Human Syntaxin-BP3 Antibody

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Detection of Human Syntaxin-BP3 by Western Blot.
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Product Details
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Human Syntaxin-BP3 Antibody Summary

Species Reactivity
Detects human Syntaxin‑BP3 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross‑reactivity with recombinant human (rh) STXBP1 and rhSTXBP2 is observed.
Polyclonal Goat IgG
Antigen Affinity-purified
E. coli-derived recombinant human Syntaxin‑BP3
Accession # O00186
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
1 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human Syntaxin-BP3 antibody by Western Blot. View Larger

Detection of Human Syntaxin-BP3 by Western Blot. Western blot shows lysates of Nalm-6 human Pre-B acute lymphocytic leukemia cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human Syntaxin-BP3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5659) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for Syntaxin-BP3 at approximately 68 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Syntaxin-BP3

Syntaxin‑BP3 (Syntaxin-binding protein 3; also PSP, Munc18-C and -3; and Unc-18C) is a 66‑70 kDa member of the SNARE-interacting Sec1/Munc18 family of proteins. It is expressed in cells that exhibit granule exocytosis, such as neutrophils, mast cells, platelets and endothelial cells. Functionally, it likely participates in the consolidation and secretion of secondary and tertiary granules. Human Syntaxin‑BP3 is 592 amino acids (aa) in length. It contains one SEC1 domain (aa 16‑592). Phosphorylation at Ser129 may stimulate granule release. There are two potential splice variants. One shows a 12 aa substitution for aa 31‑269, while a second shows a one aa Gln insertion after Lys270. Over aa 84‑231, human Syntaxin‑BP3 shares 90% aa identity with mouse Syntaxin‑BP3.

Long Name
Syntaxin-binding Protein 3
Entrez Gene IDs
6814 (Human); 20912 (Mouse); 114095 (Rat)
Alternate Names
MUNC18-3; Munc18c; Platelet Sec1 protein; Protein unc-18 homolog 3; Protein unc-18 homolog C; PSP; STXBP3; syntaxin 4 binding protein; syntaxin binding protein 3; syntaxin-binding protein 3; SyntaxinBP3; Syntaxin-BP3; unc18-3; Unc-18C

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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

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