Human IFN-beta Antibody
Human IFN-beta Antibody Summary
Due to the variation in ND50 (Neutralizing Dose) values based on the cell type and assay system, we recommend each user determine the neutralizing concentration of this antibody lot in their assay system. Using an A549/EMCV (cell/virus) system, we have not verified with reasonable consistency the neutralizing concentration of this antibody (the concentration required to inhibit the antiviral effect of human interferon beta by one half).
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.
Citations for Human IFN-beta Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 3
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poly(I:C) and LPS induce distinct IRF3 and NF-kappaB signaling during type-I IFN and TNF responses in human macrophages.
Authors: Reimer T, Brcic M, Schweizer M
J. Leukoc. Biol., 2008;83(5):1249-57.
Sample Types: Cell Lysates
Neutralizing type I IFN antibodies trigger an IFN-like response in endothelial cells.
Authors: Moll HP, Freudenthaler H, Zommer A
J. Immunol., 2008;180(8):5250-6.
Sample Types: Whole Cells
Type I IFN induction in response to Listeria monocytogenes in human macrophages: evidence for a differential activation of IFN regulatory factor 3 (IRF3).
Authors: Reimer T, Schweizer M, Jungi TW
J. Immunol., 2007;179(2):1166-77.
Sample Types: Cell Lysates
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