Human IFN-beta Antibody

Catalog # Availability Size / Price Qty
21450-1
Product Details
Citations (2)
FAQs
Supplemental Products
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Human IFN-beta Antibody Summary

Species Reactivity
Human
Specificity
Detects human interferon beta in direct ELISAs.
Source
Monoclonal Mouse IgG1 Clone # MMHB-12
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Human interferon beta
Formulation
Phosphate buffered saline (PBS) containing 0.1% bovine serum albumin (BSA)
Label
Unconjugated

Applications

Recommended Concentration
Sample
Direct ELISA
Binds to human interferon beta with high affinity.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
After receipt, the product may be stored at -20°C for short-term use ( ≤ 6 months). For long-term storage, we recommend storing the product at -70°C or below for retention of full activity. When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% bovine serum albumin (BSA).

Background: IFN-beta

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Long Name
Interferon beta
Entrez Gene IDs
3456 (Human); 15977 (Mouse); 24481 (Rat)
Alternate Names
Fibroblast interferon; IFBIFNB; IFF; IFNB1; IFNbeta; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956

Product Datasheets

Citations for Human IFN-beta Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Neutralizing type I IFN antibodies trigger an IFN-like response in endothelial cells.
    Authors: Moll HP, Freudenthaler H, Zommer A
    J. Immunol., 2008;180(8):5250-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neut
  2. TLR7 Agonist 852A Inhibition of Tumor Cell Proliferation Is Dependent on Plasmacytoid Dendritic Cells and Type I IFN.
    Authors: Inglefield JR, Dumitru CD, Alkan SS, Gibson SJ, Lipson KE, Tomai MA, Larson CJ, Vasilakos JP
    J. Interferon Cytokine Res., 2008;28(4):253-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neut

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