Mouse MAGP-1/MFAP2 Antibody

Catalog # Availability Size / Price Qty
AF4977
AF4977-SP
Product Details
Citations (2)
FAQs
Supplemental Products
Reviews

Mouse MAGP-1/MFAP2 Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse MAGP-1/MFAP2 in direct ELISAs and Western blots. In direct ELISAs, approximately 35% cross-reactivity with recombinant human MAGP-1 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse MAGP-1/MFAP2
Gln17-Cys183
Accession # P55002
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Mouse MAGP-1/MFAP2

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: MAGP-1/MFAP2

MAGP-1 (Microfibril-associated glycoprotein 1; also MFAP-2) is a 30‑33 kDa member of the MFAP family of proteins. It is secreted by endothelial and smooth muscle cells. MAGP-1 apparently mediates the release of Notch extracellular domain and also likely binds to type IV collagen and contributes to elastin fiber formation. Mature mouse MAGP-1 is 167 amino acids (aa) in length. It contains a transglutamination site at Gln20, a tyrosine sulfation motif (aa 46‑49), two potential O-linked glycosylation sites (Thr56 and Thr76), and a Cys-rich C-terminus that generates intermolecular disulfide bonds. One potential splice variant exists that is strictly intracellular and a second shows a 22 aa substitution for the C-terminal 127 amino acids. Mature mouse MAGP-1 is 94% and 87% aa identical to rat and human MAGP‑1, respectively.

Long Name
Microfibril-associated Glycoprotein 1
Entrez Gene IDs
4237 (Human); 17150 (Mouse); 313662 (Rat)
Alternate Names
MAGP1; MAGP-1; MAGP-1FLJ50901; MAGPMFAP-2; MFAP2; Microfibril-associated glycoprotein 1; microfibrillar-associated protein 2

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Citations for Mouse MAGP-1/MFAP2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Fibrillin-1 Regulates Arteriole Integrity in the Retina
    Authors: F Alonso, L Li, I Fremaux, DP Reinhardt, E Génot
    Biomolecules, 2022-09-20;12(10):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  2. Targeted deletion of fibrillin-1 in the mouse eye results in ectopia lentis and other ocular phenotypes associated with Marfan syndrome
    Authors: W Jones, J Rodriguez, S Bassnett
    Dis Model Mech, 2019-01-25;12(1):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC

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