Proteome Profiler Human Phospho-MAPK Array Kit (ARY002B): R&D Systems
Proteome Profiler Human Phospho-MAPK Array Kit

A membrane-based antibody array for the parallel determination of the relative phosphorylation of human mitogen-activated protein kinases.

Validated for analyte detection in cell lysates.

Key Benefits

  • Detects phosphorylation of 26 human kinases simultaneously
  • Requires no specialized equipment
 

Principle of the Assay

The Proteome Profiler Human Phospho-MAPK Array Kit is a membrane-based sandwich immunoassay. Samples are mixed with a cocktail of biotinylated phospho-specific detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2). Captured proteins are visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount phosphorylation in the bound analyte.

Why Use an Antibody Array to Detect Receptor Phosphorylation?

Determining the phosphorylation of multiple kinases in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.

 

Kit Contents
  • 4-Array Membranes
  • 4-Well Multi-dish
  • Lysis Buffer
  • Array Buffers
  • Wash Buffer
  • Detection Antibody Cocktail
  • Streptavidin-HRP
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed product datasheet with protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Simultaneously detect the relative phosphorylation of these of these kinases in a single sample.
Akt1 HSP27 p38 beta
Akt2 JNK1 p38 delta
Akt3 JNK2 p38 gamma
Akt pan JNK3 p53
CREB JNK pan p70 S6K
ERK1 MKK3 RSK1
ERK2 MKK6 RSK2
GSK-3 alpha/beta MSK2 TOR
GSK-3 beta p38 alpha  

Assays for analytes represented in the Human Phospho-MAPK Array Kit

Analyte DuoSet® IC ELISA Development System (Total) DuoSet® IC ELISA Development Systems (Phospho) Cell-based ELISA Kits Surveyor™ IC ELISA Kits
Akt1 (S473) DYC1775 DYC2289C    
Akt2 (S474) DYC2315      
Akt3 (S472)        
Akt pan (S473, S474, S472) DYC887B KCB887 SUV887B  
CREB (S133)   DYC2510 KCB2510  
ERK1 (T202/Y204) DYC1940 DYC1825 KCB1018 SUV1018B
JNK1 (T183/Y185)        
JNK2 (T183/Y185) DYC1846 DYC2236    
JNK3 (T221/Y223)        
JNK pan (T183/Y185, T221/Y223) DYC1205 DYC1387 KCB1205  
MKK3 (S218/T222)   DYC5585    
MKK6 (S207/T211)   DYC5586    
MSK2 (S360)        
p38 alpha (T180/Y182) DYC8691B DYC869B KCB869 SUV869B
p38 beta (T180/Y182)     KCB869  
p38 delta (T180/Y182) DYC2124 DYC2124 KCB869  
p38 gamma (T183/Y185)   DYC1664    
p53 (S46) DYC1043 DYC1489    
p70 S6K (T421/S424) DYC8962 DYC8965    
RSK1 (S380)   DYC892B    
RSK2 (S386)        
TOR (S2448)   DYC1665   SUV1665

Troubleshooting Guide

Stability and Storage

Store the unopened kit at 2°C to 8°C. Do not use past kit expiration date.

 

Data Examples
Figure 1.
View Larger Image

Figure 1.HeLa human cervical epithelial carcinoma cells were either untreated or exposed to 150 J/m2 of UV light followed by a 30 minute recovery period before lysis. Data shown are from a 2 minute exposure to X-ray film.

Figure 2
View Larger Image

Figure 2. : MCF-7 human breast cancer cells were either untreated or treated with 100 ng/mL of rhIGF-I (R&D Systems, Catalog # 291-G1) for 1 hour. Cells for rhIGF-I treatment either received a 1 hour pre-treatment with the PI3K inhibitor, LY294002, or received no pre-treatment. Data shown are from a 6 minute exposure to X-ray film.

BG01V human embryonic stem cells are licensed from ViaCyte, Inc.

 

Image Analysis Software

Quick Spots image analysis software

R&D Systems® now offers Quick Spots image analysis software designed specifically for your Proteome Profiler™ Arrays.

No more laborious set-up of templates in other imaging software, Quick Spots contains preloaded templates for each Proteome Profiler™ array. It knows where your results should be, and provides the data in less time and with less work.

Simplify your workflow today.

*Clicking on this button will navigate you away from the R&D Systems® website. Quick Spots image analysis software can be purchased through Western Vision Software.

 

Preparation and Storage
  • Stability & Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: MAP Kinase (MAPK) Array Kit
The Human Phospho-Mitogen-activated Protein Kinase (MAPK) Antibody Array (Catalog # ARY002) is an economical tool used to simultaneously detect the relative phosphorylation of 19 kinases without performing numerous immunoprecipitation and/or Western blots. Kinases are captured by 23 different antibodies spotted in duplicate on a nitrocellulose membrane. Levels of phosphorylated protein are then assessed using phospho-specific antibodies and chemiluminescence detection.
  • Entrez Gene IDs:
    5594 (Human)
  • Alternate Names:
    MAP Kinase (MAPK) Array Kit
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

70 Citations: Showing 1 - 10
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  1. Use of non-selective ?-blockers is associated with decreased tumor proliferative indices in early stage breast cancer
    Authors: A Montoya, CN Amaya, A Belmont, N Diab, R Trevino, G Villanueva, S Rains, LA Sanchez, N Badri, S Otoukesh, A Khammanivo, D Liss, ST Baca, RJ Aguilera, EB Dickerson, A Torabi, AK Dwivedi, A Abbas, K Chambers, BA Bryan, Z Nahleh
    Oncotarget, 2017;8(4):6446-6460. 2017
  2. Enzymatic cleavage of myoferlin releases a dual C2-domain module linked to ERK signalling
    Authors: AK Piper, SE Ross, GM Redpath, FA Lemckert, N Woolger, A Bournazos, PA Greer, RB Sutton, ST Cooper
    Cell. Signal, 2017;33(0):30-40. 2017
  3. Effects of Secreted Mast Cell Mediators on Retinal Pigment Epithelial Cells: Focus on Mast Cell Tryptase
    Authors: R Arai, A Usui-Ouchi, Y Ito, K Mashimo, A Murakami, N Ebihara
    Mediators Inflamm., 2017;2017(0):3124753. 2017
  4. Extracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation
    Authors: SS Oh, S Park, KW Lee, H Madhi, SG Park, HG Lee, YY Cho, J Yoo, K Dong Kim
    Cell Death Dis, 2017;8(4):e2729. 2017
  5. Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes
    Authors: M Mustapic, E Eitan, JK Werner, ST Berkowitz, MP Lazaropoul, J Tran, EJ Goetzl, D Kapogianni
    Front Neurosci, 2017;11(0):278. 2017
  6. HIV Reprograms Human Airway Basal Stem/Progenitor Cells to Acquire a Tissue-Destructive Phenotype
    Authors: NPY Chung, X Ou, KMF Khan, J Salit, RJ Kaner, RG Crystal
    Cell Rep, 2017;19(6):1091-1100. 2017
  7. Survival of head and neck cancer cells relies upon LZK kinase-mediated stabilization of mutant p53
    Authors: ZC Edwards, EW Trotter, P Torres-Ayu, P Chapman, HM Wood, K Nyswaner, J Brognard
    Cancer Res., 2017;0(0):. 2017
  8. Transmembrane TNF-alpha Reverse Signaling Inhibits Lipopolysaccharide-Induced Proinflammatory Cytokine Formation in Macrophages by Inducing TGF-beta: Therapeutic Implications.
    Authors: Pallai A, Kiss B, Vereb G, Armaka M, Kollias G, Szekanecz Z, Szondy Z
    J Immunol, 2016;196(3):1146-57. 2016
  9. Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists
    Sci Rep, 2016;6(0):34145. 2016
  10. KLRC3, a Natural Killer receptor gene, is a key factor involved in glioblastoma tumourigenesis and aggressiveness
    J Cell Mol Med, 2016;0(0):. 2016
  11. IL-17A mediates inflammatory and tissue remodelling events in early human tendinopathy
    Authors: Neal L Millar
    Sci Rep, 2016;6(0):27149. 2016
  12. Improving Drug Penetrability with iRGD Leverages the Therapeutic Response to Sorafenib and Doxorubicin in Hepatocellular Carcinoma.
    Authors: Schmithals C, Koberle V, Korkusuz H, Pleli T, Kakoschky B, Augusto E, Ibrahim A, Arencibia J, Vafaizadeh V, Groner B, Korf H, Kronenberger B, Zeuzem S, Vogl T, Waidmann O, Piiper A
    Cancer Res, 2015;75(15):3147-54. 2015
  13. Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors.
    Authors: Labidi-Galy S, Clauss A, Ng V, Duraisamy S, Elias K, Piao H, Bilal E, Davidowitz R, Lu Y, Badalian-Very G, Gyorffy B, Kang U, Ficarro S, Ganesan S, Mills G, Marto J, Drapkin R
    Oncogene, 2015;34(3):373-83. 2015
  14. MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease.
    Authors: Millar N, Gilchrist D, Akbar M, Reilly J, Kerr S, Campbell A, Murrell G, Liew F, Kurowska-Stolarska M, McInnes I
    Nat Commun, 2015;6(0):6774. 2015
  15. Murine norovirus 1 (MNV1) replication induces translational control of the host by regulating eIF4E activity during infection.
    Authors: Royall E, Doyle N, Abdul-Wahab A, Emmott E, Morley S, Goodfellow I, Roberts L, Locker N
    J Biol Chem, 2015;290(8):4748-58. 2015
  16. A stable chimeric fibroblast growth factor (FGF) can successfully replace basic FGF in human pluripotent stem cell culture.
    Authors: Onuma, Yasuko, Higuchi, Kumiko, Aiki, Yasuhiko, Shu, Yujing, Asada, Masahiro, Asashima, Makoto, Suzuki, Masashi, Imamura, Toru, Ito, Yuzuru
    PLoS ONE, 2015;10(4):e0118931. 2015
  17. ADAM8 as a drug target in pancreatic cancer.
    Authors: Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia A, Hofling S, Parsons M, Costa P, Soper R, Bossard M, Hagemann T, Roshani R, Sewald N, Ketchem R, Moss M, Rasmussen F, Miller M, Lauffenburger D, Tuveson D, Nimsky C, Bartsch J
    Nat Commun, 2015;6(0):6175. 2015
  18. Lack of Matrilin-2 favors liver tumor development via Erk1/2 and GSK-3beta pathways in vivo.
    Authors: Fullar A, Baghy K, Deak F, Peterfia B, Zsak Y, Tatrai P, Schaff Z, Dudas J, Kiss I, Kovalszky I
    PLoS ONE, 2014;9(4):e93469. 2014
  19. Galectin-1 has potential prognostic significance and is implicated in clear cell renal cell carcinoma progression through the HIF/mTOR signaling axis.
    Authors: White N, Masui O, Newsted D, Scorilas A, Romaschin A, Bjarnason G, Siu K, Yousef G
    Br J Cancer, 2014;110(5):1250-9. 2014
  20. Intracellular carbonic anhydrase activity sensitizes cancer cell pH signaling to dynamic changes in CO2 partial pressure.
    Authors: Hulikova A, Aveyard N, Harris A, Vaughan-Jones R, Swietach P
    J Biol Chem, 2014;289(37):25418-30. 2014
  21. Genome-wide study of hypomethylated and induced genes in patients with liver cancer unravels novel anticancer targets.
    Authors: Stefanska B, Cheishvili D, Suderman M, Arakelian A, Huang J, Hallett M, Han Z, Al-Mahtab M, Akbar S, Khan W, Raqib R, Tanvir I, Khan H, Rabbani S, Szyf M
    Clin Cancer Res, 2014;20(12):3118-32. 2014
  22. COX-2-independent effects of celecoxib sensitize lymphoma B cells to TRAIL-mediated apoptosis.
    Authors: Gallouet A, Travert M, Bresson-Bepoldin L, Guilloton F, Pangault C, Caulet-Maugendre S, Lamy T, Tarte K, Guillaudeux T
    Clin Cancer Res, 2014;20(10):2663-73. 2014
  23. Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors.
    Authors: Wilson C, Naves T, Vincent F, Melloni B, Bonnaud F, Lalloue F, Jauberteau M
    J Cell Sci, 2014;127(0):3983-97. 2014
  24. EGFR signaling in the HGG-02 glioblastoma cell line with an unusual loss of EGFR gene copy.
    Authors: Skoda J, Neradil J, Zitterbart K, Sterba J, Veselska R
    Oncol Rep, 2014;31(1):480-7. 2014
  25. The antiviral immune response in human conventional dendritic cells is controlled by the mammalian target of rapamycin.
    Authors: Fekete T, Pazmandi K, Szabo A, Bacsi A, Koncz G, Rajnavolgyi E
    J Leukoc Biol, 2014;96(4):579-89. 2014
  26. Molecular mechanisms underlying synergistic adhesion of sickle red blood cells by hypoxia and low nitric oxide bioavailability.
    Authors: Gutsaeva, Diana R, Montero-Huerta, Pedro, Parkerson, James B, Yerigenahally, Shobha D, Ikuta, Tohru, Head, C Alvin
    Blood, 2014;123(12):1917-26. 2014
  27. Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells.
    Authors: Ruma I, Putranto E, Kondo E, Watanabe R, Saito K, Inoue Y, Yamamoto K, Nakata S, Kaihata M, Murata H, Sakaguchi M
    Int J Oncol, 2014;45(1):209-18. 2014
  28. The niche component periostin is produced by cancer-associated fibroblasts, supporting growth of gastric cancer through ERK activation.
    Authors: Kikuchi Y, Kunita A, Iwata C, Komura D, Nishiyama T, Shimazu K, Takeshita K, Shibahara J, Kii I, Morishita Y, Yashiro M, Hirakawa K, Miyazono K, Kudo A, Fukayama M, Kashima T
    Am J Pathol, 2014;184(3):859-70. 2014
  29. TGFbeta activated kinase 1 (TAK1) at the crossroad of B cell receptor and Toll-like receptor 9 signaling pathways in human B cells.
    Authors: Szili D, Banko Z, Toth E, Nagy G, Rojkovich B, Gati T, Simon M, Herincs Z, Sarmay G
    PLoS ONE, 2014;9(5):e96381. 2014
  30. A unifying mechanism for cancer cell death through ion channel activation by HAMLET.
    Authors: Storm P, Klausen T, Trulsson M, Ho C S J, Dosnon M, Westergren T, Chao Y, Rydstrom A, Yang H, Pedersen S, Svanborg C
    PLoS ONE, 2013;8(3):e58578. 2013
  31. Sunlight UV-induced skin cancer relies upon activation of the p38alpha signaling pathway.
    Authors: Liu K, Yu D, Cho Y, Bode A, Ma W, Yao K, Li S, Li J, Bowden G, Dong Z, Dong Z
    Cancer Res, 2013;73(7):2181-8. 2013
  32. Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27.
    Authors: Lin, Shih-Pei, Lee, Yi-Ting, Wang, Jir-You, Miller, Stephani, Chiou, Shih-Hwa, Hung, Mien-Chi, Hung, Shih-Chi
    PLoS ONE, 2012;7(11):e49605. 2012
  33. The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation in vivo.
    Authors: Linley AJ, Mathieu MG, Miles AK
    J. Biol. Chem., 2012;287(17):13633-43. 2012
  34. RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells.
    Authors: Lin F, Liu Y, Lai C, Shan Y, Cheng H, Hsu P, Lee C, Lee Y, Wang H, Wang C, Cheng J, Hsiao M, Lu P
    Oncogene, 2012;31(39):4302-16. 2012
  35. Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells.
    Authors: Oliveras-Ferraros C, Cufi S, Queralt B, Vazquez-Martin A, Martin-Castillo B, de Llorens R, Bosch-Barrera J, Brunet J, Menendez JA
    Br. J. Cancer, 2012;106(8):1406-14. 2012
  36. Differential function of Akt1 and Akt2 in human adipocytes.
    Mol. Cell. Endocrinol., 2012;358(1):135-43. 2012
  37. Akt cross-links IL-4 priming, stem cell factor signaling, and IgE-dependent activation in mature human mast cells.
    Authors: Feuser K, Feilhauer K, Staib L, Bischoff SC, Lorentz A
    Mol. Immunol., 2011;48(4):546-52. 2011
  38. Mapping the transcriptional machinery of the IL-8 gene in human bronchial epithelial cells.
    Authors: Bezzerri V, Borgatti M, Finotti A, Tamanini A, Gambari R, Cabrini G
    J. Immunol., 2011;187(11):6069-81. 2011
  39. Activation of p38 mitogen-activated protein kinase by norepinephrine in T-lineage cells.
    Authors: Lajevic MD, Suleiman S, Cohen RL, Chambers DA
    Immunology, 2011;132(2):197-208. 2011
  40. Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling.
    Authors: Wei Q, Jiang H, Xiao Z
    Proc. Natl. Acad. Sci. U.S.A., 2011;108(17):7004-9. 2011
  41. Mechanisms underlying gemcitabine resistance in pancreatic cancer and sensitisation by the iMiD lenalidomide.
    Authors: Fryer RA, Barlett B, Galustian C, Dalgleish AG
    Anticancer Res., 2011;31(11):3747-56. 2011
  42. Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways.
    Authors: Li J, Cho YY, Langfald A
    Cancer Prev Res (Phila), 2011;4(8):1190-7. 2011
  43. Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma.
    Authors: Schulze D, Plohmann P, Hobel S, Aigner A
    Mol. Cancer, 2011;10(0):144. 2011
  44. Somatic cell plasticity and Niemann-pick type C2 protein: adipocyte differentiation and function.
    Authors: Csepeggi C, Jiang M, Frolov A
    J. Biol. Chem., 2010;285(39):30347-54. 2010
  45. Normalization of wound healing and diabetic markers in organ cultured human diabetic corneas by adenoviral delivery of c-Met gene.
    Authors: Saghizadeh M, Kramerov AA, Yu FS, Castro MG, Ljubimov AV
    Invest. Ophthalmol. Vis. Sci., 2010;51(4):1970-80. 2010
  46. NFAT and CREB regulate Kaposi's sarcoma-associated herpesvirus-induced cyclooxygenase 2 (COX-2).
    Authors: Sharma-Walia N, George Paul A, Patel K
    J. Virol., 2010;84(24):12733-53. 2010
  47. Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation.
    Authors: Tang Z, Arjunan P, Lee C, Li Y, Kumar A, Hou X, Wang B, Wardega P, Zhang F, Dong L, Zhang Y, Zhang SZ, Ding H, Fariss RN, Becker KG, Lennartsson J, Nagai N, Cao Y, Li X
    J. Exp. Med., 2010;207(4):867-80. 2010
  48. The use of protein array to identify targetable receptor tyrosine kinases for treatment of human colon cancer.
    Authors: Morishita A, Gong J, Nomura T
    Int. J. Oncol., 2010;37(4):829-35. 2010
  49. The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages.
    Authors: Lane AE, Tan JT, Hawkins CL
    Biochem. J., 2010;430(1):161-9. 2010
  50. PTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle.
    Authors: Feron M, Guevel L, Rouger K, Dubreil L, Arnaud MC, Ledevin M, Megeney LA, Cherel Y, Sakanyan V
    Am. J. Pathol., 2009;174(4):1459-70. 2009
  51. Episodic Src activation in uveal melanoma revealed by kinase activity profiling.
    Authors: Maat W, el Filali M, Dirks-Mulder A, Luyten GP, Gruis NA, Desjardins L, Boender P, Jager MJ, van der Velden PA
    Br. J. Cancer, 2009;101(2):312-9. 2009
  52. Study of the proinflammatory role of human differentiated omental adipocytes.
    Authors: Bassols J, Ortega FJ, Moreno-Navarrete JM, Peral B, Ricart W, Fernandez-Real JM
    J. Cell. Biochem., 2009;107(6):1107-17. 2009
  53. MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation.
    Authors: Lee KH, Chen YL, Yeh SD, Hsiao M, Lin JT, Goan YG, Lu PJ
    Oncogene, 2009;28(38):3360-70. 2009
  54. A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells.
    Authors: Eiselleova L, Matulka K, Kriz V, Kunova M, Schmidtova Z, Neradil J, Tichy B, Dvorakova D, Pospisilova S, Hampl A, Dvorak P
    Stem Cells, 2009;27(8):1847-57. 2009
  55. IL-1beta receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis.
    Authors: Schwarznau A, Hanson MS, Sperger JM, Schram BR, Danobeitia JS, Greenwood KK, Vijayan A, Fernandez LA
    J. Cell. Physiol., 2009;220(2):341-7. 2009
  56. Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells.
    Authors: Eckstein N, Servan K, Hildebrandt B, Politz A, von Jonquieres G, Wolf-Kummeth S, Napierski I, Hamacher A, Kassack MU, Budczies J, Beier M, Dietel M, Royer-Pokora B, Denkert C, Royer HD
    Cancer Res., 2009;69(7):2996-3003. 2009
  57. Reprogramming of a subpopulation of human blood neutrophils by prolonged exposure to cytokines.
    Authors: Chakravarti A, Rusu D, Flamand N, Borgeat P, Poubelle PE
    Lab. Invest., 2009;89(10):1084-99. 2009
  58. JNK is constitutively active in mantle cell lymphoma: cell cycle deregulation and polyploidy by JNK inhibitor SP600125.
    Authors: Wang M, Atayar C, Rosati S, Bosga-Bouwer A, Kluin P, Visser L
    J. Pathol., 2009;218(1):95-103. 2009
  59. The protein-tyrosine phosphatase, SRC homology-2 domain containing protein tyrosine phosphatase-2, is a crucial mediator of exogenous insulin-like growth factor signaling to human trophoblast.
    Authors: Forbes K, West G, Garside R, Aplin JD, Westwood M
    Endocrinology, 2009;150(10):4744-54. 2009
  60. Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells.
    Authors: Yoon YK, Kim HP, Han SW, Hur HS, Oh do Y, Im SA, Bang YJ, Kim TY
    Mol. Cancer Ther., 2009;8(9):2526-36. 2009
  61. Autocrine motility factor stimulates the invasiveness of malignant cells as well as up-regulation of matrix metalloproteinase-3 expression via a MAPK pathway.
    Authors: Haga A, Funasaka T, Deyashiki Y, Raz A
    FEBS Lett., 2008;582(0):1877-82. 2008
  62. Differential subcellular membrane recruitment of Src may specify its downstream signalling.
    Authors: de Diesbach P, Medts T, Carpentier S, D'Auria L, Van Der Smissen P, Platek A, Mettlen M, Caplanusi A, van den Hove MF, Tyteca D, Courtoy PJ
    Exp. Cell Res., 2008;314(7):1465-79. 2008
  63. Early gene expression analyzed by cDNA microarray and real-time PCR in osteoblasts cultured with chitosan monomer.
    Authors: Ganno T, Yamada S, Ohara N, Matsunaga T, Yanagiguchi K, Ikeda T, Ishizaki H, Hayashi Y
    J Biomed Mater Res A, 2007;82(1):188-94. 2007
  64. Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells.
    Authors: Eckstein N, Servan K, Girard L, Cai D, von Jonquieres G, Jaehde U, Kassack MU, Gazdar AF, Minna JD, Royer HD
    J. Biol. Chem., 2007;283(2):739-50. 2007
  65. S100A11, an dual mediator for growth regulation of human keratinocytes.
    Authors: Sakaguchi M, Sonegawa H, Murata H, Kitazoe M, Futami J, Kataoka K, Yamada H, Huh NH
    Mol. Biol. Cell, 2007;19(1):78-85. 2007
  66. The ERK mitogen-activated protein kinase pathway contributes to Ebola virus glycoprotein-induced cytotoxicity.
    Authors: Zampieri CA, Fortin JF, Nolan GP, Nabel GJ
    J. Virol., 2007;81(3):1230-40. 2007
  67. Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components.
    Authors: Zhou Q, Amar S
    J. Immunol., 2007;179(11):7777-90. 2007
  68. Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms.
    Authors: Hudson TS, Hartle DK, Hursting SD, Nunez NP, Wang TT, Young HA, Arany P, Green JE
    Cancer Res., 2007;67(17):8396-405. 2007
  69. Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling.
    Authors: Samoylenko A, Byts N, Rajalingam K, von Ahsen N, Rapp UR, Ehrenreich H, Siren AL
    Cell. Signal., 2007;20(1):154-62. 2007
  70. LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways.
    Authors: Tang X, Metzger D, Leeman S, Amar S
    Proc. Natl. Acad. Sci. U.S.A., 2006;103(37):13777-82. 2006
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Other Experimental Details

Other Experimental DetailsThis array is an excellent tool for screening potential phospho-MAPKs and related targets. However, it would be nice that if the total level of non-phosphorylated proteins be visualized at the same time on the membrane. In this case, the phosphorylated signals can be normalized.

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