Mouse TNF-alpha Quantikine ELISA Kit MTA00B: R&D Systems
  • Assay Length
    4.5 hours
  • Sample Type & Volume Required Per Well
    Cell Culture Supernates (50 uL), Serum (50 uL), EDTA Plasma (50 uL), Heparin Plasma (50 uL)
  • Sensitivity
    7.21 pg/mL
  • Assay Range
    10.9 - 700 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)
  • Specificity
    Natural and recombinant mouse TNF-alpha.
  • Cross-reactivity
    < 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
  • Interference
    Interference observed with 1 or more available related molecules.
Product Summary
The Quantikine Mouse TNF-alpha Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse TNF-alpha levels in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse TNF-alpha and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse TNF-alpha accurately. Results obtained using natural mouse TNF-alpha showed dose-response curves that were parallel to the standard curves obtained using the recombinant kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse TNF-alpha.

Precision
Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in twenty separate assays to assess inter-assay precision.
Cell Culture Supernates
Intra-Assay Precision Inter-Assay Precision
Sample123123
n202020202020
Mean54.611640552.6138373
Standard Deviation1.54.5112.54.618.4929.7
CV%2.73.93.18.86.28

Serum, EDTA Plasma, Heparin Plasma
Intra-Assay Precision Inter-Assay Precision
Sample123123
n202020202020
Mean50.513437553146388
Standard Deviation1.914.9511.53.698.4229.7
CV%3.83.73.175.87.7

Recovery

The recovery of mouse TNF-alpha spiked to three levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Supernates (n=6) 104 94-111
EDTA Plasma (n=4) 95 85-103
Heparin Plasma (n=4) 92 86-98
Serum (n=4) 94 88-106
Linearity
To assess the linearity of the assay, samples were spiked with various concentrations of mouse TNF-alpha in each matrix, diluted with the appropriate Calibrator Diluent and then assayed.
Mouse TNF-alpha Quantikine ELISA Kit
Preparation and Storage
  • Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: TNF-alpha

Tumor necrosis factor alpha (TNF-α), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. Human TNF-α consists of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD). Within the ECD, human TNF-α shares 97% aa sequence identity with rhesus and 71% - 92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-α. The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness.

Cleavage of membrane bound TNF-α by TACE/ADAM17 releases a 55 kDa soluble trimeric form of TNF-α. TNF-α trimers bind the ubiquitous TNF RI and the hematopoietic cell-restricted TNF RII, both of which are also expressed as homotrimers. TNF-α regulates lymphoid tissue development through control of apoptosis. It also promotes inflammatory responses by inducing the activation of vascular endothelial cells and macrophages. TNF-α is a key cytokine in the development of several inflammatory disorders. It contributes to the development of type 2 diabetes through its effects on insulin resistance and fatty acid metabolism.

    • Long Name
      Tumor Necrosis Factor alpha
    • Entrez Gene IDs
      7124 (Human); 21926 (Mouse); 24835 (Rat); 397086 (Porcine); 280943 (Bovine); 403922 (Canine); 100033834 (Equine); 493755 (Feline); 100009088 (Rabbit);
    • Alternate Names
      APC1 protein; Cachectin; Cachetin; DIF; TNF; TNF, monocyte-derived; tnfa; tnf-a; TNFalpha; TNF-alpha; TNF-alphacachectin; TNFATNF, macrophage-derived; TNFSF1A; TNFSF2; TNFSF2TNF superfamily, member 2; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; Tumor necrosis factor ligand superfamily member 2; tumor necrosis factor; tumor necrosis factor-alpha;
    Related Research Areas
    Assay Procedure
    Refer to the product for complete assay procedure.

    Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
    1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
    2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.

    3. 50 µL Assay Diluent
    4.   Add 50 µL of Assay Diluent to each well.

    5. 50 µL Standard, Control, or Sample
    6.   Add 50 µL of Standard, Control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours.
    7.   Aspirate each well and wash, repeating the process 4 times for a total of 5 washes.

    8. 100 µL Conjugate
    9.   Add 100 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours.
    10.   Aspirate and wash 5 times.

    11. 100 µL Substrate Solution
    12.   Add 100 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.

    13. 100 µL Stop Solution
    14.   Add 100 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.
    Citations:

    R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

    305 Citations: Showing 1 - 10
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    Species
    Sample Type
    1. Comprehensive comparison of three different animal models for systemic inflammation
      Authors: S Seemann, F Zohles, A Lupp
      J. Biomed. Sci., 2017;24(1):60.
      Species: Mouse
      Sample Type: Serum
    2. TDAG8, TRPV1, and ASIC3 involved in establishing hyperalgesic priming in experimental rheumatoid arthritis
      Authors: WS Hsieh, CC Kung, SL Huang, SC Lin, WH Sun
      Sci Rep, 2017;7(1):8870.
      Species: Mouse
      Sample Type: Serum
    3. MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866
      Authors: P Huang, MW Lee, K Sadrerafi, DP Heruth, LQ Zhang, D Maulik, SQ Ye
      Drug Des Devel Ther, 2017;11(0):629-641.
      Species: Mouse
      Sample Type: Serum
    4. Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation
      Authors: CS Schneider, Q Xu, NJ Boylan, J Chisholm, BC Tang, BS Schuster, A Henning, LM Ensign, E Lee, P Adstamongk, BW Simons, SS Wang, X Gong, T Yu, MP Boyle, JS Suk, J Hanes
      Sci Adv, 2017;3(4):e1601556.
      Species: Mouse
      Sample Type: Tissue Homogenates
    5. Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma
      Authors: ST Beug, CE Beauregard, C Healy, T Sanda, M St-Jean, J Chabot, DE Walker, A Mohan, N Earl, X Lun, DL Senger, SM Robbins, P Staeheli, PA Forsyth, T Alain, EC LaCasse, RG Korneluk
      Nat Commun, 2017;8(0):.
      Species: Mouse
      Sample Type: Tissue Homogenates
    6. Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
      Authors: EE To, R Vlahos, R Luong, ML Halls, PC Reading, PT King, C Chan, GR Drummond, CG Sobey, BRS Broughton, MR Starkey, R van der Sl, SR Lewin, S Bozinovski, LAJ O'Neill, T Quach, CJH Porter, DA Brooks, JJ O'Leary, S Selemidis
      Nat Commun, 2017;8(1):69.
      Species: Mouse
      Sample Type: BALF
    7. Prostate cancer downregulated SIRP-? modulates apoptosis and proliferation through p38-MAPK/NF-?B/COX-2 signaling
      Authors: C Yao, G Li, M Cai, Y Qian, L Wang, L Xiao, F Thaiss, B Shi
      Oncol Lett, 2017;13(6):4995-5001.
      Species: Human
      Sample Type: Cell Culture Supernates
    8. An avirulent Burkholderia pseudomallei ?purM strain with atypical type B LPS: expansion of the toolkit for biosafe studies of melioidosis
      Authors: MH Norris, MS Rahman Kha, HP Schweizer, A Tuanyok
      BMC Microbiol., 2017;17(1):132.
      Species: Mouse
      Sample Type: Tissue Homogenates
    9. The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy
      Authors: D Zingg, N Arenas-Ram, D Sahin, RA Rosalia, AT Antunes, J Haeusel, L Sommer, O Boyman
      Cell Rep, 2017;20(4):854-867.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    10. IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model
      Authors: S Piñeiro-He, IP López, E Alfaro-Arn, R Torrens, M Iñiguez, L Alvarez-Er, C Ruíz-Martí, JG Pichel
      Sci Rep, 2017;7(1):4290.
      Species: Mouse
      Sample Type: Tissue Homogenates
    11. A Critical Analysis of the Role of SNARE Protein SEC22B in Antigen Cross-Presentation
      Authors: SJ Wu, YS Niknafs, SH Kim, K Oravecz-Wi, C Zajac, T Toubai, Y Sun, J Prasad, D Peltier, H Fujiwara, I Hedig, ND Mathewson, R Khoriaty, D Ginsburg, P Reddy
      Cell Rep, 2017;19(13):2645-2656.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    12. Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis
      Authors: Y Guo, C Xie, X Li, J Yang, T Yu, R Zhang, T Zhang, D Saxena, M Snyder, Y Wu, X Li
      Nat Commun, 2017;8(0):15621.
      Species: Mouse
      Sample Type: Serum
    13. Focal adhesion kinase signaling regulates anti-inflammatory function of bone marrow mesenchymal stromal cells induced by biomechanical force
      Authors: HJ Lee, MF Diaz, A Ewere, SD Olson, CS Cox, PL Wenzel
      Cell. Signal., 2017;38(0):9-Jan.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    14. Protective Efficacy of the Trivalent Pseudomonas aeruginosa Vaccine Candidate PcrV-OprI-Hcp1 in Murine Pneumonia and Burn Models
      Authors: F Yang, J Gu, L Yang, C Gao, H Jing, Y Wang, H Zeng, Q Zou, F Lv, J Zhang
      Sci Rep, 2017;7(1):3957.
      Species: Mouse
      Sample Type: BALF
    15. The TNF-? antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice
      Authors: BA Patel, S Fidalgo, C Wang, L Parmar, K Mandona, A Panossian, MS Flint, RN Ranson, MJ Saffrey, MS Yeoman
      Sci Rep, 2017;7(0):42754.
      Species: Mouse
      Sample Type: Mucus
    16. Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina
      EMBO Mol Med, 2016;0(0):.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    17. Subtilisin-like protease-1 secreted through type IV secretion system contributes to high virulence of Streptococcus suis 2
      Authors: Supeng Yin
      Sci Rep, 2016;6(0):27369.
      Species: Mouse
      Sample Type: Serum
    18. Sphingosine-1-Phosphate Receptor 2 Regulates Proinflammatory Cytokine Production and Osteoclastogenesis
      PLoS ONE, 2016;11(5):e0156303.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    19. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer
      Nature, 2016;533(7604):493-8.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    20. DNMT1-PPAR? pathway in macrophages regulates chronic inflammation and atherosclerosis development in mice
      Sci Rep, 2016;6(0):30053.
      Species: Mouse
      Sample Type: Plasma
    21. Toll-Like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss
      PLoS ONE, 2016;11(8):e0158735.
      Species: Mouse
      Sample Type: BALF
    22. Protective effect of Cl-amidine against CLP-induced lethal septic shock in mice
      Sci Rep, 2016;6(0):36696.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    23. The Phosphocarrier Protein HPr Contributes to Meningococcal Survival during Infection
      PLoS ONE, 2016;11(9):e0162434.
      Species: Mouse
      Sample Type: Peritoneal Fluid
    24. Intravenous hMSCs Ameliorate Acute Pancreatitis in Mice via Secretion of Tumor Necrosis Factor-? Stimulated Gene/Protein 6
      Sci Rep, 2016;6(0):38438.
      Species: Mouse
      Sample Type: Serum
    25. C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia
      PLoS Pathog, 2016;12(12):e1006038.
      Species: Mouse
      Sample Type: Tissue Homogenates
    26. Monocyte chemotactic protein-1 deficiency reduces spontaneous metastasis of Lewis lung carcinoma in mice fed a high-fat diet
      Oncotarget, 2016;7(17):24792-9.
      Species: Mouse
      Sample Type: Plasma
    27. Anti-inflammatory effect of cannabinoid agonist WIN55, 212 on mouse experimental colitis is related to inhibition of p38MAPK
      World J. Gastroenterol., 2016;22(43):9515-9524.
      Species: Mouse
      Sample Type: Plasma
    28. Methylmercury induces the expression of TNF-? selectively in the brain of mice
      Sci Rep, 2016;6(0):38294.
      Species: Human
      Sample Type: Cell Culture Supernates
    29. Toll-like Receptor 4 Agonistic Antibody Promotes Host Defense against Chronic Pseudomonas aeruginosa Lung Infection in Mice
      Authors: S Nakamura, N Iwanaga, M Seki, K Fukudome, K Oshima, T Miyazaki, K Izumikawa, K Yanagihara, Y Miyazaki, H Mukae, S Kohno
      Infect Immun, 2016;0(0):.
      Species: Mouse
      Sample Type: Tissue Homogenates
    30. Methemoglobin is an endogenous toll-like receptor 4 ligand-relevance to subarachnoid hemorrhage.
      Authors: Kwon M, Woo S, Kurland D, Yoon S, Palmer A, Banerjee U, Iqbal S, Ivanova S, Gerzanich V, Simard J
      Int J Mol Sci, 2015;16(3):5028-46.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    31. Conditioned media from adipose stromal cells limit lipopolysaccharide-induced lung injury, endothelial hyperpermeability and apoptosis.
      Authors: Lu H, Poirier C, Cook T, Traktuev D, Merfeld-Clauss S, Lease B, Petrache I, March K, Bogatcheva N
      J Transl Med, 2015;13(0):67.
      Species: Mouse
      Sample Type: BALF
    32. Pycnogenol Attenuates the Release of Proinflammatory Cytokines and Expression of Perilipin 2 in Lipopolysaccharide-Stimulated Microglia in Part via Inhibition of NF-kappaB and AP-1 Activation.
      Authors: Fan B, Dun S, Gu J, Guo Y, Ikuyama S
      PLoS ONE, 2015;10(9):e0137837.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    33. TNFalpha Regulates SIRT1 Cleavage during Ocular Autoimmune Disease.
      Authors: Gardner P, Yazid S, Chu C, Copland D, Adamson P, Dick A, Calder V
      Am J Pathol, 2015;185(5):1324-33.
      Species: Mouse
      Sample Type: Serum
    34. Innate sensing of microbial products promotes wound-induced skin cancer.
      Authors: Hoste E, Arwert E, Lal R, South A, Salas-Alanis J, Murrell D, Donati G, Watt F
      Nat Commun, 2015;6(0):5932.
      Species: Mouse
      Sample Type: Serum
    35. HGF Gene Modification in Mesenchymal Stem Cells Reduces Radiation-Induced Intestinal Injury by Modulating Immunity.
      Authors: Wang H, Sun R, Li Y, Yang Y, Xiao F, Zhang Y, Wang S, Sun H, Zhang Q, Wu C, Wang L
      PLoS ONE, 2015;10(5):e0124420.
      Species: Mouse
      Sample Type: Serum
    36. Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis.
      Authors: Liao K, Guo M, Niu F, Yang L, Callen S, Buch S
      J Neuroinflammation, 2015;13(1):33.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    37. Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice.
      Authors: Charolidi N, Schilling T, Eder C
      PLoS ONE, 2015;10(5):e0128463.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    38. Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response.
      Authors: O'Callaghan P, Li J, Lannfelt L, Lindahl U, Zhang X
      J Biol Chem, 2015;290(24):14904-14.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    39. Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis.
      Authors: Heinbockel L, Marwitz S, Barcena Varela S, Ferrer-Espada R, Reiling N, Goldmann T, Gutsmann T, Mier W, Schurholz T, Dromann D, Brandenburg K, Martinez de Tejada G
      PLoS ONE, 2015;10(7):e0133291.
      Species: Mouse
      Sample Type: Serum
    40. Administration of a CXCL12 Analog in Endotoxemia Is Associated with Anti-Inflammatory, Anti-Oxidative and Cytoprotective Effects In Vivo.
      Authors: Seemann S, Lupp A
      PLoS ONE, 2015;10(9):e0138389.
      Species: Mouse
      Sample Type: Serum
    41. Sevoflurane inhibits nuclear factor-kappaB activation in lipopolysaccharide-induced acute inflammatory lung injury via toll-like receptor 4 signaling.
      Authors: Sun X, Li X, Wang X, Tan W, Wang J
      PLoS ONE, 2015;10(4):e0122752.
      Species: Mouse
      Sample Type: BALF
    42. IRAK-M regulates the inhibition of TLR-mediated macrophage immune response during late in vitro Leishmania donovani infection.
      Authors: Srivastav S, Saha A, Barua J, Ukil A, Das P
      Eur J Immunol, 2015;45(10):2787-97.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    43. Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer.
      Authors: Du J, Cieslak J, Welsh J, Sibenaller Z, Allen B, Wagner B, Kalen A, Doskey C, Strother R, Button A, Mott S, Smith B, Tsai S, Mezhir J, Goswami P, Spitz D, Buettner G, Cullen J
      Cancer Res, 2015;75(16):3314-26.
      Species: Mouse
      Sample Type: Serum
    44. Chronic morphine-induced microRNA-124 promotes microglial immunosuppression by modulating P65 and TRAF6.
      Authors: Qiu S, Feng Y, LeSage G, Zhang Y, Stuart C, He L, Li Y, Caudle Y, Peng Y, Yin D
      J Immunol, 2015;194(3):1021-30.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    45. Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a 133p53alpha mimic.
      Authors: Sawhney S, Hood K, Shaw A, Braithwaite A, Stubbs R, Hung N, Royds J, Slatter T
      PLoS ONE, 2015;10(2):e0116270.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    46. Rho-kinase activation in leukocytes plays a pivotal role in myocardial ischemia/reperfusion injury.
      Authors: Kitano K, Usui S, Ootsuji H, Takashima S, Kobayashi D, Murai H, Furusho H, Nomura A, Kaneko S, Takamura M
      PLoS ONE, 2014;9(3):e92242.
      Species: Mouse
      Sample Type: Serum
    47. Kruppel-like factor 9 deficiency in uterine endometrial cells promotes ectopic lesion establishment associated with activated notch and hedgehog signaling in a mouse model of endometriosis.
      Authors: Heard M, Simmons C, Simmen F, Simmen R
      Endocrinology, 2014;155(4):1532-46.
      Species: Mouse
      Sample Type: Peritoneal Fluid
    48. Prostaglandin E2 negatively regulates the production of inflammatory cytokines/chemokines and IL-17 in visceral leishmaniasis.
      Authors: Saha A, Biswas A, Srivastav S, Mukherjee M, Das P, Ukil A
      J Immunol, 2014;193(5):2330-9.
    49. Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response.
      Authors: Gupta P, Giri J, Srivastav S, Chande A, Mukhopadhyaya R, Das P, Ukil A
      FASEB J, 2014;28(4):1756-68.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    50. CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice.
      Authors: Bignon A, Gaudin F, Hemon P, Tharinger H, Mayol K, Walzer T, Loetscher P, Peuchmaur M, Berrebi D, Balabanian K
      J Immunol, 2014;192(3):886-96.
      Species: Mouse
      Sample Type: Serum
    51. Effects of a high-fat diet on spontaneous metastasis of Lewis lung carcinoma in plasminogen activator inhibitor-1 deficient and wild-type mice.
      Authors: Yan L, DeMars L
      PLoS ONE, 2014;9(10):e110869.
      Species: Mouse
      Sample Type: Plasma
    52. JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation.
      Authors: Lu B, Antoine D, Kwan K, Lundback P, Wahamaa H, Schierbeck H, Robinson M, Van Zoelen M, Yang H, Li J, Erlandsson-Harris H, Chavan S, Wang H, Andersson U, Tracey K
      Proc Natl Acad Sci U S A, 2014;111(8):3068-73.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    53. Neurodegeneration by activation of the microglial complement-phagosome pathway.
      Authors: Bodea L, Wang Y, Linnartz-Gerlach B, Kopatz J, Sinkkonen L, Musgrove R, Kaoma T, Muller A, Vallar L, Di Monte D, Balling R, Neumann H
      J Neurosci, 2014;34(25):8546-56.
      Species: Mouse
      Sample Type: Plasma
    54. Immunological priming requires regulatory T cells and IL-10-producing macrophages to accelerate resolution from severe lung inflammation.
      Authors: Aggarwal, Neil R, Tsushima, Kenji, Eto, Yoshiki, Tripathi, Ashutosh, Mandke, Pooja, Mock, Jason R, Garibaldi, Brian T, Singer, Benjamin, Sidhaye, Venkatar, Horton, Maureen, King, Landon S, D'Alessio, Franco R
      J Immunol, 2014;192(9):4453-64.
      Species: Mouse
      Sample Type: BALF
    55. OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice.
      Authors: Shimamura M, Nakagami H, Osako M, Kurinami H, Koriyama H, Zhengda P, Tomioka H, Tenma A, Wakayama K, Morishita R
      Proc Natl Acad Sci U S A, 2014;111(22):8191-6.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    56. Role of ferulic acid in the amelioration of ionizing radiation induced inflammation: a murine model.
      Authors: Das U, Manna K, Sinha M, Datta S, Das D, Chakraborty A, Ghosh M, Saha K, Dey S
      PLoS ONE, 2014;9(5):e97599.
      Species: Mouse
      Sample Type: Serum
    57. Fat storage-inducing transmembrane protein 2 is required for normal fat storage in adipose tissue.
      Authors: Miranda, Diego A, Kim, Ji-Hyun, Nguyen, Long N, Cheng, Wang, Tan, Bryan C, Goh, Vera J, Tan, Jolene S, Yaligar, Jadegoud, Kn, Bhanu Pr, Velan, S Sendhi, Wang, Hongyan, Silver, David L
      J Biol Chem, 2014;289(14):9560-72.
      Species: Mouse
      Sample Type: Plasma
    58. Diisopropylamine dichloroacetate, a novel pyruvate dehydrogenase kinase 4 inhibitor, as a potential therapeutic agent for metabolic disorders and multiorgan failure in severe influenza.
      Authors: Yamane, Kazuhiko, Indalao, Irene L, Chida, Junji, Yamamoto, Yoshikaz, Hanawa, Masaaki, Kido, Hiroshi
      PLoS ONE, 2014;9(5):e98032.
      Species: Mouse
      Sample Type: Tissue Homogenates
    59. Improvement of spinal non-viral IL-10 gene delivery by D-mannose as a transgene adjuvant to control chronic neuropathic pain.
      Authors: Dengler E, Alberti L, Bowman B, Kerwin A, Wilkerson J, Moezzi D, Limanovich E, Wallace J, Milligan E
      J Neuroinflammation, 2014;11(0):92.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    60. NF-kappaB signaling modulates radiationinduced microglial activation.
      Authors: Xue J, Dong J, Huang G, Qu X, Wu G, Dong X
      Oncol Rep, 2014;31(6):2555-60.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    61. Akt2 deficiency protects from acute lung injury via alternative macrophage activation and miR-146a induction in mice.
      Authors: Vergadi, Eleni, Vaporidi, Katerina, Theodorakis, Emmanuel, Doxaki, Christin, Lagoudaki, Eleni, Ieronymaki, Elefther, Alexaki, Vassilia, Helms, Mike, Kondili, Eumorfia, Soennichsen, Birte, Stathopoulos, Efstathi, Margioris, Andrew N, Georgopoulos, Dimitrio, Tsatsanis, Christos
      J Immunol, 2014;192(1):394-406.
      Species: Mouse
      Sample Type: BALF
    62. Peripheral surgical wounding and age-dependent neuroinflammation in mice.
      Authors: Xu Z, Dong Y, Wang H, Culley D, Marcantonio E, Crosby G, Tanzi R, Zhang Y, Xie Z
      PLoS ONE, 2014;9(5):e96752.
      Species: Mouse
      Sample Type: Tissue Homogenates
    63. Plasminogen activator inhibitor-1 deficiency ameliorates insulin resistance and hyperlipidemia but not bone loss in obese female mice.
      Authors: Tamura Y, Kawao N, Yano M, Okada K, Matsuo O, Kaji H
      Endocrinology, 2014;155(5):1708-17.
      Species: Mouse
      Sample Type: Plasma
    64. Role of TLR5 and flagella in bacillus intraocular infection.
      Authors: Parkunan, Salai Ma, Astley, Roger, Callegan, Michelle
      PLoS ONE, 2014;9(6):e100543.
      Species: Mouse
      Sample Type: Tissue Homogenates
    65. PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis.
      Authors: Yang L, Xie M, Yang M, Yu Y, Zhu S, Hou W, Kang R, Lotze M, Billiar T, Wang H, Cao L, Tang D
      Nat Commun, 2014;5(0):4436.
      Species: Human
      Sample Type: Cell Culture Supernates
    66. Toll-like receptor 2-mediated innate immune responses against Junin virus in mice lead to antiviral adaptive immune responses during systemic infection and do not affect viral replication in the brain.
      Authors: Cuevas C, Ross S
      J Virol, 2014;88(14):7703-14.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    67. Mitochondrial hyperfusion promotes NF-kappaB activation via the mitochondrial E3 ligase MULAN.
      Authors: Zemirli N, Pourcelot M, Ambroise G, Hatchi E, Vazquez A, Arnoult D
      FEBS J, 2014;281(14):3095-112.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    68. Oncolytic viral therapy with a combination of HF10, a herpes simplex virus type 1 variant and granulocyte-macrophage colony-stimulating factor for murine ovarian cancer.
      Authors: Goshima F, Esaki S, Luo C, Kamakura M, Kimura H, Nishiyama Y
      Int J Cancer, 2014;134(12):2865-77.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    69. Edwardsiella tarda-Induced cytotoxicity depends on its type III secretion system and flagellin.
      Authors: Xie H, Lu J, Rolhion N, Holden D, Nie P, Zhou Y, Yu X
      Infect Immun, 2014;82(8):3436-45.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    70. A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury.
      Authors: Campolo M, Esposito E, Ahmad A, Di Paola R, Wallace J, Cuzzocrea S
      FASEB J, 2013;27(11):4489-99.
      Species: Mouse
      Sample Type: Whole Tissue
    71. Akt Regulates TNFalpha synthesis downstream of RIP1 kinase activation during necroptosis.
      Authors: McNamara C, Ahuja R, Osafo-Addo A, Barrows D, Kettenbach A, Skidan I, Teng X, Cuny G, Gerber S, Degterev A
      PLoS ONE, 2013;8(3):e56576.
      Species: Mouse
      Sample Type: Cell Lysates
    72. Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration.
      Authors: Maina, Virginia, Marrella, Veronica, Mantero, Stefano, Cassani, Barbara, Fontana, Elena, Anselmo, Achille, Del Prete, Annalisa, Sozzani, Silvano, Vezzoni, Paolo, Poliani, Pietro L, Villa, Anna
      J Leukoc Biol, 2013;94(6):1221-30.
      Species: Mouse
      Sample Type: Tissue Homogenates
    73. mTORC1 and mTORC2 play different roles in the functional survival of transplanted adipose-derived stromal cells in hind limb ischemic mice via regulating inflammation in vivo.
      Authors: Fan W, Cheng K, Qin X, Narsinh K, Wang S, Hu S, Wang Y, Chen Y, Wu J, Xiong L, Cao F
      Stem Cells, 2013;31(1):203-14.
      Species: Mouse
      Sample Type: Tissue Homogenates
    74. Inflammation induced by MMP-9 enhances tumor regression of experimental breast cancer.
      Authors: Leifler K, Svensson S, Abrahamsson A, Bendrik C, Robertson J, Gauldie J, Olsson A, Dabrosin C
      J Immunol, 2013;190(8):4420-30.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    75. Enhanced immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to dendritic cells via Dectin-1 by incorporating beta-glucan.
      Authors: Lipinski T, Fitieh A, St Pierre J, Ostergaard H, Bundle D, Touret N
      J Immunol, 2013;190(8):4116-28.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    76. Lyn mitigates mouse airway remodeling by downregulating the TGF-beta3 isoform in house dust mite models.
      Authors: Li G, Fox J, Liu Z, Liu J, Gao G, Jin Y, Gao H, Wu M
      J Immunol, 2013;191(11):5359-70.
      Species: Mouse
      Sample Type: BALF
    77. Antisense oligonucleotide treatment enhances the recovery of acute lung injury through IL-10-secreting M2-like macrophage-induced expansion of CD4+ regulatory T cells.
      Authors: Guo Z, Wen Z, Qin A, Zhou Y, Liao Z, Liu Z, Liang Y, Ren T, Xu L
      J Immunol, 2013;190(8):4337-48.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    78. Treatment of diabetic mice with undenatured whey protein accelerates the wound healing process by enhancing the expression of MIP-1alpha, MIP-2, KC, CX3CL1 and TGF-beta in wounded tissue.
      BMC Immunol., 2012;13(0):32.
      Species: Mouse
      Sample Type: Tissue Homogenates
    79. Endothelial cell peroxisome proliferator-activated receptor gamma reduces endotoxemic pulmonary inflammation and injury.
      Authors: Reddy A, Lakshmi S, Kleinhenz J, Sutliff R, Hart C, Reddy R
      J Immunol, 2012;189(11):5411-20.
      Species: Mouse
      Sample Type: BALF
    80. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance.
      Nat Med, 2012;18(0):1279.
      Species: Mouse
      Sample Type: Serum
    81. A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-kappaB signaling and improves survival in mouse models of sepsis.
      Acta Pharmacol. Sin., 2012;33(9):1204-16.
      Species: Mouse
      Sample Type: Serum
    82. Toll-like receptor-mediated inhibition of Gas6 and ProS expression facilitates inflammatory cytokine production in mouse macrophages.
      Authors: Deng T, Zhang Y, Chen Q, Yan K, Han D
      Immunology, 2012;135(1):40-50.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    83. The axonal guidance receptor neogenin promotes acute inflammation.
      Authors: Konig K, Gatidou D, Granja T, Meier J, Rosenberger P, Mirakaj V
      PLoS ONE, 2012;7(3):e32145.
      Species: Mouse
      Sample Type: Peritoneal Lavage
    84. Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.
      Authors: Owen C, Czopek A, Agouni A, Grant L, Judson R, Lees EK, Mcilroy GD, Goransson O, Welch A, Bence KK, Kahn BB, Neel BG, Mody N, Delibegovic M
      PLoS ONE, 2012;7(2):e32700.
      Species: Mouse
      Sample Type: Serum
    85. Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-kappaB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury.
      J. Cell. Sci., 2012;91(6):921-32.
      Species: Mouse
      Sample Type: BALF
    86. Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance.
      Authors: Ernst MC, Haidl ID, Zúñiga LA, Dranse HJ, Rourke JL, Zabel BA, Butcher EC, Sinal CJ
      Endocrinology, 2012;153(2):672-82.
      Species: Mouse
      Sample Type: Serum
    87. Netrin-1 protects against L-Arginine-induced acute pancreatitis in mice.
      Authors: Chen J, Cai Q, Shen P, Yan R, Wang C, Yang D, Fu H, Chen X
      PLoS ONE, 2012;7(9):e46201.
      Species: Mouse
      Sample Type: Plasma
    88. Salmonella enterica induces joint inflammation and expression of interleukin-17 in draining lymph nodes early after onset of enterocolitis in mice.
      Authors: Noto Llana M, Sarnacki SH, Vazquez MV, Gartner AS, Giacomodonato MN, Cerquetti MC
      Infect. Immun., 2012;80(6):2231-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    89. Stress augments insulin resistance and prothrombotic state: role of visceral adipose-derived monocyte chemoattractant protein-1.
      Authors: Uchida Y, Takeshita K, Yamamoto K, Kikuchi R, Nakayama T, Nomura M, Cheng XW, Egashira K, Matsushita T, Nakamura H, Murohara T
      Diabetes, 2012;61(6):1552-61.
      Species: Mouse
      Sample Type: Serum
    90. Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype.
      Authors: Ylostalo J, Bartosh T, Coble K, Prockop D
      Stem Cells, 2012;30(10):2283-96.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    91. Protein kinase C delta (PKCdelta)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia.
      Authors: Noh KT, Son KH, Jung ID, Kang HK, Hwang SA, Lee WS, You JC, Park YM
      J. Biol. Chem., 2012;287(17):14226-33.
      Species: Mouse
      Sample Type: Serum
    92. Cutting edge: Divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis.
      Authors: Gais P, Reim D, Jusek G, Rossmann-Bloeck T, Weighardt H, Pfeffer K, Altmayr F, Janssen KP, Holzmann B
      J. Immunol., 2012;188(12):5833-7.
      Species: Mouse
      Sample Type: Plasma
    93. The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi.
      Authors: Calderon J, Maganto-Garcia E, Punzon C, Carrion J, Terhorst C, Fresno M
      PLoS Pathog., 2012;8(7):e1002799.
      Species: Mouse
      Sample Type: Serum
    94. Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury.
      Authors: Lee JS, Su X, Rackley C, Matthay MA, Gupta N
      Anat Rec (Hoboken), 2012;294(1):165-72.
      Species: Mouse
      Sample Type: BALF
    95. TLR-mediated distinct IFN-gamma/IL-10 pattern induces protective immunity against murine visceral leishmaniasis.
      Eur. J. Immunol., 2012;42(8):2087-99.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    96. The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria.
      Authors: Ghose P, Ali AQ, Fang R, Forbes D, Ballard B, Ismail N
      J. Immunol., 2011;187(3):1333-46.
      Species: Mouse
      Sample Type: Serum
    97. IL-33-activated dendritic cells are critical for allergic airway inflammation.
      Authors: Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B
      Eur. J. Immunol., 2011;41(6):1675-86.
      Species: Mouse
      Sample Type: BALF
    98. Tumors Suppress In Situ Proliferation of Cytotoxic T Cells by Promoting Differentiation of Gr-1+ Conventional Dendritic Cells through IL-6.
      Authors: Diao J, Zhao J, Winter E
      J. Immunol., 2011;186(9):5058-67.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    99. Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10.
      Authors: Wang H, Cheng F
      J. Immunol., 2011;186(0):3986.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    100. TLR4 through IFN-beta promotes low molecular mass hyaluronan-induced neutrophil apoptosis.
      Authors: Leu SW, Shi L, Xu C, Zhao Y, Liu B, Li Y, Shiedlin A, Xiang C, Shen H, Quinn DA, Hales CA, Zhao H
      J. Immunol., 2011;186(1):556-62.
      Species: Mouse
      Sample Type: BALF
    101. Sterol regulatory element-binding protein 2 (SREBP2) activation after excess triglyceride storage induces chemerin in hypertrophic adipocytes.
      Authors: Bauer S, Wanninger J, Schmidhofer S, Weigert J, Neumeier M, Dorn C, Hellerbrand C, Zimara N, Schaffler A, Aslanidis C, Buechler C
      Endocrinology, 2011;152(1):26-35.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    102. Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice.
      Authors: Kono H, Fujii H, Ogiku M, Hosomura N, Amemiya H, Tsuchiya M, Hara M
      J. Immunol., 2011;187(9):4818-25.
      Species: Mouse
      Sample Type: Serum
    103. Overexpression of sICAM-1 in the Alveolar Epithelial Space Results in an Exaggerated Inflammatory Response and Early Death in Gram Negative Pneumonia.
      Authors: Mendez MP, Monroy YK, Du M
      Respir. Res., 2011;12(1):12.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    104. Differential host determinants contribute to the pathogenesis of 2009 pandemic H1N1 and human H5N1 influenza A viruses in experimental mouse models.
      Authors: Otte A, Sauter M, Alleva L, Baumgarte S, Klingel K, Gabriel G
      Am. J. Pathol., 2011;179(1):230-9.
      Species: Mouse
      Sample Type: Serum
    105. Serotonin activates dendritic cell function in the context of gut inflammation.
      Authors: Li N, Ghia JE, Wang H, McClemens J, Cote F, Suehiro Y, Mallet J, Khan WI
      Am. J. Pathol., 2011;178(2):662-71.
      Species: Mouse
      Sample Type: Tissue Homogenates
    106. Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-kappaB signaling in resident macrophages.
      Authors: Choi H, Lee RH, Bazhanov N, Oh JY, Prockop DJ
      Blood, 2011;118(2):330-8.
      Species: Mouse
      Sample Type: Peritoneal Lavage
    107. Crawling Phagocytes Recruited in the Brain Vasculature after Pertussis Toxin Exposure through IL6, ICAM1 and ITGalphaM.
      Authors: Richard JF, Roy M, Audoy-Remus J, Tremblay P, Vallieres L
      Brain Pathol., 2011;21(0):661.
      Species: Mouse
      Sample Type: Serum
    108. HIF-VEGF pathways are critical for chronic otitis media in Junbo and Jeff mouse mutants.
      Authors: Cheeseman MT, Tyrer HE, Williams D, Hough TA, Pathak P, Romero MR, Hilton H, Bali S, Parker A, Vizor L, Purnell T, Vowell K, Wells S, Bhutta MF, Potter PK, Brown SD
      PLoS Genet., 2011;7(10):e1002336.
      Species: Mouse
      Sample Type: Serum
    109. Deletion of tristetraprolin caused spontaneous reactive granulopoiesis by a non-cell-autonomous mechanism without disturbing long-term hematopoietic stem cell quiescence.
      Authors: Kaplan IM, Morisot S, Heiser D, Cheng WC, Kim MJ, Civin CI
      J. Immunol., 2011;186(5):2826-34.
      Species: Mouse
      Sample Type: Plasma
    110. Repulsive guidance molecule-A (RGM-A) inhibits leukocyte migration and mitigates inflammation.
      Authors: Mirakaj V, Brown S, Laucher S, Steinl C, Klein G, Kohler D, Skutella T, Meisel C, Brommer B, Rosenberger P, Schwab JM
      Proc. Natl. Acad. Sci. U.S.A., 2011;108(16):6555-60.
      Species: Mouse
      Sample Type: Peritoneal Lavage
    111. Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation.
      Authors: Brenneis C, Coste O, Altenrath K, Angioni C, Schmidt H, Schuh CD, Zhang DD, Henke M, Weigert A, Brune B, Rubin B, Nusing R, Scholich K, Geisslinger G
      J. Biol. Chem., 2011;286(3):2331-42.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    112. The adaptor molecule CARD9 is essential for tuberculosis control.
      Authors: Dorhoi A, Desel C, Yeremeev V, Pradl L, Brinkmann V, Mollenkopf HJ, Hanke K, Gross O, Ruland J, Kaufmann SH
      J. Exp. Med., 2011;207(4):777-92.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    113. WNT5A Signaling Contributes to Abeta-Induced Neuroinflammation and Neurotoxicity.
      Authors: Li B, Zhong L, Yang X, Andersson T, Huang M, Tang SJ
      PLoS ONE, 2011;6(8):e22920.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    114. Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice.
      Authors: Alm AS, Li K, Yang D, Andersson R, Lu Y, Wang X
      Cytokine, 2010;49(3):256-63.
      Species: Mouse
      Sample Type: BALF
    115. Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.
      Authors: Massberg S, Grahl L, von Bruehl ML, Manukyan D, Pfeiler S, Goosmann C, Brinkmann V, Lorenz M, Bidzhekov K, Khandagale AB, Konrad I, Kennerknecht E, Reges K, Holdenrieder S, Braun S, Reinhardt C, Spannagl M, Preissner KT, Engelmann B
      Nat. Med., 2010;16(8):887-96.
      Species: Mouse
      Sample Type: Plasma
    116. Microbial exposure early in life regulates airway inflammation in mice after infection with Streptococcus pneumoniae with enhancement of local resistance.
      Authors: Yasuda Y, Matsumura Y, Kasahara K, Ouji N, Sugiura S, Mikasa K, Kita E
      Am. J. Physiol. Lung Cell Mol. Physiol., 2010;298(1):L67-78.
      Species: Mouse
      Sample Type: BALF
    117. Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands.
      Authors: Rao NV, Argyle B, Xu X, Reynolds PR, Walenga JM, Prechel M, Prestwich GD, MacArthur RB, Walters BB, Hoidal JR, Kennedy TP
      Am. J. Physiol., Cell Physiol., 2010;299(1):C97-110.
      Species: Mouse
      Sample Type: BALF
    118. IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitis.
      Authors: Hazlett LD, McClellan SA, Barrett RP, Huang X, Zhang Y, Wu M, Van Rooijen N, Szliter E
      Invest. Ophthalmol. Vis. Sci., 2010;51(3):1524-32.
      Species: Mouse
      Sample Type: Tissue Homogenates
    119. Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance.
      Authors: Kiefer FW, Zeyda M, Gollinger K, Pfau B, Neuhofer A, Weichhart T, Saemann MD, Geyeregger R, Schlederer M, Kenner L, Stulnig TM
      Diabetes, 2010;59(4):935-46.
      Species: Mouse
      Sample Type: Plasma
    120. Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages.
      Authors: Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA
      J. Immunol., 2010;185(4):2044-50.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    121. Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
      Authors: Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Hasler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S
      J. Exp. Med., 2010;207(8):1617-24.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    122. Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene.
      Authors: Sio SW, Moochhala S, Lu J
      Am. J. Respir. Crit. Care Med., 2010;181(1):36-46.
      Species: Mouse
      Sample Type: Tissue Homogenates
    123. eNOS plays a major role in adiponectin synthesis in adipocytes.
      Authors: Koh EH, Kim M, Ranjan KC, Kim HS, Park HS, Oh KS, Park IS, Lee WJ, Kim MS, Park JY, Youn JH, Lee KU
      Am. J. Physiol. Endocrinol. Metab., 2010;298(4):E846-53.
      Species: Mouse
      Sample Type: Plasma
    124. Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma.
      Authors: Veltman JD, Lambers ME, van Nimwegen M
      Br. J. Cancer, 2010;103(5):629-41.
      Species: Mouse
      Sample Type: Peritoneal Fluid
    125. TLR4 is a negative regulator in noninfectious lung inflammation.
      Authors: Zhao H, Leu SW, Shi L, Dedaj R, Zhao G, Garg HG, Shen L, Lien E, Fitzgerald KA, Shiedlin A, Shen H, Quinn DA, Hales CA
      J. Immunol., 2010;184(9):5308-14.
      Species: Mouse
      Sample Type: BALF
    126. Loss of ability to self-heal malaria upon taurine transporter deletion.
      Authors: Delic D, Warskulat U, Borsch E, Al-Qahtani S, Al-Quraishi S, Haussinger D, Wunderlich F
      Infect. Immun., 2010;78(4):1642-9.
      Species: Mouse
      Sample Type: Serum
    127. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes.
      Authors: Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nunez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA
      Nat. Immunol., 2010;11(10):897-904.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    128. Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1.
      Authors: Linke A, Goren I, Bosl MR, Pfeilschifter J, Frank S
      J. Invest. Dermatol., 2010;130(3):866-75.
      Species: Mouse
      Sample Type: Tissue Homogenates
    129. Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia.
      Authors: Schabbauer G, Matt U, Gunzl P, Warszawska J, Furtner T, Hainzl E, Elbau I, Mesteri I, Doninger B, Binder BR, Knapp S
      J. Immunol., 2010;185(1):468-76.
      Species: Mouse
      Sample Type: BALF
    130. Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages.
      Authors: McCoy AJ, Koizumi Y, Toma C, Higa N, Dixit V, Taniguchi S, Tschopp J, Suzuki T
      Eur. J. Immunol., 2010;40(10):2797-803.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    131. Systemic inflammation sensitizes the neonatal brain to excitotoxicity through a pro-/anti-inflammatory imbalance: key role of TNFalpha pathway and protection by etanercept.
      Authors: Aden U, Favrais G, Plaisant F, Winerdal M, Felderhoff-Mueser U, Lampa J, Lelievre V, Gressens P
      Brain Behav. Immun., 2010;24(5):747-58.
      Species: Mouse
      Sample Type: Tissue Homogenates
    132. TLR4 activation is required for IL-17-induced multiple tissue inflammation and wasting in mice.
      Authors: Tang H, Pang S, Wang M
      J. Immunol., 2010;185(4):2563-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    133. S100A8/A9 is not involved in host defense against murine urinary tract infection.
      Authors: Dessing MC, Butter LM, Teske GJ
      PLoS ONE, 2010;5(10):e13394.
      Species: Mouse
      Sample Type: Tissue Homogenates
    134. Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice.
      Authors: Pini M, Fantuzzi G
      J. Leukoc. Biol., 2010;87(1):51-8.
      Species: Mouse
      Sample Type: Peritoneal Lavage
    135. Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model.
      Authors: Ito H, Hoshi M, Ohtaki H, Taguchi A, Ando K, Ishikawa T, Osawa Y, Hara A, Moriwaki H, Saito K, Seishima M
      J. Immunol., 2010;185(8):4554-60.
      Species: Mouse
      Sample Type: Serum
    136. Selective triggering of apoptosis of concanavalin A-activated T cells by fraxinellone for the treatment of T-cell-dependent hepatitis in mice.
      Authors: Sun Y, Qin Y, Gong FY, Wu XF, Hua ZC, Chen T, Xu Q
      Biochem. Pharmacol., 2009;77(11):1717-24.
      Species: Mouse
      Sample Type: Serum
    137. Plasminogen activator inhibitor-1 regulates neutrophil influx during acute pyelonephritis.
      Authors: Roelofs JJ, Teske GJ, Bonta PI, de Vries CJ, Meijers JC, Weening JJ, van der Poll T, Florquin S
      Kidney Int., 2009;75(1):52-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    138. Tumor necrosis factor-alpha and interleukin-1 antagonists alleviate inflammatory skin changes associated with epidermal growth factor receptor antibody therapy in mice.
      Authors: Surguladze D, Deevi D, Claros N, Corcoran E, Wang S, Plym MJ, Wu Y, Doody J, Mauro DJ, Witte L, Busam KJ, Pytowski B, Rodeck U, Tonra JR
      Cancer Res., 2009;69(14):5643-7.
      Species: Mouse
      Sample Type: Tissue Homogenates
    139. Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage.
      Authors: Beraza N, Malato Y, Sander LE, Al-Masaoudi M, Freimuth J, Riethmacher D, Gores GJ, Roskams T, Liedtke C, Trautwein C
      J. Exp. Med., 2009;206(8):1727-37.
      Species: Mouse
      Sample Type: Tissue Homogenates
    140. Anti-inflammatory effects of ethyl acetate fraction from Melilotus suaveolens Ledeb on LPS-stimulated RAW 264.7 cells.
      Authors: Tao JY, Zheng GH, Zhao L, Wu JG, Zhang XY, Zhang SL, Huang ZJ, Xiong FL, Li CM
      J Ethnopharmacol, 2009;123(1):97-105.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    141. Intravenous tolerance modulates macrophage classical activation and antigen presentation in experimental autoimmune encephalomyelitis.
      Authors: Li H, Ciric B, Yang J, Xu H, Fitzgerald DC, Elbehi M, Fonseca-Kelly Z, Yu S, Zhang GX, Rostami A
      J. Neuroimmunol., 2009;208(1):54-60.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    142. Thalidomide protects against ischemic neuronal damage induced by focal cerebral ischemia in mice.
      Authors: Hyakkoku K, Nakajima Y, Izuta H, Shimazawa M, Yamamoto T, Shibata N, Hara H
      Neuroscience, 2009;159(2):760-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    143. Chrysanthemum indicum Linne extract inhibits the inflammatory response by suppressing NF-kappaB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophages.
      Authors: Cheon MS, Yoon T, Lee do Y, Choi G, Moon BC, Lee AY, Choo BK, Kim HK
      J Ethnopharmacol, 2009;122(3):473-7.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    144. Simultaneous absence of surfactant proteins A and D increases lung inflammation and injury after allogeneic HSCT in mice.
      Authors: Gram K, Yang S, Steiner M, Somani A, Hawgood S, Blazar BR, Panoskaltsis-Mortari A, Haddad IY
      Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(2):L167-75.
      Species: Mouse
      Sample Type: BALF
    145. IL-17 receptor signaling is required to control polymicrobial sepsis.
      Authors: Freitas A, Alves-Filho JC, Victoni T, Secher T, Lemos HP, Sonego F, Cunha FQ, Ryffel B
      J. Immunol., 2009;182(12):7846-54.
      Species: Mouse
      Sample Type: Serum
    146. Inhibitory effect of atractylenolide I on angiogenesis in chronic inflammation in vivo and in vitro.
      Authors: Wang C, Duan H, He L
      Eur. J. Pharmacol., 2009;612(1):143-52.
      Species: Mouse
      Sample Type: Air Pouch Exudate
    147. Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids.
      Authors: Mayer K, Kiessling A, Ott J, Schaefer MB, Hecker M, Henneke I, Schulz R, Gunther A, Wang J, Wu L, Roth J, Seeger W, Kang JX
      Am. J. Respir. Crit. Care Med., 2009;179(6):474-83.
      Species: Mouse
      Sample Type: BALF
    148. Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia.
      Authors: Rosenberger P, Schwab JM, Mirakaj V, Masekowsky E, Mager A, Morote-Garcia JC, Unertl K, Eltzschig HK
      Nat. Immunol., 2009;10(2):195-202.
      Species: Mouse
      Sample Type: Serum
    149. T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.
      Authors: Guarda G, Dostert C, Staehli F, Cabalzar K, Castillo R, Tardivel A, Schneider P, Tschopp J
      Nature, 2009;460(7252):269-73.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    150. TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes.
      Authors: Thaxton JE, Romero R, Sharma S
      J. Immunol., 2009;183(2):1144-54.
      Species: Mouse
      Sample Type: Serum
    151. Silencing of TLR4 decreases liver tumor burden in a murine model of colorectal metastasis and hepatic steatosis.
      Authors: Earl TM, Nicoud IB, Pierce JM, Wright JP, Majoras NE, Rubin JE, Pierre KP, Gorden DL, Chari RS
      Ann. Surg. Oncol., 2009;16(4):1043-50.
      Species: Mouse
      Sample Type: Serum
    152. Vasoactive intestinal peptide attenuates concanavalin A-mediated liver injury.
      Authors: Luo Q, Wang Y, Feng D, Xu Y, Xu L
      Eur. J. Pharmacol., 2009;607(1):226-33.
      Species: Mouse
      Sample Type: Plasma
    153. Both FcgammaRIV and FcgammaRIII are essential receptors mediating type II and type III autoimmune responses via FcRgamma-LAT-dependent generation of C5a.
      Authors: Syed SN, Konrad S, Wiege K, Nieswandt B, Nimmerjahn F, Schmidt RE, Gessner JE
      Eur. J. Immunol., 2009;39(12):3343-56.
      Species: Mouse
      Sample Type: BALF
    154. CCL2/MCP-1 controls parasite burden, cell infiltration, and mononuclear activation during acute Trypanosoma cruzi infection.
      Authors: Paiva CN, Figueiredo RT, Kroll-Palhares K, Silva AA, Silverio JC, Gibaldi D, Pyrrho Ados S, Benjamim CF, Lannes-Vieira J, Bozza MT
      J. Leukoc. Biol., 2009;86(5):1239-46.
      Species: Mouse
      Sample Type: Plasma
    155. Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair.
      Authors: Cakarova L, Marsh LM, Wilhelm J, Mayer K, Grimminger F, Seeger W, Lohmeyer J, Herold S
      Am. J. Respir. Crit. Care Med., 2009;180(6):521-32.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    156. Ethyl pyruvate administration inhibits hepatic tumor growth.
      Authors: Liang X, Chavez AR, Schapiro NE, Loughran P, Thorne SH, Amoscato AA, Zeh HJ, Beer-Stolz D, Lotze MT, de Vera ME
      J. Leukoc. Biol., 2009;86(3):599-607.
      Species: Mouse
      Sample Type: Plasma
    157. A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis.
      Authors: Crane DD, Warner SL, Bosio CM
      J. Immunol., 2009;183(7):4593-600.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    158. Bbeta(15-42) protects against acid-induced acute lung injury and secondary pseudomonas pneumonia in vivo.
      Authors: Matt U, Warszawska JM, Bauer M, Dietl W, Mesteri I, Doninger B, Haslinger I, Schabbauer G, Perkmann T, Binder CJ, Reingruber S, Petzelbauer P, Knapp S
      Am. J. Respir. Crit. Care Med., 2009;180(12):1208-17.
      Species: Mouse
      Sample Type: BALF
    159. Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model.
      Authors: Kim DY, Park JW, Jeoung D, Ro JY
      Eur. J. Pharmacol., 2009;612(1):98-105.
      Species: Mouse
      Sample Type: BALF
    160. Combined inhibition of janus kinase 1/2 for the treatment of JAK2V617F-driven neoplasms: selective effects on mutant cells and improvements in measures of disease severity.
      Authors: Liu PC, Caulder E, Li J, Waeltz P, Margulis A, Wynn R, Becker-Pasha M, Li Y, Crowgey E, Hollis G, Haley P, Sparks RB, Combs AP, Rodgers JD, Burn TC, Vaddi K, Fridman JS
      Clin. Cancer Res., 2009;15(22):6891-900.
      Species: Mouse
      Sample Type: Plasma
    161. An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells.
      Authors: Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Kaitani A, Sugiuchi M, Takahashi M, Maehara A, Enomoto Y, Oki T, Takai T, Kitamura T
      J. Immunol., 2009;183(2):925-36.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    162. Secretory lysosome targeting and induced secretion of human soluble TNF-alpha receptor in murine hematopoietic cells in vivo as a principle for immunoregulation in inflammation and malignancy.
      Authors: Johansson AC, Nandakumar KS, Persson AM, Olsson I, Hansson M
      Exp. Hematol., 2009;37(8):969-78.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    163. A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation.
      Authors: Boehme SA, Franz-Bacon K, Chen EP, Sasik R, Sprague LJ, Ly TW, Hardiman G, Bacon KB
      Int. Immunol., 2009;21(1):81-93.
      Species: Mouse
      Sample Type: Tissue Homogenates
    164. VAMP8 is essential in anaphylatoxin-induced degranulation, TNF-alpha secretion, peritonitis, and systemic inflammation.
      Authors: Pushparaj PN, Tay HK, Wang CC, Hong W, Melendez AJ
      J. Immunol., 2009;183(2):1413-8.
      Species: Mouse
      Sample Type: Serum
    165. Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse.
      Authors: Wang S, Wu D, Matthan NR, Lamon-Fava S, Lecker JL, Lichtenstein AH
      Atherosclerosis, 2009;204(1):147-55.
      Species: Mouse
      Sample Type: Plasma
    166. TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity.
      Authors: Johnson TR, Rao S, Seder RA, Chen M, Graham BS
      Vaccine, 2009;27(23):3045-52.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    167. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
      Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
      J. Immunol., 2009;183(2):1291-300.
      Species: Mouse
      Sample Type: BALF
    168. Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines.
      Authors: Hayashida K, Parks WC, Park PW
      Blood, 2009;114(14):3033-43.
      Species: Mouse
      Sample Type: Serum
    169. Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9.
      Authors: Koronyo-Hamaoui M, Ko MK, Koronyo Y, Azoulay D, Seksenyan A, Kunis G, Pham M, Bakhsheshian J, Rogeri P, Black KL, Farkas DL, Schwartz M
      J. Neurochem., 2009;111(6):1409-24.
      Species: Mouse
      Sample Type: Tissue Homogenates
    170. Targeting the chemotactic function of CD147 reduces collagen-induced arthritis.
      Authors: Damsker JM, Okwumabua I, Pushkarsky T, Arora K, Bukrinsky MI, Constant SL
      Immunology, 2009;126(1):55-62.
      Species: Mouse
      Sample Type: Tissue Homogenates
    171. Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model.
      Authors: Kudo H, Takahara T, Yata Y, Kawai K, Zhang W, Sugiyama T
      J. Hepatol., 2009;51(1):168-75.
      Species: Mouse
      Sample Type: Plasma
    172. Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
      Authors: Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini MC, Pallone F, MacDonald TT, Monteleone G
      Blood, 2009;113(15):3512-9.
      Species: Mouse
      Sample Type: Serum
    173. Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury.
      Authors: Feng D, Wang Y, Mei Y, Xu Y, Xu H, Lu Y, Luo Q, Zhou S, Kong X, Xu L
      Lab. Invest., 2009;89(2):222-30.
      Species: Mouse
      Sample Type: Plasma
    174. A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis.
      Authors: Trujillo G, O'Connor EC, Kunkel SL, Hogaboam CM
      Am. J. Pathol., 2008;172(5):1209-21.
      Species: Mouse
      Sample Type: Tissue Homogenates
    175. TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation.
      Authors: Da Silva CA, Hartl D, Liu W, Lee CG, Elias JA
      J. Immunol., 2008;181(6):4279-86.
      Species: Mouse
      Sample Type: BALF
    176. Hypoxia enhances lysosomal TNF-alpha degradation in mouse peritoneal macrophages.
      Authors: Lahat N, Rahat MA, Kinarty A, Weiss-Cerem L, Pinchevski S, Bitterman H
      Am. J. Physiol., Cell Physiol., 2008;295(1):C2-12.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    177. NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity.
      Authors: Divangahi M, Mostowy S, Coulombe F, Kozak R, Guillot L, Veyrier F, Kobayashi KS, Flavell RA, Gros P, Behr MA
      J. Immunol., 2008;181(10):7157-65.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    178. Chemical sympathectomy increases susceptibility to ocular herpes simplex virus type 1 infection.
      Authors: Templeton A, Nguyen G, Ash JD, Straub RH, Carr DJ
      J. Neuroimmunol., 2008;197(1):37-46.
      Species: Mouse
      Sample Type: Tissue Homogenates
    179. Functional roles for C5a receptors in sepsis.
      Authors: Rittirsch D, Flierl MA, Nadeau BA, Day DE, Huber-Lang M, Mackay CR, Zetoune FS, Gerard NP, Cianflone K, Kohl J, Gerard C, Sarma JV, Ward PA
      Nat. Med., 2008;14(5):551-7.
      Species: Mouse
      Sample Type: Plasma
    180. Synthetic chemerin-derived peptides suppress inflammation through ChemR23.
      Authors: Cash JL, Hart R, Russ A, Dixon JP, Colledge WH, Doran J, Hendrick AG, Carlton MB, Greaves DR
      J. Exp. Med., 2008;205(4):767-75.
      Species: Mouse
      Sample Type: Peritoneal Fluid
    181. Tranilast, an orally active anti-allergic drug, up-regulates the anti-inflammatory heme oxygenase-1 expression but down-regulates the pro-inflammatory cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW264.7 macrophages.
      Authors: Pae HO, Jeong SO, Koo BS, Ha HY, Lee KM, Chung HT
      Biochem. Biophys. Res. Commun., 2008;371(3):361-5.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    182. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
      Authors: Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT
      Nat. Immunol., 2008;9(8):857-65.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    183. Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
      Authors: Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A
      Eur. J. Pharmacol., 2008;590(1):400-8.
      Species: Mouse
      Sample Type: Tissue Homogenates
    184. Adverse functions of IL-17A in experimental sepsis.
      Authors: Flierl MA, Rittirsch D, Gao H, Hoesel LM, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ferrara JL, Ward PA
      FASEB J., 2008;22(7):2198-205.
      Species: Mouse
      Sample Type: Plasma
    185. Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses.
      Authors: Son A, Nakamura H, Okuyama H, Oka S, Yoshihara E, Liu W, Matsuo Y, Kondo N, Masutani H, Ishii Y, Iyoda T, Inaba K, Yodoi J
      Eur. J. Immunol., 2008;38(5):1358-67.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    186. The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes.
      Authors: Mabley JG, Pacher P, Murthy KG, Williams W, Southan GJ, Salzman AL, Szabo C
      J. Endocrinol., 2008;198(3):581-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    187. Staphylococcus aureus infection after splenectomy and splenic autotransplantation in BALB/c mice.
      Authors: Teixeira FM, Fernandes BF, Rezende AB, Machado RR, Alves CC, Perobelli SM, Nunes SI, Farias RE, Rodrigues MF, Ferreira AP, Oliveira SC, Teixeira HC
      Clin. Exp. Immunol., 2008;154(2):255-63.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    188. The neuropeptide substance P is a critical mediator of burn-induced acute lung injury.
      Authors: Sio SW, Puthia MK, Lu J, Moochhala S, Bhatia M
      J. Immunol., 2008;180(12):8333-41.
      Species: Mouse
      Sample Type: Tissue Homogenates
    189. Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis.
      Authors: Beraza N, Malato Y, Vander Borght S, Liedtke C, Wasmuth HE, Dreano M, De Vos R, Roskams T, Trautwein C
      Gut, 2008;57(5):655-63.
      Species: Mouse
      Sample Type: Tissue Homogenates
    190. Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection.
      Authors: Di Liberto D, Locati M, Caccamo N, Vecchi A, Meraviglia S, Salerno A, Sireci G, Nebuloni M, Caceres N, Cardona PJ, Dieli F, Mantovani A
      J. Exp. Med., 2008;205(9):2075-84.
      Species: Mouse
      Sample Type: Serum
    191. Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis.
      Authors: Zhang H, Moochhala SM, Bhatia M
      J. Immunol., 2008;181(6):4320-31.
      Species: Mouse
      Sample Type: Tissue Homogenates
    192. Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis.
      Authors: Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ
      J. Immunol., 2008;181(2):1491-8.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    193. The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors.
      Authors: Pobezinskaya YL, Kim YS, Choksi S, Morgan MJ, Li T, Liu C, Liu Z
      Nat. Immunol., 2008;9(9):1047-54.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    194. The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-gamma response.
      Authors: Palma C, Iona E, Giannoni F, Pardini M, Brunori L, Fattorini L, Del Giudice G, Cassone A
      Vaccine, 2008;26(33):4237-43.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    195. CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-kappaB activation.
      Authors: Lee SJ, Nam WD, Na HJ, Cho YL, Ha KS, Hwang JY, Lee H, Kim SO, Kwon YG, Kim YM
      Biochem. Pharmacol., 2008;76(1):79-90.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    196. Recombinant fibrinogenase from Agkistrodon acutus venom protects against sepsis via direct degradation of fibrin and TNF-alpha.
      Authors: Wang R, Qiu P, Jiang W, Cai X, Ou Y, Su X, Cai J, Chen J, Yin W, Yan G
      Biochem. Pharmacol., 2008;76(5):620-30.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    197. The essential role of IFN-gamma in the control of lethal Aggregatibacter actinomycetemcomitans infection in mice.
      Authors: Garlet GP, Cardoso CR, Campanelli AP, Garlet TP, Avila-Campos MJ, Cunha FQ, Silva JS
      Microbes Infect., 2008;10(5):489-96.
      Species: Mouse
      Sample Type: Tissue Homogenates
    198. Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion.
      Authors: Leoni G, Patel HB, Sampaio AL, Gavins FN, Murray JF, Grieco P, Getting SJ, Perretti M
      FASEB J., 2008;22(12):4228-38.
      Species: Mouse
      Sample Type: Plasma
    199. Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokines.
      Authors: Olleros ML, Martin ML, Vesin D, Fotio AL, Santiago-Raber ML, Rubbia-Brandt L, Spahr L, Hadengue A, Garcia I
      Cytokine, 2008;44(1):118-25.
      Species: Mouse
      Sample Type: Serum
    200. Suppression of activation and induction of apoptosis in RAW264.7 cells by amniotic membrane extract.
      Authors: He H, Li W, Chen SY, Zhang S, Chen YT, Hayashida Y, Zhu YT, Tseng SC
      Invest. Ophthalmol. Vis. Sci., 2008;49(10):4468-75.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    201. Purine receptor antagonist modulates serology and affective behaviors in lupus-prone mice: evidence of autoimmune-induced pain?
      Authors: Ballok DA, Sakic B
      Brain Behav. Immun., 2008;0(0):.
      Species: Mouse
      Sample Type: Serum
    202. CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia.
      Authors: Su X, Johansen M, Looney MR, Brown EJ, Matthay MA
      J. Immunol., 2008;180(10):6947-53.
      Species: Mouse
      Sample Type: BALF
    203. Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance.
      Authors: Ashare A, Nymon AB, Doerschug KC, Morrison JM, Monick MM, Hunninghake GW
      Am. J. Respir. Crit. Care Med., 2008;178(2):149-57.
      Species: Mouse
      Sample Type: Tissue Homogenates
    204. Peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J2, reduces neutrophil migration via a nitric oxide pathway.
      Authors: Napimoga MH, Vieira SM, Dal-Secco D, Freitas A, Souto FO, Mestriner FL, Alves-Filho JC, Grespan R, Kawai T, Ferreira SH, Cunha FQ
      J. Immunol., 2008;180(1):609-17.
      Species: Mouse
      Sample Type: Tissue Secretion
    205. Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury.
      Authors: Batkai S, Osei-Hyiaman D, Pan H, El-Assal O, Rajesh M, Mukhopadhyay P, Hong F, Harvey-White J, Jafri A, Hasko G, Huffman JW, Gao B, Kunos G, Pacher P
      FASEB J., 2007;21(8):1788-800.
      Species: Mouse
      Sample Type: Tissue Homogenates
    206. Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk.
      Authors: Ryu M, Kim EH, Chun M, Kang S, Shim B, Yu YB, Jeong G, Lee JS
      J Ethnopharmacol, 2007;115(2):184-93.
      Species: Mouse
      Sample Type: Air Pouch Exudate
    207. Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin.
      Authors: Rebholz B, Haase I, Eckelt B, Paxian S, Flaig MJ, Ghoreschi K, Nedospasov SA, Mailhammer R, Debey-Pascher S, Schultze JL, Weindl G, Forster I, Huss R, Stratis A, Ruzicka T, Rocken M, Pfeffer K, Schmid RM, Rupec RA
      Immunity, 2007;27(2):296-307.
      Species: Mouse
      Sample Type: Serum
    208. GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS.
      Authors: Berclaz PY, Carey B, Fillipi MD, Wernke-Dollries K, Geraci N, Cush S, Richardson T, Kitzmiller J, O&amp;amp;apos;Connor M, Hermoyian C, Korfhagen T, Whitsett JA, Trapnell BC
      Am. J. Respir. Cell Mol. Biol., 2007;36(1):114-21.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    209. Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies.
      Authors: Takemura Y, Ouchi N, Shibata R, Aprahamian T, Kirber MT, Summer RS, Kihara S, Walsh K
      J. Clin. Invest., 2007;117(2):375-86.
      Species: Mouse
      Sample Type: Peritoneal Lavage
    210. Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis.
      Authors: Bullard DC, Hu X, Schoeb TR, Collins RG, Beaudet AL, Barnum SR
      J. Immunol., 2007;178(2):851-7.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    211. Viral infection of the lungs through the eye.
      Authors: Bitko V, Musiyenko A, Barik S
      J. Virol., 2007;81(2):783-90.
      Species: Mouse
      Sample Type: Tissue Homogenates
    212. Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice.
      Authors: Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Flaherty KR, Martinez FJ, Hogaboam CM
      Am. J. Pathol., 2007;170(4):1152-64.
      Species: Mouse
      Sample Type: Tissue Homogenates
    213. Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi.
      Authors: Medeiros MM, Peixoto JR, Oliveira AC, Cardilo-Reis L, Koatz VL, Van Kaer L, Previato JO, Mendonca-Previato L, Nobrega A, Bellio M
      J. Leukoc. Biol., 2007;82(3):488-96.
      Species: Mouse
      Sample Type: Peritoneal Fluid
    214. Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeability.
      Authors: Geny B, Khun H, Fitting C, Zarantonelli L, Mazuet C, Cayet N, Szatanik M, Prevost MC, Cavaillon JM, Huerre M, Popoff MR
      Am. J. Pathol., 2007;170(3):1003-17.
      Species: Mouse
      Sample Type: Serum
    215. Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in Ehrlichia-induced immunopathology in murine ehrlichiosis.
      Authors: Ismail N, Crossley EC, Stevenson HL, Walker DH
      Infect. Immun., 2007;75(9):4608-20.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    216. The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro.
      Authors: Yeh CC, Kao SJ, Lin CC, Wang SD, Liu CJ, Kao ST
      Life Sci., 2007;80(20):1821-31.
      Species: Mouse
      Sample Type: BALF
    217. Identification of an immune-responsive mesolimbocortical serotonergic system: potential role in regulation of emotional behavior.
      Authors: Lowry CA, Hollis JH, de Vries A, Pan B, Brunet LR, Hunt JR, Paton JF, van Kampen E, Knight DM, Evans AK, Rook GA, Lightman SL
      Neuroscience, 2007;146(2):756-72.
      Species: Mouse
      Sample Type: Plasma
    218. The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells.
      Authors: Fujita H, Asahina A, Komine M, Tamaki K
      Cell. Immunol., 2007;245(2):70-9.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    219. Suppression of established experimental autoimmune uveitis by anti-LFA-1alpha Ab.
      Authors: Ke Y, Sun D, Zhang P, Jiang G, Kaplan HJ, Shao H
      Invest. Ophthalmol. Vis. Sci., 2007;48(6):2667-75.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    220. TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways.
      Authors: Shigeoka AA, Holscher TD, King AJ, Hall FW, Kiosses WB, Tobias PS, Mackman N, McKay DB
      J. Immunol., 2007;178(10):6252-8.
      Species: Mouse
      Sample Type: Tissue Homogenates
    221. Antipsoriatic effects of avarol-3'-thiosalicylate are mediated by inhibition of TNF-alpha generation and NF-kappaB activation in mouse skin.
      Authors: Amigo M, Paya M, De Rosa S, Terencio MC
      Br. J. Pharmacol., 2007;152(3):353-65.
      Species: Mouse
      Sample Type: Air Pouch Exudate
    222. Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma.
      Authors: Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, Cohn L, Simon AR
      J. Immunol., 2007;178(10):6191-9.
      Species: Mouse
      Sample Type: BALF
    223. Cathelicidin-deficient (Cnlp -/- ) mice show increased susceptibility to Pseudomonas aeruginosa keratitis.
      Authors: Huang LC, Reins RY, Gallo RL, McDermott AM
      Invest. Ophthalmol. Vis. Sci., 2007;48(10):4498-508.
      Species: Mouse
      Sample Type: Tissue Homogenates
    224. Neuronal NF-kappaB influences thermoregulation and survival in a sepsis model.
      Authors: Juttler E, Inta I, Eigler V, Herrmann O, Maegele I, Maser-Gluth C, Schwaninger M
      J. Neuroimmunol., 2007;189(1):41-9.
      Species: Mouse
      Sample Type: Serum
    225. Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis.
      Authors: Rajesh M, Pan H, Mukhopadhyay P, Batkai S, Osei-Hyiaman D, Hasko G, Liaudet L, Gao B, Pacher P
      J. Leukoc. Biol., 2007;82(6):1382-9.
      Species: Mouse
      Sample Type: Plasma
    226. Soluble vascular endothelial growth factor receptor-1 protects mice in sepsis.
      Authors: Tsao PN, Chan FT, Wei SC, Hsieh WS, Chou HC, Su YN, Chen CY, Hsu WM, Hsieh FJ, Hsu SM
      Crit. Care Med., 2007;35(8):1955-60.
      Species: Mouse
      Sample Type: Plasma
    227. Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice.
      Authors: Robertson SA, Care AS, Skinner RJ
      Biol. Reprod., 2007;76(5):738-48.
      Species: Mouse
      Sample Type: Serum
    228. Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice.
      Authors: Tang CH, Hsu TL, Lin WW, Lai MZ, Yang RS, Hsieh SL, Fu WM
      J. Biol. Chem., 2007;282(4):2346-54.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    229. The flavonoid baicalin protects against cerebrovascular dysfunction and brain inflammation in experimental heatstroke.
      Authors: Chang CP, Huang WT, Cheng BC, Hsu CC, Lin MT
      Neuropharmacology, 2007;52(3):1024-33.
      Species: Mouse
      Sample Type: Serum
    230. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice.
      Authors: Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA
      J. Immunol., 2007;179(3):1855-63.
      Species: Mouse
      Sample Type: BALF
    231. Mice lacking NKCC1 are protected from development of bacteremia and hypothermic sepsis secondary to bacterial pneumonia.
      Authors: Nguyen M, Pace AJ, Koller BH
      J. Exp. Med., 2007;204(6):1383-93.
      Species: Mouse
      Sample Type: Tissue Homogenates
    232. Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells.
      Authors: Kurooka M, Kaneda Y
      Cancer Res., 2007;67(1):227-36.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    233. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration.
      Authors: Qin L, Wu X, Block ML, Liu Y, Breese GR, Hong JS, Knapp DJ, Crews FT
      Glia, 2007;55(5):453-62.
      Species: Mouse
      Sample Type: Serum
    234. Cell-based angiopoietin-1 gene therapy for acute lung injury.
      Authors: McCarter SD, Mei SH, Lai PF, Zhang QW, Parker CH, Suen RS, Hood RD, Zhao YD, Deng Y, Han RN, Dumont DJ, Stewart DJ
      Am. J. Respir. Crit. Care Med., 2007;175(10):1014-26.
      Species: Mouse
      Sample Type: BALF
    235. Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection.
      Authors: Gregory AD, Hogue LA, Ferkol TW, Link DC
      Blood, 2007;109(8):3235-43.
      Species: Mouse
      Sample Type: Epithelial Fluid
    236. CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease.
      Authors: Hollingsworth JW, Li Z, Brass DM, Garantziotis S, Timberlake SH, Kim A, Hossain I, Savani RC, Schwartz DA
      Am. J. Respir. Cell Mol. Biol., 2007;37(2):248-53.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    237. Role of ADAM17 in the ectodomain shedding of TNF-alpha and its receptors by neutrophils and macrophages.
      Authors: Bell JH, Herrera AH, Li Y, Walcheck B
      J. Leukoc. Biol., 2007;82(1):173-6.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    238. Cathepsin-G interferes with clearance of Pseudomonas aeruginosa from mouse lungs.
      Authors: Sedor J, Hogue L, Akers K, Boslaugh S, Schreiber J, Ferkol T
      Pediatr. Res., 2007;61(1):26-31.
      Species: Mouse
      Sample Type: BALF
    239. The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality.
      Authors: Amaral FA, Fagundes CT, Guabiraba R, Vieira AT, Souza AL, Russo RC, Soares MP, Teixeira MM, Souza DG
      Am. J. Pathol., 2007;171(6):1887-93.
      Species: Mouse
      Sample Type: Serum
    240. Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion.
      Authors: Kaczorowski DJ, Nakao A, Mollen KP, Vallabhaneni R, Sugimoto R, Kohmoto J, Tobita K, Zuckerbraun BS, McCurry KR, Murase N, Billiar TR
      Transplantation, 2007;84(10):1279-87.
      Species: Mouse
      Sample Type: Serum
    241. CD14 is an essential mediator of LPS-induced airway disease.
      Authors: Brass DM, Hollingsworth JW, McElvania-TeKippe E, Garantziotis S, Hossain I, Schwartz DA
      Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(1):L77-83.
      Species: Mouse
      Sample Type: BALF
    242. Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation.
      Authors: Card JW, Carey MA, Bradbury JA, DeGraff LM, Morgan DL, Moorman MP, Flake GP, Zeldin DC
      J. Immunol., 2006;177(1):621-30.
      Species: Mouse
      Sample Type: BALF
    243. The shedding activity of ADAM17 is sequestered in lipid rafts.
      Authors: Tellier E, Rebsomen L
      Exp. Cell Res., 2006;312(20):3969-80.
      Species: Mouse
      Sample Type: Tissue Homogenates
    244. Vaccinia virus infection attenuates innate immune responses and antigen presentation by epidermal dendritic cells.
      Authors: Deng L, Dai P, Ding W, Granstein RD, Shuman S
      J. Virol., 2006;80(20):9977-87.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    245. MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis.
      Authors: Hegen M, Gaestel M, Nickerson-Nutter CL, Lin LL, Telliez JB
      J. Immunol., 2006;177(3):1913-7.
      Species: Mouse
      Sample Type: Serum
    246. Effects of bicyclol on dimethylnitrosamine-induced liver fibrosis in mice and its mechanism of action.
      Authors: Hu QW, Liu GT
      Life Sci., 2006;79(6):606-12.
      Species: Mouse
      Sample Type: Serum
    247. Tumor necrosis factor receptor deficiency exacerbated Adriamycin-induced cardiomyocytes apoptosis: an insight into the Fas connection.
      Authors: Lien YC, Lin SM, Nithipongvanitch R, Oberley TD, Noel T, Zhao Q, Daosukho C, St Clair DK
      Mol. Cancer Ther., 2006;5(2):261-9.
      Species: Mouse
      Sample Type: Serum
    248. A functional comparison of canine and murine bone marrow derived cultured mast cells.
      Authors: Lin TY, London CA,
      Vet. Immunol. Immunopathol., 2006;114(3):320-34.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    249. Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice.
      Authors: Jacomy H, Fragoso G, Almazan G, Mushynski WE, Talbot PJ
      Virology, 2006;349(2):335-46.
      Species: Rat
      Sample Type: Cell Culture Supernates
    250. Effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase, in a mouse model of acute pancreatitis induced by cerulein.
      Authors: Mazzon E, Genovese T, Di Paola R, Muia C, Crisafulli C, Malleo G, Esposito E, Meli R, Sessa E, Cuzzocrea S
      Eur. J. Pharmacol., 2006;549(1):149-56.
      Species: Mouse
      Sample Type: Tissue Homogenates
    251. Type I IFN modulates host defense and late hyperinflammation in septic peritonitis.
      Authors: Weighardt H, Kaiser-Moore S, Schlautkotter S, Rossmann-Bloeck T, Schleicher U, Bogdan C, Holzmann B
      J. Immunol., 2006;177(8):5623-30.
      Species: Mouse
      Sample Type: Peritoneal Lavage
    252. Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice.
      Authors: Robertson SA, Skinner RJ, Care AS
      J. Immunol., 2006;177(7):4888-96.
      Species: Mouse
      Sample Type: Serum
    253. CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome.
      Authors: Wieland CW, Kerver ME, Florquin S, Nolte MA, Borst J, van Lier R, van Oers MH, van der Poll T
      Int. Immunol., 2006;18(11):1531-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    254. The urokinase plasminogen activator receptor is crucially involved in host defense during acute pyelonephritis.
      Authors: Roelofs JJ, Rouschop KM, Teske GJ, Claessen N, Weening JJ, van der Poll T, Florquin S
      Kidney Int., 2006;70(11):1942-7.
      Species: Mouse
      Sample Type: Tissue Homogenates
    255. Delayed inflammatory responses to endotoxin in fibrinogen-deficient mice.
      Authors: Cruz-Topete D, Iwaki T, Ploplis VA, Castellino FJ
      J. Pathol., 2006;210(3):325-33.
      Species: Mouse
      Sample Type: Plasma
    256. Rubus coreanus Miq. extract promotes osteoblast differentiation and inhibits bone-resorbing mediators in MC3T3-E1 cells.
      Authors: Lee KH, Choi EM
      Am. J. Chin. Med., 2006;34(4):643-54.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    257. Inhalation of ultrafine carbon particles triggers biphasic pro-inflammatory response in the mouse lung.
      Authors: Andre E, Stoeger T, Takenaka S, Bahnweg M, Ritter B, Karg E, Lentner B, Reinhard C, Schulz H, Wjst M
      Eur. Respir. J., 2006;28(2):275-85.
      Species: Mouse
      Sample Type: BALF
    258. The macrophage scavenger receptor SR-AI/II and lung defense against pneumococci and particles.
      Authors: Arredouani MS, Yang Z, Imrich A, Ning Y, Qin G, Kobzik L
      Am. J. Respir. Cell Mol. Biol., 2006;35(4):474-8.
      Species: Mouse
      Sample Type: BALF
    259. Impact of the loss of Hoxa5 function on lung alveogenesis.
      Authors: Mandeville I, Aubin J, Leblanc M, Lalancette-Hebert M, Janelle MF, Tremblay GM, Jeannotte L
      Am. J. Pathol., 2006;169(4):1312-27.
      Species: Mouse
      Sample Type: BALF
    260. Tetrathiomolybdate is effective in a mouse model of arthritis.
      Authors: McCubbin MD, Hou G, Abrams GD, Dick R, Brewer GJ
      J. Rheumatol., 2006;33(12):2501-6.
      Species: Mouse
      Sample Type: Serum
    261. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.
      Authors: Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW, Biswal S
      J. Clin. Invest., 2006;116(4):984-95.
      Species: Mouse
      Sample Type: Serum
    262. Altered postnatal lung development in C3H/HeJ mice.
      Authors: Sampath V, Davis K, Senft AP, Richardson TR, Kitzmiller JA, Berclaz PY, Korfhagen TR
      Pediatr. Res., 2006;60(6):663-8.
      Species: Mouse
      Sample Type: Tissue Homogenates
    263. Leukocyte-derived IL-10 reduces subepithelial fibrosis associated with chronically inhaled endotoxin.
      Authors: Garantziotis S, Brass DM, Savov J, Hollingsworth JW, McElvania-TeKippe E, Berman K, Walker JK, Schwartz DA
      Am. J. Respir. Cell Mol. Biol., 2006;35(6):662-7.
      Species: Mouse
      Sample Type: BALF
    264. The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment.
      Authors: Burch LH, Yang IV, Whitehead GS, Chao FG, Berman KG, Schwartz DA
      Am. J. Physiol. Lung Cell Mol. Physiol., 2006;291(4):L677-82.
      Species: Mouse
      Sample Type: BALF
    265. Induction of innate immunity against herpes simplex virus type 2 infection via local delivery of Toll-like receptor ligands correlates with beta interferon production.
      Authors: Gill N, Deacon PM, Lichty B, Mossman KL, Ashkar AA
      J. Virol., 2006;80(20):9943-50.
      Species: Mouse
      Sample Type: Vaginal Lavage
    266. Role of peroxisome proliferator-activated receptor-alpha in acute pancreatitis induced by cerulein.
      Authors: Genovese T, Mazzon E, Di Paola R, Muia C, Crisafulli C, Malleo G, Esposito E, Cuzzocrea S
      Immunology, 2006;118(4):559-70.
      Species: Mouse
      Sample Type: Plasma
    267. Bim deficiency leads to exacerbation and prolongation of joint inflammation in experimental arthritis.
      Authors: Scatizzi JC, Bickel E, Hutcheson J, Haines GK, Perlman H
      Arthritis Rheum., 2006;54(10):3182-93.
      Species: Mouse
      Sample Type: Tissue Homogenates
    268. Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis.
      Authors: Nemeth ZH, Csoka B, Wilmanski J, Xu D, Lu Q, Ledent C, Deitch EA, Pacher P, Spolarics Z, Hasko G
      J. Immunol., 2006;176(9):5616-26.
      Species: Mouse
      Sample Type: Plasma
    269. GM-CSF and the impaired pulmonary innate immune response following hyperoxic stress.
      Authors: Baleeiro CE, Christensen PJ, Morris SB, Mendez MP, Wilcoxen SE, Paine R
      Am. J. Physiol. Lung Cell Mol. Physiol., 2006;291(6):L1246-55.
      Species: Mouse
      Sample Type: Tissue Homogenates
    270. Contribution of T cell subsets to the pathophysiology of Pneumocystis-related immunorestitution disease.
      Authors: Bhagwat SP, Gigliotti F, Xu H, Wright TW
      Am. J. Physiol. Lung Cell Mol. Physiol., 2006;291(6):L1256-66.
      Species: Mouse
      Sample Type: BALF
    271. The differential effects of low dose and high dose concanavalin A on cytokine profile and their importance in liver injury.
      Authors: Xu X, Wei H, Dong Z, Chen Y, Tian Z
      Inflamm. Res., 2006;55(4):144-52.
    272. Endogenous interleukin-12 improves the early antimicrobial host response to murine Escherichia coli peritonitis.
      Authors: Weijer S, Florquin S, van der Poll T
      Shock, 2005;23(1):54-8.
      Species: Mouse
      Sample Type: Peritoneal Fluid
    273. A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).
      Authors: Biswas SK, Gangi L, Paul S, Schioppa T, Saccani A, Sironi M, Bottazzi B, Doni A, Vincenzo B, Pasqualini F, Vago L, Nebuloni M, Mantovani A, Sica A
      Blood, 2005;107(5):2112-22.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    274. Intranasal exposure to Stachybotrys chartarum enhances airway inflammation in allergic mice.
      Authors: Leino MS, Alenius HT, Fyhrquist-Vanni N, Wolff HJ, Reijula KE, Hintikka EL, Salkinoja-Salonen MS, Haahtela T, Mäkelä MJ
      Am. J. Respir. Crit. Care Med., 2005;173(5):512-8.
      Species: Mouse
      Sample Type: BALF
    275. Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580.
      Authors: Conway JG, Conway&lt;/LastName&gt;&lt;ForeNam JG&lt;/Initia, McDonald B, Parham J, Keith B, Rusnak DW, Shaw E, Jansen M, Lin P, Payne A, Crosby RM, Johnson JH, Frick L, Lin MH, Depee S, Tadepalli S, Votta B, James I, Fuller K, Chambers TJ, Kull FC, Chamberlain SD, Hutchins JT
      Proc. Natl. Acad. Sci. U.S.A., 2005;102(44):16078-83.
      Species: Mouse
      Sample Type: Plasma
    276. Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation.
      Authors: Sergejeva S, Ivanov S, Lotvall J, Linden A
      Am. J. Respir. Cell Mol. Biol., 2005;33(3):248-53.
    277. Antibody-bound beta-amyloid precursor protein stimulates the production of tumor necrosis factor-alpha and monocyte chemoattractant protein-1 by cortical neurons.
      Authors: Gonzalez de Aguilar JL, Dupuis L, Larmet Y
      Neurobiol. Dis., 2005;19(1):129-41.
      Species: Mouse
      Sample Type: Cell Lysates
    278. Vaccination of apoptotic Fas ligand-expressing tumors decreased antitumor responses by enhanced production of immunosuppressive cytokines.
      Authors: Wada A, Tada Y, Shimozato O, Takiguchi Y, Tatsumi K, Kuriyama T, Tagawa M
      Anticancer Res., 2005;25(1):299-303.
      Species: Mouse
      Sample Type: Tissue Secretion
    279. Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts.
      Authors: Tanaka M, Terry RD, Mokhtari GK, Inagaki K, Koyanagi T, Kofidis T, Mochly-Rosen D, Robbins RC
      Circulation, 2004;110(11):II194-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    280. Cytokine expression in experimental chronic otitis media with effusion in mice.
      Authors: Maeda K, Hirano T, Ichimiya I, Kurono Y, Suzuki M, Mogi G
      Laryngoscope, 2004;114(11):1967-72.
      Species: Mouse
      Sample Type: Tissue Secretion
    281. Estrogen regulates the production of VEGF for osteoclast formation and activity in op/op mice.
      Authors: Kodama I, Sanada M, Yoshiko Y, Tsuda M, Ohama K
      J. Bone Miner. Res., 2004;19(2):200-6.
      Species: Mouse
      Sample Type: Serum
    282. Thyrocytes isolated from autoimmune-diseased thyroids secrete soluble tumor necrosis factor-R1 that is related to their elevated protein kinase C activity.
      Authors: LaBue M, Colburn KK, Green LM
      Thyroid, 2004;14(4):249-62.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    283. Increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P. acnes.
      Authors: Megid J, Kaneno R, Nozaki CN, Brito CJ, Almeida MF
      Comp. Immunol. Microbiol. Infect. Dis., 2004;27(6):393-411.
      Species: Mouse
      Sample Type: Serum
    284. Systemic up-regulation of sTNFR2 and IL-6 in Porphyromonas gingivalis pneumonia in mice.
      Authors: Petelin M, Naruishi K, Shiomi N, Mineshiba J, Arai H, Nishimura F, Takashiba S, Murayama Y
      Exp. Mol. Pathol., 2004;76(1):76-81.
      Species: Mouse
      Sample Type: Serum
    285. Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome.
      Authors: Hildebrandt GC, Corrion LA, Olkiewicz KM, Lu B, Lowler K, Duffner UA, Moore BB, Kuziel WA, Liu C, Cooke KR
      J. Immunol., 2004;173(3):2050-9.
      Species: Mouse
      Sample Type: Serum
    286. The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis.
      Authors: Cotena A, Platt N
      J. Immunol., 2004;173(10):6427-32.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    287. Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma.
      Authors: Virag L, Bai P, Bak I, Pacher P, Mabley JG, Liaudet L, Bakondi E, Gergely P, Kollai M, Szabo C
      Med. Sci. Monit., 2004;10(3):BR77-83.
      Species: Mouse
      Sample Type: BALF
    288. T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis.
      Authors: Hao Z, Hampel B, Yagita H, Rajewsky K
      J. Exp. Med., 2004;199(10):1355-65.
      Species: Mouse
      Sample Type: Serum
    289. A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation.
      Authors: Hildebrandt GC, Duffner UA, Olkiewicz KM, Corrion LA, Willmarth NE, Williams DL, Clouthier SG, Hogaboam CM, Reddy PR, Moore BB, Kuziel WA, Liu C, Yanik G, Cooke KR
      Blood, 2004;103(6):2417-26.
      Species: Mouse
      Sample Type: BALF
    290. Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow.
      Authors: Bleier JI, Pillarisetty VG, Shah AB, DeMatteo RP
      J. Immunol., 2004;172(12):7408-16.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    291. IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger.
      Authors: Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A
      J. Immunol., 2003;170(4):2106-12.
      Species: Mouse
      Sample Type: BALF
    292. Extracellular ubiquitin inhibits the TNF-alpha response to endotoxin in peripheral blood mononuclear cells and regulates endotoxin hyporesponsiveness in critical illness.
      Authors: Majetschak M, Krehmeier U, Bardenheuer M, Denz C, Quintel M, Voggenreiter G, Obertacke U
      Blood, 2003;101(5):1882-90.
      Species: Mouse
      Sample Type: Plasma
    293. Dual roles of IL-4 in lung injury and fibrosis.
      Authors: Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH
      J. Immunol., 2003;170(4):2083-92.
      Species: Mouse
      Sample Type: Serum
    294. Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia.
      Authors: Pawlinski R, Pedersen B, Schabbauer G, Tencati M, Holscher T, Boisvert W, Andrade-Gordon P, Frank RD, Mackman N
      Blood, 2003;103(4):1342-7.
      Species: Mouse
      Sample Type: Plasma
    295. Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis.
      Authors: Zwijnenburg PJ, van der Poll T, Florquin S, Roord JJ, van Furth AM
      Infect. Immun., 2003;71(4):2276-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    296. First-generation adenovirus vectors shorten survival time in a murine model of sepsis.
      Authors: Doerschug K, Sanlioglu S, Flaherty DM, Wilson RL, Yarovinsky T, Monick MM, Engelhardt JF, Hunninghake GW
      J. Immunol., 2002;169(11):6539-45.
      Species: Mouse
      Sample Type: Serum
    297. Overexpression of extracellular superoxide dismutase decreases lung injury after exposure to oil fly ash.
      Authors: Ghio AJ, Suliman HB, Carter JD, Abushamaa AM, Folz RJ
      Am. J. Physiol. Lung Cell Mol. Physiol., 2002;283(1):L211-8.
      Species: Mouse
      Sample Type: Tracheal Lavage
    298. Endogenous granulocyte-macrophage colony-stimulating factor overexpression in vivo results in the long-term recruitment of a distinct dendritic cell population with enhanced immunostimulatory function.
      Authors: Miller G, Pillarisetty VG, Shah AB, Lahrs S, Xing Z, DeMatteo RP
      J. Immunol., 2002;169(6):2875-85.
      Species: Mouse
      Sample Type: Serum
    299. Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection.
      Authors: Weighardt H, Kaiser-Moore S, Vabulas RM, Kirschning CJ, Wagner H, Holzmann B
      J. Immunol., 2002;169(6):2823-7.
      Species: Mouse
      Sample Type: Serum
    300. The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice.
      Authors: Fierer J, Swancutt MA, Heumann D, Golenbock D
      J. Immunol., 2002;168(12):6396-403.
      Species: Mouse
      Sample Type: Interperitoneal Fluid
    301. Resident cell chemokine expression serves as the major mechanism for leukocyte recruitment during local inflammation.
      Authors: Garcia-Ramallo E, Marques T, Prats N, Beleta J, Kunkel SL, Godessart N
      J. Immunol., 2002;169(11):6467-73.
      Species: Mouse
      Sample Type: Air Pouch Exudate
    302. The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls.
      Authors: Hanisch UK, Prinz M, Angstwurm K, Hausler KG, Kann O, Kettenmann H, Weber JR
      Eur. J. Immunol., 2001;31(7):2104-15.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    303. Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease.
      Authors: Alpdogan O, Schmaltz C, Muriglan SJ, Kappel BJ, Perales MA, Rotolo JA, Halm JA, Rich BE, van den Brink MR
      Blood, 2001;98(7):2256-65.
      Species: Mouse
      Sample Type: Serum
    304. Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression.
      Authors: Medvedev AE, Kopydlowski KM, Vogel SN
      J. Immunol., 2000;164(11):5564-74.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    305. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.
      Authors: Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Schaefer R, Grone HJ, Schaefer L
      J Biol Chem, 0;284(36):24035-48.
      Species: Mouse
      Sample Type: Plasma
    Expand to show all 305 Citations
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    Sample TestedRAW 264.7 mouse monocyte/macrophage cell line

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