Mouse OMgp Antibody

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Product Details
Citations (5)
Supplemental Products

Mouse OMgp Antibody Summary

Species Reactivity
Detects mouse OMgp in direct ELISAs and Western blots. In these formats, approximately 35% cross‑reactivity with recombinant human OMgp is observed.
Polyclonal Goat IgG
Antigen Affinity-purified
Mouse myeloma cell line NS0-derived recombinant mouse OMgp (R&D Systems, Catalog # 1674-MG)
Accession # Q63912
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Mouse OMgp (Catalog # 1674-MG)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: OMgp

Oligodendrocyte myelin glycoprotein (OMgp or OMG), Nogo, and myelin-associated glycoprotein (MAG), are three myelin-derived axon outgrowth inhibitors that collapse axonal growth cones and inhibit neurite outgrowth (1 - 3). These three structurally distinct proteins contribute to the myelin-associated inhibitory activity that prevents axonal regeneration after injury of the adult central nervous system (CNS). Mouse OMgp cDNA encodes a 440 amino acid (aa) residue glycosylphosphatidylinositol (GPI)-anchored protein that has a 24 aa signal peptide, eight leucine-rich repeats (LRR) followed by five serine/threonine-rich repeats (4). OMgp has multiple potential N-glycosylation and O-glycosylation sites. Mouse and human OMgp share approximately 88% aa sequence identity. OMgp is expressed on the surface of oligodendrocytes and on large projection neurons, including Purkinje cells of the cerebellum, pyramidal cells of the hippocampus, motoneurons of the brainstem and anterior horn cells of the spinal cord (5). The neurite outgrowth inhibitory activities of all three myelin-derived proteins are mediated by binding to a common receptor complex consisting of the Nogo receptor (NgR) and the p75 neurotrophin receptor (NGFR) (2, 3). Besides its function in the inhibition of axonal growth, OMgp has also been implicated in the inhibition of proliferation. Although the transmembrane receptor that mediates the proliferation inhibition activity has not been identified, the LRR repeats of OMgp were shown to be essential for both the proliferation inhibition and neurite outgrowth inhibition activities (6).

  1. Kottis, V. et al. (2002) J. Neurochem. 82:1566.
  2. Wang, K. et al. (2002) Nature 417:941.
  3. Wang, K. et al. (2002) Nature 420:74.
  4. Mikol, D.D. et al. (1993) Genomics 17:604.
  5. Habib, A. et al. (1998) J. Neurochem. 70:1704.
  6. Vourc’h, P. et al. (2003) J. Neurochem. 85:889.
Long Name
Oligodendrocyte-Myelin glycoprotein
Entrez Gene IDs
4974 (Human); 18377 (Mouse)
Alternate Names
oligodendrocyte myelin glycoprotein; OMG; OMgp; OMGPoligodendrocyte-myelin glycoprotein

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Citations for Mouse OMgp Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Oligodendrocyte myelin glycoprotein does not influence node of ranvier structure or assembly.
    Authors: Chang KJ, Susuki K, Dours-Zimmermann MT
    J. Neurosci., 2010-10-27;30(43):14476-81.
    Species: Mouse
    Sample Types: Recombinant Protein, Tissue Homogenates
    Applications: Dot Blot, Electron Microscopy, Western Blot
  2. Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity.
    Authors: Raiker SJ, Lee H, Baldwin KT
    J. Neurosci., 2010-09-15;30(37):12432-45.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  3. Soluble Nogo receptor down-regulates expression of neuronal Nogo-A to enhance axonal regeneration.
    Authors: Peng X, Zhou Z, Hu J, Fink DJ, Mata M
    J. Biol. Chem., 2009-11-09;285(4):2783-95.
    Species: Rat
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. Reassessment of corticospinal tract regeneration in Nogo-deficient mice.
    Authors: Lee JK, Chan AF, Luu SM, Zhu Y, Ho C, Tessier-Lavigne M, Zheng B
    J. Neurosci., 2009-07-08;29(27):8649-54.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  5. Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition.
    Authors: Robak LA, Venkatesh K, Lee H, Raiker SJ, Duan Y, Lee-Osbourne J, Hofer T, Mage RG, Rader C, Giger RJ
    J. Neurosci., 2009-05-06;29(18):5768-83.
    Species: Rat
    Sample Types: Tissue Homogenates
    Applications: Western Blot


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Secondary Antibodies

Goat IgG (H+L) Antibody


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