13 results for "NK1 Receptor Antagonists Small Molecules and Peptides" in Products
NK1 Receptor Antagonists Small Molecules and Peptides
The neurokinin 1 (NK1) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS (particularly the striatum, amygdala and some hypothalamic and thalamic nuclei) and peripheral tissues.
NK1 receptors are thought to mediate central stress reactions, mood control, excitatory neurotransmission, immune modulation and airway and lung function. The receptor displays greater potency for the endogenous agonist substance P than Neurokinin A and Neurokinin B (SP > NKA > NKB). The human gene encoding the NK1 receptor has been localized on chromosome 2 (2p13.1-p12).
Potent NK1 antagonist
| Chemical Name: | (2S,3S)-3-[[3,5-bis(Trifluoromethyl)phenyl]methoxy]-2-phenylpiperidine hydrochloride |
| Purity: | ≥98% |
Potent and selective NK1 antagonist
| Chemical Name: | (3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol |
| Purity: | ≥97% |
Potent long-acting hNK1 antagonist
| Chemical Name: | 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one |
| Purity: | ≥98% |
MRGPRX2 antagonist; also NK1 receptor antagonist
| Purity: | ≥90% |
Potent and selective NK1 antagonist
| Chemical Name: | (2S,3S)-N-(2-Methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine |
| Purity: | ≥98% |
High affinity NK1 antagonist
| Chemical Name: | (2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinamine dihydrochloride |
| Purity: | ≥98% |
Potent NK1 antagonist
| Chemical Name: | 1-[2-[(3S)-3-(3,4-Dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride |
| Purity: | ≥97% |
High affinity NK1 antagonist
| Chemical Name: | 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine hydrochloride |
| Purity: | ≥98% |
Positive allosteric modulator of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant
| Chemical Name: | 3-(2,3-Difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine |
| Purity: | ≥98% |
Highly selective human NK1 antagonist
| Chemical Name: | 1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide |
| Purity: | ≥98% |
High affinity NK1 antagonist
| Chemical Name: | (4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide |
| Purity: | ≥98% |
High affinity NK1 antagonist
| Chemical Name: | (2S,3S)-N-[[2-Methoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride |
| Purity: | ≥98% |
Potent and selective NK1 antagonist
| Chemical Name: | (2S,3S)-N-[[2-Methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride |
| Purity: | ≥98% |
