Human Stanniocalcin 1/STC-1 Antibody
Human Stanniocalcin 1/STC-1 Antibody Summary
Thr18-Ala247
Accession # P52823
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Stanniocalcin 1/STC-1
Human STC-1 is a secreted disulfide-linked homodimeric phosphorylated glycoprotein hormone (50 kDa and higher molecular weight variants) that is related to the STC protein first discovered from corpuscles of stannius in fish. It is expressed in a wide variety of tissues and has endocrine/paracrine/autocrine functions relating to calcium and phosphate homeostasis, reproduction and development. The 230 amino acid (aa) mature STC-1 contains five intrachain disulfide and one interchain disulfide bond. Human STC-1 and STC-2 share approximately 30% aa sequence homology. STC-1 is highly homologous across species. Human STC-1 shares > 95% sequence homology with mouse, rat, and bovine STC-1.
Product Datasheets
Citations for Human Stanniocalcin 1/STC-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 3
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Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A.
Authors: Kloverpris S, Mikkelsen J, Pedersen J, Jepsen M, Laursen L, Petersen S, Oxvig C
J Biol Chem, 2015;290(36):21915-24.
Species: Human
Sample Types: Protein
Applications: Western Blot -
Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC1.
Authors: Ohkouchi S, Block GJ, Katsha AM
Mol. Ther., 2012;20(2):417-23.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Production of calcium maintenance factor Stanniocalcin-1 (STC1) by the equine endometrium during the early pregnant period.
Authors: Kikuchi M, Nakano Y, Nambo Y, Haneda S, Matsui M, Miyake Y, Macleod JN, Nagaoka K, Imakawa K
J. Reprod. Dev., 2011;57(2):203-11.
Species: Equine
Sample Types: Tissue Homogenates
Applications: Western Blot
FAQs
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