IL-10/Interferon Family

IL-10 is the prototypic member of the IL-10 cytokine family, including IL-10, IL-19, IL-20, IL-22 (IL-TIF), IL-24 (human MDA-7, mouse FISP, rat C49A/Mob-5) and IL-26 (AK155). A number of viruses, including Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV), also encode viral members of the IL-10 family.

Interferons are best known for their critical functions in host defense mechanisms. The type I Interferons include the IFN-alpha family, IFN-beta, -omega, -kappa and Limitin and are important for marshalling the immune resonse to viral infection. The type II interferon group includes only IFN-gamma. IFN-gamma is a multifunctional cytokine that exerts aniti-proliferative, immunoregulatory, and proinflammatory effects improtant for numerous aspects of the immune response.