Mouse Aminopeptidase A/ENPEP Antibody
Mouse Aminopeptidase A/ENPEP Antibody Summary
Accession # P16406
Recombinant Mouse Aminopeptidase A/ENPEP
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Aminopeptidase A/ENPEP
The mouse ENPEP gene encodes Aminopeptidase A (APA), which is also known as glutamyl aminopeptidase (EAP), aspartate aminopeptidase, angiotensinase A, Ca2+-activated glutamate aminopeptidase, membrane aminopeptidase II and the BP-1/6C3 antigen (2). The various names reflect its substrate specificity (prefer Glu or Asp and angiotensin II as one of the physiological substrates), Ca2+-dependence, cellular location (type II membrane protein) and immunological reactivity to antibody BP-1/6C3. The deduced amino acid sequence of mouse ENPEP consists of a short cytoplasmic tail (residues 1 to 18), a transmembrane region (residue 19 to 39), and a long ectodomain (residues 40 to 945) (1). In addition to the N-terminal zinc metalloprotease domain, the ectodomain also contains the C‑terminal region, which functions as an intramolecular chaperone required for the correct folding, cell surface expression and activity (3). The purified rmENPEP consists of the ectodomain and is active in the assay described above.
- Wu, Q. et al. (1990) Proc. Natl. Acad. Sci. USA 87:993.
- Wang, J. and M.D. Cooper (2004) in Handbook of Proteolytic Enzymes (ed. Barrett, et al.) pp. 299, Academic Press, San Diego.
- Rozenfeld, R. et al. (2004) J. Biol. Chem. 279:43285.
Citation for Mouse Aminopeptidase A/ENPEP Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Quantitative proteomics of MDCK cells identify unrecognized roles of clathrin adaptor AP-1 in polarized distribution of surface proteins
Authors: PS Caceres, D Gravotta, PJ Zager, N Dephoure, E Rodriguez-
Proc. Natl. Acad. Sci. U.S.A., 2019;116(24):11796-11805.
Sample Types: Cell Lysates
Applications: Western Blot
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