Mouse sFRP-2 Antibody
Mouse sFRP-2 Antibody Summary
Accession # AAB70795
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Secreted Frizzled Related Proteins (sFRPs) are a family of vertebrate proteins which contain homology to the ligand-binding domain of the Frizzled family of transmembrane receptors. The sFRPs are approximately 30 - 35 kDa in size and are comprised of 3 domains: a signal sequence; a cysteine-rich domain (CRD) of about 110 amino acids (aa) with a high degree of similarity to the Frizzled proteins, including 10 conserved cysteines, and a 175 aa conserved hydrophilic carboxy terminal region. Because sFRPs contain a CRD very similar to the region responsible for binding Wnt ligands in Frizzleds, sFRPS are thought to act as soluble antagonists of Wnt signals.
sFRP-2, also known as SARP-1, SDF-5, and FRP-2, is expressed during mouse embryogenesis in the eye, brain, neural tube, craniofacial mesenchyme, joints, testis, pancreas, kidney and regions of smooth muscle cell development. Expression in the adult animal has been detected in the eye, heart, lung, along with preadipose and adipose tissues in mice and humans. Mouse and human sFRP-2 proteins share 98% aa identity, and related proteins have also been identified in chick, rabbit, and frog. A variety of activities have been reported for sFRP-2 including an increased resistance to apoptosis, antagonism of Xwnt -8 signaling in Xenopus, regulation of Wnt-4 signaling (with sFRP-1) in renal organogenesis, and inhibition of the migration of glioma cells (1 - 7).
- Rattner, A. et al. (1997) Proc. Natl. Acad. Sci. USA 94:2859.
- Melkonyan, H. et al. Proc. Natl. Acad. Sci. USA 94:13636.
- Hu, E. et al. (1998) BBRC 247:287.
- Leimeister, C. et al. (1998) Mech. Dev. 75:29.
- Roth, W. et al. (2000) Oncogene 19:4210.
- Ladher, R. et al. (2000) Dev. Biol. 218:183.
- Yoshino, K. et al. (2001) Mech. Dev. 102:45.
No product specific FAQs exist for this product, however you mayView all Antibody FAQs
Reviews for Mouse sFRP-2 Antibody
There are currently no reviews for this product. Be the first to review Mouse sFRP-2 Antibody and earn rewards!
Have you used Mouse sFRP-2 Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image