Human TGF-beta RII Antibody

Name: Human TGF-beta RII Antibody
Brand: R&D Systems
SKU: MAB2411
Price: 489 USD
Availability: InStock

R&D Systems | Catalog # MAB2411

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Product Specifications
Applications
Preparation & Storage
Calculators
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Western Blot

Cited:

Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG₁ Clone # 176510

View all TGF-beta RII Primary Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human TGF‑ beta RII isoform 2
Thr23-Asp184
Accession # NP_001020018

Specificity

Detects human TGF-beta RII and TGF-beta RIIb in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross-react with recombinant human TGF-beta RIII, recombinant mouse (rm) TGF-beta RII, or rmTGF-beta RI.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁

Applications for Human TGF-beta RII Antibody

Application

Recommended Usage

Western Blot

1 µg/mL
Sample: Recombinant Human TGF-beta RII (Catalog # 241-R2)
under non-reducing conditions only.
Human TGF-beta RII Affinity Purified Polyclonal Ab (Catalog # AF-241-NA)
is recommended for Western blot samples under reducing conditions.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background: TGF-beta RII

TGF-beta RII is a membrane-bound serine/threonine kinase. Upon ligand binding, TGF-beta RII interacts with TGF-beta RI to form the heteromeric signaling complex that transduces TGF-beta signals. A splice variant of the type II receptor, TGF-beta RIIb, containing a 25 amino acid residue insertion near the N-terminus of the mature protein has also been described.