Human/Mouse Active Caspase-3 Antibody

Catalog # Availability Size / Price Qty
AF835
AF835-SP
Caspase‑3 in Jurkat Human Cell Line.
3 Images
Product Details
Citations (138)
FAQs
Supplemental Products
Reviews (2)

Human/Mouse Active Caspase-3 Antibody Summary

Species Reactivity
Human, Mouse
Specificity
Distinguishes apoptotic cells from non-apoptotic cells in immunohistochemistry. Detects the p17 subunit of Caspase-3, but does not detect the precursor form in Western blot. We recommend R&D Systems Affinity Purified Anti-Caspase-3 (Catalog # AF-605-NA) or Monoclonal Anti-Cleaved-Caspase-3 (Catalog # MAB835) for Western blot applications.
Source
Polyclonal Rabbit IgG
Purification
Antigen Affinity-purified
Immunogen
KLH-coupled human Caspase-3 synthetic peptide
CRGTELDCGIETD
Accession # P42574
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Immunohistochemistry
1-15 µg/mL
See below
Immunocytochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Examples

Immunocytochemistry Caspase‑3 in Jurkat Human Cell Line. View Larger

Caspase‑3 in Jurkat Human Cell Line. Caspase‑3 was detected in immersion fixed anti-FAS treated Jurkat human acute T cell leukemia cell line using 0.3 µg/mL Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) for 3 hours at room temperature. Cells were stained (red) and counterstained (green). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunocytochemistry Caspase‑3 in Jurkat Human Cell Line. View Larger

Caspase‑3 in Jurkat Human Cell Line. Caspase‑3 was detected in immersion fixed Jurkat human acute T cell leukemia cell line stimulated with staurosporin using Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (yellow; Catalog # NL004) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunohistochemistry Caspase‑3  in Human Colon Cancer Tissue. View Larger

Caspase‑3 in Human Colon Cancer Tissue. Caspase‑3 was detected in immersion fixed paraffin-embedded sections of human colon cancer tissue using Rabbit Anti-Human/Mouse Active Caspase‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF835) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC003). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Caspase-3

Caspase-3 (Cysteine-aspartic acid protease 3/Casp3; also Yama, apopain and CPP32) is a 29 kDa heterodimer that belongs to the peptidase C14A family of enzymes. It is widely expressed, and considered to be the major executioner caspase in the apoptotic cascade. Human procaspase-3 is a 32 kDa, 277 amino acid (aa) protein and is normally an inactive homodimer. Following cell stress/activation, procaspase-3 undergoes proteolysis to generate an N-terminal 148 aa p17/17 kDa subunit (aa 29-175), plus a 102 aa C-terminal p12/12 kDa subunit. These subunits noncovalently heterodimerize, and associate with another p17/p12 heterodimer to form an active enzyme. There is one potential variant that shows an alternative start site nine aa upstream of the standard start site coupled with a 21 aa substitution for aa 162-277. Over aa 29-175, human and mouse caspase-3 share 87% aa identity.

Entrez Gene IDs
836 (Human); 12367 (Mouse)
Alternate Names
Apopain; apoptosis-related cysteine protease; CASP3; CASP-3; caspase 3, apoptosis-related cysteine peptidase; Caspase3; Caspase-3; CPP32; CPP-32; CPP32B; CPP32SREBP cleavage activity 1; Cysteine protease CPP32; EC 3.4.22; EC 3.4.22.56; LICE-1; PARP cleavage protease; procaspase3; Protein Yama; SCA-1; YAMA

Product Datasheets

Citations for Human/Mouse Active Caspase-3 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

138 Citations: Showing 1 - 10
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  1. Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells
    Authors: BA Brown, GM Connolly, CEJ Mill, H Williams, GD Angelini, JL Johnson, SJ George
    Aging Cell, 2018;0(0):e12844.
    Species: Mouse
    Sample Types: Whole Cell
    Applications: ICC
  2. An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages
    Authors: A López-Muño, FE Nicolás, D García-Mor, AB Pérez-Oliv, MI Navarro-Me, MA Hernández-, A Herrera-Es, S Torres-Mar, RM Ruiz-Vázqu, V Garre, V Mulero
    Sci Rep, 2018;8(1):12802.
    Species: Zebrafish
    Sample Types: Whole Tissue
    Applications: IHC - Paraffin embedded
  3. A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway
    Authors: N Antoniou, D Vlachakis, A Memou, E Leandrou, PE Valkimadi, K Melachroin, DB Re, S Przedborsk, WT Dauer, L Stefanis, HJ Rideout
    Sci Rep, 2018;8(1):3455.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  4. PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification
    Authors: I Cohen, D Zhao, C Bar, VJ Valdes, KL Dauber-Dec, MB Nguyen, M Nakayama, M Rendl, WA Bickmore, H Koseki, D Zheng, E Ezhkova
    Cell Stem Cell, 2018;22(5):726-739.e7.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  5. The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model
    Authors: PLN da Costa, D Wynne, T Fifis, L Nguyen, M Perini, C Christophi
    BMC Cancer, 2018;18(1):382.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  6. Tracking cellular and molecular changes in a species-specific manner during experimental tumor progression in vivo
    Authors: E Indersie, KB Hooks, C Capdeviell, M Fabre, N Dugot-Sena, A Desplat, S Lepreux, A Merched, CF Grosset, M Hagedorn
    Oncotarget, 2018;9(22):16149-16162.
    Species: Human
    Sample Types: Complex Sample Type
    Applications: IHC
  7. The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells via inhibition of the PI3K/Akt signaling pathway
    Authors: P Shen, J Chen, M Pan
    Mol Med Rep, 2018;18(3):3332-3340.
    Species: Rat
    Sample Types: Cell Lysates
    Applications: WB
  8. Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells
    Authors: N Dreyer-And, AS Almeida, P Jensen, M Kamand, J Okarmus, T Rosenberg, SD Friis, A Martínez S, M Blaabjerg, BW Kristensen, T Skrydstrup, JB Gramsberge, HLA Vieira, M Meyer
    PLoS ONE, 2018;13(1):e0191207.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  9. Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction
    Authors: ML Piacentino, ME Bronner
    PLoS Biol., 2018;16(6):e2004425.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: IHC-P
  10. Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice
    Authors: R Barbieri, A Contestabi, MG Ciardo, N Forte, A Marte, P Baldelli, F Benfenati, F Onofri
    Oncotarget, 2018;9(27):18760-18774.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-F
  11. Epidermal-specific deletion of TC-PTP promotes UVB-induced epidermal cell survival through the regulation of Flk-1/JNK signaling
    Authors: M Baek, M Kim, JS Lim, LD Morales, J Hernandez, S Mummidi, S Williams-B, IS Jang, AT Tsin, DJ Kim
    Cell Death Dis, 2018;9(7):730.
    Species: Human
    Sample Types: Whole Cells
  12. Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation
    Authors: RK Zwick, MC Rudolph, BA Shook, B Holtrup, E Roth, V Lei, A Van Keymeu, V Seewaldt, S Kwei, J Wysolmersk, MS Rodeheffer, V Horsley
    Nat Commun, 2018;9(1):3592.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IF
  13. Loss of Ccbe1 affects cardiac-specification and cardiomyocyte differentiation in mouse embryonic stem cells
    Authors: O Bover, T Justo, PNG Pereira, J Facucho-Ol, JM Inácio, JS Ramalho, IJ Domian, JA Belo
    PLoS ONE, 2018;13(10):e0205108.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow
  14. BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer
    Authors: M Ouarné, C Bouvard, G Boneva, C Mallet, J Ribeiro, A Desroches-, E Soleilhac, E Tillet, O Peyruchaud, S Bailly
    J. Exp. Clin. Cancer Res., 2018;37(1):209.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  15. Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
    Authors: JM Povedano, P Martinez, R Serrano, Á Tejera, G Gómez-Lópe, M Bobadilla, JM Flores, F Bosch, MA Blasco
    Elife, 2018;7(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  16. Loss of the Wnt receptor Frizzled7 in the gastric epithelium is deleterious and triggers rapid repopulation in vivo
    Authors: DJ Flanagan, N Barker, C Nowell, H Clevers, M Ernst, TJ Phesse, E Vincan
    Dis Model Mech, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  17. Glycogen synthase kinase-3 inhibition sensitizes human induced pluripotent stem cells to thiol-containing antioxidants induced apoptosis
    Authors: C Tu, R Xu, M Koleti, J Zoldan
    Stem Cell Res, 2017;23(0):182-187.
    Species: Human
    Sample Types: Whole Cells
    Applications: Func
  18. Low Dose Radiation Causes Skin Cancer In Mice And Has A Differential Effect on Distinct Epidermal Stem Cells
    Authors: T Revenco, G Lapouge, V Moers, S Broh‚e, PA Sotiropoul
    Stem Cells, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC - Paraffin embedded
  19. Oxidative damage and impairment of protein quality control systems in keratinocytes exposed to a volatile organic compounds cocktail
    Authors: M Dezest, M Le Bechec, L Chavatte, V Desauziers, B Chaput, JL Grolleau, P Descargues, C Nizard, S Schnebert, S Lacombe, AL Bulteau
    Sci Rep, 2017;7(1):10707.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  20. Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner
    Authors: KR Hughes, LC Harnisch, C Alcon-Gine, S Mitra, CJ Wright, J Ketskemety, D van Sinder, AJ Watson, LJ Hall
    Open Biol, 2017;7(1):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC - Paraffin embedded
  21. A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin
    Authors: F Oozeer, LL Yates, C Dean, CJ Formstone
    Sci Rep, 2017;7(1):1880.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  22. Caspase-3/-7-Specific Metabolic Precursor for Bioorthogonal Tracking of Tumor Apoptosis
    Authors: MK Shim, HY Yoon, S Lee, MK Jo, J Park, JH Kim, SY Jeong, IC Kwon, K Kim
    Sci Rep, 2017;7(1):16635.
    Species: Human
    Sample Types: Cell Lysates
    Applications: WB
  23. New tumor suppressor microRNAs target glypican-3 in human liver cancer
    Authors: F Cartier, E Indersie, S Lesjean, J Charpentie, KB Hooks, A Ghousein, A Desplat, N Dugot-Sena, V Trézéguet, F Sagliocco, M Hagedorn, CF Grosset
    Oncotarget, 2017;0(0):.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: IHC
  24. The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries
    Authors: S Grasso, J Chapelle, V Salemme, S Aramu, I Russo, N Vitale, L Verdun di, K Dallaglio, I Castellano, A Amici, G Centonze, N Sharma, S Lunardi, S Cabodi, F Cavallo, A Lamolinara, L Stramucci, E Moiso, P Provero, A Albini, A Sapino, J Staaf, PP Di Fiore, G Bertalot, S Pece, D Tosoni, S Confalonie, M Iezzi, P Di Stefano, E Turco, P Defilippi
    Nat Commun, 2017;8(0):14797.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  25. Constitutive WNT/CTNNB1 activation triggers spermatogonial stem cell proliferation and germ cell depletion
    Authors: AA Chassot, M Le Rolle, M Jourden, MM Taketo, NB Ghyselinck, MC Chaboissie
    Dev. Biol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  26. VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis
    Authors: JY Jang, SY Choi, I Park, DY Park, K Choe, P Kim, YK Kim, BJ Lee, M Hirashima, Y Kubota, JW Park, SY Cheng, A Nagy, YJ Park, K Alitalo, M Shong, GY Koh
    EMBO Mol Med, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  27. Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression
    Authors: CA Lyon, H Williams, R Bianco, SJ Simmonds, BA Brown, KS Wadey, FCT Smith, JL Johnson, SJ George
    Sci Rep, 2017;7(1):17342.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  28. Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
    Authors: JC Klein, K Moses, G Zelinskyy, S Sody, J Buer, S Lang, I Helfrich, U Dittmer, CJ Kirschning, S Brandau
    Nat Commun, 2017;8(0):14600.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  29. Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium
    Authors: LA Murray, R Dunmore, A Camelo, CA Da Silva, MJ Gustavsson, DM Habiel, TL Hackett, CM Hogaboam, MA Sleeman, DA Knight
    Respir. Res., 2017;18(1):82.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Not Specified
  30. Oxidative damage and impairment of protein quality control systems in keratinocytes exposed to a volatile organic compounds cocktail
    Authors: M Dezest, M Le Bechec, L Chavatte, V Desauziers, B Chaput, JL Grolleau, P Descargues, C Nizard, S Schnebert, S Lacombe, AL Bulteau
    Sci Rep, 2017;7(1):10707.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  31. Combined effects of atorvastatin and aspirin on growth and apoptosis in human prostate cancer cells
    Authors: Y He, H Huang, C Farischon, D Li, Z Du, K Zhang, X Zheng, S Goodin
    Oncol. Rep, 2017;37(2):953-960.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  32. The Process of Engraftment of Myogenic Cells in Skeletal Muscles of Primates: Understanding Clinical Observations and Setting Directions in Cell Transplantation Research
    Authors: D Skuk, JP Tremblay
    Cell Transplant, 2017;26(11):1763-1779.
    Species: Primate
    Sample Types: Whole Tissue
    Applications: IF
  33. Oxidative damage and impairment of protein quality control systems in keratinocytes exposed to a volatile organic compounds cocktail
    Authors: M Dezest, M Le Bechec, L Chavatte, V Desauziers, B Chaput, JL Grolleau, P Descargues, C Nizard, S Schnebert, S Lacombe, AL Bulteau
    Sci Rep, 2017;7(1):10707.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  34. Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb
    Authors: JD Aridas, CA McDonald, MC Paton, T Yawno, AE Sutherland, I Nitsos, Y Pham, M Ditchfield, MC Fahey, F Wong, A Malhotra, M Castillo-M, K Bhakoo, EM Wallace, G Jenkin, SL Miller
    J. Physiol. (Lond.), 2016;594(5):1421-35.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC - Paraffin embedded
  35. Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary
    Authors: M-C De Cian
    Oncogene, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC - Paraffin embedded
  36. Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue.
    Authors: Jacob F, Yonis A, Cuello F, Luther P, Schulze T, Eder A, Streichert T, Mannhardt I, Hirt M, Schaaf S, Stenzig J, Force T, Eschenhagen T, Hansen A
    PLoS ONE, 2016;11(2):e0145937.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  37. CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex
    Stem Cell Reports, 2016;7(1):69-79.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC - PFA fixed
  38. Brinp1 (-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density
    Authors: SR Berkowicz, TJ Featherby, Z Qu, A Giousoh, NA Borg, JI Heng, JC Whisstock, PI Bird
    Mol Autism, 2016;7(0):22.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC - Frozen
  39. Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice
    J Neurosci, 2016;36(17):4758-70.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Not Specified
  40. Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo
    Redox Biol, 2016;11(0):219-230.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: WB
  41. Proliferation, differentiation and migration of SCA1(-)/CD31(-) cardiac side population cells in vitro and in vivo
    Authors: Simon X Liang
    Int. J. Cardiol., 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  42. Axonal Cleaved Caspase-3 Regulates Axon Targeting and Morphogenesis in the Developing Auditory Brainstem
    Authors: Karina S Cramer
    Front Neural Circuits, 2016;10(0):84.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: IHC
  43. Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations
    PLoS ONE, 2016;11(11):e0166053.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  44. Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture
    Authors: F Lorenzi, R Babaei-Jad, J Sheard, B Spencer-De, AS Nateri
    Mol Ther Methods Clin Dev, 2016;3(0):16024.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  45. Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin
    Nat. Cell Biol., 2016;18(6):619-31.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC OCT-embedded
  46. cMyc Regulates the Size of the Premigratory Neural Crest Stem Cell Pool
    Cell Rep, 2016;17(10):2648-2659.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  47. Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response.
    Authors: Sesen J, Dahan P, Scotland S, Saland E, Dang V, Lemarie A, Tyler B, Brem H, Toulas C, Cohen-Jonathan Moyal E, Sarry J, Skuli N
    PLoS ONE, 2015;10(4):e0123721.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC - Not specified
  48. Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.
    Authors: Moyon S, Dubessy A, Aigrot M, Trotter M, Huang J, Dauphinot L, Potier M, Kerninon C, Melik Parsadaniantz S, Franklin R, Lubetzki C
    J Neurosci, 2015;35(1):4-20.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Frozen
  49. Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours.
    Authors: Petersson, Monika, Reuter, Karen, Brylka, Heike, Kraus, Andreas, Schettina, Peter, Niemann, Catherin
    Nat Commun, 2015;6(0):5874.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Not Specified
  50. Interactions of highly and low virulent Flavobacterium columnare isolates with gill tissue in carp and rainbow trout.
    Authors: Declercq, Annelies, Chiers, Koen, Van den Broeck, Wim, Dewulf, Jeroen, Eeckhaut, Venessa, Cornelissen, Maria, Bossier, Peter, Haesebrouck, Freddy, Decostere, Annemie
    Vet Res, 2015;46(0):25.
    Species: Fish - Cyprinus carpio (Carp)
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  51. The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.
    Authors: Douglas T, Champagne C, Morizot A, Lapointe J, Saleh M
    J Immunol, 2015;195(5):2365-73.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC - Paraffin embedded
  52. Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs.
    Authors: Sharma S, Chintala N, Vadrevu S, Patel J, Karbowniczek M, Markiewski M
    J Immunol, 2015;194(11):5529-38.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow
  53. Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a 133p53alpha mimic.
    Authors: Sawhney S, Hood K, Shaw A, Braithwaite A, Stubbs R, Hung N, Royds J, Slatter T
    PLoS ONE, 2015;10(2):e0116270.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  54. An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress.
    Authors: Quereda V, Porlan E, Canamero M, Dubus P, Malumbres M
    Cell Death Differ, 2015;23(3):430-41.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  55. Exacerbated experimental colitis in TNFAIP8-deficient mice.
    Authors: Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen Y
    J Immunol, 2015;194(12):5736-42.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  56. Epidermal growth factor attenuates tubular necrosis following mercuric chloride damage by regeneration of indigenous, not bone marrow-derived cells.
    Authors: Yen T, Alison M, Goodlad R, Otto W, Jeffery R, Cook H, Wright N, Poulsom R
    J Cell Mol Med, 2015;19(2):463-73.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC - paraffin
  57. Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.
    Authors: Brindle N, Joyce J, Rostker F, Lawlor E, Swigart-Brown L, Evan G, Hanahan D, Shchors K
    PLoS ONE, 2015;10(4):e0120348.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-OCT embedded
  58. Hepatocyte-specific deletion of ARNT (aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury.
    Authors: Scott C, Cha K, Rao R, Liddle C, George J, Gunton J
    PLoS ONE, 2015;10(3):e0121650.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  59. Apoptosis-Related Factors in the Luteal Phase of the Domestic Cat and Their Involvement in the Persistence of Corpora Lutea in Lynx.
    Authors: Amelkina O, Zschockelt L, Painer J, Serra R, Villaespesa F, Braun B, Jewgenow K
    PLoS ONE, 2015;10(11):e0143414.
    Species: Feline
    Sample Types: Whole Tissue
    Applications: IHC - paraffin
  60. TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.
    Authors: Matsuda T, Murao N, Katano Y, Juliandi B, Kohyama J, Akira S, Kawai T, Nakashima K
    Nat Commun, 2015;6(0):6514.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC Fluorescence
  61. Preclinical studies identify non-apoptotic low-level caspase-3 as therapeutic target in pemphigus vulgaris.
    Authors: Luyet C, Schulze K, Sayar B, Howald D, Muller E, Galichet A
    PLoS ONE, 2015;10(3):e0119809.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC Fluorescence
  62. Attenuation of Cerebral Ischemic Injury in Smad1 Deficient Mice.
    Authors: Wong J, Chen L, Huang Y, Sehba F, Friedel R, Zou H
    PLoS ONE, 2015;10(8):e0136967.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Frozen
  63. BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus.
    Authors: Levet S, Ouarne M, Ciais D, Coutton C, Subileau M, Mallet C, Ricard N, Bidart M, Debillon T, Faravelli F, Rooryck C, Feige J, Tillet E, Bailly S
    Proc Natl Acad Sci U S A, 2015;112(25):E3207-15.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Not Specified
  64. Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERalpha(+) tumorigenesis.
    Authors: Chan S, Rickert C, Vermi W, Sheehan K, Arthur C, Allen J, White J, Archambault J, Lonardi S, McDevitt T, Bhattacharya D, Lorenzi M, Allred D, Schreiber R
    Cell Death Differ, 2014;21(2):234-46.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  65. Pseudomonas aeruginosa-induced apoptosis in airway epithelial cells is mediated by gap junctional communication in a JNK-dependent manner.
    Authors: Losa D, Kohler T, Bellec J, Dudez T, Crespin S, Bacchetta M, Boulanger P, Hong S, Morel S, Nguyen T, van Delden C, Chanson M
    J Immunol, 2014;192(10):4804-12.
    Species: Human
    Sample Types: Cell Lysates
    Applications: WB
  66. Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-beta.
    Authors: Wiener Z, Band A, Kallio P, Hogstrom J, Hyvonen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, Louvard D, Ben-Neriah Y, Alitalo K
    Proc Natl Acad Sci U S A, 2014;111(21):E2229-36.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Flow
  67. Differential sensitivity of prefrontal cortex and hippocampus to alcohol-induced toxicity.
    Authors: Fowler, Anna-Kat, Thompson, Jeremy, Chen, Lixia, Dagda, Marisela, Dertien, Janet, Dossou, Katina S, Moaddel, Ruin, Bergeson, Susan E, Kruman, Inna I
    PLoS ONE, 2014;9(9):e106945.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  68. Germline quality control: eEF2K stands guard to eliminate defective oocytes.
    Authors: Chu H, Liao Y, Novak J, Hu Z, Merkin J, Shymkiv Y, Braeckman B, Dorovkov M, Nguyen A, Clifford P, Nagele R, Harrison D, Ellis R, Ryazanov A
    Dev Cell, 2014;28(5):561-72.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  69. Short term morphine exposure in vitro alters proliferation and differentiation of neural progenitor cells and promotes apoptosis via mu receptors.
    Authors: Willner D, Cohen-Yeshurun A, Avidan A, Ozersky V, Shohami E, Leker R
    PLoS ONE, 2014;9(7):e103043.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  70. Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling.
    Authors: Fan J, Ponferrada V, Sato T, Vemaraju S, Fruttiger M, Gerhardt H, Ferrara N, Lang R
    Development, 2014;141(2):448-59.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Not Specified
  71. Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
    Authors: Park D, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong K, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong Y, Koh G
    J Clin Invest, 2014;124(9):3960-74.
  72. Biphasic influence of Miz1 on neural crest development by regulating cell survival and apical adhesion complex formation in the developing neural tube.
    Authors: Kerosuo L, Bronner M
    Mol Biol Cell, 2014;25(3):347-55.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: IHC
  73. Endoplasmic reticulum stress in amelogenesis imperfecta and phenotypic rescue using 4-phenylbutyrate.
    Authors: Brookes, Steven J, Barron, Martin J, Boot-Handford, Ray, Kirkham, Jennifer, Dixon, Michael
    Hum Mol Genet, 2014;23(9):2468-80.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  74. mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.
    Authors: Grahammer F, Haenisch N, Steinhardt F, Sander L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg M, Hall M, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber T
    Proc Natl Acad Sci U S A, 2014;111(27):E2817-26.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  75. LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea.
    Authors: Deng M, Luo X, Pan L, Yang H, Xie X, Liang G, Huang L, Hu F, Kiernan A, Gan L
    J Neurosci, 2014;34(30):10072-7.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  76. Essential role for the TRF2 telomere protein in adult skin homeostasis.
    Authors: Martinez P, Ferrara-Romeo I, Flores J, Blasco M
    Aging Cell, 2014;13(4):656-68.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  77. Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke.
    Authors: Mracsko E, Liesz A, Stojanovic A, Lou W, Osswald M, Zhou W, Karcher S, Winkler F, Martin-Villalba A, Cerwenka A, Veltkamp R
    J Neurosci, 2014;34(50):16784-95.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC Fluorescence
  78. Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.
    Authors: Lindgren G, Ekblad L, Vallon-Christersson J, Kjellen E, Gebre-Medhin M, Wennerberg J
    BMC Cancer, 2014;14(0):648.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Not Specified
  79. Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers.
    Authors: Edlund R, Ohyama T, Kantarci H, Riley B, Groves A
    Dev Biol, 2014;390(1):1-13.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  80. Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.
    Authors: Kumar L, Chou J, Yee C, Borzutzky A, Vollmann E, von Andrian U, Park S, Hollander G, Manis J, Poliani P, Geha R
    J Exp Med, 2014;211(5):929-42.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  81. The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice.
    Authors: Xu J, Xiao M, Jakovcevski I, Sivukhina E, Hargus G, Cui Y, Irintchev A, Schachner M, Bernreuther C
    J Cell Sci, 2014;127(0):641-52.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  82. Mechanism of cystogenesis in nephrotic kidneys: a histopathological study.
    Authors: Saraga M, Vukojevic K, Krzelj V, Puretic Z, Bocina I, Durdov M, Weber S, Dworniczak B, Ljubanovic D, Saraga-Babic M
    BMC Nephrol, 2013;15(0):3.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC - Not specified
  83. Diet-induced obesity exacerbates auditory degeneration via hypoxia, inflammation, and apoptosis signaling pathways in CD/1 mice.
    Authors: Hwang J, Hsu C, Yu W, Liu T, Yang W
    PLoS ONE, 2013;8(4):e60730.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  84. Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid.
    Authors: Tzeng, Tsai-Ten, Tsay, Huey-Jen, Chang, Luping, Hsu, Chia-Lin, Lai, Tzu-Hsua, Huang, Fong-Lee, Shiao, Young-Ji
    J Biomed Sci, 2013;20(0):90.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Fresh
  85. Increased chondrocyte apoptosis is associated with progression of osteoarthritis in spontaneous Guinea pig models of the disease.
    Authors: Zamli Z, Adams M, Tarlton J, Sharif M
    Int J Mol Sci, 2013;14(9):17729-43.
    Species: Guinea Pig
    Sample Types: Whole Tissue
    Applications: IHC
  86. Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death.
    Authors: Wahlin, Karl J, Enke, Raymond, Fuller, John A, Kalesnykas, Giedrius, Zack, Donald J, Merbs, Shannath
    PLoS ONE, 2013;8(11):e79140.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: IHC Frozen
  87. The temporal and spatial profiles of cell loss following experimental spinal cord injury: effect of antioxidant therapy on cell death and functional recovery.
    Authors: Ling, Xiang, Bao, Feng, Qian, Hao, Liu, Danxia
    BMC Neurosci, 2013;14(0):146.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  88. Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-kappaB and Src protein kinase signaling pathways.
    Authors: Shakibaei M, Mobasheri A, Lueders C, Busch F, Shayan P, Goel A
    PLoS ONE, 2013;8(2):e57218.
    Species: Human
    Sample Types: Cell Lysates
    Applications: WB
  89. Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals.
    Authors: Perez de Castro I, Aguirre-Portoles C, Fernandez-Miranda G, Canamero M, Cowley D, Van Dyke T, Malumbres M
    Cancer Res, 2013;73(22):6804-15.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  90. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.
    Authors: Olive V, Sabio E, Bennett M, De Jong C, Biton A, McGann J, Greaney S, Sodir N, Zhou A, Balakrishnan A, Foth M, Luftig M, Goga A, Speed T, Xuan Z, Evan G, Wan Y, Minella A, He L
    Elife, 2013;2(0):e00822.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  91. Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.
    Authors: Stott, Simon R, Metzakopian, Emmanoui, Lin, Wei, Kaestner, Klaus H, Hen, Rene, Ang, Siew-Lan
    J Neurosci, 2013;33(18):8022-34.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC OCT-embedded
  92. An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration.
    Authors: Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E
    Nature, 2012;485(7396):104-8.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Frozen
  93. Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis.
    Cell Death Differ., 2012;19(11):1761-8.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  94. Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy.
    Authors: McIntyre A, Patiar S, Wigfield S
    Clin. Cancer Res., 2012;18(11):3100-11.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  95. Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain.
    Authors: Hernandez-Miranda LR, Cariboni A, Faux C, Ruhrberg C, Cho JH, Cloutier JF, Eickholt BJ, Parnavelas JG, Andrews WD
    J. Neurosci., 2011;31(16):6174-87.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Frozen
  96. Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation.
    Authors: Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, Lashnits E, Morisada T, Le T, O'Brien S, Epstein DM, Koh GY, McDonald DM
    Am. J. Pathol., 2011;178(6):2897-909.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  97. Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I and other hyperammonemic syndromes.
    Authors: Perez CJ, Jaubert J, Guenet JL, Barnhart KF, Ross-Inta CM, Quintanilla VC, Aubin I, Brandon JL, Otto NW, DiGiovanni J, Gimenez-Conti I, Giulivi C, Kusewitt DF, Conti CJ, Benavides F
    Am. J. Pathol., 2010;177(4):1958-68.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  98. ALK1 signaling regulates early postnatal lymphatic vessel development.
    Authors: Niessen K, Zhang G, Ridgway JB, Chen H, Yan M
    Blood, 2010;115(8):1654-61.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  99. MicroRNA-183 family members regulate sensorineural fates in the inner ear.
    Authors: Li H, Kloosterman W, Fekete DM
    J. Neurosci., 2010;30(9):3254-63.
    Species: Zebrafish
    Sample Types: Whole Tissue
    Applications: IHC
  100. Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.
    Authors: Sotiropoulou PA, Candi A, Mascre G, De Clercq S, Youssef KK, Lapouge G, Dahl E, Semeraro C, Denecker G, Marine JC, Blanpain C
    Nat. Cell Biol., 2010;12(6):572-82.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow
  101. Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth.
    Authors: Hashizume H, Falcon BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD, McDonald DM
    Cancer Res., 2010;70(6):2213-23.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  102. Mitogen-activated protein kinase-signaling regulates the ability of Muller glia to proliferate and protect retinal neurons against excitotoxicity.
    Authors: Fischer AJ, Scott MA, Ritchey ER, Sherwood P
    Glia, 2009;57(14):1538-52.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: IHC Frozen
  103. Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease.
    Authors: Borchers MT, Wesselkamper SC, Curull V, Ramirez-Sarmiento A, Sanchez-Font A, Garcia-Aymerich J, Coronell C, Lloreta J, Agusti AG, Gea J, Howington JA, Reed MF, Starnes SL, Harris NL, Vitucci M, Eppert BL, Motz GT, Fogel K, McGraw DW, Tichelaar JW, Orozco-Levi M
    J. Clin. Invest., 2009;119(3):636-49.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  104. Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain.
    Authors: Yawno T, Hirst JJ, Castillo-Melendez M, Walker DW
    Neuroscience, 2009;163(3):838-47.
    Species: Ovine
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  105. Repeated ethanol exposure during late gestation alters the maturation and innate immune status of the ovine fetal lung.
    Authors: Sozo F, O'Day L, Maritz G, Kenna K, Stacy V, Brew N, Walker D, Bocking A, Brien J, Harding R
    Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(3):L510-8.
    Species: Ovine
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  106. A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3.
    Authors: Stedman A, Lecaudey V, Havis E, Anselme I, Wassef M, Gilardi-Hebenstreit P, Schneider-Maunoury S
    Dev. Biol., 2009;327(2):566-77.
    Species: Zebrafish
    Sample Types: Whole Tissue
    Applications: IHC
  107. Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins.
    Authors: Michaelis M, Bliss J, Arnold SC, Hinsch N, Rothweiler F, Deubzer HE, Witt O, Langer K, Doerr HW, Wels WS, Cinatl J
    Clin. Cancer Res., 2008;14(20):6531-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  108. The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.
    Authors: Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Yla-Herttuala S, Wedge SR, Jurgensmeier JM, Alitalo K
    Cancer Res., 2008;68(12):4754-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  109. Cystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-kappaB activity in conditions of oxidative stress.
    Authors: Boncoeur E, Roque T, Bonvin E, Saint-Criq V, Bonora M, Clement A, Tabary O, Henrion-Caude A, Jacquot J
    Am. J. Pathol., 2008;172(5):1184-94.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  110. Tendon-muscle crosstalk controls muscle bellies morphogenesis, which is mediated by cell death and retinoic acid signaling.
    Authors: Rodriguez-Guzman M, Montero JA, Santesteban E, Ganan Y, Macias D, Hurle JM
    Dev. Biol., 2007;302(1):267-80.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: IHC
  111. Cytochemical and ultrastructural study of anoikis and secondary necrosis in enterocytes detached in vivo.
    Authors: do Vale A, Costa-Ramos C, Silva DS, Macedo PM, Fernandes R, Sampaio P, Dos Santos NM, Silva MT
    Apoptosis, 2007;12(6):1069-83.
    Species: Fish
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  112. Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis.
    Authors: Benosman S, Gross I, Clarke N, Jochemsen AG, Okamoto K, Loeffler JP, Gaiddon C
    Cell Death Differ., 2007;14(12):2047-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  113. Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep.
    Authors: Yawno T, Yan EB, Walker DW, Hirst JJ
    Neuroscience, 2007;146(4):1726-33.
    Species: Ovine
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  114. Gam1-associated alterations of drug responsiveness through activation of apoptosis.
    Authors: Wu F, Chiocca S, Beck WT, Mo YY
    Mol. Cancer Ther., 2007;6(6):1823-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  115. Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene.
    Authors: Blouw B, Haase VH, Song H, Bergers G, Johnson RS
    Oncogene, 2007;26(31):4531-40.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  116. Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres.
    Authors: Siegl-Cachedenier I, Flores I, Klatt P, Blasco MA
    J. Cell Biol., 2007;179(2):277-90.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  117. Protein C is an autocrine growth factor for human skin keratinocytes.
    Authors: Xue M, Campbell D, Jackson CJ
    J. Biol. Chem., 2007;282(18):13610-6.
    Species: Human
    Sample Types: Cell Lysates
    Applications: WB
  118. Cytotoxic action of phorbol esters on human pancreatic cancer cells.
    Authors: Bond JA, Gescher AJ, Verschoyle RD, Lemoine NR, Errington R, Wiltshire M, Smith PJ, Wynford-Thomas D
    Int. J. Cancer, 2007;121(7):1445-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  119. Helicobacter felis and Helicobacter bizzozeronii induce gastric parietal cell loss in Mongolian gerbils.
    Authors: De Bock M, Decostere A, Hellemans A, Haesebrouck F, Ducatelle R
    Microbes Infect., 2006;8(2):503-10.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  120. Wnt signals mediate a fate decision between otic placode and epidermis.
    Authors: Ohyama T, Mohamed OA, Taketo MM, Dufort D, Groves AK
    Development, 2006;133(5):865-75.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  121. Mechanisms of apoptosis after ischemia and reperfusion: role of the renin-angiotensin system.
    Authors: Kossmehl P, Kurth E, Faramarzi S, Habighorst B, Shakibaei M, Wehland M, Kreutz R, Infanger M, J Danser AH, Grosse J, Paul M, Grimm D
    Apoptosis, 2006;11(3):347-58.
    Species: Porcine
    Sample Types: Tissue Homogenates
    Applications: WB
  122. Evolution of the androgen receptor pathway during progression of prostate cancer.
    Authors: Hendriksen PJ, Dits NF, Kokame K, Veldhoven A, van Weerden WM, Bangma CH, Trapman J, Jenster G
    Cancer Res., 2006;66(10):5012-20.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  123. Invasive trophoblasts stimulate vascular smooth muscle cell apoptosis by a fas ligand-dependent mechanism.
    Authors: Harris LK, Keogh RJ, Wareing M, Baker PN, Cartwright JE, Aplin JD, Whitley GS
    Am. J. Pathol., 2006;169(5):1863-74.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC Frozen
  124. Involvement of the Edar signaling in the control of hair follicle involution (catagen).
    Authors: Fessing MY, Sharova TY, Sharov AA, Atoyan R, Botchkarev VA
    Am. J. Pathol., 2006;169(6):2075-84.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Fresh
  125. Expression and functional analysis of Bax inhibitor-1 in human breast cancer cells.
    Authors: Grzmil M, Kaulfuss S, Thelen P, Hemmerlein B, Schweyer S, Obenauer S, Kang TW, Burfeind P
    J. Pathol., 2006;208(3):340-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  126. Canonical notch signaling functions as a commitment switch in the epidermal lineage.
    Authors: Blanpain C, Lowry WE, Pasolli HA, Fuchs E
    Genes Dev., 2006;20(21):3022-35.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  127. Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice.
    Authors: Jacomy H, Fragoso G, Almazan G, Mushynski WE, Talbot PJ
    Virology, 2006;349(2):335-46.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  128. Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
    Authors: Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD
    J. Immunol., 2005;175(4):2589-97.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  129. The pseudorabies virus US3 protein kinase possesses anti-apoptotic activity that protects cells from apoptosis during infection and after treatment with sorbitol or staurosporine.
    Authors: Geenen K, Favoreel HW, Olsen L, Enquist LW, Nauwynck HJ
    Virology, 2005;331(1):144-50.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: ICC
  130. Effects of systemically administered NT-3 on sensory neuron loss and nestin expression following axotomy.
    Authors: Kuo LT, Simpson A, Schanzer A, Tse J, An SF, Scaravilli F, Groves MJ
    J. Comp. Neurol., 2005;482(4):320-32.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  131. Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block.
    Authors: Salomonsson S, Sonesson SE, Ottosson L, Muhallab S, Olsson T, Sunnerhagen M, Kuchroo VK, Thoren P, Herlenius E, Wahren-Herlenius M
    J. Exp. Med., 2005;201(1):11-7.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  132. Apoptosis and active caspase-3 expression in human granulosa cells.
    Authors: Glamoclija V, Vilovic K, Saraga-Babic M, Baranovic A, Sapunar D
    Fertil. Steril., 2005;83(2):426-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  133. Higher resistance of porcine trigeminal ganglion neurons towards pseudorabies virus-induced cell death compared with other porcine cell types in vitro.
    Authors: Geenen K, Favoreel HW, Nauwynck HJ
    J. Gen. Virol., 2005;86(0):1251-60.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: ICC
  134. Blockade of the type I IGF receptor expression in human prostate cancer cells inhibits proliferation and invasion, up-regulates IGF binding protein-3, and suppresses MMP-2 expression.
    Authors: Grzmil M, Hemmerlein B, Thelen P, Schweyer S, Burfeind P
    J. Pathol., 2004;202(1):50-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  135. Evidence of caspase-3 activation in hyposmotic stress-induced necrosis.
    Authors: Niquet J, Allen SG, Baldwin RA, Wasterlain CG
    Neurosci. Lett., 2004;356(3):225-7.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  136. Lactate dehydrogenase-elevating virus induces apoptosis in cultured macrophages and in spinal cords of C58 mice coincident with onset of murine amyotrophic lateral sclerosis.
    Authors: Zitterkopf NL, McNeal DW, Eyster KM, Bradley DS, Cafruny WA
    Virus Res., 2004;106(1):35-42.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  137. Analysis of central regulatory pathways in p53-deficient primary cultures of malignant fibrous histiocytoma exposed to ifosfamide.
    Authors: Schlott T, Taubert H, Fayyazi A, Schweyer S, Bartel F, Korabiowska M, Brinck U
    Anticancer Res., 2004;24(6):3819-29.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  138. Early events in the anoikis program occur in the absence of caspase activation.
    Authors: Wang P, Valentijn AJ, Gilmore AP, Streuli CH
    J. Biol. Chem., 2003;278(22):19917-25.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC

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Cell and Tissue Staining Kits

Immunohistochemistry Reagents

Isotype Controls

Normal Rabbit IgG Control

Ctrl,CyTOF-ready

Reconstitution Buffers

Secondary Antibodies

Reviews for Human/Mouse Active Caspase-3 Antibody

Average Rating: 4.5 (Based on 2 Reviews)

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Human/Mouse Active Caspase-3 Antibody
By Anonymous on 12/22/2017
Application: ICC/IF Sample Tested: Spleen tissue Species: Mouse

Used to check for apoptose of macrophages


Human/Mouse Active Caspase-3 Antibody
By Anonymous on 05/17/2017
Application: IHC Sample Tested: Brain (hippocampus) Species: Rat

Active Caspase-3 (red) on fresh frozen, formaldehyde-fixed 10um sections of CA3 region of hippocampus. Good signal, but difficult to image because of high background from NeuN (green).