Human LBP Antibody
Human LBP Antibody Summary
Accession # AAD21962
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lipopolysaccharide-binding protein (LBP), a 58 kDa glycoprotein synthesized in hepatocytes, belongs to a family of lipid-binding proteins which includes bactericidal/permeability increasing protein (BPI), phospholipid ester transfer protein (PLTP), and cholesterol ester transfer protein (CETP). LBP binds to the lipid A portion of lipopolysaccharide (LPS) to facilitate the process of LPS monomerization, catalyze the binding of LPS monomers to CD14, and promote LPS-induced immune response. LBP is present at low concentrations in normal human serum and may increase up to 30-fold during the acute phase response. Studies indicate that LBP also acts catalytically in the transfer of LPS to HDL, thus accelerating LPS detoxification. In addition, LBP and soluble CD14 can also function in phospholipid transport.
- Hailman, E. et al. (1994) J. Exp. Med. 179:269.
- Jack, R.S. et al. (1997) Nature 389:742.
- Schumann, R.R. et al. (2000) Chem. Immunol. 74:42.
Citation for Human LBP Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Inhibition of lipid A-mediated type I interferon induction by bactericidal/permeability-increasing protein (BPI).
Authors: Azuma M, Matsuo A, Fujimoto Y, Fukase K, Hazeki K, Hazeki O, Matsumoto M, Seya T
Biochem. Biophys. Res. Commun., 2007;354(2):574-8.
Sample Types: Whole Cells
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