Human TFCP2L1 Antibody
Human TFCP2L1 Antibody Summary
Met1-Lys180
Accession # Q9NZI6
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human TFCP2L1 by Western Blot. Western blot shows lysates of human placental tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human TFCP2L1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5726) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for TFCP2L1 at approximately 54 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TFCP2L1
TFCP2L1 (Transcription factor CP2‑like protein # 1; also LBP‑9) is a 54 kDa (predicted) member of the CP2 subfamily, grh/CP2 family of proteins. It is expressed in placental synctiotrophoblast cells, and regulates the production of CYP11A1/P450scc. P450scc is a cholesterol cleavage enzyme that generates pregnenolone, a necessary intermediate in the formation of progesterone. TFCP2L1 both positively and negatively regulates P450scc synthesis through homodimerization and heterodimerization with LBP‑1b. Human TFCP2L1 is 479 amino acids (aa) in length. It contains a transcriptional repressor region (aa 100‑200) and a dimerization domain (aa 300‑479). There is one splice variant that shows a deletion of aa 400‑464. Human TFCP2L1 is 73% aa identical to human TFCP2, and 93% aa identical to mouse CRTR‑1, a closely related molecule that may not represent the actual mouse ortholog to TFCP2L1.
Product Datasheets
Citations for Human TFCP2L1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
12
Citations: Showing 1 - 10
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Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state
Authors: H Ozaki, H Suga, M Sakakibara, M Soen, N Miyake, T Miwata, S Taga, T Nagai, M Kano, K Mitsumoto, T Miyata, T Kobayashi, M Sugiyama, T Onoue, H Takagi, D Hagiwara, S Iwama, R Banno, G Iguchi, Y Takahashi, K Muguruma, H Inoue, H Arima
Scientific Reports, 2022;12(1):17381.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Revealing cell populations catching the early stages of human embryo development in naive pluripotent stem cell cultures
Authors: M Moya-Jódar, A Ullate-Ago, P Barlabé, JR Rodríguez-, G Abizanda, C Barreda, X Carvajal-V, A Vilas-Zorn, JP Romero, L Garate, X Agirre, G Coppiello, F Prósper, XL Aranguren
Stem Cell Reports, 2022;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
The transcription factor TFCP2L1 promotes primordial germ cell-like cell specification of pluripotent stem cells
Authors: M Zhang, J Ji, X Wang, X Zhang, Y Zhang, Y Li, X Wang, X Li, Q Ban, SD Ye
The Journal of Biological Chemistry, 2021;0(0):101217.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells
Authors: K Takahashi, D Jeong, S Wang, M Narita, X Jin, M Iwasaki, SD Perli, BR Conklin, S Yamanaka
Cell Rep, 2020;31(9):107715.
Species: Human
Sample Types:
Applications: ICC -
Identification of ALPPL2 as a Naive Pluripotent State-Specific Surface Protein Essential for Human Naive Pluripotency Regulation
Authors: Y Bi, Z Tu, Y Zhang, P Yang, M Guo, X Zhu, C Zhao, J Zhou, H Wang, Y Wang, S Gao
Cell Rep, 2020;30(11):3917-3931.e5.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation
Authors: LTP Khoa, YC Tsan, F Mao, DM Kremer, P Sajjakulnu, L Zhang, B Zhou, X Tong, NV Bhanu, C Choudhary, BA Garcia, L Yin, GD Smith, TL Saunders, SL Bielas, CA Lyssiotis, Y Dou
Cell Stem Cell, 2020;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency
Authors: N Bredenkamp, J Yang, J Clarke, GG Stirparo, F von Meyenn, S Dietmann, D Baker, R Drummond, Y Ren, D Li, C Wu, M Rostovskay, S Eminli-Mei, A Smith, G Guo
Stem Cell Reports, 2019;13(6):1083-1098.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate
Authors: JL Sardina, S Collombet, TV Tian, A Gómez, B Di Stefano, C Berenguer, J Brumbaugh, R Stadhouder, C Segura-Mor, M Gut, IG Gut, S Heath, S Aranda, L Di Croce, K Hochedling, D Thieffry, T Graf
Cell Stem Cell, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Immunoprecipitation -
Honey bee Royalactin unlocks conserved pluripotency pathway in mammals
Authors: DC Wan, SL Morgan, AL Spencley, N Mariano, EY Chang, G Shankar, Y Luo, TH Li, D Huh, SK Huynh, JM Garcia, CM Dovey, J Lumb, L Liu, KV Brown, A Bermudez, R Luong, H Zeng, VL Mascetti, SJ Pitteri, J Wang, H Tu, M Quarta, V Sebastiano, R Nusse, TA Rando, JE Carette, JF Bazan, KC Wang
Nat Commun, 2018;9(1):5078.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys
Authors: Y Kang, Z Ai, K Duan, C Si, Y Wang, Y Zheng, J He, Y Yin, S Zhao, B Niu, X Zhu, L Liu, L Xiang, L Zhang, Y Niu, W Ji, T Li
Cell Rep, 2018;25(9):2563-2576.e9.
Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Sample Types: Whole Cells
Applications: ICC -
Trim33 regulates early maturation of mouse embryoid bodies in vitro
Authors: S Rajderkar, C Panaretos, V Kaartinen
Biochem Biophys Rep, 2017;12(0):185-192.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
alpha-Intercalated cells defend the urinary system from bacterial infection.
Authors: Paragas N, Kulkarni R, Werth M, Schmidt-Ott K, Forster C, Deng R, Zhang Q, Singer E, Klose A, Shen T, Francis K, Ray S, Vijayakumar S, Seward S, Bovino M, Xu K, Takabe Y, Amaral F, Mohan S, Wax R, Corbin K, Sanna-Cherchi S, Mori K, Johnson L, Nickolas T, D'Agati V, Lin C, Qiu A, Al-Awqati Q, Ratner A, Barasch J
J Clin Invest, 2014;124(7):2963-76.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC
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1:500 concentration used
