Mouse IL-17/IL-17A Antibody

(75 citations)   
  • Species Reactivity
    Mouse
  • Specificity
    Detects mouse IL-17 in direct ELISAs and Western blots. In direct ELISAs, approximately 40% reactivity with recombinant mouse
    (rm) IL-17A/IL-17F heterodimer is observed. No cross-reactivity with recombinant human IL-17, recombinant canine IL-17, rmIL-17B,
    rmIL‑17C, rmIL-17D, rmIL-17E, or rmIL-17F is observed.
  • Source
    Monoclonal Rat IgG2A Clone # 50104
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    E. coli-derived recombinant mouse IL‑17
    Thr22-Ala158
    Accession # Q62386
  • Formulation
    Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
  • Endotoxin Level
    <0.10 EU per 1 μg of the antibody by the LAL method.
  • Label
    Unconjugated
Applications
  •  
    Recommended
    Concentration
    Sample
  • Western Blot
    1 µg/mL
    See below
  • Neutralization
    Measured by its ability to neutralize IL‑17-induced IL‑6 secretion in the NIH‑3T3 mouse embryonic fibroblast cell line. Yao, Z. et al. (1995) Immunity 3:811. The Neutralization Dose (ND50) is typically 0.05-0.15 µg/mL in the presence of 10 ng/mL Recombinant Mouse IL‑17.
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of Recombinant Mouse
IL‑17/IL‑17A by Western Blot.
Western blot shows 25 ng of Recombinant Mouse IL‑17/
IL‑17A (Catalog # 421-ML), Recombinant Human IL‑17/IL‑17A (Catalog # 317-ILB), Recombinant Rat IL‑17/IL‑17A (Catalog # 8410-IL), and Recombinant Mouse IL‑17F (Catalog # 2057-IL). PVDF Membrane was probed with 1 µg/mL of Rat Anti-Mouse IL‑17/
IL‑17A Monoclonal Antibody (Catalog # MAB421) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for IL‑17/IL‑17A at approximately 15 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 3.
IL‑6 Secretion Induced by
IL‑17 and Neutralization by Mouse IL‑17 Antibody.
Recombinant Mouse IL‑17 (Catalog # 421-ML) stimulates IL‑6 secretion in the NIH‑3T3 mouse embryonic fibroblast cell line in a dose-dependent manner (orange line), as measured by the Mouse IL‑6 Quantikine ELISA Kit (Catalog # M6000B). IL‑6 secretion elicited by Recombinant Mouse IL‑17 (10 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse IL‑17 Monoclonal Antibody (Catalog # MAB421). The ND50 is typically
0.05-0.15 µg/mL.
Preparation and Storage
  • Reconstitution
    Reconstitute at 0.5 mg/mL in sterile PBS.
  • Shipping
    The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
  • Stability & Storage
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-17/IL-17A

Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. cDNA clones encoding IL-17 have been isolated from activated rat, mouse and human T cells. Mouse IL-17 cDNA encodes a 158 amino acid (aa) residue precursor protein with a 21 amino acid residue signal peptide that is cleaved to yield the 137 aa residue mature  IL-17. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. At the amino acid level, mIL-17 shows 57% and 87% sequence identity with herpesvirus and rat IL-17, respectively. An IL-17 specific mouse cell surface receptor (IL-17 R) has been cloned. While the expression of IL-17 mRNA is restricted to activated alpha beta TCR+CD4-CD8-T cells, the expression of mIL-17 R mRNA has been detected in virtually all cells and tissues tested. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-kappa B and costimulation of T cell proliferation.

  • References:
    1. Kennedy, J. et al. (1996) J. Interferon Cytokine Res. 16:611.
    2. Yao, Z. et al. (1995) J. Immunol. 155:5483.
    3. Yao, Z. et al. (1995) Immunity 3:811.
    4. Rouvier, E. et al. (1993) J. Immunol. 150:5445.
  • Long Name:
    Interleukin 17
  • Entrez Gene IDs:
    3605 (Human); 16171 (Mouse); 301289 (Rat); 481837 (Canine)
  • Alternate Names:
    CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; IL17interleukin-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

75 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. Spirulina lipopolysaccharides inhibit tumor growth in a Toll-like receptor 4-dependent manner by altering the cytokine milieu from interleukin-17/interleukin-23 to interferon-?
    Authors: H Okuyama, A Tominaga, S Fukuoka, T Taguchi, Y Kusumoto, S Ono
    Oncol. Rep, 2017;37(2):684-694.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  2. IL-35 induces N2 phenotype of neutrophils to promote tumor growth
    Authors: JM Zou, J Qin, YC Li, Y Wang, D Li, Y Shu, C Luo, SS Wang, G Chi, F Guo, GM Zhang, ZH Feng
    Oncotarget, 2017;8(20):33501-33514.
    Species: Mouse
    Sample Type: In Vivo
    Application: Neut
  3. Galectin-1-Driven Tolerogenic Programs Aggravate Yersinia enterocolitica Infection by Repressing Antibacterial Immunity
    Authors: RC Davicino, SP Méndez-Hue, RJ Eliçabe, JC Stupirski, I Autenrieth, MS Di Genaro, GA Rabinovich
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: In Vivo
    Application: Neut
  4. IL-17A Is an Important Effector of the Immune Response of the Mammary Gland to Escherichia coli Infection.
    Authors: Porcherie A, Gilbert F, Germon P, Cunha P, Trotereau A, Rossignol C, Winter N, Berthon P, Rainard P
    J Immunol, 2016;196(2):803-12.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  5. Seminal plasma induces inflammation in the uterus through the ?? T/IL-17 pathway
    Authors: ZH Song, ZY Li, DD Li, WN Fang, HY Liu, DD Yang, CY Meng, Y Yang, JP Peng
    Sci Rep, 2016;6(0):25118.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  6. Interleukin-27 Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17-Neutrophil Response
    Authors: Gustavo F S Quirino
    Infect Immun, 2016;0(0):.
    Species: Mouse
    Sample Type: In Vivo
    Application: Neut
  7. IL-17 Augments B Cell Activation in Ocular Surface Autoimmunity
    J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Neut
  8. Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency.
    Authors: Abdel Fattah E, Bhattacharya A, Herron A, Safdar Z, Eissa N
    J Immunol, 2015;194(11):5407-16.
    Species: Mouse
    Sample Type: In Vivo
    Application: Neut
  9. IL17 Mediates Pelvic Pain in Experimental Autoimmune Prostatitis (EAP).
    Authors: Murphy S, Schaeffer A, Done J, Wong L, Bell-Cohn A, Roman K, Cashy J, Ohlhausen M, Thumbikat P
    PLoS ONE, 2015;10(5):e0125623.
    Species: Mouse
    Sample Type: In Vivo
    Application: Neut
  10. Interleukin-17A and Neutrophils in a Murine Model of Bird-Related Hypersensitivity Pneumonitis.
    Authors: Ishizuka M, Miyazaki Y, Masuo M, Suhara K, Tateishi T, Yasui M, Inase N
    PLoS ONE, 2015;10(9):e0137978.
    Species: Mouse
    Sample Type: In Vivo
    Application: Neut
  11. Dendritic Cells Regulate Treg-Th17 Axis in Obstructive Phase of Bile Duct Injury in Murine Biliary Atresia.
    Authors: Liu Y, Li K, Yang L, Tang S, Wang X, Cao G, Li S, Lei H, Zhang X
    PLoS ONE, 2015;10(9):e0136214.
    Species: Mouse
    Sample Type: In Vivo
    Application: Neut
  12. Neonatal Streptococcus pneumoniae infection may aggravate adulthood allergic airways disease in association with IL-17A.
    Authors: Yang B, Liu R, Yang T, Jiang X, Zhang L, Wang L, Wang Q, Luo Z, Liu E, Fu Z
    PLoS ONE, 2015;10(3):e0123010.
    Species: Mouse
    Sample Type: In Vivo
    Application: Neut
  13. Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells.
    Authors: Kim Y, Lim H, Jung H, Wetsel R, Chung Y
    PLoS ONE, 2015;10(3):e0120294.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Neut
  14. Therapeutic efficacy of IL-17A antibody injection in preventing the development of colitis associated carcinogenesis in mice.
    Authors: Qi H, Yang H, Xu G, Ren J, Hua W, Shi Y, Torsvik M, Florholmen J, Cui G
    Immunobiology, 2015;220(1):54-9.
    Species: Mouse
    Sample Type: In Vivo
    Application: Blocking
  15. IKKbeta in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites.
    Authors: Bonnegarde-Bernard A, Jee J, Fial M, Aeffner F, Cormet-Boyaka E, Davis I, Lin M, Tome D, Karin M, Sun Y, Boyaka P
    Mucosal Immunol, 2014;7(2):257-67.
    Species: Mouse
    Sample Type: In Vivo
    Application: Functional Assay
  16. Systemic inflammatory response elicited by superantigen destabilizes T regulatory cells, rendering them ineffective during toxic shock syndrome.
    Authors: Tilahun A, Chowdhary V, David C, Rajagopalan G
    J Immunol, 2014;193(6):2919-30.
    Species: Mouse
    Sample Type: In Vivo
    Application: Neut
  17. Interleukin-17A modulates circulating tumor cells in tumor draining vein of colorectal cancers and affects metastases.
    Authors: Tseng J, Yang C, Liang S, Liu R, Yang S, Lin J, Chen Y, Wu Y, Jiang J, Lin C
    Clin Cancer Res, 2014;20(11):2885-97.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  18. Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-alpha and interleukin-1beta but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain.
    Authors: Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, Hoshino M, Imamura T, Akiyama C, Yasuhara R, Mishima K, Maruyama T, Kohda C, Tanaka K, Potempa J, Yasuda H, Baba K, Kamijo R
    J Biol Chem, 2014;289(22):15621-30.
    Species: Porphyromonas gingivalis
    Sample Type: Recombinant Protein
    Application: WB
  19. Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis.
    Authors: Klein M, Brouwer M, Angele B, Geldhoff M, Marquez G, Varona R, Hacker G, Schmetzer H, Hacker H, Hammerschmidt S, van der Ende A, Pfister H, van de Beek D, Koedel U
    PLoS ONE, 2014;9(4):e93057.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  20. CD8 T cells regulate allergic contact dermatitis by modulating CCR2-dependent TNF/iNOS-expressing Ly6C+ CD11b+ monocytic cells.
    Authors: Chong S, Tan K, Wong F, Chua Y, Tang Y, Ng L, Angeli V, Kemeny D
    J Invest Dermatol, 2014;134(3):666-76.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  21. IL-17A produced by neutrophils protects against pneumonic plague through orchestrating IFN-gamma-activated macrophage programming.
    Authors: Bi Y, Zhou J, Yang H, Wang X, Zhang X, Wang Q, Wu X, Han Y, Song Y, Tan Y, Du Z, Yang H, Zhou D, Cui Y, Zhou L, Yan Y, Zhang P, Guo Z, Wang X, Liu G, Yang R
    J Immunol, 2014;192(2):704-13.
    Species: Mouse
    Sample Type: In Vivo
    Application: Neut
  22. gammadelta T cells are required for pulmonary IL-17A expression after ozone exposure in mice: role of TNFalpha.
    Authors: Mathews J, Williams A, Brand J, Wurmbrand A, Chen L, Ninin F, Si H, Kasahara D, Shore S
    PLoS ONE, 2014;9(5):e97707.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  23. Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis.
    Authors: Singh T, Schon M, Wallbrecht K, Gruber-Wackernagel A, Wang X, Wolf P
    PLoS ONE, 2013;8(1):e51752.
    Species: Mouse
    Sample Type: In Vivo
    Application: Neut
  24. Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis.
    Authors: Hou L, Jie Z, Desai M, Liang Y, Soong L, Wang T, Sun J
    J Immunol, 2013;190(2):621-9.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  25. Transcription factors GATA-3 and RORgammat are important for determining the phenotype of allergic airway inflammation in a murine model of asthma.
    Authors: Ano S, Morishima Y, Ishii Y, Yoh K, Yageta Y, Ohtsuka S, Matsuyama M, Kawaguchi M, Takahashi S, Hizawa N
    J Immunol, 2013;190(3):1056-65.
    Species: Mouse
    Sample Type: In Vivo
    Application: Neut
  26. Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum.
    Authors: Wu S, Yu J, Liu F, Miaw S, Wu-Hsieh B
    J Immunol, 2013;190(7):3427-37.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  27. Salmonella enterica induces joint inflammation and expression of interleukin-17 in draining lymph nodes early after onset of enterocolitis in mice.
    Authors: Noto Llana M, Sarnacki SH, Vazquez MV, Gartner AS, Giacomodonato MN, Cerquetti MC
    Infect. Immun., 2012;80(6):2231-9.
    Species: Mouse
    Sample Type: In Vivo
    Application: InVivo
  28. Differential effects of peptidoglycan recognition proteins on experimental atopic and contact dermatitis mediated by Treg and Th17 cells.
    Authors: Park SY, Gupta D, Kim CH
    PLoS ONE, 2011;6(9):e24961.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  29. Innate immune responses to systemic Acinetobacter baumannii infection in mice: neutrophils, but not interleukin-17, mediate host resistance.
    Authors: Breslow JM, Meissler JJ, Hartzell RR
    Infect. Immun., 2011;79(8):3317-27.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  30. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
    Authors: Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L
    J. Exp. Med., 2011;208(3):491-503.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Neut
  31. IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung.
    Authors: Khader SA, Guglani L, Rangel-Moreno J
    J. Immunol., 2011;187(10):5402-7.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  32. TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycin-induced pulmonary fibrosis in mice.
    Authors: Kim HS, Go H, Akira S, Chung DH
    J. Immunol., 2011;187(8):4007-17.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  33. Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease.
    Authors: Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM
    J. Immunol., 2010;184(8):4159-69.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  34. Lack of TNFR p55 results in heightened expression of IFN-gamma and IL-17 during the development of reactive arthritis.
    Authors: Elicabe RJ, Cargnelutti E, Serer MI, Stege PW, Valdez SR, Toscano MA, Rabinovich GA, Di Genaro MS
    J. Immunol., 2010;185(7):4485-95.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  35. Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy.
    Authors: Shen H, Harris G, Chen W, Sjostedt A, Ryden P, Conlan W
    PLoS ONE, 2010;5(10):e13349.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  36. Th17 immune responses contribute to the pathophysiology of aplastic anemia.
    Authors: de Latour RP, Visconte V, Takaku T
    Blood, 2010;116(20):4175-84.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  37. A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice.
    Authors: Gao Q, Jiang Y, Ma T, Zhu F, Gao F, Zhang P, Guo C, Wang Q, Wang X, Ma C, Zhang Y, Chen W, Zhang L
    J. Immunol., 2010;185(10):5820-7.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  38. IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis.
    Authors: Lo Re S, Dumoutier L, Couillin I, Van Vyve C, Yakoub Y, Uwambayinema F, Marien B, van den Brule S, Van Snick J, Uyttenhove C, Ryffel B, Renauld JC, Lison D, Huaux F
    J. Immunol., 2010;184(11):6367-77.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  39. IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury.
    Authors: Li L, Huang L, Vergis AL, Ye H, Bajwa A, Narayan V, Strieter RM, Rosin DL, Okusa MD
    J. Clin. Invest., 2010;120(1):331-42.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  40. Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis.
    Authors: Cruz A, Fraga AG, Fountain JJ, Rangel-Moreno J, Torrado E, Saraiva M, Pereira DR, Randall TD, Pedrosa J, Cooper AM, Castro AG
    J. Exp. Med., 2010;207(8):1609-16.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  41. Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta.
    Authors: Han G, Wang R, Chen G
    Immunology, 2010;129(2):197-206.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  42. Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis.
    Authors: Wondimu Z, Santodomingo-Garzon T, Le T, Swain MG
    Am. J. Pathol., 2010;177(5):2334-46.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  43. Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung.
    Authors: Redford PS, Boonstra A, Read S, Pitt J, Graham C, Stavropoulos E, Bancroft GJ, O'Garra A
    Eur. J. Immunol., 2010;40(8):2200-10.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  44. IL-22 defines a novel immune pathway of antifungal resistance.
    Authors: De Luca A, Zelante T, D'Angelo C
    Mucosal Immunol, 2010;3(4):361-73.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  45. Encephalitogenicity of complete Freund's adjuvant relative to CpG is linked to induction of Th17 cells.
    Authors: Tigno-Aranjuez JT, Jaini R, Tuohy VK, Lehmann PV, Tary-Lehmann M
    J. Immunol., 2009;183(9):5654-61.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  46. Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis.
    Authors: Otani K, Watanabe T, Tanigawa T, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T
    Biochem. Biophys. Res. Commun., 2009;382(2):252-8.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  47. IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function.
    Authors: Bai H, Cheng J, Gao X, Joyee AG, Fan Y, Wang S, Jiao L, Yao Z, Yang X
    J. Immunol., 2009;183(9):5886-95.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  48. Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.
    Authors: He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S, Freyschmidt EJ, Bryce P, McKenzie AN, Umetsu DT, Oettgen HC, Geha RS
    J. Allergy Clin. Immunol., 2009;124(4):761-70.e1.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  49. Interleukin-17 causes neutrophil mediated inflammation in ovalbumin-induced uveitis in DO11.10 mice.
    Authors: Zhang Z, Zhong W, Spencer D, Chen H, Lu H, Kawaguchi T, Rosenbaum JT
    Cytokine, 2009;46(1):79-91.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  50. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
    Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
    J. Immunol., 2009;183(2):1291-300.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  51. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.
    Authors: Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH, Sayegh MH
    Proc. Natl. Acad. Sci. U.S.A., 2009;106(26):10734-9.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  52. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.
    Authors: Hamada H, Garcia-Hernandez Mde L, Reome JB, Misra SK, Strutt TM, McKinstry KK, Cooper AM, Swain SL, Dutton RW
    J. Immunol., 2009;182(6):3469-81.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  53. Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response.
    Authors: Oyoshi MK, Elkhal A, Kumar L, Scott JE, Koduru S, He R, Leung DY, Howell MD, Oettgen HC, Murphy GF, Geha RS
    Proc. Natl. Acad. Sci. U.S.A., 2009;106(35):14954-9.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  54. Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression.
    Authors: Chauhan SK, El Annan J, Ecoiffier T, Goyal S, Zhang Q, Saban DR, Dana R
    J. Immunol., 2009;182(3):1247-52.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  55. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses.
    Authors: Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F, Housseau F, Pardoll DM, Sears CL
    Nat. Med., 2009;15(9):1016-22.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  56. Peroxisome proliferator-activated receptor gamma agonist down-regulates IL-17 expression in a murine model of allergic airway inflammation.
    Authors: Park SJ, Lee KS, Kim SR, Min KH, Choe YH, Moon H, Chae HJ, Yoo WH, Lee YC
    J. Immunol., 2009;183(5):3259-67.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  57. Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection.
    Authors: Bozza S, Zelante T, Moretti S, Bonifazi P, DeLuca A, D'Angelo C, Giovannini G, Garlanda C, Boon L, Bistoni F, Puccetti P, Mantovani A, Romani L
    J. Immunol., 2008;180(6):4022-31.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  58. Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice.
    Authors: Koenders MI, Devesa I, Marijnissen RJ, Abdollahi-Roodsaz S, Boots AM, Walgreen B, di Padova FE, Nicklin MJ, Joosten LA, van den Berg WB
    Arthritis Rheum., 2008;58(11):3461-70.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  59. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.
    Authors: D'Angelo C, Segal BH
    Nature, 2008;451(7175):211-5.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  60. Interferon-gamma regulates idiopathic pneumonia syndrome, a Th17+CD4+ T-cell-mediated graft-versus-host disease.
    Authors: Mauermann N, Burian J, von Garnier C, Dirnhofer S, Germano D, Schuett C, Tamm M, Bingisser R, Eriksson U, Hunziker L
    Am. J. Respir. Crit. Care Med., 2008;178(4):379-88.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  61. Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase.
    Authors: Iwanami K, Matsumoto I, Tanaka-Watanabe Y, Inoue A, Mihara M, Ohsugi Y, Mamura M, Goto D, Ito S, Tsutsumi A, Kishimoto T, Sumida T
    Arthritis Rheum., 2008;58(3):754-63.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  62. CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice.
    Authors: Burrell BE, Csencsits K, Lu G, Grabauskiene S, Bishop DK
    J. Immunol., 2008;181(6):3906-14.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  63. A distinct subset of natural killer T cells produces IL-17, contributing to airway infiltration of neutrophils but not to airway hyperreactivity.
    Authors: Lee KA, Kang MH, Lee YS, Kim YJ, Kim DH, Ko HJ, Kang CY
    Cell. Immunol., 2008;251(1):50-5.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  64. Promotion of the local differentiation of murine Th17 cells by synovial macrophages during acute inflammatory arthritis.
    Authors: Egan PJ, van Nieuwenhuijze A, Campbell IK, Wicks IP
    Arthritis Rheum., 2008;58(12):3720-9.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  65. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.
    Authors: Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, Vacca C, Conte C, Mosci P, Bistoni F, Puccetti P, Kastelein RA, Kopf M, Romani L
    Eur. J. Immunol., 2007;37(10):2695-706.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  66. Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production.
    Authors: Shibata K, Yamada H, Hara H, Kishihara K, Yoshikai Y
    J. Immunol., 2007;178(7):4466-72.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  67. T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
    Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
    J. Allergy Clin. Immunol., 2007;119(3):662-70.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Neut
  68. Functional relevance of the IL-23-IL-17 axis in lungs in vivo.
    Authors: Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhall C, Sjostrand M, Kolls JK, Anderson GP, Linden A
    Am. J. Respir. Cell Mol. Biol., 2007;36(4):442-51.
    Species: Mouse
    Sample Type:
    Application: In vivo
  69. IL-23 enhances host defense against vaccinia virus infection via a mechanism partly involving IL-17.
    Authors: Kohyama S, Ohno S, Isoda A, Moriya O, Belladonna ML, Hayashi H, Iwakura Y, Yoshimoto T, Akatsuka T, Matsui M
    J. Immunol., 2007;179(6):3917-25.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  70. Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity.
    Authors: Harris TJ, Grosso JF, Yen HR, Xin H, Kortylewski M, Albesiano E, Hipkiss EL, Getnet D, Goldberg MV, Maris CH, Housseau F, Yu H, Pardoll DM, Drake CG
    J. Immunol., 2007;179(7):4313-7.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  71. Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge.
    Authors: He R, Oyoshi MK, Jin H, Geha RS
    Proc. Natl. Acad. Sci. U.S.A., 2007;104(40):15817-22.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  72. Exacerbation of antigen-induced arthritis in IFN-gamma-deficient mice as a result of unrestricted IL-17 response.
    Authors: Irmler IM, Gajda M, Brauer R
    J. Immunol., 2007;179(9):6228-36.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  73. Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation.
    Authors: Sergejeva S, Ivanov S, Lotvall J, Linden A
    Am. J. Respir. Cell Mol. Biol., 2005;33(3):248-53.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Neut
  74. Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi.
    Authors: Burchill MA, Nardelli DT, England DM, DeCoster DJ, Christopherson JA, Callister SM, Schell RF
    Infect. Immun., 2003;71(6):3437-42.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
  75. Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways.
    Authors: Miyamoto M, Prause O, Sjostrand M, Laan M, Lotvall J, Linden A
    J. Immunol., 2003;170(9):4665-72.
    Species: Mouse
    Sample Type: In Vivo
    Application: In vivo
Expand to show all 75 Citations
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