Human IL-19 Antibody
Human IL-19 Antibody Summary
Accession # Q9UHD0
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Cell Proliferation Induced by IL‑19 and Neutralization by Human IL‑19 Antibody. Recombinant Human IL-19 (Catalog # 1035-IL) stimulates proliferation in the BaF3 mouse pro-B cell line co-transfected with human IL-20 Ra and IL-20 R beta in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human IL-19 (3 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL-19 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1035). The ND50 is typically 1-3 µg/mL.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Human Interleukin 19 (IL-19) is a member of the IL-10 family of related cytokines. Its gene contains two alternate translation initiation sites, generating precursors of 215 amino acids (aa) and 177 aa, respectively. Both isoforms are processed to 17 kDa, 153 aa mature molecules. IL-19 contains seven helices and is secreted as a 35 kDa monomer. There are two potential N-linked glycosylation sites, and it is likely that the molecule is glycosylated. Mature human IL-19 shares 69% aa sequence identity with the mature mouse homologue. Although mouse IL-19 is active on human cells, human IL-19 is not active on mouse cells. IL-19 expression is limited to activated keratinocytes and monocytes. IL-19 binds a receptor complex consisting of the IL-20 receptor alpha (IL-20 R alpha, also known as IL-20 R1) and the IL-20 receptor beta (IL-20 R beta or IL-20 R2). This receptor complex is also shared by IL-20 and IL-24. Functionally, IL-19 induces IL-6 and TNF-alpha production by monocytes, and drives T-helper cell differentiation towards a Th2 response (1‑5).
- Gallagher, G. et al. (2000) Genes Immun. 1:442.
- Gallagher, G. et al. (2004) Int. Immunopharmacol. 4:615.
- Laio, Y-C. et al. (2002) J. Immunol. 169:4288.
- Romer, J. et al. (2003) J. Invest. Dermatol. 121:1306.
- Pestka, S. et al. (2004) Annu. Rev. Immunol. 22:929.
Citations for Human IL-19 Antibody
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Citations: Showing 1 - 2
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IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression.
Authors: Tohyama M, Hanakawa Y, Shirakata Y, Dai X, Yang L, Hirakawa S, Tokumaru S, Okazaki H, Sayama K, Hashimoto K
Eur. J. Immunol., 2009-10-01;39(10):2779-88.
Sample Types: Whole Tissue
Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: important implications in asthma.
Authors: Huang F, Wachi S, Thai P, Loukoianov A, Tan KH, Forteza RM, Wu R
J. Allergy Clin. Immunol., 2008-06-01;121(6):1415-21, 1421.
Sample Types: Cell Culture Supernates
Applications: ELISA Development
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