215 results for "BRD4" in Products
BRD4 Products
BRD4 is encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq]
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #BL-149-2H5 |
| Applications: | IHC, WB, Flow, ICC/IF, IP, + 1 More |
![Western Blot: BRD4 Antibody (BL-149-2H5) [NBP2-76393]](https://resources.rndsystems.com/images/products/BRD4-Antibody-BL-149-2H5-Western-Blot-NBP2-76393-img0008.jpg "Western Blot: BRD4 Antibody (BL-149-2H5) [NBP2-76393]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF, Simple Western |
![BRD4 Antibody - BSA Free Immunohistochemistry-Paraffin: BRD4 Antibody - BSA Free [NBP1-86640]](https://resources.rndsystems.com/images/products/nbp1-86640_rabbit-polyclonal-brd4-antibody-30420251343633.jpg "Immunohistochemistry-Paraffin: BRD4 Antibody - BSA Free [NBP1-86640]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #BL-151-6F11 |
| Applications: | IHC, WB, Flow, ICC/IF, IP |
![Western Blot: BRD4 Antibody (BL-151-6F11) [NBP2-76394]](https://resources.rndsystems.com/images/products/BRD4-Antibody-BL-151-6F11-Western-Blot-NBP2-76394-img0011.jpg "Western Blot: BRD4 Antibody (BL-151-6F11) [NBP2-76394]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL1115 |
| Applications: | IHC, WB, ICC/IF, Mycoplasma |
![Western Blot: BRD4 Antibody (CL1115) [NBP2-52958]](https://resources.rndsystems.com/images/products/BRD4-Antibody-CL1115-Western-Blot-NBP2-52958-img0008.jpg "Western Blot: BRD4 Antibody (CL1115) [NBP2-52958]")
Potent and selective BET bromodomain inhibitor; cell permeable
| Chemical Name: | (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester |
| Purity: | ≥98% |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP |
![Immunohistochemistry-Paraffin: BRD4 Antibody [NBP1-18874]](https://resources.rndsystems.com/images/products/BRD4-Antibody-Immunohistochemistry-Paraffin-NBP1-18874-img0034.jpg "Immunohistochemistry-Paraffin: BRD4 Antibody [NBP1-18874]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF, ChIP |
![Immunocytochemistry/ Immunofluorescence: BRD4 Antibody [NBP2-38931]](https://resources.rndsystems.com/images/products/BRD4-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-38931-img0003.jpg "Immunocytochemistry/ Immunofluorescence: BRD4 Antibody [NBP2-38931]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL1118 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: BRD4 Antibody (CL1118) [NBP2-52959]](https://resources.rndsystems.com/images/products/BRD4-Antibody-CL1118-Western-Blot-NBP2-52959-img0007.jpg "Western Blot: BRD4 Antibody (CL1118) [NBP2-52959]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL1115 |
| Applications: | IHC, WB, ICC/IF |
![BRD4 Antibody (CL1115) Immunocytochemistry/ Immunofluorescence: BRD4 Antibody (CL1115) [NBP3-52064]](https://resources.rndsystems.com/images/products/nbp3-52064_mouse-brd4-mab-cl1115-immunocytochemistry-immunofluorescence-27320261528204.jpg "Immunocytochemistry/ Immunofluorescence: BRD4 Antibody (CL1115) [NBP3-52064]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL1115 |
| Applications: | IHC, WB, ICC/IF |
![BRD4 Antibody (CL1115) - Azide and BSA Free Immunohistochemistry-Paraffin: BRD4 Antibody [NBP3-44012]](https://resources.rndsystems.com/images/products/nbp3-44012_mouse-brd4-mab-cl1115-azide-and-bsa-free-28220251235179.jpg "Immunohistochemistry-Paraffin: BRD4 Antibody [NBP3-44012]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL1118 |
| Applications: | IHC, WB, ICC/IF |
![BRD4 Antibody (CL1118) - Azide and BSA Free Western Blot: BRD4 Antibody [NBP3-44014]](https://resources.rndsystems.com/images/products/nbp3-44014_mouse-brd4-mab-cl1118-azide-and-bsa-free-28220251211189.jpg "Western Blot: BRD4 Antibody [NBP3-44014]")
| Reactivity: | Human |
| Source: | E. coli |
| Accession #: | O60885.2 |
| Applications: | Bioactivity |
(+)-JQ1 based Degrader (PROTAC®) that preferentially degrades BRD4
| Chemical Name: | (2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% |
BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes
| Chemical Name: | 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one dihydrochloride |
| Purity: | ≥98% |
ERK5/BMK1 inhibitor; also BRD4 inhibitor
| Chemical Name: | 2-[[2-Ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one |
| Purity: | ≥98% |
Negative Control for MZ 1 (Cat. No. 6154)
| Chemical Name: | (2S,4S)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% |
(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo
| Chemical Name: | (6S)-4-(4-Chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Purity: | ≥98% |
Potent and selective (+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo
| Chemical Name: | (6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Purity: | ≥98% |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #RAB-C131 |
| Applications: | WB, ELISA, Flow, ICC/IF, IP, + 1 More |
BET bromodomain inhibitor
| Chemical Name: | 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide |
| Purity: | ≥98% |
Broad spectrum bromodomain inhibitor
| Chemical Name: | N-[(6-3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate |
| Purity: | ≥98% |
BET bromodomain inhibitor; arrests cell cycle at G1 phase
| Alternate Names: | TEN 010 |
| Chemical Name: | (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Purity: | ≥98% |
BET bromodomain inhibitor; orally bioavailable
| Alternate Names: | Birabresib |
| Chemical Name: | (6S)-4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Purity: | ≥98% |
(+)-JQ1 based PROTAC® with selectivity for BRD4
| Chemical Name: | (2S,4R)-1-(2R)-2-Acetamido-3-[[6-[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamido]hexyl]thio]-3-methylbutanoyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl)pyrrolidinine-2-carboxamide |
| Purity: | ≥98% |
Potent and high affinity BET bromodomain inhibitor; anti-inflammatory; orally bioavailable.
| Alternate Names: | GSK525762A,Molibresib |
| Chemical Name: | (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide |
| Purity: | ≥98% |
