Human MuSK Antibody

Catalog # Availability Size / Price Qty
Product Details
Citations (2)
Supplemental Products
Reviews (2)

Human MuSK Antibody Summary

Species Reactivity
Detects human MuSK in direct ELISAs and Western blots. In direct ELISAs, less than 40% cross-reactivity with recombinant rat MuSK is observed.
Polyclonal Goat IgG
Antigen Affinity-purified
Mouse myeloma cell line NS0-derived recombinant human MuSK
Accession # O15146
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Human MuSK

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: MuSK

MuSK (muscle-specific kinase) is a 100 kDa type I transmembrane (TM) protein belonging to the receptor tyrosine kinase family. It is found in the postsynaptic membrane of skeletal muscle motor endplates. MuSK does not bind agrin directly, but is part of an agrin receptor complex that promotes the clustering of acetylcholine receptor at the neuromuscular junction (NMJ). Over residues 22‑503, human MuSK shares 92% amino acid sequence identity with mouse MuSK. Human MuSK apparently has multiple isoforms. One contains deletions at residues 307‑394 and 454‑461, while a second is a short soluble form that contains residues 120‑209 plus a unique 24 aa C‑terminal tail.

Long Name
Muscle-specific Receptor Tyrosine Kinase
Entrez Gene IDs
4593 (Human); 18198 (Mouse); 81725 (Rat); 102127677 (Cynomolgus Monkey)
Alternate Names
EC 2.7.10; EC; MGC126323; MGC126324; muscle, skeletal, receptor tyrosine kinase; MuSK; skeletal receptor tyrosine-protein kinase

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Citations for Human MuSK Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody.
    Authors: Cantor S, Zhang W, Delestree N, Remedio L, Mentis G, Burden S
    Elife, 2018;7(0):.
  2. Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.
    Authors: Hallock PT, Xu CF, Park TJ
    Genes Dev., 2010;24(21):2451-61.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot


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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

Goat IgG (H+L) Antibody


Reviews for Human MuSK Antibody

Average Rating: 3 (Based on 2 Reviews)

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Human MuSK Antibody
By Mia Huang on 05/19/2017
Application: Simple Western Sample Tested: Differentiated C2C12 myoblast cells Species: Mouse

C2C12 differentiated myotubes, following IP with an anti-MuSK antibody (different from this Ab), SDS-PAGE, and transferred into PVDF membrane. After blocking with 5% BSA/TBST, blot was probed with 1:400 of AF562 (4C, o/n). Subsequent probing with a HRP-anti-goat secondary Ab yielded excellent publishable results, with 100 kDa MuSK band visible.

Human MuSK Antibody
By Anonymous on 05/16/2017
Application: WB Sample Tested: Differentiated C2C12 myoblast cells Species: Mouse

Differentiated C2C12 mouse skeletal muscle lysates IP'ed for MuSK using a donated Ab. IP works well and I can detect phosphorylation of MuSK using a general phosphotyrosine Ab, but upon stripping, blocking, and probing with this Ab, I am unable to detect MuSK (perhaps due to high background signal). Probing with a different MuSK Ab is much cleaner

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