity
    Human
  • Specificity
    Detects human CXCR4. It will also react with cells expressing feline CXCR4 but not rat CXCR4.
  • Source
    Monoclonal Mouse IgG2B Clone # 44716
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    3T3 cells transfected with human CXCR4
  • Formulation
    Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
  • Endotoxin Level
    <0.10 EU per 1 μg of the antibody by the LAL method.
  • Label
    Unconjugated
Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    0.25 µg/106 cells
    See below
  • Immunohistochemistry
    8-25 µg/mL
    See below
  • CyTOF-ready
    Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
  • Neutralization
    Measured by its ability to neutralize CXCL12/SDF‑1 alpha -induced chemotaxis in the BaF3 mouse pro‑B cell line transfected with human CXCR4. The Neutralization Dose (ND50) is typically 2.5-12 µg/mL in the presence of 1 ng/mL Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF‑1 alpha.
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of CXCR4 in Jurkat Human Cell Line by Flow Cytometry. Jurkat human acute T cell leukemia cell line was stained with Mouse Anti-Human CXCR4 Monoclonal Antibody (Catalog # MAB172, filled histogram) or isotype control antibody (Catalog # MAB004, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B). View our protocol for Staining Membrane-associated Proteins.
Immunohistochemistry
CXCR4 in Human Lymph Node. CXCR4 was detected in immersion fixed paraffin-embedded sections of human lymph node using 15 µg/mL Human CXCR4 Monoclonal Antibody (Catalog # MAB172) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-AEC Cell & Tissue Staining Kit (red; Catalog # CTS003) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Immunohistochemistry
CXCR4 in Human Spleen. CXCR4 was detected in immersion fixed paraffin-embedded sections of human spleen using Mouse Anti-Human CXCR4 Monoclonal Antibody (Catalog # MAB172) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm and nuclei. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Chemotaxis Induced by CXCL12/SDF‑1 alpha and Neutralization by Human CXCR4 Antibody. Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF‑1 alpha (Catalog # 350-NS) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR4 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF‑1 alpha (1 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human CXCR4 Monoclonal Antibody (Catalog # MAB172). The ND50 is typically 2.5-12 µg/mL.
Preparation and Storage
  • Reconstitution
    Reconstitute at 0.5 mg/mL in sterile PBS.
  • Shipping
    The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
  • Stability & Storage
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CXCR4
CXCR4 is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T-cell tropic HIV-1 and -2 viral entry into cells. While primarily a membrane protein, CXCR4 undergoes trafficking and internalization in response to stimulation with phorbol esters and ligand (1). Cytoplasmic and nuclear localization of CXCR4 has been observed in colorectal and renal carcinomas (2,3) and it has been used as the basis of prognosis and metastatic state (3,4,5).
  • References:
    1. Orsini, M.J. et al. (1999) J. Biol. Chem. 274:31076.
    2. Zagzag, D. et al. (2005) Cancer Res. 65:6178.
    3. Speetjens, F.M. et al. (2009) Cancer Microenvironment 2:1.
    4. Wang, L. et al. (2009) Oncology Reports 22:1333.
    5. Amara, S. et al. (2015) Cancer Biomark. 15:869.
  • Entrez Gene IDs:
    7852 (Human); 12767 (Mouse); 60628 (Rat); 483900 (Canine); 493676 (Feline)
  • Alternate Names:
    CD184; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CXCR4; CXC-R4; CXCR-4; D2S201ESDF-1 receptor; FB22; Fusin; HM89NPYRL; HSY3RR; LAP3; LCR1; LESTRCD184 antigen; Leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; NPY3RWHIM; NPYR; NPYY3R; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

31 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. Cell-based therapy using miR-302-367 expressing cells represses glioblastoma growth
    Authors: M Fareh, F Almairac, L Turchi, F Burel-Vand, P Paquis, D Fontaine, S Lacas-Gerv, MP Junier, H Chneiweiss, T Virolle
    Cell Death Dis, 2017;8(3):e2713.
    Species: Human
    Sample Type: Cell Lysates
    Application: WB
  2. Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices
    Proc Natl Acad Sci USA, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: IHC Fresh
  3. Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveals a Mechanism for Regulation of Tumor Progression
    Authors: CJ Coke, KA Scarlett, MA Chetram, KJ Jones, BJ Sandifer, AS Davis, AI Marcus, CV Hinton
    J. Biol. Chem., 2016;291(19):9991-10005.
    Species: Human
    Sample Type: Whole Cells
    Application: Neut
  4. The long pentraxin PTX3 promotes fibrocyte differentiation.
    Authors: Pilling D, Cox N, Vakil V, Verbeek J, Gomer R
    PLoS ONE, 2015;10(3):e0119709.
    Species: Human
    Sample Type: Whole Cells
    Application: IHC Fresh
  5. CXCL16 and CXCR6 are coexpressed in human lung cancer in vivo and mediate the invasion of lung cancer cell lines in vitro.
    Authors: Hu, Weidong, Liu, Yue, Zhou, Wenhui, Si, Lianlian, Ren, Liang
    PLoS ONE, 2014;9(6):e99056.
    Species: Human
    Sample Type: Whole Cells
    Application: ICC
  6. Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer.
    Authors: Hartmann N, Giese N, Giese T, Poschke I, Offringa R, Werner J, Ryschich E
    Clin Cancer Res, 2014;20(13):3422-33.
    Species: Human
    Sample Type: Whole Tissue
    Application: IHC
  7. An important role of the SDF-1/CXCR4 axis in chronic skin inflammation.
    Authors: Zgraggen, Silvana, Huggenberger, Reto, Kerl, Katrin, Detmar, Michael
    PLoS ONE, 2014;9(4):e93665.
    Species: Human
    Sample Type: Whole Tissue
    Application: IHC Paraffin-embedded
  8. Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node.
    Authors: Yin X, Johns S, Kim D, Mikulski Z, Salanga C, Handel T, Macal M, Zuniga E, Fuster M
    J Immunol, 2014;192(5):2133-42.
    Species: Human
    Sample Type: Whole Cells
    Application: Functional Assay
  9. Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanisms.
    Authors: Jarajapu Y, Hazra S, Segal M, Li Calzi S, Jadhao C, Qian K, Mitter S, Raizada M, Boulton M, Grant M
    PLoS ONE, 2014;9(4):e93965.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  10. PCaAnalyser: a 2D-image analysis based module for effective determination of prostate cancer progression in 3D culture.
    Authors: Hoque, Md Tamji, Windus, Louisa C, Lovitt, Carrie J, Avery, Vicky M
    PLoS ONE, 2013;8(11):e79865.
    Species: Human
    Sample Type: Whole Cells
    Application: ICC
  11. Expression of the chemokine receptor CXCR7 in CXCR4-expressing human 143B osteosarcoma cells enhances lung metastasis of intratibial xenografts in SCID mice.
    Authors: Brennecke P, Arlt M, Muff R, Campanile C, Gvozdenovic A, Husmann K, Holzwarth N, Cameroni E, Ehrensperger F, Thelen M, Born W, Fuchs B
    PLoS ONE, 2013;8(9):e74045.
    Species: Human
    Sample Type: Whole Tissue
    Application: IHC Paraffin-embedded
  12. CXC chemokine receptor 4 is essential for maintenance of renal cell carcinoma-initiating cells and predicts metastasis.
    Authors: Gassenmaier M, Chen D, Buchner A, Henkel L, Schiemann M, Mack B, Schendel D, Zimmermann W, Pohla H
    Stem Cells, 2013;31(8):1467-76.
    Species: Human
    Sample Type: Whole Cells
    Application: IHC Paraffin-embedded
  13. The expressions of MIF and CXCR4 protein in tumor microenvironment are adverse prognostic factors in patients with esophageal squamous cell carcinoma.
    Authors: Zhang, Lin, Ye, Shu-Biao, Ma, Gang, Tang, Xiao-Fen, Chen, Shi-Ping, He, Jia, Liu, Wan-Li, Xie, Dan, Zeng, Yi-Xin, Li, Jiang
    J Transl Med, 2013;11(0):60.
    Species: Human
    Sample Type: Whole Tissue
    Application: IHC Paraffin-embedded
  14. Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070.
    Authors: O'Boyle, G, Swidenbank, I, Marshall, H, Barker, C E, Armstrong, J, White, S A, Fricker, S P, Plummer, R, Wright, M, Lovat, P E
    Br J Cancer, 2013;108(8):1634-40.
  15. The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer.
    Authors: Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev IS, Tacheuchi S, Mouri H, Yamashita K, Ohtsubo K, Yano S
    Clin. Cancer Res., 2011;17(11):3619-30.
    Species: Human
    Sample Type: Whole Tissue
    Application: IHC Paraffin-embedded
  16. Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancer.
    Authors: Pfeiffer M, Hartmann TN, Leick M, Catusse J, Schmitt-Graeff A, Burger M
    Br. J. Cancer, 2009;100(12):1949-56.
    Species: Human
    Sample Type: Cell Lysates
    Application: IP
  17. A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells.
    Authors: Hansson M, Olesen DR, Peterslund JM, Engberg N, Kahn M, Winzi M, Klein T, Maddox-Hyttel P, Serup P
    Dev. Biol., 2009;330(2):286-304.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Flow
  18. Clinical and biological significance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents.
    Authors: Gilbert DC, Chandler I, McIntyre A, Goddard NC, Gabe R, Huddart RA, Shipley J
    J. Pathol., 2009;217(1):94-102.
    Species: Human
    Sample Type: Whole Cells
    Application: ICC
  19. Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention.
    Authors: Franciszkiewicz K, Le Floc'h A, Jalil A, Vigant F, Robert T, Vergnon I, Mackiewicz A, Benihoud K, Validire P, Chouaib S, Combadiere C, Mami-Chouaib F
    Cancer Res., 2009;69(15):6249-55.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  20. Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells.
    Authors: Williams CK, Segarra M, Sierra Mde L, Sainson RC, Tosato G, Harris AL
    Cancer Res., 2008;68(6):1889-95.
    Species: Human
    Sample Type: Whole Cells
    Application: Neut
  21. Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts.
    Authors: Tait LR, Pauley RJ, Santner SJ, Heppner GH, Heng HH, Rak JW, Miller FR
    Int. J. Cancer, 2007;120(10):2127-34.
    Species: Human
    Sample Type: Whole Cells
    Application: ICC
  22. Human melanoma metastases express functional CXCR4.
    Authors: Scala S, Giuliano P, Ascierto PA, Ierano C, Franco R, Napolitano M, Ottaiano A, Lombardi ML, Luongo M, Simeone E, Castiglia D, Mauro F, De Michele I, Calemma R, Botti G, Caraco C, Nicoletti G, Satriano RA, Castello G
    Clin. Cancer Res., 2006;12(8):2427-33.
    Species: Human
    Sample Type: Whole Cells
    Application: ICC
  23. Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF.
    Authors: Misao Y, Takemura G, Arai M, Ohno T, Onogi H, Takahashi T, Minatoguchi S, Fujiwara T, Fujiwara H
    Cardiovasc. Res., 2006;71(3):455-65.
    Species: Rabbit
    Sample Type: Whole Tissue
    Application: IHC Paraffin-embedded
  24. Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis.
    Authors: Haringman JJ, Smeets TJ, Reinders-Blankert P
    Ann. Rheum. Dis., 2006;65(3):294-300.
    Species: Human
    Sample Type: Whole Tissue
    Application: IHC Frozen
  25. Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
    Authors: Marchal-Somme J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, Crestani B, Soler P
    J. Immunol., 2006;176(10):5735-9.
    Species: Human
    Sample Type: Whole Tissue
    Application: IHC Frozen
  26. Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus.
    Authors: Meller S, Winterberg F, Gilliet M, Muller A, Lauceviciute I, Rieker J, Neumann NJ, Kubitza R, Gombert M, Bunemann E, Wiesner U, Franken-Kunkel P, Kanzler H, Dieu-Nosjean MC, Amara A, Ruzicka T, Lehmann P, Zlotnik A, Homey B
    Arthritis Rheum., 2005;52(5):1504-16.
    Species: Human
    Sample Type: Whole Tissue
    Application: IHC Fresh/Frozen
  27. Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone.
    Authors: Liao TS, Yurgelun MB, Chang SS, Zhang HZ, Murakami K, Blaine TA, Parisien MV, Kim W, Winchester RJ, Lee FY
    J. Orthop. Res., 2005;23(1):203-9.
    Species: Human
    Sample Type: Whole Cells
    Application: ICC
  28. CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer.
    Authors: Mori T, Doi R, Koizumi M, Toyoda E, Ito D, Kami K, Masui T, Fujimoto K, Tamamura H, Hiramatsu K, Fujii N, Imamura M
    Mol. Cancer Ther., 2004;3(1):29-37.
    Species: Human
    Sample Type: Whole Cells
    Application: ICC
  29. Intracellular localization and constitutive endocytosis of CXCR4 in human CD34+ hematopoietic progenitor cells.
    Authors: Zhang Y, Foudi A, Geay JF, Berthebaud M, Buet D, Jarrier P, Jalil A, Vainchenker W, Louache F
    Stem Cells, 2004;22(6):1015-29.
    Species: Human
    Sample Type: Whole Cells
    Application: ICC
  30. CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin.
    Authors: Cardones AR, Murakami T, Hwang ST
    Cancer Res., 2003;63(20):6751-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  31. CXCR4 function requires membrane cholesterol: implications for HIV infection.
    Authors: Nguyen DH, Taub D
    J. Immunol., 2002;168(8):4121-6.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
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