Human ULBP-4/RAET1E Antibody Summary
Accession # Q8TD07
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of Human ULBP‑4/RAET1E by Western Blot. Western blot shows lysates of human liver tissue. PVDF Membrane was probed with 2 µg/mL of Goat Anti-Human ULBP-4/RAET1E Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6285) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for ULBP-4/RAET1E at approximately 32 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
ULBP-4 (UL16 binding protein 4; also NKG2D Ligand 4, Latel and RAET1E) is a 30-40 kDa glycoprotein member of the MHC Class I family of molecules. It has widespread tissue expression, and is particularly prominent on tumor cells. ULBP4 is a monomeric, non-antigen presenting MHC molecule that does not interact with beta 2-microglobulin. It is a ligand for both TCR gamma δ and homodimeric NKG2D, the latter which appears on NK, CD8+ and gamma δ T cells. NKG2D ligation induces cellular cytotoxicity and cytokine secretion. Mature human ULBP4 is a 234 amino acid (aa) type I transmembrane protein. It contains a 196 aa extracellular region (aa 30-225), and a short 15 aa cytoplasmic domain. Multiple splice variants exist. One shows a five aa substitution for aa 208-263, a second shows a deletion of aa 28-63, a third shows a two aa substitution for aa 208-263, while a fourth possesses an 18 aa substitution for Gly30. Soluble ULBP4 is described to be 35 kDa in size. There is no reported rodent counterpart to ULBP4.
Citations for Human ULBP-4/RAET1E Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells
Authors: Y Han, W Xie, DG Song, DJ Powell
J Hematol Oncol, 2018;11(1):92.
Sample Types: Whole Cells
Applications: CAR-T (Flow Cytometry)
Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus.
Authors: Bjorkstrom NK, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, Michaelsson J, Malmberg KJ, Klingstrom J, Ahlm C, Ljunggren HG
J. Exp. Med., 2011;208(1):13-21.
Sample Types: Whole Cells
Applications: Flow Cytometry
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