Human IL-6 DuoSet ELISA Summary
* Provided that the recommended microplates, buffers, diluents, substrates and solutions are used, and the assay is run as summarized in the Assay Procedure provided.
This DuoSet ELISA Development kit contains the basic components required for the development of sandwich ELISAs to measure natural and recombinant human IL-6. The suggested diluent is suitable for the analysis of most cell culture supernate samples. Diluents for complex matrices, such as serum and plasma, should be evaluated prior to use in this DuoSet.
Product Features
- Optimized capture and detection antibody pairings with recommended concentrations save lengthy development time
- Development protocols are provided to guide further assay optimization
- Assay can be customized to your specific needs
- Economical alternative to complete kits
Kit Content
- Capture Antibody
- Detection Antibody
- Recombinant Standard
- Streptavidin conjugated to horseradish-peroxidase (Streptavidin-HRP)
Other Reagents Required
DuoSet Ancillary Reagent Kit 2 (5 plates): (Catalog # DY008) containing 96 well microplates, plate sealers, substrate solution, stop solution, plate coating buffer (PBS), wash buffer, and Reagent Diluent Concentrate 2.
The components listed above may be purchased separately:
PBS: (Catalog # DY006), or 137 mM NaCl, 2.7 mM KCl, 8.1 mM Na2HPO4, 1.5 mM KH2PO4, pH 7.2 - 7.4, 0.2 µm filtered
Wash Buffer: (Catalog # WA126), or 0.05% Tween® 20 in PBS, pH 7.2-7.4
Reagent Diluent: (Catalog # DY995), or 1% BSA in PBS, pH 7.2-7.4, 0.2 µm filtered
Substrate Solution: 1:1 mixture of Color Reagent A (H2O2) and Color Reagent B (Tetramethylbenzidine) (Catalog # DY999)
Stop Solution: 2 N H2SO4 (Catalog # DY994)
Microplates: R&D Systems (Catalog # DY990)
Plate Sealers: ELISA Plate Sealers (Catalog # DY992)
Data Example
Product Datasheets
Preparation and Storage
Background: IL-6
Interleukin 6 (IL-6) is a pleiotropic, a-helical, 22-28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. Mature human IL-6 is 183 amino acids (aa) in length and shares 39% aa sequence identity with mouse and rat IL-6. Alternative splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties. Cells known to express IL-6 include CD8+ T cells, fibroblasts, synoviocytes, adipocytes, osteoblasts, megakaryocytes, endothelial cells (under the influence of endothelins), sympathetic neurons, cerebral cortex neurons, adrenal medulla chromaffin cells, retinal pigment cells, mast cells, keratinocytes, Langerhans cells, fetal and adult astrocytes, neutrophils, monocytes, eosinophils, colonic epithelial cells, B1 B cells and pancreatic islet beta cells. IL-6 production is generally correlated with cell activation and is normally kept in control by glucocorticoids, catecholamines, and secondary sex steroids. Normal human circulating IL-6 is in the 1 pg/mL range, with slight elevations during the menstrual cycle, modest elevations in certain cancers, and large elevations after surgery.
IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 Ra, triggering IL-6 Ra association with gp130 and gp130 dimerization. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 Ra are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 Ra elicit responses from gp130-expressing cells that lack cell surface IL-6 Ra. Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 Ra is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes. Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 Ra but not from other cytokines that use gp130 as a co-receptor.
IL-6, along with TNF-a and IL-1, drives the acute inflammatory response. IL-6 is almost solely responsible for fever and the acute phase response in the liver, and it is important in the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in conditions such as obesity, insulin resistance, inflammatory bowel disease, arthritis, and sepsis. IL-6 modulates bone resorption and is a major effector of inflammatory joint destruction in rheumatoid arthritis through its promotion of Th17 cell development and activity. It contributes to atherosclerotic plaque development and destabilization as well as the development of inflammation-associated carcinogenesis.
Assay Procedure
GENERAL ELISA PROTOCOL
Plate Preparation
- Dilute the Capture Antibody to the working concentration in PBS without carrier protein. Immediately coat a 96-well microplate with 100 μL per well of the diluted Capture Antibody. Seal the plate and incubate overnight at room temperature.
- Aspirate each well and wash with Wash Buffer, repeating the process two times for a total of three washes. Wash by filling each well with Wash Buffer (400 μL) using a squirt bottle, manifold dispenser, or autowasher. Complete removal of liquid at each step is essential for good performance. After the last wash, remove any remaining Wash Buffer by aspirating or by inverting the plate and blotting it against clean paper towels.
- Block plates by adding 300 μL Reagent Diluent to each well. Incubate at room temperature for a minimum of 1 hour.
- Repeat the aspiration/wash as in step 2. The plates are now ready for sample addition.
Assay Procedure
- Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at room temperature.
- Repeat the aspiration/wash as in step 2 of Plate Preparation.
- Add 100 μL of the Detection Antibody, diluted in Reagent Diluent, to each well. Cover with a new adhesive strip and incubate 2 hours at room temperature.
- Repeat the aspiration/wash as in step 2 of Plate Preparation.
- Add 100 μL of the working dilution of Streptavidin-HRP to each well. Cover the plate and incubate for 20 minutes at room temperature. Avoid placing the plate in direct light.
- Repeat the aspiration/wash as in step 2.
- Add 100 μL of Substrate Solution to each well. Incubate for 20 minutes at room temperature. Avoid placing the plate in direct light.
- Add 50 μL of Stop Solution to each well. Gently tap the plate to ensure thorough mixing.
- Determine the optical density of each well immediately, using a microplate reader set to 450 nm. If wavelength correction is available, set to 540 nm or 570 nm. If wavelength correction is not available, subtract readings at 540 nm or 570 nm from the readings at 450 nm. This subtraction will correct for optical imperfections in the plate. Readings made directly at 450 nm without correction may be higher and less accurate.
Citations for Human IL-6 DuoSet ELISA
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Cerebrospinal fluid of chronic osteoarthritic patients induced interleukin-6 release in human glial cell-line T98G
Authors: W Liu, C Li, FCK Tan, HJ Neo, YH Chan, CM Low, TL Lee
BMC Anesthesiol, 2020;20(1):69.
Species: Human
Sample Types: Cell Culture Supernates
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The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by &beta-Glucan
Authors: ST Keating, L Groh, CDCC van der He, H Rodriguez, JC Dos Santos, S Fanucchi, J Okabe, H Kaipananic, JH van Puffel, L Helder, MP Noz, V Matzaraki, Y Li, LCJ de Bree, VACM Koeken, SJCFM Moorlag, VP Mourits, J Domínguez-, M Oosting, EP Bulthuis, WJH Koopman, M Mhlanga, A El-Osta, LAB Joosten, MG Netea, NP Riksen
Cell Rep, 2020;31(3):107548.
Species: Human
Sample Types: Cell Culture Supernates
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Endometrial stromal cells exhibit a distinct phenotypic and immunomodulatory profile
Authors: S Queckbörne, E Syk Lundbe, K Gemzell-Da, LC Davies
Stem Cell Res Ther, 2020;11(1):15.
Species: Human
Sample Types: Cell culture supernat
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The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus
Authors: T Furukawa, N van Rhijn, M Fraczek, F Gsaller, E Davies, P Carr, S Gago, R Fortune-Gr, S Rahman, JM Gilsenan, E Houlder, CH Kowalski, S Raj, S Paul, P Cook, JE Parker, S Kelly, RA Cramer, JP Latgé, S Moye-Rowle, E Bignell, P Bowyer, MJ Bromley
Nat Commun, 2020;11(1):427.
Species: Human
Sample Types: Cell Culture Supernates
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Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium
Authors: I Gomez, B Ward, C Souilhol, C Recarti, M Ariaans, J Johnston, A Burnett, M Mahmoud, LA Luong, L West, M Long, S Parry, R Woods, C Hulston, B Benedikter, C Niespolo, R Bazaz, S Francis, E Kiss-Toth, M van Zandvo, A Schober, P Hellewell, PC Evans, V Ridger
Nat Commun, 2020;11(1):214.
Species: Human
Sample Types: Cell Culture Supernates
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Oral administration of ferulic acid or ethyl ferulate attenuates retinal damage in sodium iodate-induced retinal degeneration mice
Authors: M Kohno, K Musashi, HO Ikeda, T Horibe, A Matsumoto, K Kawakami
Sci Rep, 2020;10(1):8688.
Species: Human
Sample Types: Cell Culture Supernates
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OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion
Authors: T O'Loughlin, AJ Kruppa, ALR Ribeiro, JR Edgar, A Ghannam, AM Smith, F Buss
J. Cell. Sci., 2020;0(0):.
Species: Human
Sample Types: Tissue Culture Supernates
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Antifibrotic Effects of a Barbituric Acid Derivative on Liver Fibrosis by Blocking the NF-&kappaB Signaling Pathway in Hepatic Stellate Cells
Authors: YH Wang, FM Suk, CL Liu, TL Chen, YC Twu, MH Hsu, YJ Liao
Front Pharmacol, 2020;11(0):388.
Species: Human
Sample Types: Cell Culture Supernates
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Narciclasine, an isocarbostyril alkaloid, has preferential activity against primary effusion lymphoma
Authors: R Gopalakris, H Matta, S Choi, PM Chaudhary
Sci Rep, 2020;10(1):5712.
Species: Mouse
Sample Types: Plasma
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Interleukin (IL)-17/IL-36 axis participates to the crosstalk between endothelial cells and keratinocytes during inflammatory skin responses
Authors: L Mercurio, CM Failla, L Capriotti, C Scarponi, F Facchiano, M Morelli, S Rossi, G Pagnanelli, C Albanesi, A Cavani, S Madonna
PLoS ONE, 2020;15(4):e0222969.
Species: Human
Sample Types: Cell Culture Supernates
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Berberine Inhibits Pro-inflammatory Cytokine-induced IL-6 and CCL11 Production via Modulation of STAT6 Pathway in Human Bronchial Epithelial Cells
Authors: J Ma, CC Chan, WC Huang, ML Kuo
Int J Med Sci, 2020;17(10):1464-1473.
Species: Human
Sample Types: Cell Culture Supernates
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Matrix metalloproteinase-7 could be a predictor for acute inflammation in psoriatic patients
Authors: A Abbes, Y Zayani, W Zidi, MB Hammami, A Mebazaa, D El Euch, A Ben Ammar, H Sanhaji, MV El May, M Mokni, M Feki, M Allal-Elas
Cytokine, 2020;134(0):155195.
Species: Human
Sample Types: Serum
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SIRT7 deficiency suppresses inflammation, induces EndoMT, and increases vascular permeability in primary pulmonary endothelial cells
Authors: AE Wyman, TTT Nguyen, P Karki, ME Tulapurkar, CO Zhang, J Kim, TG Feng, AJ Dabo, NW Todd, IG Luzina, P Geraghty, RF Foronjy, JD Hasday, AA Birukova, SP Atamas, KG Birukov
Sci Rep, 2020;10(1):12497.
Species: Human
Sample Types: Cell Culture Supernates
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The Delivery of &alpha1-Antitrypsin Therapy Through Transepidermal Route: Worthwhile to Explore
Authors: S Tumpara, B Martinez-D, G Gomez-Mari, B Liu, DS DeLuca, E Korenbaum, D Jonigk, F Jugert, FM Wurm, MJ Wurm, T Welte, S Janciauski
Front Pharmacol, 2020;11(0):983.
Species: Human
Sample Types: Cell Culture Supernates
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Altered iron metabolism in cystic fibrosis macrophages: the impact of CFTR modulators and implications for Pseudomonas aeruginosa survival
Authors: HF Hazlett, TH Hampton, DS Aridgides, DA Armstrong, JA Dessaint, DL Mellinger, AB Nymon, A Ashare
Sci Rep, 2020;10(1):10935.
Species: Human
Sample Types: Cell Culture Supernates
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Reprogramming of profibrotic macrophages for treatment of bleomycin-induced pulmonary fibrosis
Authors: F Zhang, EA Ayaub, B Wang, E Puchulu-Ca, YH Li, SU Hettiarach, SD Lindeman, Q Luo, S Rout, M Srinivasar, A Cox, K Tsoyi, C Nickerson-, IO Rosas, PS Low
EMBO Mol Med, 2020;0(0):e12034.
Species: Human
Sample Types: Cell Culture Supernates
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Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1
Authors: T Maekawa, H Tamura, H Domon, T Hiyoshi, T Isono, D Yonezawa, N Hayashi, N Takahashi, K Tabeta, T Maeda, M Oda, A Ziogas, V? Alexaki, T Chavakis, Y Terao, G Hajishenga
JCI Insight, 2020;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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Data describing expression of formyl peptide receptor 2 in human articular chondrocytes
Authors: A Strid Holm, CA Jonsson, M Mohaddes, C Lundqvist, H Forsman, I Gjertsson, K Önnheim
Data Brief, 2020;31(0):105866.
Species: Human
Sample Types: Cell Culture Supernates
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Circulating growth/differentiation factor 15 is associated with human CD56bright natural killer cell dysfunction and nosocomial infection in severe systemic inflammation
Authors: H Kleinertz, M Hepner-Sch, S Ehnert, M Claus, R Halbgebaue, L Boller, M Huber-Lang, P Cinelli, C Kirschning, S Flohé, A Sander, C Waydhas, S Vonderhage, M Jäger, M Dudda, C Watzl, SB Flohé
EBioMedicine, 2019;0(0):.
Species: Human
Sample Types: Serum
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Resistance to lysosomotropic drugs used to treat kidney and breast cancers involves autophagy and inflammation and converges in inducing CXCL5
Authors: S Giuliano, M Dufies, PD Ndiaye, J Viotti, D Borchielli, J Parola, V Vial, Y Cormerais, M Ohanna, V Imbert, E Chamorey, N Rioux-Lecl, A Savina, JM Ferrero, B Mograbi, G Pagès
Theranostics, 2019;9(4):1181-1199.
Species: Human
Sample Types: Cell Culture Supernates
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Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma
Authors: EA Ebbing, AP van der Za, A Steins, A Creemers, S Hermsen, R Rentenaar, M Klein, C Waasdorp, GKJ Hooijer, SL Meijer, KK Krishnadat, CJA Punt, MI van Berge, SS Gisbertz, OM van Delden, MCCM Hulshof, JP Medema, HWM van Laarho, MF Bijlsma
Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):.
Species: Human
Sample Types: Serum
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The effect of compressive force combined with mechanical vibration on human alveolar bone osteoblasts
Authors: C Chatmahamo, A Pravithara, S Suttapreya, C Leethanaku
J Oral Biol Craniofac Res, 2019;9(1):81-85.
Species: Human
Sample Types: Cell Culture Supernates
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25(OH)D3 and 1.25(OH)2D3 inhibits TNF-? expression in human monocyte derived macrophages
Authors: A Rafique, L Rejnmark, L Heickendor, HJ Møller
PLoS ONE, 2019;14(4):e0215383.
Species: Human
Sample Types: Cell Culture Supernates
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Human metapneumovirus activates NOD-like receptor protein 3 inflammasome via its small hydrophobic protein which plays a detrimental role during infection in mice
Authors: VB Lê, J Dubois, C Couture, MH Cavanagh, O Uyar, A Pizzorno, M Rosa-Calat, MÈ Hamelin, G Boivin
PLoS Pathog., 2019;15(4):e1007689.
Species: Human
Sample Types: Cell Culture Supernates
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Secondhand smoke exposure and sleep-related breathing problems in toddlers
Authors: JA Groner, L Nicholson, H Huang, JA Bauer
Acad Pediatr, 2019;0(0):.
Species: Human
Sample Types: Serum
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Calcineurin inhibitors reduce NFAT-dependent expression of antifungal pentraxin-3 by human monocytes
Authors: K Bendí?ková, F Tidu, M De Zuani, MH Kohoutková, I Andrej?ino, A Pompeiano, S B?lášková, G Forte, T Zelante, J Fri?
J. Leukoc. Biol., 2019;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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Long intergenic non-coding RNAs regulate human lung fibroblast function: Implications for idiopathic pulmonary fibrosis
Authors: MR Hadjichara, BT Roux, E Csomor, CA Feghali-Bo, LA Murray, DL Clarke, MA Lindsay
Sci Rep, 2019;9(1):6020.
Species: Human
Sample Types: Cell Culture Supernates
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Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis
Authors: C Wei, C Yang, S Wang, D Shi, C Zhang, X Lin, Q Liu, R Dou, B Xiong
Mol. Cancer, 2019;18(1):64.
Species: Human
Sample Types: Cell Culture Supernates
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Engulfment, persistence and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential
Authors: D Raghunatha, PM Radford, C Gell, D Negus, C Moore, R Till, PJ Tighe, SP Wheatley, L Martinez-P, RE Sockett, J Tyson
Sci Rep, 2019;9(1):4293.
Species: Human
Sample Types: Cell Culture Supernates
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R. nukuhivensis acts by reinforcing skin barrier function, boosting skin immunity and by inhibiting IL-22 induced keratinocyte hyperproliferation
Authors: F Abdallah, G Lecellier, P Raharivelo, C Pichon
Sci Rep, 2019;9(1):4132.
Species: Human
Sample Types: Cell Culture Supernates
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D-2-Hydroxyglutarate and L-2-Hydroxyglutarate Inhibit IL-12 Secretion by Human Monocyte-Derived Dendritic Cells
Authors: I Ugele, ZE Cárdenas-C, K Hammon, M Wehrstein, C Bruss, K Peter, K Singer, E Gottfried, J Boesch, P Oefner, K Dettmer, K Renner, M Kreutz
Int J Mol Sci, 2019;20(3):.
Species: Human
Sample Types: Cell Culture Supernates
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The contraceptive medroxyprogesterone acetate, unlike norethisterone, directly increases R5 HIV-1 infection in human cervical explant tissue at physiologically relevant concentrations
Authors: RM Ray, MF Maritz, C Avenant, M Tomasicchi, S Dlamini, Z van der Sp, JP Hapgood
Sci Rep, 2019;9(1):4334.
Species: Human
Sample Types: Tissue Culture Supernates
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High expression of S100 calgranulin genes in peripheral blood mononuclear cells from patients with Takayasu arteritis
Authors: J Kabeerdoss, M Thomas, R Goel, H Mohan, S Danda, J L, D Danda
Cytokine, 2019;114(0):61-66.
Species: Human
Sample Types: Cell Culture Supernates
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In Vitro Induction of T Helper 17 Cells by Synergistic Activation of Human Monocyte-Derived Langerhans Cell-Like Cells with Bacterial Agonists
Authors: R Gramlich, E Aliahmadi, M Peiser
Int J Mol Sci, 2019;20(6):.
Species: Human
Sample Types: Cell Culture Supernates
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An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation
Authors: C Harris, SD Thorpe, S Rushwan, W Wang, CL Thompson, JL Peacock, MM Knight, B Gooptu, A Greenough
J Biomech, 2019;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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Regulation of radiosensitivity by 4-methylumbelliferone via the suppression of interleukin-1 in fibrosarcoma cells
Authors: R Saga, K Hasegawa, K Murata, M Chiba, T Nakamura, K Okumura, E Tsuruga, Y Hosokawa
Oncol Lett, 2019;17(3):3555-3561.
Species: Human
Sample Types: Cell Culture Supernates
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Human Blood and Tonsil Plasmacytoid Dendritic Cells Display Similar Gene Expression Profiles but Exhibit Differential Type I IFN Responses to Influenza A Virus Infection
Authors: S Vangeti, J Gertow, M Yu, S Liu, F Baharom, S Scholz, D Friberg, M Starkhamma, A Ahlberg, A Smed-Sören
J. Immunol., 2019;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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Large-scale secretome analyses unveil the superior immunosuppressive phenotype of umbilical cord stromal cells as compared to other adult mesenchymal stromal cells
Authors: A Islam, I Urbarova, JA Bruun, I Martinez-Z
Eur Cell Mater, 2019;37(0):153-174.
Species: Human
Sample Types: Cell Culture Supernates
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Cancer-associated fibroblasts induce epithelial-mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling
Authors: CR Goulet, A Champagne, G Bernard, D Vandal, S Chabaud, F Pouliot, S Bolduc
BMC Cancer, 2019;19(1):137.
Species: Human
Sample Types: Cell Culture Supernates
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Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection
Authors: I Santecchia, F Vernel-Pau, O Rasid, J Quintin, M Gomes-Sole, IG Boneca, C Werts
PLoS Pathog., 2019;15(5):e1007811.
Species: Human
Sample Types: Cell Culture Supernates
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Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes
Authors: CR Ojha, M Rodriguez, MKM Karuppan, J Lapierre, F Kashanchi, N El-Hage
PLoS ONE, 2019;14(2):e0208543.
Species: Human
Sample Types: Cell Culture Supernates
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Effects of continuous moderate exercise with partial blood flow restriction during hemodialysis: A protocol for a randomized clinical trial
Authors: RK Cardoso, AM Araujo, RB Orcy, M Bohlke, JP Oses, FB Del Vecchi, FC Barcellos, MC Gonzalez, AJ Rombaldi
MethodsX, 2019;6(0):190-198.
Species: Human
Sample Types: Serum
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Blood inflammatory and endothelial markers in women with von Willebrand disease
Authors: I Govorov, K Bremme, A Larsson, M Holmström, E Komlichenk, R Chaireti, M Mints
PLoS ONE, 2019;14(1):e0210544.
Species: Human
Sample Types: Plasma
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Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazole
Authors: CR McDonald, AM Weckman, AL Conroy, P Olwoch, P Natureeba, MR Kamya, DV Havlir, G Dorsey, KC Kain
Sci Rep, 2019;9(1):6758.
Species: Human
Sample Types: Plasma
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Evolving understanding of cardiovascular, cerebrovascular and peripheral arterial disease in people living with HIV and role of novel biomarkers. A study of the Spanish CoRIS cohort, 2004-2015
Authors: M Masiá, S Padilla, JA García, J García-Abe, M Fernández, I Bernardino, M Montero, J Peraire, B Pernas, F Gutiérrez
PLoS ONE, 2019;14(4):e0215507.
Species: Human
Sample Types: Plasma
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Targeting TGFbetaR2-mutant tumors exposes vulnerabilities to stromal TGFbeta blockade in pancreatic cancer
Authors: H Huang, Y Zhang, V Gallegos, N Sorrelle, MM Zaid, J Toombs, W Du, S Wright, M Hagopian, Z Wang, AN Hosein, AA Sathe, C Xing, EJ Koay, KE Driscoll, RA Brekken
EMBO Mol Med, 2019;0(0):e10515.
Species: Human
Sample Types: Tissue Lysates
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HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells
Authors: J Hyun, RS McMahon, AL Lang, JS Edwards, AD Badilla, ME Greene, GW Stone, S Pallikkuth, M Stevenson, DM Dykxhoorn, S Kottilil, S Pahwa, E Thomas
PLoS Pathog., 2019;15(7):e1007883.
Species: Human
Sample Types: Cell Culture Supernates
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Changes in monocyte subsets are associated with clinical outcomes in severe malarial anaemia and cerebral malaria
Authors: J Royo, M Rahabi, C Kamaliddin, S Ezinmegnon, D Olagnier, H Authier, A Massougbod, J Alao, Y Ladipo, P Deloron, G Bertin, B Pipy, A Coste, A Aubouy
Sci Rep, 2019;9(1):17545.
Species: Human
Sample Types: Plasma
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Replication of Genome-Wide Association Analysis Identifies New Susceptibility Loci at Long Noncoding RNA Regions for Vogt-Koyanagi-Harada Disease
Authors: J Qi, L Du, J Deng, Y Qin, G Su, S Hou, M Lv, Q Zhang, A Kijlstra, P Yang
Invest. Ophthalmol. Vis. Sci., 2019;60(14):4820-4829.
Species: Human
Sample Types: Whole Cells
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Diverse Human VH antibody fragments with bio-therapeutic properties from the Crescendo Mouse
Authors: Y Teng, JL Young, B Edwards, P Hayes, L Thompson, C Johnston, C Edwards, Y Sanders, M Writer, D Pinto, Y Zhang, M Roode, P Chovanec, L Matheson, AE Corcoran, A Fernandez, L Montoliu, B Rossi, V Tosato, K Gjuracic, D Nikitin, C Bruschi, B McGuinness, T Sandal, M Romanos
N Biotechnol, 2019;55(0):65-76.
Species: Human
Sample Types: Cell Culture Supernates
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Disrupting prolonged sitting reduces IL-8 and lower leg swell in active young adults
Authors: S Dogra, M Wolf, MP Jeffrey, RCA Foley, H Logan-Spre, H Jones-Tagg, JM Green-John
BMC Sports Sci Med Rehabil, 2019;11(0):23.
Species: Human
Sample Types: Saliva
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Relative Contributions of Extracellular and Internalized Bacteria to Early Macrophage Proinflammatory Responses to Streptococcus pneumoniae
Authors: J Periselner, G Ercoli, T Pollard, S Chimalapat, E Camberlein, G Szylar, C Hyams, G Tomlinson, FC Petersen, RA Floto, M Noursadegh, JS Brown
MBio, 2019;10(5):.
Species: Human
Sample Types: Cell Culture Supernates
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β-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: a Crucial Role for IL-32
Authors: JC Dos Santos, AM Barroso de, MV Teodoro Si, B Cirovic, LCJ de Bree, MSMA Damen, SJCFM Moorlag, RS Gomes, MM Helsen, M Oosting, ST Keating, A Schlitzer, MG Netea, F Ribeiro-Di, LAB Joosten
Cell Rep, 2019;28(10):2659-2672.e6.
Species: Human
Sample Types: Cell Culture Supernates
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Omega-3 Fatty Acid-Derived Resolvin D2 Regulates Human Placental Vascular Smooth Muscle and Extravillous Trophoblast Activities
Authors: A Ulu, PK Sahoo, AG Yuil-Valde, M Mukherjee, M Van Ormer, PG Muthuraj, M Thompson, A Anderson B, CK Hanson, SK Natarajan, TM Nordgren
Int J Mol Sci, 2019;20(18):.
Species: Human
Sample Types: Cell Culture Supernates
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Translational regulation contributes to the secretory response of chondrocytic cells following exposure to interleukin-1 β
Authors: BT McDermott, MJ Peffers, B McDonagh, SR Tew
J. Biol. Chem., 2019;294(35):13027-13039.
Species: Human
Sample Types: Cell Culture Supernates
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Correction of bleeding in experimental severe hemophilia A by systemic delivery of factor VIII-encoding mRNA
Authors: J Russick, S Delignat, P Milanov, O Christophe, G Boros, CV Denis, PJ Lenting, SV Kaveri, S Lacroix-De
Haematologica, 2019;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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Th1/17-Biased Inflammatory Environment Associated with COPD Alters the Response of Airway Epithelial Cells to Viral and Bacterial Stimuli
Authors: Y Chen, RK Kumar, PS Thomas, C Herbert
Mediators Inflamm., 2019;2019(0):7281462.
Species: Human
Sample Types: Cell Culture Supernates
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Type 1 diabetic mellitus patients with increased atherosclerosis risk display decreased CDKN2A/2B/2BAS gene expression in leukocytes
Authors: S Martínez-H, V Sánchez-Ga, A Herrero-Ce, Á Vinué, JT Real, JF Ascaso, DJ Burks, H González-N
J Transl Med, 2019;17(1):222.
Species: Human
Sample Types: Plasma
-
Increased frequency of activated CD8+ T cell effectors in patients with psoriatic arthritis
Authors: M Diani, F Casciano, L Marongiu, M Longhi, A Altomare, PD Pigatto, P Secchiero, R Gambari, G Banfi, AA Manfredi, G Altomare, F Granucci, E Reali
Sci Rep, 2019;9(1):10870.
Species: Human
Sample Types: Serum
-
Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface
Authors: CM Weight, C Venturini, S Pojar, SP Jochems, J Reiné, E Nikolaou, C Solórzano, M Noursadegh, JS Brown, DM Ferreira, RS Heyderman
Nat Commun, 2019;10(1):3060.
Species: Human
Sample Types: Cell Culture Supernates
-
Inhibition of Proteasome Activity Upregulates IL-6 Expression in RPE Cells through the Activation of P38 MAPKs
Authors: T Qin, S Gao
J Ophthalmol, 2018;2018(0):5392432.
Species: Human
Sample Types: Cell Culture Supernates
-
Human cytomegalovirus replication induces endothelial cell interleukin-11
Authors: KLR Gustafsson, T Renné, C Söderberg-, LM Butler
Cytokine, 2018;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
GWAS for Interleukin-1? levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
Authors: S Offenbache, Y Jiao, SJ Kim, J Marchesan, KL Moss, L Jing, K Divaris, S Bencharit, CS Agler, T Morelli, S Zhang, L Sun, WT Seaman, D Cowley, SP Barros, JD Beck, M Munz, AS Schaefer, KE North
Nat Commun, 2018;9(1):3686.
Species: Human
Sample Types: Cell Culture Supernates
-
CD47 as a potential prognostic marker for oral leukoplakia and oral squamous cell carcinoma
Authors: X Ye, X Wang, R Lu, J Zhang, X Chen, G Zhou
Oncol Lett, 2018;15(6):9075-9080.
Species: Human
Sample Types: Cell Culture Supernates
-
TiO2 nanoparticles can selectively bind CXCL8 impacting on neutrophil chemotaxis
Authors: J Batt, M Milward, I Chapple, M Grant, H Roberts, O Addison
Eur Cell Mater, 2018;35(0):13-24.
-
Effect of combined inhibition of p110 alpha PI3K isoform and STAT3 pathway in ovarian cancer platinum-based resistance
Authors: A Le Naour, R Mevel, B Thibault, E Courtais, E Chantalat, JP Delord, B Couderc, J Guillermet, A Martinez
Oncotarget, 2018;9(43):27220-27232.
Species: Human
Sample Types: Serum
-
Annexin A1, FPR2/ALX, and inflammatory cytokine expression in peritoneal endometriosis
Authors: LK Volpato, VV Horewicz, F Bobinski, DF Martins, AP Piovezan
J. Reprod. Immunol., 2018;129(0):30-35.
Species: Human
Sample Types: Peritoneal Fluid
-
Direct antiviral properties of TLR ligands against HBV replication in immune-competent hepatocytes
Authors: J Lucifora, M Bonnin, L Aillot, F Fusil, S Maadadi, L Dimier, M Michelet, O Floriot, A Ollivier, M Rivoire, M Ait-Gougho, S Daffis, SP Fletcher, A Salvetti, FL Cosset, F Zoulim, D Durantel
Sci Rep, 2018;8(1):5390.
Species: Human
Sample Types: Cell Culture Supernates
-
Crosstalk Between Nuclear Glucose-Regulated Protein 78 and Tumor Protein 53 Contributes to the Lipopolysaccharide Aggravated Apoptosis of Endoplasmic Reticulum Stress-Responsive Porcine Intestinal Epithelial Cells
Authors: Q Jiang, G Liu, J Chen, K Yao, Y Yin
Cell. Physiol. Biochem., 2018;48(6):2441-2455.
Species: Porcine
Sample Types: Cell Culture Supernates
-
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy
Authors: SE Logue, EP McGrath, P Cleary, S Greene, K Mnich, A Almanza, E Chevet, RM Dwyer, A Oommen, P Legembre, F Godey, EC Madden, B Leuzzi, J Obacz, Q Zeng, JB Patterson, R Jäger, AM Gorman, A Samali
Nat Commun, 2018;9(1):3267.
Species: Human
Sample Types: Cell Culture Supernates
-
Serum metabolomic profiling predicts synovial gene expression in rheumatoid arthritis
Authors: R Narasimhan, R Coras, SB Rosenthal, SR Sweeney, A Lodi, S Tiziani, D Boyle, A Kavanaugh, M Guma
Arthritis Res. Ther., 2018;20(1):164.
Species: Human
Sample Types: Serum
-
Anti-inflammatory activity of CKC-containing cationic emulsion eye drop vehicles
Authors: P Daull, S Guenin, V Hamon de A, JS Garrigue
Mol. Vis., 2018;24(0):459-470.
Species: Human
Sample Types: Cell Culture Supernates
-
Plasma inflammatory and immune proteins as predictors of intra-amniotic infection and spontaneous preterm delivery in women with preterm labor: a retrospective study
Authors: H Park, KH Park, YM Kim, SY Kook, SJ Jeon, HN Yoo
BMC Pregnancy Childbirth, 2018;18(1):146.
Species: Human
Sample Types: Amniotic Fluid
-
The Effects of Varying Degree of MWCNT Carboxylation on Bioactivity in Various In Vivo and In Vitro Exposure Models
Authors: RF Hamilton, Z Wu, S Mitra, A Holian
Int J Mol Sci, 2018;19(2):.
Species: Human
Sample Types: Cell Culture Supernates
-
IL-6 and CXCL8 mediate osteosarcoma-lung interactions critical to metastasis
Authors: AC Gross, H Cam, DA Phelps, AJ Saraf, HK Bid, M Cam, CA London, SA Winget, MA Arnold, L Brandolini, X Mo, JM Hinckley, PJ Houghton, RD Roberts
JCI Insight, 2018;3(16):.
Species: Human
Sample Types: Cell Culture Supernates
-
Disabled-2 (DAB2) Overexpression Inhibits Monocyte-Derived Dendritic Cells' Function in Vogt-Koyanagi-Harada Disease
Authors: S Yi, R Chang, J Hu, Y Qiu, Q Wang, Q Cao, G Yuan, G Su, C Zhou, Y Wang, A Kijlstra, P Yang
Invest. Ophthalmol. Vis. Sci., 2018;59(11):4662-4669.
Species: Human
Sample Types: Cell Culture Supernates
-
Human Mesenchymal Stem Cell Secretome from Bone Marrow or Adipose-Derived Tissue Sources for Treatment of Hypoxia-Induced Pulmonary Epithelial Injury
Authors: N Shologu, M Scully, JG Laffey, D O'Toole
Int J Mol Sci, 2018;19(10):.
Species: Human
Sample Types: Cell Culture Supernates
-
Diabetes mellitus secondary to pancreatic diseases (type 3c): The effect of smoking on the exocrine-endocrine interactions of the pancreas
Authors: M ?liwi?ska-, S Milnerowic, H Milnerowic
Diab Vasc Dis Res, 2018;0(0):1479164118764.
Species: Human
Sample Types: Whole Cells
Applications: ELISA Detection -
Electrophilic properties of itaconate and derivatives regulate the�I?B?-ATF3 inflammatory axis
Authors: M Bambouskov, L Gorvel, V Lampropoul, A Sergushich, E Loginichev, K Johnson, D Korenfeld, ME Mathyer, H Kim, LH Huang, D Duncan, H Bregman, A Keskin, A Santeford, RS Apte, R Sehgal, B Johnson, GK Amarasingh, MP Soares, T Satoh, S Akira, T Hai, C de Guzman, K Auclair, TP Roddy, SA Biller, M Jovanovic, E Klechevsky, KM Stewart, GJ Randolph, MN Artyomov
Nature, 2018;556(7702):501-504.
Species: Human
Sample Types: Cell Culture Supernates
-
Effects of agricultural organic dusts on human lung-resident mesenchymal stem (stromal) cell function
Authors: TM Nordgren, KL Bailey, AJ Heires, D Katafiasz, DJ Romberger
Toxicol. Sci., 2018;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Interferon-gamma inhibits seminal plasma induction of colony stimulating factor 2 in mouse and human reproductive tract epithelial cells
Authors: DJ Sharkey, DJ Glynn, JE Schjenken, KP Tremellen, SA Robertson
Biol. Reprod., 2018;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Broad adsorption of sepsis-related PAMP and DAMP molecules, mycotoxins, and cytokines from whole blood using CytoSorb� sorbent porous polymer beads
Authors: MC Gruda, KG Ruggeberg, P O'Sullivan, T Guliashvil, AR Scheirer, TD Golobish, VJ Capponi, PP Chan
PLoS ONE, 2018;13(1):e0191676.
Species: Human
Sample Types: Complex Sample Type
-
Interaction between Toll-Like Receptor 9-CpG Oligodeoxynucleotides and Hepatitis B Virus Virions Leads to Entry Inhibition in Hepatocytes and Reduction of Alpha Interferon Production by Plasmacytoid Dendritic Cells
Authors: L Aillot, M Bonnin, M Ait-Gougho, N Bendriss-V, S Maadadi, L Dimier, M Subic, C Scholtes, I Najera, F Zoulim, J Lucifora, D Durantel
Antimicrob. Agents Chemother., 2018;62(4):.
Species: Human
Sample Types: Cell Culture Supernates
-
Association of genetic variations in PTPN2 and CD122 with ocular Behcet's disease
Authors: Q Zhang, H Li, S Hou, H Yu, G Su, B Deng, J Qi, C Zhou, A Kijlstra, P Yang
Br J Ophthalmol, 2018;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Epicutaneous administration of the pattern recognition receptor agonist polyinosinic-polycytidylic acid activates the MDA5/MAVS pathway in Langerhans cells
Authors: P Tajpara, C Schuster, E Schön, P Kienzl, M Vierhapper, M Mildner, A Elbe-Bürge
FASEB J., 2018;0(0):fj201701090R.
Species: Human
Sample Types: Cell Culture Supernates
-
Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases
Authors: N Gour, S Lajoie, U Smole, M White, D Hu, P Goddard, S Huntsman, C Eng, A Mak, S Oh, JH Kim, A Sharma, S Plante, IH Salem, Y Resch, X Xiao, N Yao, A Singh, S Vrtala, J Chakir, EG Burchard, AP Lane, M Wills-Karp
Sci Immunol, 2018;3(20):.
Species: Human
Sample Types: Cell Culture Supernates
-
EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes
Authors: A Rutkowska, DR Shimshek, AW Sailer, KK Dev
Neuropharmacology, 2018;133(0):121-128.
Species: Human
Sample Types: Cell Culture Supernates
-
Hemolysis and Inflammatory Response to Extracorporeal Circulation during On-Pump CABG: Comparison between Roller and Centrifugal Pump Systems
Authors: AC Passaroni, ML Felicio, NLKL Campos, MAM Silva, WB Yoshida
Braz J Cardiovasc Surg, 2018;33(1):64-71.
Species: Human
Sample Types: Plasma
-
Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak
Authors: F Colavita, S Vita, E Lalle, F Carletti, L Bordi, D Vincenti, I Pozzetto, M Aiuti, F Vairo, MR Capobianch, M Lichtner, C Castillett
Open Forum Infect Dis, 2018;5(11):ofy276.
Species: Human
Sample Types: Plasma
-
Variable localization of Toll-like receptors in human fallopian tube epithelial cells
Authors: F Amjadi, Z Zandieh, E Salehi, R Jafari, N Ghasemi, A Aflatoonia, A Fazeli, R Aflatoonia
Clin Exp Reprod Med, 2018;45(1):1-9.
Species: Human
Sample Types: Cell Culture Supernates
-
Phosphatase of regenerating liver-3 (PRL-3) is overexpressed in classical Hodgkin lymphoma and promotes survival and migration
Authors: MA Hjort, H Hov, P Abdollahi, EN Vandsemb, UM Fagerli, B Lund, TS Slørdahl, M Børset, TB Rø
Exp Hematol Oncol, 2018;7(0):8.
Species: Human
Sample Types: Cell Culture Supernates
-
Caspase-2 associates with FAN through direct interaction and overlapping functionality
Authors: J Forsberg, X Li, AV Zamaraev, T Panaretaki, B Zhivotovsk, M Olsson
Biochem. Biophys. Res. Commun., 2018;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Reduced MBD2 expression enhances airway inflammation in bronchial epithelium in COPD
Authors: Z Zeng, M Li, J Chen, Q Li, Q Ning, J Zhao, Y Xu, J Xie, J Yu
Int J Chron Obstruct Pulmon Dis, 2018;13(0):703-715.
Species: Human
Sample Types: Cell Cultuer Supernates
-
A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
Authors: LBS Hansen, HM Roager, NB Søndertoft, RJ Gøbel, M Kristensen, M Vallès-Col, S Vieira-Sil, S Ibrügger, MV Lind, RB Mærkedahl, MI Bahl, ML Madsen, J Havelund, G Falony, I Tetens, T Nielsen, KH Allin, HL Frandsen, B Hartmann, JJ Holst, MH Sparholt, J Holck, A Blennow, JM Moll, AS Meyer, C Hoppe, JH Poulsen, V Carvalho, D Sagnelli, MD Dalgaard, AF Christense, MC Lydolph, AB Ross, S Villas-Bôa, S Brix, T Sicheritz-, K Buschard, A Linneberg, JJ Rumessen, CT Ekstrøm, C Ritz, K Kristianse, HB Nielsen, H Vestergaar, NJ Færgeman, J Raes, H Frøkiær, T Hansen, L Lauritzen, R Gupta, TR Licht, O Pedersen
Nat Commun, 2018;9(1):4630.
Species: Human
Sample Types: Cell Culture Supernates
-
Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer
Authors: MH Kubala, V Punj, VR Placencio-, H Fang, GE Fernandez, R Sposto, YA DeClerck
Cell Rep, 2018;25(8):2177-2191.e7.
Species: Human
Sample Types: Cell Culture Supernates
-
A Transient Pseudosenescent Secretome Promotes Tumor Growth after Antiangiogenic Therapy Withdrawal
Authors: M Mastri, A Tracz, CR Lee, M Dolan, K Attwood, JG Christense, S Liu, JML Ebos
Cell Rep, 2018;25(13):3706-3720.e8.
Species: Human
Sample Types: Cell Culture Supernates
-
iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
Authors: I Oikonomidi, E Burbridge, M Cavadas, G Sullivan, B Collis, H Naegele, D Clancy, J Brezinova, T Hu, A Bileck, C Gerner, A Bolado, A von Kriegs, SJ Martin, F Steinberg, K Strisovsky, C Adrain
Elife, 2018;7(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
Authors: F Mizoguchi, K Slowikowsk, K Wei, JL Marshall, DA Rao, SK Chang, HN Nguyen, EH Noss, JD Turner, BE Earp, PE Blazar, J Wright, BP Simmons, LT Donlin, GD Kalliolias, SM Goodman, VP Bykerk, LB Ivashkiv, JA Lederer, N Hacohen, PA Nigrovic, A Filer, CD Buckley, S Raychaudhu, MB Brenner
Nat Commun, 2018;9(1):789.
Species: Human
Sample Types: Cell Culture Supernates
-
Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression
Authors: CC Wei, YJ Kung, CS Chen, CY Chang, CJ Lin, PT Tien, HY Chang, HJ Chen, YS Huang, HJ Lin, L Wan
EBioMedicine, 2018;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Genome wide analysis of TLR1/2- and TLR4-activated SZ95 sebocytes reveals a complex immune-competence and identifies serum amyloid A as a marker for activated sebaceous glands
Authors: D Tör?csik, D Kovács, S Póliska, Z Szentkeres, M Lovászi, K Hegyi, A Szegedi, CC Zouboulis, M Ståhle
PLoS ONE, 2018;13(6):e0198323.
Species: Human
Sample Types: Cell Culture Supernates
-
Association of Long Noncoding RNAs Polymorphisms With Ankylosing Spondylitis, Vogt-Koyanagi-Harada Disease, and Behcet's Disease
Authors: Y Yue, J Zhang, L Yang, S Liu, J Qi, Q Cao, C Zhou, Y Wang, A Kijlstra, P Yang, S Hou
Invest. Ophthalmol. Vis. Sci., 2018;59(2):1158-1166.
Species: Human
Sample Types: Cell Culture Supernates
-
Distinct Properties of Human M-CSF and GM-CSF Monocyte-Derived Macrophages to Simulate Pathological Lung Conditions In Vitro: Application to Systemic and Inflammatory Disorders with Pulmonary Involvement
Authors: A Lescoat, A Ballerie, Y Augagneur, C Morzadec, L Vernhet, O Fardel, P Jégo, S Jouneau, V Lecureur
Int J Mol Sci, 2018;19(3):.
Species: Human
Sample Types: Cell Culture Supernates
-
Minocycline modulates NF?B phosphorylation and enhances antimicrobial activity against Staphylococcus aureus in mesenchymal stromal/stem cells
Authors: AD Guerra, WE Rose, P Hematti, WJ Kao
Stem Cell Res Ther, 2017;8(1):171.
Species: Human
Sample Types: Cell Culture Supernates
-
In vitro and in vivo antagonistic activity of new probiotic culture against Clostridium difficile and Clostridium perfringens
Authors: N Goli?, K Veljovi?, N Popovi?, J Djoki?, I Strahini?, I Mrvaljevi?, A Terzi?-Vid
BMC Microbiol., 2017;17(1):108.
Species: Human
Sample Types: Cell Culture Supernates
-
MicroRNA-320a protects against osteoarthritis cartilage degeneration by regulating the expressions of BMI-1 and RUNX2 in chondrocytes
Authors: H Peng, D Liang, B Li, C Liang, W Huang, H Lin
Pharmazie, 2017;72(4):223-226.
Species: Human
Sample Types: Cell Culture Supernates
-
Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro
Authors: BR Oh, DH Suh, D Bae, N Ha, YI Choi, HJ Yoo, JK Park, EY Lee, EB Lee, YW Song
Arthritis Res. Ther., 2017;19(1):154.
Species: Human
Sample Types: Cell Culture Supernates
-
Clinical significance of histologic chorioamnionitis with a negative amniotic fluid culture in patients with preterm labor and premature membrane rupture
Authors: JW Park, KH Park, EY Jung
PLoS ONE, 2017;12(3):e0173312.
Species: Human
Sample Types: Amniotic Fluid
-
Adipogenic differentiation of MSC alters their immunomodulatory properties in a tissue-specific manner
Authors: H Munir, LS Ward, L Sheriff, S Kemble, S Nayar, F Barone, GB Nash, HM McGettrick
Stem Cells, 2017;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Pre- and post-surgical evaluation of the inflammatory response in patients with aortic stenosis treated with different types of prosthesis
Authors: ME Soto, JL Salas, J Vargas-Bar, R Marquez, A Rodriguez-, R Bojalil-Pa, I Pérez-Torr, V Guarner-La
BMC Cardiovasc Disord, 2017;17(1):100.
Species: Human
Sample Types: Serum
-
Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory FADDosome Complex upon TRAIL Stimulation
Authors: CM Henry, SJ Martin
Mol. Cell, 2017;65(4):715-729.e5.
Species: Human
Sample Types: Cell Culture Supernates
-
Amniotic Fluid Infection, Cytokine Levels, and Mortality and Adverse Pulmonary, Intestinal, and Neurologic Outcomes in Infants at 32 Weeks' Gestation or Less
Authors: EY Jung, KH Park, BR Han, SH Cho, HN Yoo, J Lee
J. Korean Med. Sci, 2017;32(3):480-487.
Species: Human
Sample Types: Amniotic Fluid
-
Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis
Authors: D Nicholas, EA Proctor, FM Raval, BC Ip, C Habib, E Ritou, TN Grammatopo, D Steenkamp, H Dooms, CM Apovian, DA Lauffenbur, BS Nikolajczy
PLoS ONE, 2017;12(2):e0170975.
Species: Human
Sample Types: Cell Culture Supernates
-
Iron nanomedicines induce Toll-like receptor activation, cytokine production and complement activation
Authors: Johan J F Verhoef
Biomaterials, 2017;119(0):68-77.
Species: Human
Sample Types: Cell Culture Supernates
-
Mild intracellular acidification by dexamethasone attenuates mitochondrial dysfunction in a human inflammatory proximal tubule epithelial cell model
Authors: TJJ Schirris, J Jansen, M Mihajlovic, LP van den He, R Masereeuw, FGM Russel
Sci Rep, 2017;7(1):10623.
Species: Human
Sample Types: Cell Culture Supernates
-
Serum retinol-binding protein-induced endothelial inflammation is mediated through the activation of toll-like receptor 4
Authors: M Du, A Martin, F Hays, J Johnson, RA Farjo, KM Farjo
Mol. Vis., 2017;23(0):185-197.
Species: Human
Sample Types: Cell Culture Supernates
-
Resistin as a Prooxidant Factor and Predictor of Endothelium Damage in Patients with Mild Acute Pancreatitis Exposed to Tobacco Smoke Xenobiotics
Authors: M ?ciskalska, G Marek, Z Grzebienia, H Milnerowic
Mediators Inflamm., 2017;2017(0):3039765.
Species: Human
Sample Types: Plasma
-
Associations between TNFSF4, TNFSF8 and TNFSF15 and Beh�et's disease but not VKH syndrome in Han Chinese
Authors: Y Jiang, L Cheng, X Li, W Zhou, L Zhang
Oncotarget, 2017;8(62):105037-105046.
Species: Human
Sample Types: Cell Culture Supernates
-
Increased expression of Siglec-9 in chronic obstructive pulmonary disease
Authors: Z Zeng, M Li, M Wang, X Wu, Q Li, Q Ning, J Zhao, Y Xu, J Xie
Sci Rep, 2017;7(1):10116.
Species: Human
Sample Types: Cell Culture Supernates
-
Pathogenic role of glycan-specific IgG antibodies in IgA nephropathy
Authors: YF Zhao, L Zhu, LJ Liu, SF Shi, JC Lv, H Zhang
BMC Nephrol, 2017;18(1):301.
Species: Human
Sample Types: Cell Culture Supernates
-
Frequency and clinical significance of short cervix in patients with preterm premature rupture of membranes
Authors: SM Lee, KH Park, EY Jung, JA Jang, HN Yoo
PLoS ONE, 2017;12(3):e0174657.
Species: Human
Sample Types: Amniotic Fluid
-
Expression of MicroRNA in Host Cells Infected with Helicobacter pylori
Authors: JW Chung, SH Jeong, SM Lee, JH Pak, GH Lee, JY Jeong, JH Kim
Gut Liver, 2017;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-? Expression
Authors: K Eriksson, A Svensson, AS Hait, K Schlüter, P Tunbäck, I Nordström, L Padyukov, JÅ Liljeqvist, TH Mogensen, SR Paludan
J. Immunol., 2017;0(0):.
Species: Human
Sample Types: Plasma
-
Improvement of cardiometabolic markers after fish oil intervention in young Mexican adults and the role of PPAR? L162V and PPAR?2 P12A
Authors: A Binia, C Vargas-Mar, M Ancira-Mor, LM Gosoniu, I Montoliu, E Gámez-Vald, DC Soria-Cont, A Angeles-Qu, R Gonzalez-A, S Fernández, D Martínez-C, B Hernández-, M Ramírez-So, C Pérez-Orte, Y Rodríguez-, I Castan, I Rubio-Alia, F Vadillo-Or, R Márquez-Ve, R Bojalil, JC López-Alva, P Valet, M Kussmann, I Silva-Zole, ME Tejero
J. Nutr. Biochem., 2017;43(0):98-106.
Species: Human
Sample Types: Serum
-
IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity
Authors: MJ Pearson, D Herndler-B, MA Tariq, TA Nicholson, AM Philp, HL Smith, ET Davis, SW Jones, JM Lord
Sci Rep, 2017;7(1):3451.
Species: Human
Sample Types: Cell Culture Supernates
-
Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions
Authors: M Mihajlovic, M Fedecostan, MJ Oost, SKP Steenhuis, EGWM Lentjes, I Maitimu-Sm, MJ Janssen, LB Hilbrands, R Masereeuw
Int J Mol Sci, 2017;18(12):.
Species: Human
Sample Types: Cell Culture Supernates
-
Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways
Authors: A Burban, A Sharanek, R Hüe, M Gay, S Routier, A Guillouzo, C Guguen-Gui
Sci Rep, 2017;7(1):1815.
Species: Human
Sample Types: Cell Culture Supernates
-
Tumor-Derived Mesenchymal Stem Cells Use Distinct Mechanisms to Block the Activity of Natural Killer Cell Subsets
Authors: S Galland, J Vuille, P Martin, I Letovanec, A Caignard, G Fregni, I Stamenkovi
Cell Rep, 2017;20(12):2891-2905.
Species: Human
Sample Types: Cell Culture Supernates
-
cfDNA correlates with endothelial damage after cardiac surgery with prolonged cardiopulmonary bypass and amplifies NETosis in an intracellular TLR9-independent manner
Authors: A Paunel-Gör, M Wacker, M El Aita, S Hassan, G Schlachten, A Deppe, YH Choi, E Kuhn, TO Mehler, T Wahlers
Sci Rep, 2017;7(1):17421.
Species: Human
Sample Types: Plasma
-
Human gestation-associated tissues express functional cytosolic nucleic acid sensing pattern recognition receptors
Authors: AH Bryant, GE Menzies, LM Scott, S Spencer-Ha, LB Davies, RA Smith, RH Jones, CA Thornton
Clin. Exp. Immunol, 2017;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Changes in peripheral immune cell numbers and functions in octogenarian walkers - an acute exercise study
Authors: KS van der Ge, Q Wang, TM Eijsvogels, HJ Koenen, I Joosten, E Brouwer, MT Hopman, JF Jacobs, AM Boots
Immun Ageing, 2017;14(0):5.
Species: Human
Sample Types: Cell Culture Supernates
-
Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype
Authors: SJ Snelling, S Bas, GJ Puskas, SG Dakin, D Suva, A Finckh, C Gabay, P Hoffmeyer, AJ Carr, A Lübbeke
PLoS ONE, 2017;12(4):e0175109.
Species: Human
Sample Types: Serum
-
The Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Cellular Senescence of Cultivated Human Corneal Endothelial Cells
Authors: A Hongo, N Okumura, M Nakahara, EP Kay, N Koizumi
Invest. Ophthalmol. Vis. Sci., 2017;58(9):3325-3334.
Species: Human
Sample Types: Cell Culture Supernates
-
Prevention of influenza virus induced bacterial superinfection by standardized Echinacea purpurea, via regulation of surface receptor expression in human bronchial epithelial cells
Authors: V Selvarani, S Roland, S Andy, H James
Virus Res, 2017;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Allostimulatory capacity of conditionally immortalized proximal tubule cell lines for bioartificial kidney application
Authors: M Mihajlovic, LP van den He, JG Hoenderop, J Jansen, MJ Wilmer, AJF Westheim, WA Allebes, D Stamatiali, LB Hilbrands, R Masereeuw
Sci Rep, 2017;7(1):7103.
Species: Human
Sample Types: Cell Culture Supernates
-
Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function
Authors: RM Petri, A Hackel, K Hahnel, CA Dumitru, K Bruderek, SB Flohe, A Paschen, S Lang, S Brandau
Stem Cell Reports, 2017;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Demyelination induced by oxidative stress is regulated by sphingosine 1-phosphate receptors
Authors: SA O'Sullivan, M Velasco-Es, KK Dev
Glia, 2017;0(0):.
-
Collagen-Based Medical Device as a Stem Cell Carrier for Regenerative Medicine
Authors: L Aubert, M Dubus, H Rammal, C Bour, C Mongaret, C Boulagnon-, R Garnotel, C Schneider, R Rahouadj, C Laurent, SC Gangloff, F Velard, C Mauprivez, H Kerdjoudj
Int J Mol Sci, 2017;18(10):.
Species: Human
Sample Types: Cell Culture Supernates
-
Reduced microRNA-503 expression augments lung fibroblast VEGF production in chronic obstructive pulmonary disease
Authors: J Ikari, AJ Nelson, J Obaid, A Giron-Mart, K Ikari, F Makino, S Iwasawa, Y Gunji, M Farid, X Wang, H Basma, D Demeo, C Feghali-Bo, O Holz, K Rabe, X Liu, SI Rennard
PLoS ONE, 2017;12(9):e0184039.
Species: Human
Sample Types: Cell Culture Supernates
-
Vitamin D both facilitates and attenuates the cellular response to lipopolysaccharide
Authors: L Chen, MS Eapen, GR Zosky
Sci Rep, 2017;7(0):45172.
Species: Human
Sample Types: Cell Culture Supernates
-
MicroRNA-143 and -145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis
Authors: BK Hong, S You, SA Yoo, D Park, D Hwang, CS Cho, WU Kim
Exp. Mol. Med., 2017;49(8):e363.
Species: Human
Sample Types: Cell Culture Supernates
-
DNA Sensing via TLR-9 Constitutes a Major Innate Immunity Pathway Activated during Erythema Nodosum Leprosum
J Immunol, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Serum from Varicose Patients Induces Senescence-Related Dysfunction of Vascular Endothelium Generating Local and Systemic Proinflammatory Conditions
Oxid Med Cell Longev, 2016;2016(0):2069290.
Species: Human
Sample Types: Serum
-
Acanthamoeba castellanii (Genotype T4) Stimulates the Production of Interleukin-10 as well as Pro-inflammatory Cytokines in THP-1 Cells, Human Peripheral Blood Mononuclear Cells and Human Monocyte-Derived Macrophages
Infect Immun, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Novel approach to study the cardiovascular effects and mechanism of action of urban particulate matter using lung epithelial-endothelial tetra-culture system
Authors: Kyu Hyuck Chung
Toxicol In Vitro, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Genetic polymorphisms of cell adhesion molecules in Behcet's disease in a Chinese Han population
Authors: M Zheng, L Zhang, H Yu, J Hu, Q Cao, G Huang, Y Huang, G Yuan, A Kijlstra, P Yang
Sci Rep, 2016;6(0):24974.
Species: Human
Sample Types: Cell Culture Supernates
-
Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-?B-mediated cytokine production
Authors: Soh Yamamoto
Biochem. Biophys. Res. Commun, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Engineering a 3D microfluidic culture platform for tumor-treating field application
Sci Rep, 2016;6(0):26584.
Species: Human
Sample Types: Cell Culture Supernates
-
Differential IL-1? secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability
Sci Rep, 2016;6(0):39035.
Species: Human
Sample Types: Cell Culture Supernates
-
Graphene-augmented nanofiber scaffolds demonstrate new features in cells behaviour
Sci Rep, 2016;6(0):30150.
Species: Human
Sample Types: Cell Culture Supernates
-
Altered Systemic Adipokines in Patients with Chronic Urticaria
Authors: Hoang Kim Tu Trinh
Int. Arch. Allergy Immunol, 2016;171(2):102-110.
Species: Human
Sample Types: Serum
-
Dual Inhibition of Rip2 and IRAK1/4 Regulates IL-1? and IL-6 in Sarcoidosis Alveolar Macrophages and Peripheral Blood Mononuclear Cells
J Immunol, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Temperature responsive porous silicon nanoparticles for cancer therapy - spatiotemporal triggering through infrared and radiofrequency electromagnetic heating
J Control Release, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin
J Immunol, 2016;196(11):4681-91.
Species: Human
Sample Types: Cell Culture Supernates
-
Analysis of receptor tyrosine kinase genetics identifies two novel risk loci in GAS6 and PROS1 in Beh�et's disease
Sci Rep, 2016;6(0):26662.
Species: Human
Sample Types: Cell Culture Supernates
-
Hepcidin-Induced Iron Deficiency Is Related to Transient Anemia and Hypoferremia in Kawasaki Disease Patients
Int J Mol Sci, 2016;17(5):.
Species: Human
Sample Types: Plasma
-
Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion
PLoS ONE, 2016;11(11):e0166500.
Species: Human
Sample Types: Cell Culture Supernates
-
Biocompatibility of primers and an adhesive used for implant-retained maxillofacial prostheses: An in�vitro analysis
Authors: Daniela Micheline Dos Santos
J Prosthet Dent, 2016;0(0):.
-
Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-?
Aging Cell, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of Mycobacterium tuberculosis
J. Immunol., 2016;197(12):4727-4735.
Species: Human
Sample Types: Cell Culture Supernates
-
Nitro-Oleic Acid Prevents Hypoxia- and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction
Authors: Michaela Pekarova
Cardiovasc Drugs Ther, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Modulating endotoxin activity by combinatorial bioengineering of meningococcal lipopolysaccharide
Sci Rep, 2016;6(0):36575.
Species: Human
Sample Types: Cell Culture Supernates
-
Comparative Ability of Mesenchymal Stromal Cells from Different Tissues to Limit Neutrophil Recruitment to Inflamed Endothelium
PLoS ONE, 2016;11(5):e0155161.
Species: Human
Sample Types: Cell Culture Supernates
-
Amyloid precursor protein mediated changes in intestinal epithelial phenotype in vitro.
Authors: Puig K, Manocha G, Combs C
PLoS ONE, 2016;10(3):e0119534.
Species: Human
Sample Types: Cell Culture Supernates
-
Stand-Sit Microchip for High-Throughput, Multiplexed Analysis of Single Cancer Cells
Sci Rep, 2016;6(0):32505.
Applications: ChIP -
Essential Oils from Ugandan Medicinal Plants: In Vitro Cytotoxicity and Effects on IL-1?-Induced Proinflammatory Mediators by Human Gingival Fibroblasts
Evid Based Complement Alternat Med, 2016;2016(0):5357689.
Species: Human
Sample Types: Cell Culture Supernates
-
Characterization of the MMP/TIMP Imbalance and Collagen Production Induced by IL-1? or TNF-? Release from Human Hepatic Stellate Cells
Authors: S Robert, T Gicquel, A Bodin, V Lagente, E Boichot
PLoS ONE, 2016;11(4):e0153118.
Species: Human
Sample Types: Cell Culture Supernates
-
MODELING STROMA-INDUCED DRUG RESISTANCE IN A TISSUE-ENGINEERED TUMOR MODEL OF EWING SARCOMA
Authors: Marco Santoro
Tissue Eng Part A, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
IL-17 Promotes Neutrophil-Mediated Immunity by Activating Microvascular Pericytes and Not Endothelium
J Immunol, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Cancer-associated mesenchymal stroma fosters the stemness of osteosarcoma cells in response to intratumoral acidosis via NF-?B acivation
Authors: Sofia Avnet
Int. J. Cancer, 2016;0(0):.
Species: Human
Sample Types: Serum
-
Interaction among activated lymphocytes and mesenchymal cells through podoplanin is critical for a high IL-17 secretion
Authors: Mélissa Noack
Arthritis Res Ther, 2016;18(0):148.
Species: Human
Sample Types: Cell Culture Supernates
-
High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus.
Authors: Scheuplein V, Seifried J, Malczyk A, Miller L, Hocker L, Vergara-Alert J, Dolnik O, Zielecki F, Becker B, Spreitzer I, Konig R, Becker S, Waibler Z, Muhlebach M
J Virol, 2015;89(7):3859-69.
Species: Human
Sample Types: Cell Culture Supernates
-
BET bromodomains regulate transforming growth factor-beta-induced proliferation and cytokine release in asthmatic airway smooth muscle.
Authors: Perry M, Durham A, Austin P, Adcock I, Chung K
J Biol Chem, 2015;290(14):9111-21.
Species: Human
Sample Types: Cell Culture Supernates
-
Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production.
Authors: Kearney C, Cullen S, Tynan G, Henry C, Clancy D, Lavelle E, Martin S
Cell Death Differ, 2015;22(8):1313-27.
Species: Human
Sample Types: Cell Culture Supernates
-
Exposure to diesel exhaust particle extracts (DEPe) impairs some polarization markers and functions of human macrophages through activation of AhR and Nrf2.
Authors: Jaguin M, Fardel O, Lecureur V
PLoS ONE, 2015;10(2):e0116560.
Species: Human
Sample Types: Cell Culture Supernates
-
The effects of knockdown of rho-associated kinase 1 and zipper-interacting protein kinase on gene expression and function in cultured human arterial smooth muscle cells.
Authors: Deng J, Wang X, Chen Y, O'Brien E, Gui Y, Walsh M
PLoS ONE, 2015;10(2):e0116969.
Species: Human
Sample Types: Cell Culture Supernates
-
LPS-Stimulated Whole Blood Cytokine Production Is Not Related to Disease Behavior in Patients with Quiescent Crohn's Disease.
Authors: Broekman M, Roelofs H, Hoentjen F, Wiegertjes R, Stoel N, Joosten L, de Jong D, Wanten G
PLoS ONE, 2015;10(7):e0133932.
Species: Human
Sample Types: Plasma
-
Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells.
Authors: Price L, Shao D, Meng C, Perros F, Garfield B, Zhu J, Montani D, Dorfmuller P, Humbert M, Adcock I, Wort S
Respir Res, 2015;16(0):114.
Species: Human
Sample Types: Cell Culture Supernates
-
Transcriptomic Analyses of the Biological Effects of Airborne PM2.5 Exposure on Human Bronchial Epithelial Cells.
Authors: Zhou Z, Liu Y, Duan F, Qin M, Wu F, Sheng W, Yang L, Liu J, He K
PLoS ONE, 2015;10(9):e0138267.
Species: Human
Sample Types: Cell Culture Supernates
-
Effect of lipopolysaccharide on glucocorticoid receptor function in control nasal mucosa fibroblasts and in fibroblasts from patients with chronic rhinosinusitis with nasal polyps and asthma.
Authors: Fernandez-Bertolin L, Mullol J, Fuentes-Prado M, Roca-Ferrer J, Alobid I, Picado C, Pujols L
PLoS ONE, 2015;10(5):e0125443.
Species: Human
Sample Types: Cell Culture Supernates
-
Cytosolic phospholipase A2 modulates TLR2 signaling in synoviocytes.
Authors: Sommerfelt R, Feuerherm A, Skuland T, Johansen B
PLoS ONE, 2015;10(4):e0119088.
Species: Human
Sample Types: Cell Culture Supernates
-
An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells.
Authors: Campia I, Buondonno I, Castella B, Rolando B, Kopecka J, Gazzano E, Ghigo D, Riganti C
PLoS ONE, 2015;10(5):e0126159.
Species: Human
Sample Types: Cell Culture Supernates
-
SRSF1 facilitates cytosolic DNA-induced production of type I interferons recognized by RIG-I.
Authors: Xue F, Li X, Zhao X, Wang L, Liu M, Shi R, Zheng J
PLoS ONE, 2015;10(2):e0115354.
Species: Human
Sample Types: Cell Culture Supernates
-
Interleukin-23 Receptor Gene Polymorphism May Enhance Expression of the IL-23 Receptor, IL-17, TNF-alpha and IL-6 in Behcet's Disease.
Authors: Jiang Z, Hennein L, Tao Y, Tao L
PLoS ONE, 2015;10(7):e0134632.
Species: Human
Sample Types: Cell Culture Supernates
-
In vitro progesterone modulation on bacterial endotoxin-induced production of IL-1beta, TNFalpha, IL-6, IL-8, IL-10, MIP-1alpha, and MMP-9 in pre-labor human term placenta.
Authors: Garcia-Ruiz G, Flores-Espinosa P, Preciado-Martinez E, Bermejo-Martinez L, Espejel-Nunez A, Estrada-Gutierrez G, Maida-Claros R, Flores-Pliego A, Zaga-Clavellina V
Reprod Biol Endocrinol, 2015;13(0):115.
Species: Human
Sample Types: Cell Culture Supernates
-
Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M.
Authors: Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, Richards C
Respir Res, 2015;16(0):14.
Species: Human
Sample Types: Cell Culture Supernates
-
Porphyromonas gingivalis GroEL induces osteoclastogenesis of periodontal ligament cells and enhances alveolar bone resorption in rats.
Authors: Lin F, Hsiao F, Huang C, Shih C, Tsao N, Tsai C, Yang S, Chang N, Hung S, Lin Y
PLoS ONE, 2014;9(7):e102450.
Species: Human
Sample Types: Cell Culture Supernates
-
Identification of the flagellin glycosylation system in Burkholderia cenocepacia and the contribution of glycosylated flagellin to evasion of human innate immune responses.
Authors: Hanuszkiewicz A, Pittock P, Humphries F, Moll H, Rosales A, Molinaro A, Moynagh P, Lajoie G, Valvano M
J Biol Chem, 2014;289(27):19231-44.
Species: Human
Sample Types: Cell Culture Supernates
-
Circulating autoantibodies to endothelial progenitor cells: binding characteristics and association with risk factors for atherosclerosis.
Authors: George J, Matucci-Cerinic M, Bar I, Shimoni S
PLoS ONE, 2014;9(6):e97836.
Species: Human
Sample Types: Serum
-
Roles for the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, in feedback control of inflammatory gene expression and repression by dexamethasone.
Authors: Shah S, King E, Chandrasekhar A, Newton R
J Biol Chem, 2014;289(19):13667-79.
Species: Human
Sample Types: Cell Culture Supernates
-
Bacterial siderophores that evade or overwhelm lipocalin 2 induce hypoxia inducible factor 1alpha and proinflammatory cytokine secretion in cultured respiratory epithelial cells.
Authors: Holden V, Lenio S, Kuick R, Ramakrishnan S, Shah Y, Bachman M
Infect Immun, 2014;82(9):3826-36.
Species: Human
Sample Types: Cell Culture Supernates
-
Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.
Authors: Mimura N, Hideshima T, Shimomura T, Suzuki R, Ohguchi H, Rizq O, Kikuchi S, Yoshida Y, Cottini F, Jakubikova J, Cirstea D, Gorgun G, Minami J, Tai Y, Richardson P, Utsugi T, Iwama A, Anderson K
Cancer Res, 2014;74(16):4458-69.
Species: Human
Sample Types: Cell Culture Supernates
-
Optofluidic laser for dual-mode sensitive biomolecular detection with a large dynamic range.
Authors: Wu X, Oo M, Reddy K, Chen Q, Sun Y, Fan X
Nat Commun, 2014;5(0):3779.
Species: Human
Sample Types: Protein
-
Activin A as a mediator of NK-dendritic cell functional interactions.
Authors: Seeger P, Bosisio D, Parolini S, Badolato R, Gismondi A, Santoni A, Sozzani S
J Immunol, 2014;192(3):1241-8.
Species: Human
Sample Types: Whole Cells
-
TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells.
Authors: Liu B, Cao Y, Huizinga T, Hafler D, Toes R
Eur J Immunol, 2014;44(7):2121-9.
Species: Human
Sample Types: Cell Culture Supernates
-
Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes.
Authors: Dreymueller D, Martin C, Schumacher J, Groth E, Boehm J, Reiss L, Uhlig S, Ludwig A
J Immunol, 2014;192(2):722-31.
Species: Human
Sample Types: Cell Culture Supernates
-
Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels.
Authors: Arndts, Kathrin, Specht, Sabine, Debrah, Alexande, Tamarozzi, Francesc, Klarmann Schulz, Ute, Mand, Sabine, Batsa, Linda, Kwarteng, Alexande, Taylor, Mark, Adjei, Ohene, Martin, Coralie, Layland, Laura E, Hoerauf, Achim
PLoS Negl Trop Dis, 2014;8(2):e2679.
Species: Human
Sample Types: Cell Culture Supernates
-
TRAF5 and TRAF3IP2 gene polymorphisms are associated with Behcet's disease and Vogt-Koyanagi-Harada syndrome: a case-control study.
Authors: Xiang Q, Chen L, Hou S, Fang J, Zhou Y, Bai L, Liu Y, Kijlstra A, Yang P
PLoS ONE, 2014;9(1):e84214.
Species: Human
Sample Types: Cell Culture Supernates
-
A functional variant of PTPN22 confers risk for Vogt-Koyanagi-Harada syndrome but not for ankylosing spondylitis.
Authors: Zhang Q, Qi J, Hou S, DU L, Yu H, Cao Q, Zhou Y, Liao D, Kijlstra A, Yang P
PLoS ONE, 2014;9(5):e96943.
Species: Human
Sample Types: Cell Culture Supernates
-
Engagement of SLAMF2/CD48 prolongs the time frame of effective T cell activation by supporting mature dendritic cell survival.
Authors: Kis-Toth K, Tsokos G
J Immunol, 2014;192(9):4436-42.
Species: Human
Sample Types: Cell Culture Supernates
-
Mycobacterium tuberculosis impairs dendritic cell functions through the serine hydrolase Hip1.
Authors: Madan-Lala R, Sia J, King R, Adekambi T, Monin L, Khader S, Pulendran B, Rengarajan J
J Immunol, 2014;192(9):4263-72.
Species: Human
Sample Types: Cell Culture Supernates
-
Inflammatory and cytotoxic effects of acrolein, nicotine, acetylaldehyde and cigarette smoke extract on human nasal epithelial cells.
Authors: Comer D, Elborn J, Ennis M
BMC Pulm Med, 2014;14(0):32.
Species: Human
Sample Types: Cell Culture Supernates
-
Neisseria gonorrhoeae modulates iron-limiting innate immune defenses in macrophages.
Authors: Zughaier, Susu M, Kandler, Justin L, Shafer, William
PLoS ONE, 2014;9(1):e87688.
Species: Human
Sample Types: Cell Culture Supernates
-
IL-17A RNA aptamer: possible therapeutic potential in some cells, more than we bargained for in others?
Authors: Doble, Rosella, McDermott, Michael, Cesur, Ozlem, Stonehouse, Nicola J, Wittmann, Miriam
J Invest Dermatol, 2014;134(3):852-5.
Species: Human
Sample Types: Cell Culture Supernates
-
Lipopolysaccharide promotes contraction of uterine myocytes via activation of Rho/ROCK signaling pathways.
Authors: Hutchinson J, Rajagopal S, Yuan M, Norman J
FASEB J, 2014;28(1):94-105.
Species: Human
Sample Types: Cell Culture Supernates
-
Role of non-coding RNAs in maintaining primary airway smooth muscle cells.
Authors: Perry, Mark M, Tsitsiou, Eleni, Austin, Philip J, Lindsay, Mark A, Gibeon, David S, Adcock, Ian M, Chung, Kian Fan
Respir Res, 2014;15(0):58.
Species: Human
Sample Types: Cell Culture Supernates
-
RNA:DNA hybrids are a novel molecular pattern sensed by TLR9.
Authors: Rigby R, Webb L, Mackenzie K, Li Y, Leitch A, Reijns M, Lundie R, Revuelta A, Davidson D, Diebold S, Modis Y, MacDonald A, Jackson A
EMBO J, 2014;33(6):542-58.
Species: Human
Sample Types: Cell Culture Supernates
-
Anti-inflammatory effects of green soybean extract irradiated with visible light.
Authors: Tanaka K, Ohgo Y, Katayanagi Y, Yasui K, Hiramoto S, Ikemoto H, Nakata Y, Miyoshi N, Isemura M, Ohashi N, Imai S
Sci Rep, 2014;4(0):4732.
Species: Human
Sample Types: Cell Culture Supernates
-
Opposite cytokine synthesis by fibroblasts in contact co-culture with osteosarcoma cells compared with transwell co-cultures.
Authors: David M, Kelly E, Zoellner H
Cytokine, 2013;62(1):48-51.
Species: Human
Sample Types: Cell Culture Supernates
-
Ex vivo cytokine release and pattern recognition receptor expression of subjects exposed to dampness: pilot study to assess the outcome of mould exposure to the innate immune system.
Authors: Punsmann S, Liebers V, Lotz A, Bruning T, Raulf M
PLoS ONE, 2013;8(12):e82734.
Species: Human
Sample Types: Serum
-
Human cytomegalovirus induces a biphasic inflammatory response in primary endothelial cells.
Authors: Jeffery H, Soderberg-Naucler C, Butler L
J Virol, 2013;87(11):6530-5.
Species: Human
Sample Types: Cell Culture Supernates
-
Tumor necrosis factor receptor 1 associates with CD137 ligand and mediates its reverse signaling.
Authors: Moh M, Lorenzini P, Gullo C, Schwarz H
FASEB J, 2013;27(8):2957-66.
Species: Human
Sample Types: Cell Culture Supernates
-
Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion.
Authors: Boyd A, Bennuru S, Wang Y, Sanprasert V, Law M, Chaussabel D, Nutman T, Semnani R
Infect Immun, 2013;81(5):1420-9.
Species: Human
Sample Types: Cell Culture Supernates
-
Tetra- and penta-acylated lipid A structures of Porphyromonas gingivalis LPS differentially activate TLR4-mediated NF-kappaB signal transduction cascade and immuno-inflammatory response in human gingival fibroblasts.
Authors: Herath T, Darveau R, Seneviratne C, Wang C, Wang Y, Jin L
PLoS ONE, 2013;8(3):e58496.
Species: Human
Sample Types: Cell Culture Supernates
-
Decidual natural killer cell interactions with trophoblasts are impaired in pregnancies at increased risk of preeclampsia.
Authors: Wallace A, Host A, Whitley G, Cartwright J
Am J Pathol, 2013;183(6):1853-61.
Species: Human
Sample Types: Cell Culture Supernates
-
Leptin enhances the secretion of interleukin (IL)-18, but not IL-1beta, from human monocytes via activation of caspase-1.
Authors: Jitprasertwong P, Jaedicke K, Nile C, Preshaw P, Taylor J
Cytokine, 2013;65(2):222-30.
Species: Human
Sample Types: Cell Culture Supernates
-
Selective activation of human dendritic cells by OM-85 through a NF-kB and MAPK dependent pathway.
Authors: Parola C, Salogni L, Vaira X, Scutera S, Somma P, Salvi V, Musso T, Tabbia G, Bardessono M, Pasquali C, Mantovani A, Sozzani S, Bosisio D
PLoS ONE, 2013;8(12):e82867.
Species: Human
Sample Types: Cell Culture Supernates
-
Association of TLR2 gene polymorphisms with ocular Behcet's disease in a Chinese Han population.
Authors: Fang J, Hu R, Hou S, Ye Z, Xiang Q, Qi J, Zhou Y, Kijlstra A, Yang P
Invest Ophthalmol Vis Sci, 2013;54(13):8384-92.
Species: Human
Sample Types: Cell Culture Supernates
-
S100A12 suppresses pro-inflammatory, but not pro-thrombotic functions of serum amyloid A.
Authors: Chung Y, Goyette J, Tedla N, Hsu K, Geczy C
PLoS ONE, 2013;8(4):e62372.
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Effects of high-dose cholecalciferol on serum markers of inflammation and immunity in patients with early chronic kidney disease.
Authors: Alvarez J, Zughaier S, Law J, Hao L, Wasse H, Ziegler T, Tangpricha V
Eur J Clin Nutr, 2013;67(3):264-9.
Species: Human
Sample Types: Serum
-
1,25-dihydroxyvitamin D3 protects against macrophage-induced activation of NFkappaB and MAPK signalling and chemokine release in human adipocytes.
Authors: Ding C, Wilding J, Bing C
PLoS ONE, 2013;8(4):e61707.
Species: Human
Sample Types: Cell Culture Supernates
-
Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production.
Authors: Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, Chakir J, Gounni AS
PLoS ONE, 2012;7(4):e34965.
Species: Human
Sample Types: Cell Culture Supernates
-
Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).
Authors: Suh HS, Choi N, Tarassishin L, Lee SC
PLoS ONE, 2012;7(4):e35115.
Species: Human
Sample Types: Cell Culture Supernates
-
Characterization and function of the human macrophage dopaminergic system: implications for CNS disease and drug abuse.
J Neuroinflammation, 2012;9(0):203.
Species: Human
Sample Types: Cell Culture Supernates
-
IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist.
Authors: van de Veerdonk FL, Stoeckman AK, Wu G, Boeckermann AN, Azam T, Netea MG, Joosten LA, Van der Meer JW, Hao R, Kalabokis V, Dinarello CA
Proc. Natl. Acad. Sci. U.S.A., 2012;109(8):3001-5.
Species: Human
Sample Types: Cell Culture Supernates
-
ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes.
Authors: Wilhelmsen K, Mesa K, Lucero J, Xu F, Hellman J
J Biol Chem, 2012;287(32):26478-94.
Species: Human
Sample Types: Cell Culture Supernates
-
Transglutaminase is essential for IgA nephropathy development acting through IgA receptors.
Authors: Berthelot L, Papista C, Maciel TT, Biarnes-Pelicot M, Tissandie E, Wang PH, Tamouza H, Jamin A, Bex-Coudrat J, Gestin A, Boumediene A, Arcos-Fajardo M, England P, Pillebout E, Walker F, Daugas E, Vrtosvnik F, Flamant M, Benhamou M, Cogne M, Moura IC, Monteiro RC
J. Exp. Med., 2012;209(4):793-806.
Species: Human
Sample Types: Cell Culture Supernates
-
Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti.
Authors: Arndts K, Deininger S, Specht S, Klarmann U, Mand S, Adjobimey T, Debrah AY, Batsa L, Kwarteng A, Epp C, Taylor M, Adjei O, Layland LE, Hoerauf A
PLoS Negl Trop Dis, 2012;6(4):e1611.
Species: Human
Sample Types: Cell Culture Supernates
-
Impact of vitamin D supplementation on markers of inflammation in adults with cystic fibrosis hospitalized for a pulmonary exacerbation.
Eur J Clin Nutr, 2012;66(9):1072-4.
Species: Human
Sample Types: Plasma
-
Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:C.
Authors: Drannik AG, Nag K, Yao XD, Henrick BM, Sallenave JM, Rosenthal KL
PLoS ONE, 2012;7(4):e35866.
Species: Human
Sample Types: Cell Culture Supernates
-
GLI2 Transcription Factor Mediates Cytokine Cross-talk in the Tumor Microenvironment.
Authors: Elsawa SF, Almada LL, Ziesmer SC, Novak AJ, Witzig TE, Ansell SM, Fernandez-Zapico ME
J. Biol. Chem., 2011;286(24):21524-34.
Species: Human
Sample Types: Cell Culture Supernates
-
Inhibition of IL-32 activation by alpha-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model.
Authors: Marcondes AM, Li X, Tabellini L, Bartenstein M, Kabacka J, Sale GE, Hansen JA, Dinarello CA, Deeg HJ
Blood, 2011;118(18):5031-9.
Species: Human
Sample Types: Cell Culture Supernates
-
IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes.
Authors: Pennino D, Eyerich K, Scarponi C, Carbone T, Eyerich S, Nasorri F, Garcovich S, Traidl-Hoffmann C, Albanesi C, Cavani A
J. Immunol., 2010;184(9):4880-8.
Species: Human
Sample Types: Cell Culture Supernates
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Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6.
Authors: Eikawa S, Ohue Y, Kitaoka K
J. Immunol., 2010;185(11):6734-40.
Species: Human
Sample Types: Pleural Effusion
-
Soluble erythropoietin receptor contributes to erythropoietin resistance in end-stage renal disease.
Authors: Khankin EV, Mutter WP, Tamez H
PLoS ONE, 2010;5(2):e9246.
Species: Human
Sample Types: Serum
-
PI3K/p110{delta} is a novel therapeutic target in multiple myeloma.
Authors: Ikeda H, Hideshima T, Fulciniti M
Blood, 2010;116(9):1460-8.
Species: Human
Sample Types: Cell Culture Supernates
-
Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells.
Authors: Hao Q, Wang L, Tang H
Am. J. Physiol., Cell Physiol., 2009;296(4):C821-7.
Species: Human
Sample Types: Cell Culture Supernates
-
Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling.
Authors: Huang QQ, Sobkoviak R, Jockheck-Clark AR, Shi B, Mandelin AM, Tak PP, Haines GK, Nicchitta CV, Pope RM
J. Immunol., 2009;182(8):4965-73.
Species: Human
Sample Types: Cell Culture Supernates
-
TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23.
Authors: Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M
Eur. J. Immunol., 2009;39(5):1221-30.
Species: Human
Sample Types: Cell Culture Supernates
-
Helminth antigens modulate immune responses in cells from multiple sclerosis patients through TLR2-dependent mechanisms.
Authors: Correale J, Farez M
J. Immunol., 2009;183(9):5999-6012.
Species: Human
Sample Types: Cell Culture Supernates
-
Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.
Authors: Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G
Circulation, 2009;119(10):1424-32.
Species: Human
Sample Types: Plasma
-
Carbon dioxide inhalation causes pulmonary inflammation.
Authors: Abolhassani M, Guais A, Chaumet-Riffaud P, Sasco AJ, Schwartz L
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(4):L657-65.
Species: Human
Sample Types: Cell Culture Supernates
-
Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women.
Authors: Hawn TR, Scholes D, Wang H, Li SS, Stapleton AE, Janer M, Aderem A, Stamm WE, Zhao LP, Hooton TM
PLoS ONE, 2009;4(12):e8300.
Species: Human
Sample Types: Urine
-
Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1.
Authors: Christophi GP, Panos M, Hudson CA, Tsikkou C, Mihai C, Mejico LJ, Jubelt B, Massa PT
Clin. Immunol., 2009;133(1):27-44.
Species: Human
Sample Types: Plasma
-
Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.
Authors: Scutera S, Fraone T, Musso T, Cappello P, Rossi S, Pierobon D, Orinska Z, Paus R, Bulfone-Paus S, Giovarelli M
J. Immunol., 2009;183(5):3004-13.
Species: Human
Sample Types: Cell Culture Supernates
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Reduced ex vivo interleukin-6 production by dietary fish oil is not modified by linoleic acid intake in healthy men.
Authors: Damsgaard CT, Lauritzen L, Calder PC, Kjaer TR, Frokiaer H
J. Nutr., 2009;139(7):1410-4.
Species: Human
Sample Types: Cell Culture Supernates
-
Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages.
Authors: Birrell MA, Wong S, Catley MC, Belvisi MG
J. Cell. Physiol., 2008;214(1):27-37.
Species: Human
Sample Types: Cell Culture Supernates
-
p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications.
Authors: Ishitsuka K, Hideshima T, Neri P, Vallet S, Shiraishi N, Okawa Y, Shen Z, Raje N, Kiziltepe T, Ocio EM, Chauhan D, Tassone P, Munshi N, Campbell RM, Dios AD, Shih C, Starling JJ, Tamura K, Anderson KC
Br. J. Haematol., 2008;141(5):598-606.
Species: Human
Sample Types: Cell Culture Supernates
-
Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production.
Authors: Ahmed S, Marotte H, Kwan K, Ruth JH, Campbell PL, Rabquer BJ, Pakozdi A, Koch AE
Proc. Natl. Acad. Sci. U.S.A., 2008;105(38):14692-7.
Species: Human
Sample Types: Tissue Homogenates
-
Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12.
Authors: Lamhamedi-Cherradi SE, Martin RE, Ito T, Kheradmand F, Corry DB, Liu YJ, Moyle M
J. Immunol., 2008;180(9):6000-9.
Species: Human
Sample Types: Cell Culture Supernates
-
Helminth infections associated with multiple sclerosis induce regulatory B cells.
Authors: Correale J, Farez M, Razzitte G
Ann. Neurol., 2008;64(2):187-99.
Species: Human
Sample Types: Cell Culture Supernates
-
Reduced response to adiponectin and lower abundance of adiponectin receptor proteins in type 2 diabetic monocytes.
Authors: Weigert J, Neumeier M, Wanninger J, Wurm S, Kopp A, Schober F, Filarsky M, Schaffler A, Zeitoun M, Aslanidis C, Buechler C
FEBS Lett., 2008;582(12):1777-82.
Species: Human
Sample Types: Cell Culture Supernates
-
Altered interleukin-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with pre-eclampsia.
Authors: Zhao S, Gu Y, Dong Q, Fan R, Wang Y
Placenta, 2008;29(12):1024-8.
Species: Human
Sample Types: Cell Culture Supernates
-
Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma.
Authors: Breitkreutz I, Raab MS, Vallet S, Hideshima T, Raje N, Mitsiades C, Chauhan D, Okawa Y, Munshi NC, Richardson PG, Anderson KC
Leukemia, 2008;22(10):1925-32.
Species: Human
Sample Types: Cell Culture Supernates
-
Adenosine receptors in regulation of dendritic cell differentiation and function.
Authors: Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM
Blood, 2008;112(5):1822-31.
Species: Human
Sample Types: Cell Culture Supernates
-
Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma.
Authors: Breitkreutz I, Raab MS, Vallet S, Hideshima T, Raje N, Chauhan D, Munshi NC, Richardson PG, Anderson KC
Br. J. Haematol., 2007;139(1):55-63.
Species: Human
Sample Types: Cell Culture Supernates
-
Early cytokine responses after percutaneous magnetic resonance imaging guided laser thermoablation of malignant liver tumors.
Authors: Kallio R, Sequeiros R, Surcel HM, Ohtonen P, Kiviniemi H, Syrjala H
Cytokine, 2007;34(5):278-83.
Species: Human
Sample Types: Serum
-
Preadipocyte response and impairment of differentiation in an inflammatory environment.
Authors: Poulain-Godefroy O, Froguel P
Biochem. Biophys. Res. Commun., 2007;356(3):662-7.
Species: Human
Sample Types: Cell Culture Supernates
-
Cytokine response to strenuous exercise in athletes and non-athletes--an adaptive response.
Authors: Gokhale R, Chandrashekara S, Vasanthakumar KC
Cytokine, 2007;40(2):123-7.
Species: Human
Sample Types: Plasma
-
Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling.
Authors: Weindl G, Naglik JR, Kaesler S, Biedermann T, Hube B, Korting HC, Schaller M
J. Clin. Invest., 2007;117(12):3664-3672.
Species: Human
Sample Types: Cell Culture Supernates
-
Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses.
Authors: Birrell MA, Catley MC, Hardaker E, Wong S, Willson TM, McCluskie K, Leonard T, Farrow SN, Collins JL, Haj-Yahia S, Belvisi MG
J. Biol. Chem., 2007;282(44):31882-90.
Species: Human
Sample Types: Cell Culture Supernates
-
Influence of microvascular endothelial cells on transcriptional regulation of proximal tubular epithelial cells.
Authors: Aydin S, Signorelli S, Lechleitner T, Joannidis M, Pleban C, Perco P, Pfaller W, Jennings P
Am. J. Physiol., Cell Physiol., 2007;294(2):C543-54.
Species: Human
Sample Types: Cell Culture Supernates
-
Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis.
Authors: Wu T, Xie C, Wang HW, Zhou XJ, Schwartz N, Calixto S, Mackay M, Aranow C, Putterman C, Mohan C
J. Immunol., 2007;179(10):7166-75.
Species: Human
Sample Types: Urine
-
Role of matrix metalloproteinases in the inflammatory response in human airway cell-based assays and in rodent models of airway disease.
Authors: Birrell MA, Wong S, Dekkak A, De Alba J, Haj-Yahia S, Belvisi MG
J. Pharmacol. Exp. Ther., 2006;318(2):741-50.
Species: Human
Sample Types: Cell Culture Supernates
-
The effects of dexamethasone and dehydroepiandrosterone (DHEA) on cytokines and receptor expression in a human osteoblastic cell line: potential steroid-sparing role for DHEA.
Authors: Harding G, Mak YT, Evans B, Cheung J, MacDonald D, Hampson G
Cytokine, 2006;36(1):57-68.
Species: Human
Sample Types: Cell Culture Supernates
-
TLR3 can directly trigger apoptosis in human cancer cells.
Authors: Salaun B, Coste I, Rissoan MC, Lebecque SJ, Renno T
J. Immunol., 2006;176(8):4894-901.
Species: Human
Sample Types: Cell Culture Supernates
-
Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk.
Authors: LeBouder E, Rey-Nores JE, Raby AC, Affolter M, Vidal K, Thornton CA, Labeta MO
J. Immunol., 2006;176(6):3742-52.
Species: Human
Sample Types: Cell Culture Supernates
-
A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression.
Authors: Macagno A, Molteni M, Rinaldi A
J. Exp. Med., 2006;203(6):1481-92.
Species: Human
Sample Types: Cell Culture Supernates
-
ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin.
Authors: Karadag A, Zhou M, Croucher PI
Blood, 2006;107(8):3271-8.
Species: Human
Sample Types: Cell Culture Supernates
-
Comparison of serum levels of inflammatory markers in patients with coronary vasospasm without significant fixed coronary artery disease versus patients with stable angina pectoris and acute coronary syndromes with significant fixed coronary artery disease.
Authors: Hung MJ, Cherng WJ, Cheng CW, Li LF
Am. J. Cardiol., 2006;97(10):1429-34.
Species: Human
Sample Types: Serum
-
Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1).
Authors: Palmer G, Trolliet S, Talabot-Ayer D, Mezin F, Magne D, Gabay C
Cytokine, 2005;31(2):153-60.
Species: Human
Sample Types: Cell Culture Supernates
-
Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists.
Authors: Fritz JH, Girardin SE, Fitting C, Werts C, Mengin-Lecreulx D, Caroff M, Cavaillon JM, Philpott DJ, Adib-Conquy M
Eur. J. Immunol., 2005;35(8):2459-70.
Species: Human
Sample Types: Cell Culture Supernates
-
Microbial exposure, symptoms and inflammatory mediators in nasal lavage fluid of kitchen and clerical personnel in schools.
Authors: Lignell U, Meklin T, Putus T, Vepsalainen A, Roponen M, Torvinen E, Reeslev M, Pennanen S, Hirvonen MR, Kalliokoski P, Nevalainen A
Int J Occup Med Environ Health, 2005;18(2):139-50.
Species: Human
Sample Types: Nasal Lavage Fluid
-
Biocompatibility pattern of a bicarbonate/lactate-buffered peritoneal dialysis fluid in APD: a prospective, randomized study.
Authors: Fusshoeller A, Plail M, Grabensee B, Plum J
Nephrol. Dial. Transplant., 2004;19(8):2101-6.
Species: Human
Sample Types: Peritoneal Dialysate
-
IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate.
Authors: Miranda-Carus ME, Balsa A, Benito-Miguel M, Perez de Ayala C, Martin-Mola E
J. Immunol., 2004;173(2):1463-76.
Species: Human
Sample Types: Cell Culture Supernates
-
IL-1, IL-6 and TNF-alpha concentrations in the peritoneal fluid of women with pelvic adhesions.
Authors: Cheong YC, Shelton JB, Laird SM, Richmond M, Kudesia G, Li TC, Ledger WL
Hum. Reprod., 2002;17(1):69-75.
Species: Human
Sample Types: Peritoneal Fluid
-
The correlation of adhesions and peritoneal fluid cytokine concentrations: a pilot study.
Authors: Cheong YC, Laird SM, Shelton JB, Ledger WL, Li TC, Cooke ID
Hum. Reprod., 2002;17(4):1039-45.
Species: Human
Sample Types: Peritoneal Fluid
-
Comparison of inflammatory elements in nasal lavage and induced sputum following occupational exposure to moldy-building microbes.
Authors: Purokivi M, Hirvonen MR, Roponen M, Randell J, Vahteristo M, Tukiainen H
Inhal Toxicol, 2002;14(6):653-62.
Species: Human
Sample Types: Sputum
-
Inflammatory mediators in nasal lavage, induced sputum and serum of employees with rheumatic and respiratory disorders.
Authors: Roponen M, Kiviranta J, Seuri M, Tukiainen H, Myllykangas-Luosujarvi R, Hirvonen MR
Eur. Respir. J., 2001;18(3):542-8.
Species: Human
Sample Types: Serum
-
Reproducibility of measurements of exhaled NO, and cell count and cytokine concentrations in induced sputum.
Authors: Purokivi M, Randell J, Hirvonen MR, Tukiainen H
Eur. Respir. J., 2000;16(2):242-6.
Species: Human
Sample Types: Sputum
-
Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients.
Authors: Bellini A, Marini MA, Bianchetti L, Barczyk M, Schmidt M, Mattoli S
Mucosal Immunol, 0;5(2):140-9.
Species: Human
Sample Types: Cell Culture Supernates
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IL6 secretion was measured in the supernatant of LPS-stimulated (100 ng/ml) cultured human dendritic cells after 18 hours.
Monocytes were stimulated with LPS (100 ng/ml) for 24 hours. After 24 hours, IL-6 was assessed in the supernatant.
Detection of IL-6 produced by BCMA-specific CAR-T cells in response to BCMA-negative and BCMA-positive hematopoietic cell lines.
We used this kit for the quantification of IL 6 in human serum and plasma. We could not see any signals, but very well-described protocol.
Cultured Monocytes