Mouse IL-6 Antibody

Catalog # Availability Size / Price Qty
MAB406-SP
MAB406-100
MAB406-500
Best Seller
Detection of Recombinant Mouse IL‑6 by Western Blot.
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Product Details
Citations (71)
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Mouse IL-6 Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse IL-6 in ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) IL‑6, recombinant porcine IL‑6, recombinant rat IL-6, rhIL-11, rhCT-1, or rhCLC is observed.
Source
Monoclonal Rat IgG1 Clone # MP5-20F3
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
COS-7 African green monkey SV40 transformed kidney fibroblast-like cell line-derived recombinant mouse IL-6
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below

Mouse IL-6 Sandwich Immunoassay

Recommended Concentration
Reagent
ELISA Capture (Matched Antibody Pair)
2-8 µg/mL 

Use in combination with:

Detection Reagent: Mouse IL‑6 Biotinylated Antibody (Catalog # BAF406)

Standard: Recombinant Mouse IL-6 Protein (Catalog # 406-ML)

Neutralization
Measured by its ability to neutralize IL‑6-induced proliferation in the T1165.85.2.1 mouse plasmacytoma cell line. Nordan, R.P. et al. (1987) J. Immunol. 139:813. The Neutralization Dose (ND50) is typically 0.005-0.025 µg/mL in the presence of 0.25 ng/mL Recombinant Mouse IL‑6.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Recombinant Mouse IL-6 antibody by Western Blot. View Larger

Detection of Recombinant Mouse IL‑6 by Western Blot. Western blot shows 25 ng of Recombinant Mouse IL-6 (406-ML), Recombinant Human IL-6 (206-IL) and Recombinant Rat IL-6 (506-RL). PVDF Membrane was probed with 1 µg/mL of Rat Anti-Mouse IL-6 Monoclonal Antibody (Catalog # MAB406) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (HAF005). A specific band was detected for IL-6 at approximately 18 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 3.

Neutralization Cell Proliferation Induced by IL‑6 and Neutralization by Mouse IL‑6 Antibody. View Larger

Cell Proliferation Induced by IL‑6 and Neutralization by Mouse IL‑6 Antibody. Recombinant Mouse IL-6 (406-ML) stimulates proliferation in the T1165.85.2.1 mouse plasmacytoma cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IL-6 (0.25 ng/mL) is neutralized (green line) by increasing concentrations of Mouse IL-6 Monoclonal Antibody (Catalog # MAB406). The ND50 is typically 0.005-0.025 µg/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-6

Interleukin-6 (IL-6) is a pleiotropic, alpha -helical, phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. Mature mouse IL-6 is 187 amino acids (aa) in length that is typically expressed as a 22-28 kDA molecular weight protein. Mouse IL-6 shares 39% and 85% aa sequence identity with human and rat IL-6, respectively. Alternative splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R alpha, triggering IL-6 R alpha association with gp130 and gp130 dimerization. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha. Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R alpha is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes. Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R alpha but not from other cytokines that use gp130 as a co-receptor. IL-6, along with TNF-alpha and IL-1, function to drive the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 can also function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise. In addition, it enhances hematopoietic stem cell proliferation and the differentiation of Th17 cells, memory B cells, and plasma cells.

Long Name
Interleukin 6
Entrez Gene IDs
3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 280826 (Bovine); 403985 (Canine); 102138971 (Cynomolgus Monkey); 100034196 (Equine); 493687 (Feline); 463288 (Primate); 100008733 (Rabbit)
Alternate Names
B-cell differentiation factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CTL differentiation factor ; HSF; hybridoma growth factor; IFNB2; IFN-beta-2; IL6; IL-6; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; interleukin-6; MGI-2A

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Citations for Mouse IL-6 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

71 Citations: Showing 1 - 10
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  1. CD1d-dependent natural killer T-cells inactivation aggravates sepsis-induced myocardial injury via T lymphocytes infiltration and IL-6 production in mice
    Authors: Chen, LR;Hui-Yang, ;Lu-Liu, ;Wang, XX;Zhang, XM;Wang, HX;
    International immunopharmacology
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  2. The fetal response to maternal inflammation is dependent upon maternal IL-6 in a murine model
    Authors: Bermick, J;Watson, S;Lueschow, S;McElroy, SJ;
    Cytokine
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  3. Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity
    Authors: J Liu, Y Cheng, X Zhang, Y Chen, H Zhu, K Chen, S Liu, Z Li, X Cao
    Cell Reports, 2023-01-18;42(1):111991.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  4. IL6 supports long-term expansion of hepatocytes in vitro
    Authors: R Guo, M Jiang, G Wang, B Li, X Jia, Y Ai, S Chen, P Tang, A Liu, Q Yuan, X Xie
    Nature Communications, 2022-11-29;13(1):7345.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  5. Single-cell transcriptomics reveals a senescence-associated IL-6/CCR6 axis driving radiodermatitis
    Authors: M Paldor, O Levkovitch, D Eidelshtei, R Adar, CD Enk, Y Marmary, S Elgavish, Y Nevo, H Benyamini, I Plaschkes, S Klein, A Mali, S Rose-John, A Peled, E Galun, JH Axelrod
    Oncogene, 2022-07-04;0(0):e15653.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  6. Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling
    Authors: B Czaya, K Heitman, I Campos, C Yanucil, D Kentrup, D Westbrook, O Gutierrez, JL Babitt, G Jung, IB Salusky, M Hanudel, C Faul
    Elife, 2022-03-18;11(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  7. Irradiated fibroblasts increase interleukin-6 expression and induce migration of head and neck squamous cell carcinoma
    Authors: S Suzuki, S Toyoma, Y Kawasaki, T Yamada
    PLoS ONE, 2022-01-28;17(1):e0262549.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  8. M1 macrophages impair tight junctions between endothelial cells after spinal cord injury
    Authors: Y Luo, F Yao, X Hu, Y Li, Y Chen, Z Li, Z Zhu, S Yu, D Tian, L Cheng, M Zheng, J Jing
    Brain research bulletin, 2022-01-04;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  9. Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions
    Authors: L Porcher, S Bruckmeier, SD Burbano, JE Finnell, N Gorny, J Klett, SK Wood, MP Kelly
    Journal of Neuroinflammation, 2021-09-22;18(1):219.
    Species: Mouse, Rat
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  10. Transgenic inhibition of interleukin-6 trans-signaling does not prevent skeletal pathologies in mucolipidosis type II mice
    Authors: LM Westermann, A Baranowsky, G Di Lorenzo, T Danyukova, J Soul, JM Schwartz, G Hendrickx, M Amling, S Rose-John, C Garbers, T Schinke, S Pohl
    Scientific Reports, 2021-02-11;11(1):3556.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  11. Macrophage and adipocyte interaction as a source of inflammation in kidney disease
    Authors: C Martos-Rus, G Katz-Green, Z Lin, E Serrano, D Whitaker-M, M Domingo-Vi, M Roche, K Ramaswamy, DC Hooper, B Falkner, MP Martinez C
    Scientific Reports, 2021-02-03;11(1):2974.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  12. Aging Impairs Mitochondrial Function and Mitophagy and Elevates Interleukin 6 Within the Cerebral Vasculature
    Authors: DJ Tyrrell, MG Blin, J Song, SC Wood, DR Goldstein
    J Am Heart Assoc, 2020-11-23;9(23):e017820.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Isotype Control
  13. &beta2-Adrenergic Receptors Increase Cardiac Fibroblast Proliferation Through the G&alphas/ERK1/2-Dependent Secretion of Interleukin-6
    Authors: MA Tanner, TP Thomas, CA Maitz, LA Grisanti
    Int J Mol Sci, 2020-11-12;21(22):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  14. p38&alpha in Macrophages Aggravates Arterial Endothelium Injury by Releasing IL-6 through phosphorylating Megakaryocytic Leukemia 1
    Authors: M Zhang, J Gao, X Zhao, M Zhao, D Ma, X Zhang, D Tian, B Pan, X Yan, J Wu, X Meng, H Yin, L Zheng
    Redox Biology, 2020-11-01;38(0):101775.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  15. Linking skeletal muscle aging with osteoporosis by lamin A/C deficiency
    Authors: L Xiong, K Zhao, Y Cao, HH Guo, JX Pan, X Yang, X Ren, L Mei, WC Xiong
    PLoS Biol., 2020-06-01;18(6):e3000731.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Western Blot
  16. Adipocytes promote tumor progression and induce PD-L1 expression via TNF-&alpha/IL-6 signaling
    Authors: Z Li, C Zhang, JX Du, J Zhao, MT Shi, MW Jin, H Liu
    Cancer Cell Int., 2020-05-20;20(0):179.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  17. Inhibition of Serine Protease Activity Protects Against High Fat Diet-Induced Inflammation and Insulin Resistance
    Authors: CS Kuo, JS Chen, LY Lin, GW Schmid-Sch, S Chien, PH Huang, JW Chen, SJ Lin
    Sci Rep, 2020-02-03;10(1):1725.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  18. Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis
    Authors: Y Takagaki, SM Lee, Z Dongqing, M Kitada, K Kanasaki, D Koya
    Autophagy, 2020-01-22;0(0):1-10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  19. B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression
    Authors: N Eckert, K Werth, S Willenzon, L Tan, R Förster
    J. Leukoc. Biol., 2019-12-16;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  20. Berberine ameliorates lipopolysaccharide?induced inflammatory responses in mouse inner medullary collecting duct?3 cells by downregulation of NF?kappaB pathway
    Authors: DG Kim, JW Choi, IJ Jo, MJ Kim, HS Lee, SH Hong, HJ Song, GS Bae, SJ Park
    Mol Med Rep, 2019-11-19;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  21. Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure
    Authors: GT Gardner, JG Travers, J Qian, GS Liu, K Haghighi, N Robbins, M Jiang, Y Li, GC Fan, J Rubinstein, BC Blaxall, EG Kranias
    JACC Basic Transl Sci, 2019-04-29;4(2):188-199.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  22. Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC
    Authors: B John, C Naczki, C Patel, A Ghoneum, S Qasem, Z Salih, N Said
    Oncogene, 2019-02-14;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  23. Direct Conversion of Mouse Fibroblasts into Neural Stem Cells by Chemical Cocktail Requires Stepwise Activation of Growth Factors and Nup210
    Authors: Y Tang, S Xiong, P Yu, F Liu, L Cheng
    Cell Rep, 2018-07-31;24(5):1355-1362.e3.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes
    Authors: T Mitani, T Takaya, N Harada, S Katayama, R Yamaji, S Nakamura, H Ashida
    Arch. Biochem. Biophys., 2018-04-04;646(0):98-106.
    Species: Mouse
    Sample Types: Plasma
    Applications: ELISA Capture
  25. Transcription factor 21 (Tcf21) promotes proinflammatory interleukin 6 expression and extracellular matrix remodeling in visceral adipose stem cells
    Authors: T Akama, TH Chun
    J. Biol. Chem., 2018-03-14;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Functional Assay, ICC
  26. Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulatingadipose stromal interleukin 6 production in mice
    Authors: X Sun, K Gupta, B Wu, D Zhang, B Yuan, X Zhang, HC Chiang, C Zhang, TJ Curiel, MP Bendeck, S Hursting, Y Hu, R Li
    J. Biol. Chem., 2018-01-03;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. The calcineurin-NFAT axis contributes to host defense during Pseudomonas aeruginosa lung infection
    Authors: Z Pang, RD Junkins, AJ MacNeil, C McCormick, Z Cheng, WM Chen, TJ Lin
    J. Leukoc. Biol., 2017-10-10;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: ELISA Development (Capture)
  28. IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3
    Authors: R Lv, J Zhao, M Lei, D Xiao, Y Yu, J Xie
    Cell. Physiol. Biochem., 2017-08-09;42(5):1961-1972.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA Development (Capture)
  29. Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression
    Authors: TS Zaman, H Arimochi, S Maruyama, C Ishifune, SI Tsukumo, A Kitamura, K Yasutomo
    J. Immunol., 2017-08-04;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6
    Authors: SI Ohkura, S Usui, SI Takashima, N Takuwa, K Yoshioka, Y Okamoto, Y Inagaki, N Sugimoto, T Kitano, M Takamura, T Wada, S Kaneko, Y Takuwa
    PLoS ONE, 2017-08-03;12(8):e0182329.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  31. Inhibitory effect ofquercetinon titaniumparticle-inducedendoplasmic reticulum stress (ERS)-related apoptosisandin vivoosteolysis
    Authors: L Zhang, Z Tian, W Li, X Wang, Z Man, S Sun
    Biosci. Rep., 2017-07-31;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development (Capture)
  32. The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity
    Sci Rep, 2016-07-21;6(0):29994.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  33. Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis
    Authors: Jung-Yeon Lim
    Sci Rep, 2016-06-01;6(0):26851.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development (Capture)
  34. IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer
    Authors: MS Caetano, H Zhang, AM Cumpian, L Gong, N Unver, EJ Ostrin, S Daliri, SH Chang, CE Ochoa, S Hanash, C Behrens, II Wistuba, C Sternberg, H Kadara, CG Ferreira, SS Watowich, SJ Moghaddam
    Cancer Res., 2016-04-01;76(11):3189-99.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo, Neutralization
  35. Radiation-driven lipid accumulation and dendritic cell dysfunction in cancer.
    Authors: Gao F, Liu C, Guo J, Sun W, Xian L, Bai D, Liu H, Cheng Y, Li B, Cui J, Zhang C, Cai J
    Sci Rep, 2015-04-29;5(0):9613.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment.
    Authors: Li P, Shan J, Chen X, Zhang D, Su L, Huang X, Yu B, Zhi Q, Li C, Wang Y, Tomei S, Cai Q, Ji J, Li J, Chouchane L, Yu Y, Sun F, Xu Z, Liu B, Zhu Z
    Cell Res, 2015-04-28;25(5):588-603.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Blocking
  37. KIM-1-mediated phagocytosis reduces acute injury to the kidney.
    Authors: Yang L, Brooks C, Xiao S, Sabbisetti V, Yeung M, Hsiao L, Ichimura T, Kuchroo V, Bonventre J
    J Clin Invest, 2015-03-09;125(4):1620-36.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: ELISA Development (Capture)
  38. Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration.
    Authors: Levy O, Calippe B, Lavalette S, Hu S, Raoul W, Dominguez E, Housset M, Paques M, Sahel J, Bemelmans A, Combadiere C, Guillonneau X, Sennlaub F
    EMBO Mol Med, 2015-02-01;7(2):211-26.
    Species: Human, Mouse
    Sample Types: Whole Organism, Whole Tissue
    Applications: IHC, In Vivo
  39. Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.
    Authors: Chandler, Ronald L, Damrauer, Jeffrey, Raab, Jesse R, Schisler, Jonathan, Wilkerson, Matthew, Didion, John P, Starmer, Joshua, Serber, Daniel, Yee, Della, Xiong, Jessie, Darr, David B, Pardo-Manuel de Villena, Fernando, Kim, William, Magnuson, Terry
    Nat Commun, 2015-01-27;6(0):6118.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  40. Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6).
    Authors: Volonte D, Zou H, Bartholomew J, Liu Z, Morel P, Galbiati F
    J Biol Chem, 2014-12-15;290(7):4202-14.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  41. Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis.
    Authors: Bonapace L, Coissieux M, Wyckoff J, Mertz K, Varga Z, Junt T, Bentires-Alj M
    Nature, 2014-10-22;515(7525):130-3.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  42. Autocrine interleukin-6 drives skin-derived mesenchymal stem cell trafficking via regulating voltage-gated Ca(2+) channels.
    Authors: Ke F, Zhang L, Liu Z, Liu J, Yan S, Xu Z, Bai J, Zhu H, Lou F, Wang H, Shi Y, Jiang Y, Su B, Wang H
    Stem Cells, 2014-10-01;32(10):2799-810.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC-P
  43. Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-alpha, and IL-1beta.
    Authors: Zhao Y, Xiao X, Frank S, Lin H, Xia Y
    Am J Physiol Endocrinol Metab, 2014-06-03;307(2):E186-98.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  44. Stabilization and augmentation of circulating AIM in mice by synthesized IgM-Fc.
    Authors: Kai, Toshihir, Yamazaki, Tomoko, Arai, Satoko, Miyazaki, Toru
    PLoS ONE, 2014-05-07;9(5):e97037.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  45. Blockade of Fas signaling in breast cancer cells suppresses tumor growth and metastasis via disruption of Fas signaling-initiated cancer-related inflammation.
    Authors: Liu Q, Tan Q, Zheng Y, Chen K, Qian C, Li N, Wang Q, Cao X
    J Biol Chem, 2014-03-13;289(16):11522-35.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  46. Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.
    Authors: Ramkhelawon B, Hennessy E, Menager M, Ray T, Sheedy F, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner K, Moore K
    Nat Med, 2014-03-02;20(4):377-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Microarray analyses demonstrate the involvement of type I interferons in psoriasiform pathology development in D6-deficient mice.
    Authors: Baldwin H, Pallas K, King V, Jamieson T, McKimmie C, Nibbs R, Carballido J, Jaritz M, Rot A, Graham G
    J Biol Chem, 2013-11-05;288(51):36473-83.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  48. Catecholamine stress alters neutrophil trafficking and impairs wound healing by beta2-adrenergic receptor-mediated upregulation of IL-6.
    Authors: Kim M, Gorouhi F, Ramirez S, Granick J, Byrne B, Soulika A, Simon S, Isseroff R
    J Invest Dermatol, 2013-10-11;134(3):809-17.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  49. Basophils control T-cell responses and limit disease activity in experimental murine colitis.
    Authors: Gomez M, Talke Y, Hofmann C, Ketelsen I, Hermann F, Reich B, Goebel N, Schmidbauer K, Dunger N, Bruhl H, Renner K, Syed S, Mack M
    Mucosal Immunol, 2013-06-12;7(1):188-99.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  50. Maternal immune activation during gestation interacts with Disc1 point mutation to exacerbate schizophrenia-related behaviors in mice.
    Authors: Lipina T, Zai C, Hlousek D, Roder J, Wong A
    J Neurosci, 2013-05-01;33(18):7654-66.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  51. Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections.
    Authors: Junkins R, MacNeil A, Wu Z, McCormick C, Lin T
    J Immunol, 2013-04-15;190(10):5178-86.
    Species: Mouse
    Sample Types: BALF
    Applications: ELISA Development (Capture)
  52. Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation.
    Authors: Mills, Lisa D, Zhang, Yaqing, Marler, Ronald J, Herreros-Villanueva, Marta, Zhang, Lizhi, Almada, Luciana, Couch, Fergus, Wetmore, Cynthia, Pasca di Magliano, Marina, Fernandez-Zapico, Martin E
    J Biol Chem, 2013-03-12;288(17):11786-94.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Neutralization
  53. Response patterns of cytokines/chemokines in two murine strains after irradiation.
    Authors: Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, Salzman P, Wang W, Liu C, Vidyasagar S, Zhang L, Ju S, Okunieff P, Zhang L
    Cytokine, 2012-01-25;58(2):169-77.
    Species: Mouse
    Sample Types: Plasma
    Applications: Luminex Development
  54. CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis.
    Authors: Roy M, Richard JF, Dumas A, Vallieres L
    J Neuroinflammation, 2012-01-23;9(0):18.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  55. Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus.
    Authors: Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, Chan YR, Ouyang W, Brown GD, Weaver CT, Steele C
    Infect. Immun., 2011-10-28;80(1):410-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  56. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
    Authors: Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L
    J. Exp. Med., 2011-03-07;208(3):491-503.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  57. Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin.
    Authors: Wu W, Mehta H, Chakrabarty K, Booth JL, Duggan ES, Patel KB, Ballard JD, Coggeshall KM, Metcalf JP
    J. Immunol., 2009-10-07;183(9):5799-806.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  58. Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis.
    Authors: Osuchowski MF, Connett J, Welch K, Granger J, Remick DG
    Crit. Care Med., 2009-05-01;37(5):1567-73.
    Species: Mouse
    Sample Types: Plasma
    Applications: ELISA Development
  59. ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis.
    Authors: Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T
    Microbes Infect., 2009-03-13;11(4):524-30.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  60. CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis.
    Authors: Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T
    Immunology, 2008-04-03;125(2):272-9.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: ELISA Development
  61. Tumor-specific Th17-polarized cells eradicate large established melanoma.
    Authors: Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, Paulos CM, Palmer DC, Touloukian CE, Ptak K, Gattinoni L, Wrzesinski C, Hinrichs CS, Kerstann KW, Feigenbaum L, Chan CC, Restifo NP
    Blood, 2008-03-19;112(2):362-73.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  62. Maternal immune activation alters fetal brain development through interleukin-6.
    Authors: Smith SE, Li J, Garbett K, Mirnics K, Patterson PH
    J. Neurosci., 2007-10-03;27(40):10695-702.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  63. Comparison of the roles of IL-1, IL-6, and TNFalpha in cell culture and murine models of aseptic loosening.
    Authors: Taki N, Tatro JM, Lowe R, Goldberg VM, Greenfield EM
    Bone, 2006-12-21;40(5):1276-83.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  64. A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model.
    Authors: Haraguchi G, Suzuki J, Kosuge H, Ogawa M, Koga N, Muto S, Itai A, Kagechika H, Shudo K, Isobe M
    J. Mol. Cell. Cardiol., 2006-09-11;41(5):885-92.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  65. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality.
    Authors: Osuchowski MF, Welch K, Siddiqui J, Remick DG
    J. Immunol., 2006-08-01;177(3):1967-74.
    Species: Mouse
    Sample Types: Plasma
    Applications: ELISA Development
  66. Glechoma hederacea inhibits inflammatory mediator release in IFN-gamma and LPS-stimulated mouse peritoneal macrophages.
    Authors: An HJ, Jeong HJ, Um JY, Kim HM, Hong SH
    J Ethnopharmacol, 2006-03-10;106(3):418-24.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  67. Role of interleukin-6 in cardiomyocyte/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation.
    Authors: Fredj S, Bescond J, Louault C, Delwail A, Potreau D
    J. Cell. Physiol., 2005-08-01;204(2):428-36.
    Species: Mouse
    Sample Types: Cell Culture Supernates, Whole Cells
    Applications: ELISA Development, Neutralization
  68. Sequential ELISA to profile multiple cytokines from small volumes.
    Authors: Osuchowski MF, Siddiqui J, Copeland S, Remick DG
    J. Immunol. Methods, 2005-07-01;302(1):172-81.
    Species: Mouse
    Sample Types: Plasma
    Applications: ELISA Development
  69. Selective macrophage suppression during sepsis.
    Authors: Ellaban E, Bolgos G, Remick D
    Cell. Immunol., 2005-02-26;231(1):103-11.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  70. Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways.
    Authors: Miyamoto M, Prause O, Sjostrand M, Laan M, Lotvall J, Linden A
    J. Immunol., 2003-05-01;170(9):4665-72.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  71. Tick salivary gland extract-activated transmission of Borrelia afzelii spirochaetes.
    Authors: Pechova J, Stĕpánová G, Kovar L, Kopecky J
    Folia Parasitol., 2002-01-01;49(2):153-9.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development

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Mouse IL-6 Antibody
By Anonymous on 08/12/2021
Application: WB Sample Tested: Heart tissue Species: Mouse

Mouse IL-6 Antibody
By Anonymous on 02/10/2021
Application: WB Sample Tested: Ear tissue,Heart tissue Species: Mouse

Mouse IL‑6 Antibody
By Anonymous on 04/11/2019
Application: Cell Invasion Sample Tested: Cancer-associated Fibroblasts,tumor cells Species: Mouse

Mouse IL‑6 Antibody
By Anonymous on 05/11/2018
Application: Cell Depl Sample Tested: Pancreatic cancer cells Species: Mouse

Mouse IL-6 Antibody
By Anonymous on 12/08/2017
Application: ELISA Sample Tested: Human recombinant antibody Species: Mouse