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Transcription Factor Bifunctional Regulators

The members of this group can act as either transcriptional co-activators or transcriptional repressors, depending on the transcription factor being regulated and the cellular context. For example, although Wilms tumor gene on the X chromosome (WTX) promotes the activation of the tumor suppressor p53 transcription factor, it also negatively regulates Wnt/beta-catenin-dependent transcription. The rest of the proteins listed here also have dual roles in transcriptional regulation.