Key Product Details

Species Reactivity

Validated:

Rat

Cited:

Mouse, Rat

Applications

Validated:

Immunohistochemistry

Cited:

Immunohistochemistry, Immunocytochemistry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 1126B
View all mu Opioid R/OPRM1 Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide with a short amino acid sequence from the N-terminus of rat μ Opioid R/OPRM1
Accession # P33535

Specificity

Detects rat μ Opioid R/OPRM1 in direct ELISAs.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Rat μ Opioid R/OPRM1 Antibody

µ Opioid R/OPRM1 antibody in Rat Spinal Cord by Immunohistochemistry (IHC-Fr).

μ Opioid R/OPRM1 in Rat Spinal Cord.

µ Opioid R/OPRM1 was detected in perfusion fixed frozen sections of rat spinal cord using Rabbit Anti-Rat µ Opioid R/OPRM1 Monoclonal Antibody (Catalog # MAB8629) at 1 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (red; Catalog # NL004) and counterstained with DAPI (blue). Specific staining was localized to dorsal horn. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.

Applications for Rat μ Opioid R/OPRM1 Antibody

Application
Recommended Usage

Immunohistochemistry

1-25 µg/mL
Sample: Perfusion fixed frozen sections of rat spinal cord

Formulation, Preparation, and Storage

Purification

Protein A or G purified from cell culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: mu Opioid R/OPRM1

The mu-type opioid receptor (MOR), also known as OPRM1, is a 60‑70 kDa variably glycosylated G protein-coupled receptor that mediates the biological effects of many alkaloid and peptide opioids including morphine. MOR is primarily expressed on neurons in the brain, spinal cord, and gastrointestinal tract as well as on immune cells. MOR activation induces analgesia, euphoria, sedation, respiratory depression, and reduced intestinal motility. Following agonist binding, MOR is phosphorylated and internalized which contributes to opioid tolerance and desensitization. OPRM1 can form heterdimers with several other 7TM GPCRs including the delta-type Opioid Receptor (DOR), Nociceptin/Orphanin Receptor (ORL1), Neurokinin 1 Receptor (NK1), Somatostatin Receptor 2 (SSTR2), Cannabinoid Receptor 1, CCR5, and the alpha 2A-Adrenergic Receptor (ADRA2A). Rat MOR shares 94% and 98% aa sequence identity with human and mouse MOR, respectively.

Long Name

mu Opioid Receptor

Alternate Names

LMOR, MOP, mOpioidR, MOR, MOR1, OPRM1

Entrez Gene IDs

4988 (Human); 18390 (Mouse); 25601 (Rat)

Gene Symbol

OPRM1

UniProt

P33535

Additional mu Opioid R/OPRM1 Products

Product Documents for Rat μ Opioid R/OPRM1 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Rat μ Opioid R/OPRM1 Antibody

For research use only

Citations for Rat μ Opioid R/OPRM1 Antibody

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Protocols

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